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| 1 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 2 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 3 | Selective sphincteroplasty of the papilla in cases at risk due to atypical anatomy显示文摘AIM: To analyze the indications, effi cacy and safety of sphincteroplasty in our centre. METHODS: A retrospective study of sphincteroplasty in 53 cases of papilla at high risk was performed in 2004-2006. The procedure consisted of duodenoscopy with Olympus TJF 145 Videoduodenoscope, approach to the biliary tract using a catheter with a guidewire, and dilatation of the papilla with a dilatation balloon catheter using a syringe with a manometer for control of the fi lling pressure. RESULTS: The indications included intradiverticular papilla in 26 patients (49/), stenosis of a previous sphincterotomy in 19 patients (35.8/), small size of the papilla in 4 patients (7.5/), Billroth Ⅱ gastrectomy in 3 patients (5.6/), and coagulopathy in one patient (1.9/). The efficacy was 97.8/, with all the calculi extracted from the common bile duct in 84.4/ of the patients, even though 21 of the patients (39.6/) had calculi with a diameter equal to or greater than 10 mm. Seven patients (13.2/) presented complications: haemorrhage in 1 patient (1.9/) and mild pancreatitis in 6 patients (11.3/). The mean hospital stay in case of complications was of 3 ± 0.63 d. CONCLUSION: Sphincteroplasty is highly effective, with a complication rate similar to that of sphincterotomy, furthermore, the complications are of low clinical importance. The use of the 10 mm balloon makes it possible to extract calculi with a diameter of over 15 mm and to extract more than 3 calculi without increasing the rate of complications and reduces the need to resort tolithotripsy or rescue sphincterotomy. | F Mugica G Urdapilleta A Castiella A Berbiela F Alzate E Zapata L Zubiaurre P Lopez JI Arenas | 2007 | World Journal of Gastroenterology2007，13，22： | 5 |
| 4 | Non-invasive methods for liver fi brosis prediction in hemochromatosis:One step beyond显示文摘Advances in recent years in the understanding of, and the genetic diagnosis of hereditary hemochromatosis (HH) have changed the approach to iron overload he-reditary diseases. The ability to use a radiologic tool (MRI) that accurately provides liver iron concentration determination, and the presence of non-invasive sero-logic markers for fibrosis prediction (ser um ferritin, platelet count, transaminases, etc), have diminished the need for liver biopsy for diagnosis and prognosis of this disease. Consequently, the role of liv er biopsy in iron metabolism disorders is changing. Furthermore, the irruption of transient elastography to assess liver stiffness, and, more recently, the ability to determine liver f ibrosis by means of MRI elastography will change this role even more, with a potential drastic decline in hepatic biopsies in years to come. This review will provide a brief summary of the different non-invasive methods available nowadays for diagnosis and prognosis in HH, and point out potential new techniques that could come about in the next years for fibrosis prediction, thus avoiding the need for liver biopsy in a greater number of patients. It is possible that liver biopsy will remain useful for the diagnosis of associated diseases, where other non-invasive means are not po-ssible, or for those rare cases displaying discrepancies between radiological and biochemical markers. | Agustin Castiella Eva Zapata José M Alústiza | 2010 | World Journal of Hepatology2010，2，7： | 3 |
