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| 1 | Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome显示文摘Objective To investigate the dynamic changes observed in serum levels of interleukins (ILs), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in severe acute respiratory syndrome (SARS) patients.Methods Sixty-one cases of SARS with positive antibodies to SARS coronavirus (SARS-CoV) were classified into the following categories: initial stage (3-7 days), peak stage (8-14 days), and remission and recovery stage (15-27 days). Forty-four healthy individuals were used as controls. Serum levels of ILs, TNF-α and TGF-β1 were measured in all subjects. Serum antibodies to SARS-CoV were detected only in SARS cases. Results The mean concentration of serum IL-6 in SARS patients did not differ from that in the control group in initial and peak stages, but became significantly higher in remission and recovery stage compared with the control group, initial and peak stages (P<0.01). The mean concentration of serum IL-8 in SARS patients did not differ from that of the control group in initial stage, but was significantly higher than control group in peak stage and remission and recovery stage (P<0.05). And it was more significantly higher in remission and recovery stage than in peak stage (P<0.01). The mean concentrations of IL-16 and TNF-α in SARS patients were higher than those of the control group for every length of the clinical courses investigated, and were especially high in remission and recovery stage (P<0.01). SARS patients experienced higher concentration of serum IL-13 compared with the controls in initial stage (P<0.01), but returned to normal levels in peak stage and in remission and recovery stage. The mean concentration of serum IL-18 in SARS patients was significantly lower than that of the control group during all clinical courses (P<0.05). The mean concentration of serum TGF-β1 in SARS patients was higher than that of the control group during all clinical courses. Although TGF-β1 in serum decreased in remission and recovery stage in SARS patients, the average was still higher than that of the control group (P<0.01).Conclusions Most proinflammatory cytokines and TGF-β1 were elevated during the early phase of SARS, which may be associated with lung infiltration and proliferation. Concurrently, the mean concentration of serum IL-13 decreased gradually, and the mean concentration of serum IL-18 level in SARS patients was lower than that of the control group during all the courses of SARS, suggesting that the immune state of the patients with SARS was obviously abnormal. Observing the dynamic changes in blood cytokine levels can provide a scientific basis to assess pathogenesis and efficacy of clinical treatment of SARS. | PangBS WangZ ZhangLM TongZH XuLL HuangXX GuoWJ ZhuM WangC LiXW HeZP LiHX ZhaoFJ | 2003 | Chinese Medical Journal2003，，9： | 12 |
| 2 | An thin films fabricated by ultra-high vacuum electron-beam evaporation with ammonia for silicon-on-insulator application显示文摘 | ZHUM CHEN P FU RKY | | 0，，239： | 1 |
| 3 | Sunlight-assisted degradation of dye pollutant in Ag3PO4suspension显示文摘 | Gem M Zhum N Zho Y | 2012 | Industrial and Engineering Chemistry Research2012，51，： | 1 |
| 4 | Anewgenusoffunnel-webspiderswithnotesonrelationshipsofthefivegenerafromChina(Araneae∶Agelenidae)显示文摘 | ZhangZS(张志升) ZhuMS(朱明生)andSongDX(宋大祥) | 2006 | OrientalInsects2006，40，： | 1 |
| 5 | 显示文摘 | 朱明山(ZhuMS) 陈鹏磊(ChenPL) 刘鸣华(LiuMH) | 2013 | 化学进展2013，25，： | 1 |
| 6 | Effect of endogenous Sulfur dioxide in re-gulating cardiovascular oxidative stress显示文摘 | ZhuM DuJ LiuAD | 2014 | Histol Histopathol2014，29，9： | 1 |
| 7 | Human adipose tissue is a souree of multipotent stem cells显示文摘 | Zuk PA ZhuM Ashjian P | 2002 | Mol Biol Cell2002，13，： | 1 |
| 8 | Lotusjaponicus clath rin heavy Chain1 is associated with Rho-Like GTPase ROP6 and involved in nodule formation显示文摘 | WANGC ZHUM DUAN L etal | 2015 | Plant Physiology2015，167，4： | 1 |
| 9 | Multilineage cellsfrom human adipose tissue:Imphcations for cell-based therapies 显示文摘 | ZukPA ZhuM MizuaoH | 2001 | Tissue Eng2001，7，： | 1 |
| 10 | Acomparisonoftheproductionofethanolbetweensimultaneoussaccharificationandfermentationandseparatehydrolysisandfermentationusingunpretreatedcassavapulpandenzymecocktail显示文摘 | ZhuM LiP GongX etal | 2012 | BiosciBiotechnolBiochem2012，76，4： | 1 |
| 11 | ThevalueofhepatitisBXantigenasaprognosticmarkerinthedevelopmentofhepatocellularcarcinoma显示文摘 | ZhuM LondonT DuanLX etal | 1993 | IntJCancer1993，55，： | 1 |
| 12 | Determinationof marine primary productivity显示文摘 | FeiZ-L(费尊乐) ZhuM—Y(朱明远) | 1984 | 海洋科学进展1984，2，1： | 1 |
| 13 | Multilineage cells from human adipose tissue:implications for cell-based therapies显示文摘 | Zuk PA ZhuM MizunoH | 2001 | Tissue Eng2001，7，2： | 1 |
| 14 | The effect of age on osteogenic,adipogenic and proliferative potential of female adipose-derived stemcells显示文摘 | ZhuM Kohan E Bradley J | 2009 | J Tissue Eng Regen Med2009，3，4： | 1 |
| 15 | AnovelmethodforsynthesisofphosphomolybdicacidGmodifiedPd/CcataGlystsforoxygenreductionreaction显示文摘 | ZhuM Y GaoXL LuoGQ etal | 2013 | JPowerSources2013，225，： | 1 |
| 16 | Establishpostresponsiblepharmaciststostrengthenpharmaceuticalcareteam[J]显示文摘 | GUODH SUNY ZHUM etal | 2011 | 中国药师2011，14，10： | 1 |
| 17 | The syn- thesis, light-harvesting, and photocatalysis of naphthyl- porphyrin functionalized platinum nanocomposites显示文摘 | MingS ZhuM H DuYK Yang P | 2010 | Dyes and Pigments2010，86，： | 1 |
| 18 | Mesoderm is committed to hemato-endothelial and cardiac lineages in human embryoid bodies by sequential exposure to cytokines显示文摘 | ZhuM ZhaoJ ChenG | 2013 | Exp Cell Res2013，319，1： | 1 |
| 19 | Photocatalytic degradation of dimethoate using nanosized TiO2 powder显示文摘 | Chen J Q Wang D ZhuM X | | 0，，1： | 1 |
| 20 | Multilineage cells from human adipose tissue:implication for cell- based therapies显示文摘 | ZukPA ZhuM MizunoH | 2001 | Tissue Eng2001，7，2： | 1 |
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