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| 1 | drug-induced autoimmune liver disease:a diagnostic dilemma of an increasingly reported disease显示文摘The aetiology of autoimmune hepatitis(AIH) is uncer-tain but the disease can be triggered in susceptible patients by external factors such as viruses or drugs.AIH usually develops in individuals with a genetic back-ground mainly consisting of some risk alleles of the major histocompatibility complex(HLA).Many drugs have been linked to AIH phenotypes,which sometimes persist after drug discontinuation,suggesting that they awaken latent autoimmunity.At least three clini-cal scenarios have been proposed that refers to drug- induced autoimmune liver disease(DIAILD):AIH with drug-induced liver injury(DILI); drug induced-AIH(DI-AIH); and immune mediated DILI(IM-DILI).In addi-tion,there are instances showing mixed features of DI-AIH and IM-DILI,as well as DILI cases with positive autoantibodies.Histologically distinguishing DILI from AIH remains a challenge.Even more challenging is the differentiation of AIH from DI-AIH mainly relying in histological features; however,a detailed standard-ised histologic evaluation of large cohorts of AIH and DI-AIH patients would probably render more subtle features that could be of help in the differential diag-nosis between both entities.Growing information on the relationship of drugs and AIH is being available,being drugs like statins and biologic agents more fre-quently involved in cases of DIAILD.In addition,there is some evidence on the fact that patients diagnosed with DIAILD may have had a previous episode of hepa-totoxicity.Further collaborative studies in DIAILD will strengthen the knowledge and understanding of this intriguing and complex disorder which might represent different phenotypes across the spectrum of | Agustin Castiella Eva Zapata M Isabel Lucena Raúl J Andrade | 2014 | World Journal of Hepatology2014，6，4： | 13 |
| 2 | Non-lymphoid cells of the Anuran spleen:An ultrastructural study in the natterjack,Bufocalamita显示文摘 | Zapata A Carela M S Leceta J | 1983 | Amer J Anat1983，167，： | 1 |
| 3 | AMPAR trafficking in synapse maturation and plasticity显示文摘 | Bassani S Folci A Zapata J | 2013 | Cell Mol Life Sci2013，70，23： | 1 |
| 4 | Reduction of pomegranate chilling injury during storage after heat treatment: Role of polyamines显示文摘 | MIRDEHGHAN S H RAHEMIC M MARTINEZ-ROMERO D GUILLEN F VALVERDE J M ZAPATA P J SERRANO M VALERO D | 2007 | Postharvest Biology and Technology2007，44，： | 1 |
| 5 | Ultrastructure of splenic white pulp of the turtle,Mauremyscaspica显示文摘 | Zapata A Leceta J Barrutia M G | 1981 | Cell Tissue Res1981，220，： | 1 |
| 6 | An adaptive-network-based fuzzy inference system for classification of welding defects 显示文摘 | ZAPATA J VILAR R RUIZ R | 2010 | NDT & E International2010，43，3： | 1 |
| 7 | Dynamics of expression of apoptosis regulatory proteins Bid,Bcl-2,Bcl-x,Bax,and Bak during development of murine nervous system显示文摘 | Krajewska M Mai J K Zapata J M | 2002 | Cell Death Differ2002，9，2： | 1 |
| 8 | Efficacy of 1-MCP Treatment in Tomato Fruit显示文摘 | GUILLEN F CASTILLO S ZAPATA P J | 2007 | Postharvest Biology and Technology2007，43，： | 1 |
| 9 | Polyamines and ethylene changes during germina- tion of different plant species under salinity显示文摘 | Zapata P J Serrano M A Pretel M T | 2004 | Plant Science2004，167，4： | 1 |
| 10 | Energy Consumption of As- phalt and ReinforcedConcrete Pavement Materials and Construction显示文摘 | Zapata P Gambatese J A | 2005 | Journal of Infrastructure Systems2005，11，1： | 1 |
| 11 | Pars plana vitrectomy,laser retinopexy,and aqueous tamponade for pseudophakic rhegmatogenous retinal detachment显示文摘 | Martinez-Castillo V Zapata MA Boixadera A Fonollosa A García-Arumí J | | 0，，02： | 1 |
| 12 | Evaluation of mustard meal as organic fertilizer on tel under field and greenhouse conditions 显示文摘 | Balesh T Zapata F Aune J B | 2005 | Nutrient Cycling in Agroecosystems2005，73，： | 1 |
| 13 | Security on VANETs:Privacy,Misbehaving Nodes,False Information and Secure Data Aggregation显示文摘 | Antolino Rivas D Barcelo-Ordinas J M Guerrero Zapata M | 2011 | Network and Computer Applications2011，34，6： | 1 |
| 14 | Trust in Typical and High - reliability Contexts : Building and Reacting to Trust an'long Firefighters 显示文摘 | Colquitt J A Lepine J A Zapata C P | 2011 | Academy of Management Journal2011，54，5： | 1 |
| 15 | Kinetic separation of hexane isomers by fixed-bed adsorption with a microporous metal-organic framework显示文摘 | PATRICK S B ZAPATA F SILVA J A C | 2007 | J Phys Chem B2007，111，22： | 1 |
| 16 | Impairment of the apaptoticaetivity of Bax by missense mutations found in gastrointestinal cancers显示文摘 | Gil J Yamamoto H Zapata J M etal | 1999 | Cancer Res1999，59，9： | 1 |
| 17 | Effect of variables on thequality of hematite precipitated from sulfate solutions 显示文摘 | RUIZ M C ZAPATA J PADILLA R | 2007 | Hydrometallurgy2007，89，2： | 1 |
| 18 | Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals显示文摘 | Zapata W Rodriguez B Weber J | 2008 | Curr HIV Res2008，6，6： | 1 |
| 19 | Valuation of project portfolios:an endogenously discounted metho显示文摘 | ZAPATA J C REKLAITIS G V | 2010 | Euro- pean Journal of Operational Research2010，206，3： | 1 |
| 20 | Tools to maintain postharvest fruit and vegetable quality through the inhibition of ethylene action: a review显示文摘 | MARTINEZ-ROMERO D BALIEN G SERRANO M GUILLENF VALVERDE J M ZAPATA P CASTILLO S VALERO D | 2007 | Critical Reviews in Food Science and Nutrition2007，47，： | 1 |
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