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44篇 您的检索式:作者名="ZHAO Yujing"
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1Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF,and the neutralization of miR-150 attenuate tumor development显示文摘Tumor-associated macrophages(TAMs)mostly exhibit M2-like(alternatively activated)properties and play posi-tive roles in angiogenesis and tumorigenesis.Vascular en-dothelial growth factor(VEGF)is a key angiogenic factor.During tumor development,TAMs secrete VEGF and other factors to promote angiogenesis;thus,anti-treatment against TAMs and VEGF can repress cancer development,which has been demonstrated in clinical trials and on an experimental level.In the present work,we show that miR-150 is an oncomir because of its promotional effect on VEGF.MiR-150 targets TAMs to up-regulate their secre-tion of VEGF in vitro.With the utilization of cell-derived vesicles,named microvesicles(MVs),we transferred an-tisense RNA targeted to miR-150 into mice and found that the neutralization of miR-150 down-regulates miR-150 and VEGF levels in vivo and attenuates angiogenesis.There-fore,we proposed the therapeutic potential of neutralizing miR-150 to treat cancer and demonstrated a novel,natu-ral,microvesicle-based method for the transfer of nucleic acids.Yuchen Liu Luming Zhao Dameng Li Yuan Yin Chen-Yu Zhang Jing Li Yujing Zhang 2013Protein & Cell2013,4,12:18
2The discovery of the oldest rocks in the Kuluketage area and its geological implications显示文摘The basement rocks in the Kuluketage area are composed predominately of tonalite-trondhjemite-granodiorite rocks, and occured mainly in Xinger and Korla. U-Pb dating of TTG gneiss near Korla yielded a late Neoarchean weighted mean 207Pb/206Pb age of 2.65 Ga, which is the oldest published age for the TTG rocks in the Kuluketage area and thus suggests that Archean terrane in the area was formed in the late Neoarchean. The Korla gneiss is much younger than the TTG rocks in the northern Altyn Tagh, eastern Tarim Craton, indicating that the oldest terrane of the Tarim Craton was exposed probably in the northern Altyn Tagh. Until late Neoarchean, the Tarim continent extends to the Kuluketage area and finally had generated a relatively large uniform Archean basement within the craton. Zircon Hf isotopic analyses of the TTG gneiss give low εHf(t) values (-5 to 1) with Paleoarchean to Mesoarchean two-stage model ages (TDM2) between 3.0 and 3.3 Ga, suggesting that the basement rocks in the northern Tarim Craton were derived dominately from partial melting of Paleoarchean to Mesoarchean juvenile crustal material. The Hf model ages, therefore, indicate that no continent crust older than 3.3 Ga existed in the Kuluketage area.LONG XiaoPing YUAN Chao SUN Min XIAO WenJiao ZHAO GuoChun ZHOU KeFa WANG YuJing HU AiQin 2011Science China Earth Sciences2011,54,3:16
3The levels, sources and reactivity of volatile organic compounds in a typical urban area of Northeast China显示文摘Air concentrations of volatile organic compounds(VOCs) were continually measured at a monitoring site in Shenyang from 20 August to 16 September 2017. The average concentrations of alkanes, alkenes, aromatics and carbonyls were 28.54, 6.30, 5.59 and9.78 ppbv, respectively. Seven sources were identified by the Positive Matrix Factorization model based on the measurement data of VOCs and CO. Vehicle exhaust contributed the most(36.15%) to the total propene-equivalent concentration of the measured VOCs,followed by combustion emission(16.92%), vegetation emission and secondary formation(14.33%), solvent usage(10.59%), petrochemical industry emission(9.89%), petrol evaporation(6.28%), and liquefied petroleum gas(LPG) usage(5.84%). Vehicle exhaust, solvent usage and combustion emission were found to be the top three VOC sources for O_3 formation potential, accounting for 34.52%, 16.55% and 11.94%, respectively. The diurnal variation of the total VOCs from each source could be well explained by their emission characteristics,e.g., the two peaks of VOC concentrations from LPG usage were