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| 1 | Thymosin alpha 1:A comprehensive review of the literature显示文摘Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying,enhancing,and restoring immune function.Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies,as an enhancer of vaccine response,and as a means of curbing morbidity and mortality in sepsis and numerous infections.Studies have postulated that thymosin alpha 1 could help improve the outcome in severely ill corona virus disease 2019 patients by repairing damage caused by overactivation of lymphocytic immunity and how thymosin alpha 1 could prevent the excessive activation of T cells.In this review,we discuss key literature on the background knowledge and current clinical uses of thymosin alpha 1.Considering the known biochemical properties including antibacterial and antiviral properties,timehonored applications,and the new promising findings regarding the use of thymosin,we believe that thymosin alpha 1 deserves further investigation into its antiviral properties and possible repurposing as a treatment against severe acute respiratory syndrome coronavirus-2. | Asimina Dominari Donald Hathaway III Krunal Pandav Wanessa Matos Sharmi Biswas Gowry Reddy Sindhu Thevuthasan Muhammad Adnan Khan Anoopa Mathew Sarabjot Singh Makkar Madiha Zaidi Michael Maher Mourad Fahem Renato Beas Valeria Castaneda Trissa Paul John Halpern Diana Baralt | 2020 | World Journal of Virology2020，9，5： | 11 |
| 2 | Does urodynamics predict voiding after benign prostatic hyperplasia surgery in patients with detrusor underactivity?显示文摘Objective:We sought to determine if urodynamic study(UDS)predicted voiding outcomes in men with detrusor underactivity(DU)and benign prostatic enlargement(BPE)who underwent photovaporization of the prostate(PVP).Methods:Between September 2010 and July 2015,106 male patients with BPE and DU were identified.All patients underwent PVP.Urinary retention was noted by the preoperative necessity for an indwelling or intermittent catheter.Data collection included comorbidities,quality of life(QoL)scores,prostate volume,prostate-specific antigen(PSA),UDS and perioperative outcomes.UDS parameters included volume at first desire to void,volume at first urge to void,volume of severe urge,volume at capacity,compliance,detrusor contractions,maximum urinary flow rate(Qmax),and postvoid residual(PVR).Results:A total of 106 men were included in this analysis,who had urinary retention with a Foley catheter or clean intermittent catheterization(CIC)at the time of surgery.At baseline we found patients who voided had a detrusor pressure at Qmax(Pdet@Qmax)of 10.05±6.45 cmH2O compared to 16.78±12.17 cmH2O in those who did not void(p=0.071).Postoperatively,96(90.6%,mean age 76.9±26.2 years)of patients voided successfully while 10(9.4%,mean age 80.52±9.61 years)of patients remained in urinary retention.Mean baseline Qmax was 4.895±5.452 mL/s and 2.900±3.356 mL/s(p=0.087)in those who voided and did not respectively.PVR was 319.23±330.62 mL in those who voided and 276.88263.27 mL(p=0.344)in those who did not void.No UDS parameter predicted who would void postoperatively or improvements in QoL.Conclusions:The patients with DU and BPE might be able to successfully void after undergoing PVP regardless of UDS findings.All men who voided had improved international prostate symptom score and QoL scores compared to baseline and these parameters were durable up to 12 months. | Dominique Thomas Kevin C.Zorn Nadir Zaidi Stephanie Ashley Chen Yiye Zhang Alexis Te Bilal Chughtai | 2019 | Asian Journal of Urology2019，6，3： | 8 |
