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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 3 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 4 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 5 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 6 | Mechanism of chain propagation for the synthesis of polyoxymethylene dimethyl ethers显示文摘Polyoxymethylene dimethyl ethers(PODE)were synthesized from the reaction of paraformaldehyde with dimethoxymethane(DMM)over different acid catalysts at different conditions.Products were found to follow the Schulz-Flory distribution law.The chain propagation proceeds through the insertion of an individual segment of CH2O one by one,while the simultaneous insertion of a few CH2O segments or their assembly is unlikely.Due to the restriction of this law,it is difficult to increase the selectivity to the desired products(e.g.,PODE3 4). | Yupei Zhao Zheng Xu Hui Chen Yuchuan Fu Jianyi Shen | 2013 | Journal of Energy Chemistry2013，22，6： | 36 |
| 7 | Development of a New Index for Integrating Landscape Patterns with Ecological Processes at Watershed Scale显示文摘Understanding the relationship between landscape patterns and ecological processes has been a central yet challenging research theme in landscape ecology. Over the past decades,many landscape metrics have been proposed but few directly incorporated ecological processes. In this paper,we developed a landscape index,namely,location-weighted landscape index(LWLI) to highlight the role of landscape type in ecological processes,such as nutrient losses and soil erosion. Within the framework of the Lorenz curve theory,we develop this index by integrating landscape pattern and point-based measurements at a watershed scale. The index can be used to characterize the contribution of landscape pattern to ecological processes(e.g. nutrient losses) with respect to a specific monitoring point in a watershed. Through a case study on nutrient losses in an agricultural area in northeastern China,we found that nutrient losses tended to be higher for a watershed with a higher LWLI value,and vice versa. It implied that LWLI can be used to evaluate the potential risk of nutrient losses or soil erosion by comparing their values across watersheds. In addition,this index can be extended to characterize ecological processes,such as the effect of landscape pattern on wildlife inhabitation and urban heat island effect. Finally,we discuss several problems that should be paid attention to when applying this index to a heterogeneous landscape site. | CHEN Liding TIAN Huiying FU Bojie ZHAO Xinfeng | 2009 | Chinese Geographical Science2009，19，1： | 38 |
| 8 | Ginsenoside Rbl protects cardiomyocytes against CoCl2-induced apoptosis in neonatal rats by inhibiting mitochondria permeability transition pore opening显示文摘 | Hong-liang KONG Zhan-quan LI Ying-jun ZHAO Shu-mei ZHAO Li ZHU Tong LI Yao FU Hui-jun LI | 2010 | Acta Pharmacologica Sinica2010，31，6： | 35 |
| 9 | Reactive Current Allocation and Control Strategies Improvement of Low Voltage Ride Though for Doubly Fed Induction Wind Turbine Generation System显示文摘为满足风电机组低电压穿越(low voltage ride through,LVRT)的测试要求及其电气模型一致性评估需要,提出考虑向电网注入无功电流的双馈风电机组LVRT的控制策略。在阐述风电机组LVRT测试要求及控制原理的基础上,推导双馈发电机(doubly fed induction generator,DFIG)定子侧及网侧变流器输出无功电流极限表达式,研究电网电压跌落深度和发电机总输出有功功率对其无功电流极限值的影响规律,进而提出DFIG在LVRT期间的无功电流分配算法和改进的有功、无功功率控制策略。最后,以某实际2 MW双馈风电机组为例,分别对风速为5和12 m/s、电网电压对称跌落至20%和50%工况下的LVRT运行性能进行仿真比较和样机测试。与传统LVRT控制方法的对比表明,所提改进控制策略能更好地满足风电机组LVRT的测试要求。样机测试结果进一步证明了改进控制策略和仿真模型的有效性。 | LI Hui FU Bo YANG Chao ZHAO Bin TANG Xianhu | 2012 | 中国电机工程学报2012，32，22： | 36 |
