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| 1 | Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase显示文摘Human endogenous retrovirus W env(HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis(MS). These diseases are accompanied by immunological reactions in the central nervous system(CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter – nitric oxide(NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env. Moreover, HERV-W env increased the expression and function of human inducible nitric oxide synthase(hi NOS) and enhanced the promoter activity of hi NOS. Microglial migration was also enhanced. These data revealed that HERV-W env might contribute to increase NO production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible NOS. Results from this study might lead to the identification of novel targets for the treatment of neuropsychological diseases, including neuroinflammatory diseases, stroke, and neurodegenerative diseases. | Ran Xiao Shan Li Qian Cao Xiuling Wang Qiujin Yan Xiaoning Tu Ying Zhu Fan Zhu | 2017 | Virologica Sinica2017，32，3： | 3 |
| 2 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 3 | Coal petrology and genesis of Jurassic coal in the Ordos Basin,China显示文摘简单结构和浅埋葬深度描绘的厚煤床的多重集合在 Ordos 盆的早、中间的侏罗记阶层被开发,西北的中国。这高质量的煤的巨大的储备有高商业的价值。我们学习了煤岩石学的特征和它的 maceral 分发到决定 macerals 贡献到油和气体的产生。结果证明因为主要是在上面的河的系统的一系列高看台的沼泽地的盆唯一的 depositional 环境,在 Ordos 盆的侏罗记煤有特殊 petrological 特征。这些 petrographic 特征是一些沙身体被移植河形成的典型内陆湖的发展的结果。在埋葬以后,泥炭继续经历氧化条件,产生广泛的更高的 inertinite 在煤满足的这个过程和 vitrinite 部件被改变到 semi-vitrinite。这些侏罗记煤的宏观的 petrographic 类型主要是半迟钝的煤,迟钝的煤, semilustrous 和有光泽的煤。半迟钝的煤和迟钝的煤的比例在盆边缘是更高的,特别在北边缘附近的区域。semilustrous 和有光泽的煤的数字向南并且向中央盆增加。这种状况显示不同形成煤的沼泽地环境让学生在煤部件上控制效果。另一观察是在 Ordos 煤序列,特别在更低的部分,一些沙岩床是厚的,直到有一种粗糙的谷物尺寸的 20 m。在 macerals 的更高的 fusinite 内容与更多的完全、常规的植物房间结构伴随一个更高的 semi-vitrinite 内容。fusinite 结构清楚、很好保存。在埋葬以后,房顶和地板岩石的岩性学能继续影响煤岩石学的进化。在房顶和地板的沙身体展出好物理条件以便毛孔水能维持氧化,循环和连接的一个长期的状态到煤。煤部件因此很长时间留在氧化环境。在盆中心,在埋葬和随后的煤床很快进入了减少的环境以后,相反地,开发的湖的外形和泥炭被 mudstone 很快盖住。作为结果,丰富的胶凝化作用发生了, vitrinite 内容增加了。Exinite 经常在煤床上在一个特定的位置积累了。尽管平均 exinite 内容不总体上高,它显著地确实贡献全部的烃产生。exinite 内容被低估了,特别非结晶的沥青的液体和它的重要性这里被强调。原因是液体容易流进有强壮的刚硬的 fusinite,或流进一些裂缝,在它通常被忽视的地方。 | Weihua Ao Wenhui Huang Chengmin Weng Xiuling Xiao Dameng Liu Xiuyi Tang Ping Chen Zhigen Zhao Huan Wan Robert B.Finkelman | 2012 | Geoscience Frontiers2012，3，1： | 3 |
| 4 | Human leukemia antigen-A0201-restricted epitopes of humanendogenous retrovirus W family envelope(HERV-W env)inducestrong cytotoxic T lymphocyte responses显示文摘Human endogenous retrovirus W family(HERV-W) envelope(env) has been reported to be related to several human diseases, including autoimmune disorders, and it could activate innate immunity.However, there are no reports investigating whether human leukemia antigen(HLA)-A~*0201^+restriction is involved in the immune response caused by HERV-W env in neuropsychiatric diseases. In the present study, HERV-W env-derived epitopes presented by HLA-A~*0201 are described with the potential for use in adoptive immunotherapy. Five peptides displaying HLAA~*0201-binding motifs were predicted using SYFEPITHI and BIMAS, and synthesized. A CCK-8 assay showed peptides W, Q and T promoted lymphocyte proliferation. Stimulation of peripheral blood mononuclear cells from HLA-A~*0201^+ donors with each of these peptides induced peptidespecific CD8^+ T cells. High numbers of IFN-γ-secreting T cells were also detectable after several weekly stimulations with W, Q and T. Besides lysis of HERV-W env-loaded target cells, specific apoptosis was also observed. These data demonstrate that human T cells can be sensitized toward HERV-W env peptides(W, Q and T) and, moreover, pose a high killing potential toward HERV-W env-expressing U251 cells. In conclusion, peptides W Q and T, which are HERV-W env antigenic epitopes, have both antigenicity and immunogenicity, and can cause strong T cell immune responses. Our data strengthen the view that HERV-W env should be considered as an autoantigen that can induce autoimmunity in neuropsychiatric diseases, such as multiple sclerosis and schizophrenia. These data might provide an experimental foundation for a HERV-W env peptide vaccine and new insight into the treatment of neuropsychiatric diseases. | Xiaoning Tu Shan Li Lijuan Zhao Ran Xiao Xiuling Wang Fan Zhu | 2017 | Virologica Sinica2017，32，4： | 3 |