in line with the cooking times for breakfast and lunch. Wind rose plots of the VOCs from each source could reveal the possible distribution of the sources around the monitoring site. The O_3 pollution episodes during the measurement period were found to be coincident with the elevation of VOCs, which was mainly due to the air parcel from the southeast direction where petrochemical industry emission was found to be dominant, suggesting that the petrochemical industry emission from the southeast was probably a significant cause of O_3 pollution in Shenyang.Zhuobiao Ma Chengtang Liu Chenglong Zhang Pengfei Liu Can Ye Chaoyang Xue Di Zhao Jichen Sun Yiming Du Fahe Chai Yujing Mu 2019Journal of Environmental Sciences2019,31,5:12
4Expression of voltage.gated sodium channel Nav1.5 in non.metastatic colon cancer and its associations with estrogen receptor(ER)-βexpression and clinical outcomes显示文摘Background: Voltage-gated sodium channel 1.5(Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes and estrogen receptor-β(ER-β)expression in non-metastatic colon cancer patients receiving radical resection.Methods: A total of 269 consecutive patients with pathologically confirmed stages Ⅰ-Ⅲ colon cancer who underwent radical resection were selected. Nav1.5 and ER-β expression was detected by using immunohistochemistry(IHC)on tissue microarray constructed from paraffin-embedded specimens. IHC score was determined according to the percentage and intensity of positively stained cells. Statistical analysis was performed with the X-tile method, k coefficient, Chi square test or Fisher's exact test, logistic regression, log-rank test, and Cox proportional hazards models.Results: We found that Nav1.5 was commonly expressed in tumor tissues with higher mean IHC score as compared with matched tumor-adjacent normal tissues(5.1 ± 3.5 vs. 3.5 ± 2.7, P < 0.001).The high expression of Nav1.5 in colon cancer tissues was associated with high preoperative carcinoembryonic antigen level [odds ratio(OR) = 2.980;95% confidential interval(CI)1.163-7.632; P = 0.023] and high ER-β expression(OR = 2.808; 95% CI 1.243-6.343;p = 0.00 3). Log-rank test results showed that high Nav1.5 expression contributed to a low 5-year disease-free survival(DFS) rate in colon cancer patients(77.2% vs. 92.1%, P = 0.048), especially in patients with high ER-β expression tumor(76.2% vs. 91.3%, P = 0.032). Analysis with Cox proportional hazards model demonstrated that high Nav1.5 expression[hazard ratio(HR) = 2.738; 95% CI 1.100-6.819;P = 0.030] and lymph node metastasis(HR = 2.633; 95% CI 1.632-4.248; P < 0.001) were prognostic factors for unfavorable DFS in colon cancer patients.Conclusions: High expression of Nav1.5 was associated with high expression of ER-β and indicated unfavorable oncologic prognosis in patients with non-metastatic colon cancer.Jianhong Peng Qingjian Ou Xiaojun Wu Rongxin Zhang Qian Zhao Wu Jiang Zhenhai Lu Desen Wan Zhizhong Pan Yujing Fang 2017Chinese Journal of Cancer2017,36,12:7
5Induction of matrix metalloproteinase-9 and-2 activity in mouse blastocyst by fibronectin-integrin interaction显示文摘Fibronectin, a major extracellular matrix, plays an important role in embryo implantation by mediating embryo adhesion and outgrowth. In this work, mouse blastocysts produced pro-matrix metalloproteinase-9, pro-matrix metalloproteinase-2 and 64 ku matrix metalloproteinase-2 when they were co-cultured with fibronectin. In contrast, mouse blastocysts did not produce these proteinases without fibronectin. Focal adhesion kinase is a fundamental molecule of integrin signaling pathway and its antisense oligodeoxynucleiotide inhibited blastocyst matrix metalloproteinases expression induced by fibronectin. The results indicated that fibronectin triggered matrix metalloproteinase-9 and -2 expression in mouse blastocyst through its integrin receptors and subsequent signaling pathway, which enhanced the synchronization of blastocyst invasiveness and uterine receptivity and ensured the accuracy of events relative to implantation in timing and spatiality.TIE Guodong CAO Yujing ZHAO Xingxu Duan Enkui 2000Chinese Science Bulletin2000,45,14:7