| 10 | Deferoxamine promotes recovery of traumatic spinal cord injury by inhibiting ferroptosis显示文摘Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows:(1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group.(2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group.(3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury.(4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group.(5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2(ACSF2) and iron-responsive element-binding protein 2(IREB2) were up-regulated in the Deferoxamine group.(6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. | Xue Yao Yan Zhang Jian Hao Hui-Quan Duan Chen-Xi Zhao Chao Sun Bo Li Bao-You Fan Xu Wang Wen-Xiang Li Xuan-Hao Fu Yong Hu Chang Liu Xiao-Hong Kong Shi-Qing Feng | 2019 | Neural Regeneration Research2019，14，3： | 35 |
| 11 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 12 | Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns显示文摘 | Wei Xiao Qing-Fang Duan Wen-Ya Fu Xin-Zuo Chi Feng-Ying Wang Da-Qing Ma Tian-Long Wang Lei Zhao | 2015 | Chinese Medical Journal2015，，14： | 35 |
| 13 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 14 | Wnt3a signaling promotes proliferation,myogenic differentiation,and migration of rat bone marrow mesenchymal stem cells显示文摘瞄准:调查在增长,迁居,和老鼠骨髓的生肌的、脂肪形成的的区别上发信号的无翼相关的 MMTV 集成地点 3A (Wnt3a ) 的效果间充质的干细胞(rMSC ) 。方法:主要 MSC 被孤立并且从 Sprague-Dawley 老鼠有教养、由流动血细胞计数描绘。老鼠 L 房间是有 Wnt3a cDNA 的 transfected,并且调节了包含活跃 Wnt3a 蛋白质的媒介被准备。房间增长被房间计数和 5-bromodeoxyuridine 加入试金评估。rMSC 的迁居被使用 transwell 迁居和创伤愈合试金执行。在 rMSC 的生肌的、脂肪形成的的区别被轻显微镜学,免疫荧光,和 RT-PCR 在生肌的或脂肪形成的介绍以后在不同时间点检验。结果:发信号的 Wnt3a 导致了 beta-catenin 原子易位并且在 rMSC 激活 Wnt 小径。面对 Wnt3a, rMSC 比控制房间更快增殖了,使他们的区别潜在。而且,发信号的 Wnt3a 在在生肌的是有教养的以后导致了表示 rMSC 的 desmin 和肌浆球蛋白重链中的 2.62% 个和 3.76% 中等。生肌的区别基因,包括的 Pax7, MyoD, Myf5, Myf4,和肌浆蛋白在,在 Wnt3a 处理以后被激活。在另一方面, Wnt3a 在 rMSC 禁止了脂肪形成的区别通过下面 CCAAT/enhancer-binding 蛋白质高山的调整表示哈(C/EBPalpha ) 并且 peroxisome 激活 proliferator 的受体鲸鱼群妈(PPARgamma ) 。而且, Wnt3a 支持了 rMSC 的迁居能力。结论:结果显示在 rMSC 表明罐头 induce 生肌的区别的那 Wnt3a。发信号的 Wnt3a 也涉及增长的规定和 rMSC 的移植。这些结果能在人为基于房间的织物修理提供一个合理基础。 | Yan-chang SHANG Shu-hui WANG Fu XIONG Cui-ping ZHAO Fu-ning PENG Shan-wei FENG Mei-shan LI YongLI Cheng ZHANG | 2007 | Acta Pharmacologica Sinica2007，28，11： | 34 |
| 15 | Prevention of postoperative intracranial infection in patients with cerebrospinal fluid rhinorrhea显示文摘背景 Intracranial 感染是学习试图与脑髓的液体 rhinorrhea 在病人识别手术后的 intracranial 感染的风险因素并且为 167 个病人全部的 prevention.Methods A 建议建议的 neurosurgery.This 的普通手术后的复杂并发症( 113 男性和 54 男性, 34.4 年的平均年龄)与四年级生操作的脑髓的液体 rhinorrhea ,作者是回顾地,收集的 reviewed.The 数据包括了病原学,以前的历史。 | YANG Zhi-jun ZHONG Hong-liang WANG Zhen-min ZHAO Fu LIU Pi-nan | 2011 | Chinese Medical Journal2011，，24： | 34 |
| 16 | Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro显示文摘 | Fan, Yue-Zu Fu, Jin-Ye Zhao, Ze-Ming Chen, Chun-Qiu | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，1： | 25 |
| 17 | A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood显示文摘新复合 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl )-5,6,7,8-tetrahydro-4H-chromen-4-one (1 ) 从中国沉香被孤立[Aquilaria sinensis (愁相) Gilg ] 。它的结构被阐明根据光谱数据。与 14.6 渭 g /mL 的 IC50 价值由 MTT 方法在 vitro 对人的胃的癌症房间线(SGC-7901 ) 加重 1 显示出的 cytotoxicity。 | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai | 2008 | Chinese Chemical Letters2008，19，8： | 25 |
| 18 | Multivariate analysis of surface water quality in the Three Gorges area of China and implications for water management显示文摘Multivariate statistical techniques,cluster analysis,non-parametric tests,and factor analysis were applied to analyze a water quality dataset including 13 parameters at 37 sites of the Three Gorges area,China,from 2003–2008 to investigate spatio-temporal variations and identify potential pollution sources.Using cluster analysis,the twelve months of the year were classified into three periods of lowflow (LF),normal-flow (NF),and high-flow (HF);and the 37 monitoring sites were divided into low pollution (LP),moderate pollution (MP),and high pollution (HP).Dissolved oxygen (DO),potassium permanganate index (COD Mn ),and ammonia-nitrogen (NH 4 +-N) were identified as