| 5 | Effects of organic additives on hydrothermal zirconia nanocrystallites 显示文摘 | Xiuling Jiao Dairong Chen Lihua Xiao | 2003 | Journal of Crystal Growth2003，258，12： | 1 |
| 6 | Effects of organic additives on hydrothermal zirconia nanocrystallites显示文摘 | Xiuling Jiao Dairong Chen Lihua Xiao | 2003 | Journal of Crystal Growth2003，，1： | 1 |
| 7 | Characterization of Phthalides in Ligusticum chuanxiong by Liquid Chromatographic-Atmospheric Pressure Chemical Ionization-Mass Spectrometry显示文摘 | Xiaozhe Zhang Hongbin Xiao Qing Xu Xiuling Li Jianing Wang Xinmiao Liang | 2003 | Journal of Chromatographic Science2003，，8： | 1 |
| 8 | Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis显示文摘 | Junjie Chai Menghebat Jiao Wei Sun Deyu Liang Bin Shi Jincao Fu Chen Li Xiong Mao Yiding Wang Xiuling Dolikun Guliber Wang Yanchun Gao Fanghua Xiao Shuhua | 2003 | Parasitology International2003，，1： | 1 |
| 9 | LC–MS/MS determination of naringin, hesperidin and neohesperidin in rat serum after orally administrating the decoction of Bulpleurum falcatum L. and Fractus aurantii显示文摘 | Xiuling Li Hongbin Xiao Xinmiao Liang Dazhuo Shi Jiangang Liu | 2003 | Journal of Pharmaceutical and Biomedical Analysis2003，，1： | 1 |
| 10 | Asymptotic controllability of a class of discrete-time systems with disturbances显示文摘This article deals with the uniformly globally asymptotic controllability of discrete nonlinear systems with disturbances.It is shown that the system is uniformly globally asymptotic controllability with respect to a closed set if and only if there exists a smooth control Lyapunov function.Further, it is obtained that the control Lyapunov function may be used to construct a feedback law to stabilize the closed-loop system.In addition, it is proved that for periodic discrete systems, the resulted control Lyapunov functions are also time periodic. | Cai Xiushan Wang Xiao Xu Xiuling | 2009 | Journal of Systems Engineering and Electronics2009，20，6： | 0 |
| 11 | Role of exercise training on insulin resistance and TNF-α in high-fat diet rats显示文摘This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-αin high-fat diet-induced insulin-resistant rats.Thirty male Wistar rats were randomly divided into two groups:normal control group(NC;n=8)that accepted normal chow and high-fat diet group(HF;n=22)that fed on high-fat diet to induce insulin resistance model.The HF group was randomly assigned to two subgroups after 18 weeks:sedentary group(SE;n=10)and exercise training group(ET;n=12)that performed swimming exercise training for 6 weeks,while both groups continued high-fat diet.Changes of body weight,lipid profile,and fasting plasma glucose and insulin were measured.The insulin sensitivity index(ISI)was calculated.Serum concentration of TNF-αwas detected by ELISA.The expression of TNF-αmRNA and protein in adipose tissue was examined by using real-timefluorescence quantitative polymerase chain reaction(PCR)and Western blot,respectively.After 18 weeks,compared with the NC group,body weight,blood lipid,glucose,and insulin in the HF group were significantly elevated,while the ISI decreased obviously,which suggested that insulin resistance appeared in the HF group.After exercise training for 6 weeks,compared with the SE group,both ISI and serum TNF-αconcentration in the ET group were decreased significantly;however,the expression levels of TNF-αmRNA and protein in adipose tissue increased by 27.5%and 20.5%,respectively.In conclusion,exercise training ameliorates insulin resis-tance.The reduction of the level of serum TNF-αand the increased expression of TNF-αin adipose tissue by exercise training may be involved in this mechanism. | Hui SUN Xiuling DENG Fangxi XIAO Lulu CHEN Huiqing LI | 2009 | Frontiers of Medicine2009，3，4： | 0 |
| 12 | Pacer通过与Stx17相互作用把PI3KC3和HOPS复合物亚基招募到自噬膜泡显示文摘文章简介自噬是基于溶酶体的胞内降解途径,对维持细胞的稳态维持有重要作用。自噬参与生物体发育、免疫反应、代谢调节、细胞凋亡和衰老等多种过程。自噬异常与神经退行性疾病、免疫紊乱等发生密切相关。 | Xiawei Cheng Xiuling Ma Xianming Ding Lin Li Xiao Jiang Zhirong Shen She Chen Wei Liu 龚渭华 孙启明 | 2018 | 科学新闻2018，0，4： | 0 |
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