6Heterogeneously supported pseudo-single atom Pt as sustainable hydrosilylation catalyst显示文摘Huachao Zai Yizhou Zhao Shanyu Chen Lei Ge Changfeng Chen Qi Chen Yujing Li 2018Nano Research2018,11,5:6
7Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis显示文摘Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response outcomes.Although the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains unknown.Here,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.Pharmacological modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory injury.Mechanistically,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of MDSCs.Our studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation.Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian Wang Zhengguo Zhang Yu Wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao Ruoning Wang Guangwei Liu 2018Cellular & Molecular Immunology2018,15,6:4
8The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu 2022Science China(Life Sciences)2022,65,12:4
9mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration显示文摘Hair follicles(HFs)undergo cycles of degeneration(catagen),rest(telogen),and regeneration(anagen)phases.Anagen begins when the hair follicle stem cells(HFSCs)obtain sufficient activation cues to overcome suppressive signals,mainly the BMP pathway,from their niche cells.Here,we unveil that mTOR complex 1(mTORC1)signaling is activated in HFSCs,which coincides with the HFSC activation at the telogen-to-anagen transition.By using both an inducible conditional gene targeting strategy and a pharmacological inhibition method to ablate or inhibit mTOR signaling in adult skin epithelium before anagen initiation,we demonstrate that HFs that cannot respond to mTOR signaling display significantly delayed HFSC activation and extended telogen.Unexpectedly,BMP signaling activity is dramatically prolonged in mTOR signaling-deficient HFs.Through both gain-and loss-of-function studies in vitro,we show that mTORC1 signaling negatively affects BMP signaling,which serves as a main mechanism whereby mTORC1 signaling facilitates HFSC activation.Indeed,in vivo suppression of BMP by its antagonist Noggin rescues the HFSC activation defect in mTORC1-null skin.Our findings reveal a critical role for mTOR signaling in regulating stem cell activation through counterbalancing BMP-mediated repression during hair regeneration.Zhili Deng Xiaohua Lei Xudong Zhang Huishan Zhang Shuang Liu Qi Chen Huimin Hu Xinyue Wang Lina Ning Yujing Cao Tongbiao Zhao Jiaxi Zhou Ting Chen Enkui Duan 2015Journal of Molecular Cell Biology2015,7,1:3
10PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level.Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li 2023Nano-Micro Letters2023,15,9:3
11Effect of potential HONO sources on peroxyacetyl nitrate(PAN)formation in eastern China in winter显示文摘As an important secondary photochemical pollutant,peroxyacetyl nitrate(PAN)has been studied over decades,yet its simulations usually underestimate the corresponding observations,especially in polluted areas.Recent observations in north China found unusually high concentrations of PAN during wintertime heavy haze events,but the current model still cannot reproduce the observations,and researchers speculated that nitrous acid(HONO)played a key role in PAN formation.For the first time we systematically assessed the impact of potential HONO sources on PAN formation mechanisms in eastern China using the Weather Research and Forecasting/Chemistry(WRF-Chem)model in February of 2017.The results showed that the potential HONO sources significantly improved the PAN simulations,remarkably accelerated the RO x(sum of hydroxyl,hydroperoxyl,and organic peroxy radicals)cycles,and resulted in 80%–150%enhancements of PAN near the ground in the coastal areas of eastern China and 10%–50%enhancements in the areas around 35–40°N within 3 km during a heavy haze period.The direct precursors of PAN were aldehyde and methylglyoxal,and the primary precursors of PAN were alkenes with C>3,xylenes,propene and toluene.The above results suggest that the potential HONO sources should be considered in regional and global chemical transport models when conducting PAN studies.Jingwei Zhang Yitian Guo Yu Qu Yong Chen Ruipeng Yu Chaoyang Xue Rui Yang Qiang Zhang Xingang Liu Yujing Mu Jing Wang Can Ye Haihan Zhao Qiangqiang Sun Ziwen Wang Junling An 2020Journal of Environmental Sciences2020,32,8:3