| 5 | Three-dimensional simulation of horseshoe vortex and local scour around a vertical cylinder using an unstructured finite-volume technique显示文摘A Large Eddy Simulation model is developed to simulate the hydrodynamics and scour process around a circular cylinder.The Navier-Stokes solver is based on the projection method and a second-order unstructured finite-volume method.A sigma-coordinate system is used to obtain an accurate representation of the evolution of the sediment-water interface.Bed erosion is simulated by solving the sediment continuity equation using a mass-conservating sand-slide algorithm and a bedload transport rate,which is based on a description of physical processes(Engelund&Freds?e,1976).Simulations of flow around a vertical cylinder for free-slip bed,rigid bed,and live-bed cases are done.The mean velocity profile and shear stress validate the accuracy of this model.Horseshoe vortex and lee-wake vortex shedding structure are simulated,and the results are thoroughly discussed in depth.The formation and the temporal development of the scour hole and other topographic bed features are successfully reproduced.The current paper reports the first known investigation of both scour evolution and coherent structure using large-eddy simulation. | Wei Zhang Miguel Uh Zapata Xin Bai Damien Pham-Van-Bang Kim Dan Nguyen | 2020 | International Journal of Sediment Research2020，35，3： | 3 |
| 6 | Transformation of a texas cotton cultivar by using agrobacterium and the shoot apex显示文摘 | Zapata C Park SH EI-Zik KM | 1999 | Theor Appl Genet1999，98，92： | 2 |
| 7 | Critical Function for SIP, a Ubiquitin E3 Ligase Component of the β-Catenin Degradation Pathway, for Thymocyte Development and G1 Checkpoint显示文摘 | Toru Fukushima Juan M. Zapata Netai C. Singha Michael Thomas Christina L. Kress Maryla Krajewska Stan Krajewski Ze’ev Ronai John C. Reed Shu-ichi Matsuzawa | 2006 | Immunity2006，，1： | 2 |
| 8 | Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells 显示文摘 | Gutierrez G Mendoza C Zapata E | 2007 | Atherosclerosis2007，190，1： | 1 |
| 9 | Non-lymphoid cells of the Anuran spleen:An ultrastructural study in the natterjack,Bufocalamita显示文摘 | Zapata A Carela M S Leceta J | 1983 | Amer J Anat1983，167，： | 1 |
| 10 | Ontogeny of the im- mune system of fish 显示文摘 | ZAPATA A DIEZ B CEJALVO T | 2006 | Fish Shellfish Immunol2006，20，2： | 1 |
| 11 | Effects of NMDA-R1 antisense oligodeoxynucleotide administration: behavioral and radioligand binding studies显示文摘 | Zapata A Capdevila JL Tarrason G | 1997 | Brain Res1997，745，： | 1 |
| 12 | Simple but Effective Ferrocene Derivative as aRedox, Colorimetric,and Fluorescent Receptor forHighly Selective Recognition of Zn2+ Ions 显示文摘 | ZAPATA F CABALLERO A ESPINOSA A etal | 2007 | OrgLett2007，，9： | 1 |
| 13 | AMPAR trafficking in synapse maturation and plasticity显示文摘 | Bassani S Folci A Zapata J | 2013 | Cell Mol Life Sci2013，70，23： | 1 |
| 14 | Effect of ethylene concentration on quality parameters of fresh tomatoes stored using a carbon-heat hybrid ethylene scrubber显示文摘 | Domingo Martínez-Romero Fabián Guillén Salvador Castillo Pedro Javier Zapata Daniel Valero María Serrano | 2008 | Postharvest Biology and Technology2008，，2： | 1 |
| 15 | Reduction of pomegranate chilling injury during storage after heat treatment: Role of polyamines显示文摘 | MIRDEHGHAN S H RAHEMIC M MARTINEZ-ROMERO D GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 16 | Ultrastructure of splenic white pulp of the turtle,Mauremyscaspica显示文摘 | Zapata A Leceta J Barrutia M G | 1981 | Cell Tissue Res1981，220，： | 1 |
| 17 | An adaptive-network-based fuzzy inference system for classification of welding defects 显示文摘 | ZAPATA J VILAR R RUIZ R | 2010 | NDT & E International2010，43，3： | 1 |
| 18 | Are hepatocellular carcinoma surveillance programs effective at improving the therapeutic options显示文摘 | ZAPATA E ZUBIAURRE L CASTIELLA A | 2010 | Rev esp enferm dig(Madrid)2010，102，8： | 1 |
| 19 | Dynamics of expression of apoptosis regulatory proteins Bid,Bcl-2,Bcl-x,Bax,and Bak during development of murine nervous system显示文摘 | Krajewska M Mai J K Zapata J M | 2002 | Cell Death Differ2002，9，2： | 1 |
| 20 | Ontogeny of the immune system of fish显示文摘 | Zapata A Diez B Cejalvo T | 2006 | Fish Shellfish Immunol2006，20，2： | 1 |
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