significant variables affecting temporal and spatial variations by non-parametric tests.Factor analysis identified that the major pollutants in the HP region were organic matters and nutrients during NF,heavy metals during LF,and petroleum during HF.In the MP region,the identified pollutants primarily included organic matter and heavy metals year-around,while in the LP region,organic pollution was significant during both NF and HF,and nutrient and heavy metal levels were high during both LF and HF.The main sources of pollution came from domestic wastewater and agricultural activities and runoff;however,they contributed differently to each region in regards to pollution levels.For the HP region,inputs from wastewater treatment plants were significant;but for MP and LP regions,water pollution was more likely from the combined effects of agriculture,domestic wastewater,and chemical industry.These results provide fundamental information for developing better water pollution control strategies for the Three Gorges area. | Jian Zhao Guo Fu Kun Lei Yanwu Li | 2011 | Journal of Environmental Sciences2011，23，9： | 25 |
| 19 | DNA methylation changes detected by methylation-sensitive amplified polymorphism in two contrasting rice genotypes under salt stress显示文摘DNA methylation,one of the most important epigenetic phenomena,plays a vital role in tuning gene expression during plant development as well as in response to environmental stimuli.In the present study,a methylation-sensitive amplified polymorphism(MSAP) analysis was performed to profile DNA methylation changes in two contrasting rice genotypes under salt stress.Consistent with visibly different phenotypes in response to salt stress,epigenetic markers classified as stable inter-cultivar DNA methylation differences were determined between salt-tolerant FL478 and salt-sensitive IR29.In addition,most tissue-specific DNA methylation loci were conserved,while many of the growth stage-dependent DNA methylation loci were dynamic between the two genotypes.Strikingly,salt stress induced a decrease in DNA methylation specifically in roots at the seedling stage that was more profound in IR29 than in the FL478.This result may indicate that demethylation of genes is an active epigenetic response to salt stress in roots at the seedling stage,and helps to further elucidate the implications of DNA methylation in crop growth and development. | Wensheng Wang Xiuqin Zhao Yajiao Pan Linghua Zhu Binying Fu Zhikang Li | 2011 | Journal of Genetics and Genomics2011，38，9： | 25 |
| 20 | Aerosol scattering coefficients and major chemical compositions of fine particles observed at a rural site in the central Pearl River Delta,South China显示文摘During November-December 2010 aerosol scattering coefficients were monitored using a single-waved (525 nm) Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine particle (PM 2.5) samples were also collected during the period using quartz filters for the analysis of major chemical components including organic carbon (OC),elemental carbon (EC),sulfate,nitrate and ammonium.In average,these five components accounted for about 85% of PM 2.5 mass and contributed 42% (OC),19% (SO 4 2 -),12% (NO 3 -),8.4% (NH 4+) and 3.7% (EC),to PM 2.5 mass.A relatively higher mass scattering efficiency of 5.3 m 2/g was obtained for fine particles based on the linear regression between scattering coefficients and PM 2.5 mass concentrations.Chemical extinction budget based on IMPROVE approach revealed that ammonium sulfate,particulate organic matter,ammonium nitrate and EC in average contributed about 32%,28%,20% and 6% to the light extinction coefficients,respectively. | Xinming Wang Xiang Ding Xiaoxin Fu Quanfu He Shaoyi Wang Francois Bernard Xiuying Zhao Dui Wu | 2012 | Journal of Environmental Sciences2012，24，1： | 25 |
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