12IGF-Ⅱ and IGFBP-1 reversely regulate blastocyst implantation in mouse显示文摘Insulin-like growth factor (IGF)-Ⅱ and IGF binding protein (IGFBP)-1, members of IGF family, are important in the cyclic development of endometrium and the blastocyst implantation. In the present study, the indirect immunofluorescence showed that IGF- Ⅱ and IGFBP-1 were specifically expressed at the maternal-fetal interface. In a co-culture system, IGF-Ⅱ significantly enhanced the attachment and outgrowth of the blastocyst on monolayer of uterine epithelial cells, while IGFBP-1 did not affect the blastocyst attachment, but markedly inhibited the blastocyst outgrowth. The results of zymography showed that IGF- Ⅱ enhanced the activities of MMP-2 and MMP-9, while IGFBP-1 did not affect the activities of MMP-2 and MMP-9. In conclusion, the equilibrium between the invasion of tro-phoblast and the inhibition of deciduas may be regulated by the interaction between the IGF- Ⅱ -expressing invading cy-totrophoblast and maternal deciduas-derived IGFBP-1.TIAN Yongqiang, TIE Guodong, CAO Yujing, ZHAO Xingxu & DUAN Enkui1. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China 2. College of Vet Medicine, Gansu Agricultural University, Lanzhou 730070, China 2002Chinese Science Bulletin2002,47,21:3
13Implementation of One-Way Quantum Computing with a Hybrid Solid-State Quantum System显示文摘We proposed an efficient scheme for implementing the large-scale one-way Quantum computing(QC)with a novel hybrid solid-state quantum system. This system consists of N Nitrogen-vacancy(N-V) centers coupled to N separate Transmission line resonators(TLRs), which are interconnected by a Current-biased Josephson junction(CBJJ) superconducting phase qubit. We showed the way of preparation of N-qubit linear cluster state with N N-V centers, then we demonstrated the way of extending cluster state by connecting two pieces of linear cluster states into two-dimensional cluster state, last, with our designed new structures, we demonstrated the QC basic operations.It means that our scheme may open up promising possibilities for implementing the practical and scalable one-way quantum computers with the hybrid solid-state quantum system. We discussed the experimental feasibility of our system.ZHAO Yujing CHEN Xiongwen SHI Zhengang ZHOU Fang XIANG Shaohua SONG Kehui 2017Chinese Journal of Electronics2017,26,1:3
14Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway显示文摘Yi Yang Wang Li Yang Liu Yuning Sun Yan Li Qing Yao Jianning Li Qian Zhang Yujing Gao Ling Gao Jiajun Zhao 2014The Journal of Nutritional Biochemistry2014,,:3
15Heterojunction-Type Photocatalytic System Based on Inorganic Halide Perovskite CsPbBr3显示文摘of main observation and conclusion The heterojunction-type structure has shown significant merits in tuning the optical properties and carrier physics.Inspired by the excellent absorption capability of halide perovskite materials for visible light,a series of CsPbBr3/TiO2 heterojunction-type photocatalysts with various all-inorganic-perovskite/TiO2 ratios are successfully fabricated by the ligand-assisted reprecipitation(LARP)method.The heterojunction structure extends the light absorption of TiO2 with good chemical and structural stability.A Pb-O interaction at the CsPbBr3/TiO2 interface is observed by the XPS and confirmed by the TRPL showing improved interface carrier transport and stability.The heterojunction-type catalyst shows drastically enhanced photocatalytic activity towards the direct oxidation of toluene with 02 molecule,as an important reaction for organic chemical synthesis.The optimized sample shows an activity of 2356μmol·g^-1·h^-1 at 75℃,4 times of that of the naked CsPbBr3 nanocrystals,and 3 times of that of the bare TiO2.Based on the investigation with trapping agents,a reaction mechanism is hence proposed suggesting that the photo-generated hole may be involved in the rate-limiting step.This work demonstrates the potential of inorganic halide perovskite-based heterojunction structure for photocatalytic applications.Enbo Zhu Yizhou Zhao Yi Dai Qiuhe Wang Yuanyuan Dong Qi Chen Yujing Li 2020Chinese Journal of Chemistry2020,38,12:3
16Polarization microwave-induced thermoacoustic imaging for quantitative characterization of deep biological tissue microstructures显示文摘Polarization optical imaging can be used to characterize anisotropy in biological tissue microstructures and has been demonstrated to be a powerful tool for clinical diagnosis. However, the approach is limited by an inability to image targets deeper than ~1 mm due to strong optical scattering in biological tissues. As such, we propose a novel polarization microwave-induced thermoacoustic imaging(P-MTAI) technique to noninvasively detect variations in deep tissue by exploiting the thermoacoustic signals induced by four pulsed microwaves of varying polarization orientations. The proposed P-MTAI method overcomes the penetration limits of conventional polarization optical imaging and provides submillimeter resolution over depths of several centimeters. As part of the paper, the structural characteristics of tissues were quantified using a new parameter, the degree of microwave absorption anisotropy. P-MTAI was also applied to the noninvasive detection of morphological changes in cardiomyocytes as they transitioned from ordered to disordered states, providing a potential indication of myocardial infarction.YUJING LI SHANXIANG ZHANG LINGHUA WU ZHONGWEN CHENG ZHENHUI ZHANG HAOHAO WANG SHUXIANG ZHAO MINGYANG REN SIHUA YANG DA XING HUAN QIN 2022Photonics Research2022,10,5:2
17Large Room-Temperature Magnetoresistance in van der Waals Ferromagnet/Semiconductor Junctions显示文摘A magnetic tunnel junction(MTJ)is the core component in memory technologies,such as the magnetic random-access memory,magnetic sensors and programmable logic devices.In particular,MTJs based on twodimensional van der Waals(vd W)heterostructures offer unprecedented opportunities for low power consumption and miniaturization of spintronic devices.However,their operation at room temperature remains a challenge.Here,we report a large tunnel magnetoresistance(TMR)of up to 85%at room temperature(T=300 K)in vdW MTJs based on a thin(<10 nm)semiconductor spacer WSe_(2)layer embedded between two Fe_(3)GaTe_(2e)lectrodes with intrinsic above-room-temperature ferromagnetism.The TMR in the MTJ increases with decreasing temperature up to 164%at T=10 K.The demonstration of TMR in ultra-thin MTJs at room temperature opens a realistic and promising route for next-generation spintronic applications beyond the current state of the art.Wenkai Zhu Shihong Xie Hailong Lin Gaojie Zhang Hao Wu Tiangui Hu Ziao Wang Xiaomin Zhang Jiahan Xu Yujing Wang Yuanhui Zheng Faguang Yan Jing Zhang Lixia Zhao Amalia Patanè Jia Zhang Haixin Chang Kaiyou Wang 2022Chinese Physics Letters2022,39,12:2
18Electro-Fenton oxidation of pesticides with a novel Fe 3 O 4 @Fe 2 O 3 /activated carbon aerogel cathode: High activity, wide pH range and catalytic mechanism显示文摘Hongying Zhao Yujing Wang Yanbin Wang Tongcheng Cao Guohua Zhao 2012Applied Catalysis B: Environmental2012,,:2
19Geochemistry, zircon U–Pb ages and Lu–Hf isotopes of early Paleozoic plutons in the northwestern Chinese Tianshan: Petrogenesis and geological implications显示文摘Zongying Huang Xiaoping Long Alfred Kr?ner Chao Yuan Qiang Wang Min Sun Guochun Zhao Yujing Wang 2013LITHOS2013,,:1
20Carbon nanotube/raspberry hollow Pd nanosphere hybrids for methanol, ethanol, and formic acid electro-oxidation in alkaline media显示文摘Zhelin Liu Bo Zhao Cunlan Guo Yujing Sun Yan Shi Haibin Yang Zhuang Li 2010Journal of Colloid And Interface Science2010,,:1
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