| 3 | Takotsubo cardiomyopathy:Pathophysiology and role of cardiac biomarkers in differential diagnosis显示文摘Takotsubo cardiomyopathy(TC) is characterized by reversible ventricular dysfunction, not limited to the distribution of an epicardial coronary artery. A disease primarily afflicting post-menopausal women, it is frequently mistaken for acute anterior wall myocardial infarction. Alternatively called Stress Cardiomyopathy, physical or emotional triggers are identified in only three fourths of TC patients. Long considered a benign condition, recent findings suggest poor short term prognosis similar to acute coronary syndrome(ACS). Despite the widely recognized pathophysiological role of catecholamine excess, its diagnostic role is uncertain. TC is suspected based on typical wall motion abnormalities in ventriculogram or echocardiogram. Several additional electrocardiographic, laboratory and imaging parameters have been studied with the goal of clinical diagnosis of TC. While several clinical clues differentiate it from ACS, a clinical diagnosis is often elusive leading to avoidable cardiac catheterizations. Natriuretic peptides(NPs), a family of peptide hormones released primarily in response to myocardial stretch, play a significant role in pathophysiology, diagnosis as well as treatment of congestive heart failure. TC with its prominent ventricular dysfunction is associated with a significant elevation of NPs. NPs are elevated in ACS as well but the degree of elevation is typically lesser than in TC. Markers of myocardial injury such as troponin are usually elevated to a higher degree in ACS than in TC. This differential elevation of NPs and markers of myocardial injury may play a role in early clinical recognition of TC. | Prabhakaran Gopalakrishnan Ramsha Zaidi Muhammad Rizwan Sardar | 2017 | World Journal of Cardiology2017，9，9： | 7 |
| 4 | 褐铁矿处理水中六价铬显示文摘Cr(Ⅵ)是土壤和水体中常见的有毒污染物,将Cr(Ⅵ )转化为毒性较低的Cr(Ⅲ)是常用而有效的治理方法.本文采用褐铁矿对水中Cr(Ⅵ )进行处理研究,考察了褐铁矿投加量、Cr(Ⅵ)初始浓度、pH值、反应温度、铁矿石粒径大小以及添加不同物质等因素对褐铁矿去除效果的影响.结果表明,褐铁矿对Cr(Ⅵ)有很好的还原去除效果,Cr(Ⅵ)去除效率随褐铁矿用量的增加而增大,随Cr(Ⅵ )初始浓度的增加而减小,pH值越低越有利于反应的进行.铁矿石颗粒的直径越小,比表面积越大,也对反应越有利,而温度对Cr(Ⅵ)的去除影响不大.100目的褐铁矿颗粒去除Cr(Ⅵ )的能力为7.77mgCr(VI)/g.使用褐铁矿不仅可以将Cr(Ⅵ)还原为Cr(Ⅲ),还能将Cr(Ⅵ )彻底从水中去除. | 吴燕君 王倩 Zaidi Houda 张珍 徐新华 | 2008 | 浙江大学学报(理学版)2008，35，6： | 6 |
| 5 | NS1 antigen: A new beam of light in the early diagnosis of dengue infection显示文摘Objective: To evaluate NS1 antigen detection ELISA for the early laboratory diagnosis of dengue virus infection. Methods: The present study was conducted to evaluate the overall positivity of NS1 antigen detection ELISA and its comparison with viral RNA detection via real time PCR and Ig M antibodies detection by ELISA. Results: A total of 1 270 serum samples were tested 86%(1 097/1 270) were detected positive by one or more than one diagnostic test. Out of 1 270, 64%(807/1 270) were positive by NS1 ELISA and 52%(662/1 270), 51%(646/1 270) were positive by real-time RT-PCR and Ig M ELISA respectively.Conclusions: NS1 antigen detection ELISA is highly suitable diagnostic tools and it also has great value for use in outbreak and epidemic situation. | Muhammad Suleman Rani Faryal Muhammad Masroor Alam Salmaan Sharif Shahzad Shaukat Uzma Bashir Aamir Adnan Khurshid Mehar Angez Massab Umair Mian Muhammad Sufian Yasir Arshad Ghulam Mujtaba Syed Sohail Zahoor Zaidi | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 6 |
| 6 | Effect of intermetallic compounds on the fracture behavior of dissimilar friction stir welding joints of Mg and Al alloys显示文摘Joining Mg to Al is challenging because of the deterioration of mechanical properties caused by the formation of intermetallic compounds(IMCs) at the Mg/Al interface. This study aims to improve the mechanical properties of welded samples by preventing the fracture location at the Mg/Al interface. Friction stir welding was performed to join Mg to Al at different rotational and travel speeds. The microstructure of the welded samples showed the IMCs layers containing Al12Mg17(γ) and Al3Mg2(β) at the welding zone with a thickness(< 3.5 μm). Mechanical properties were mainly affected by the thickness of the IMCs, which was governed by welding parameters. The highest tensile strength was obtained at 600 r/min and 40 mm/min with a welding efficiency of 80%. The specimens could fracture along the boundary at the thermo-mechanically affected zone in the Mg side of the welded joint. | Amir Hossein Baghdadi Zainuddin Sajuri Nor Fazilah Mohamad Selamat Mohd Zaidi Omar Yukio Miyashita Amir Hossein Kokabi | 2019 | International Journal of Minerals,Metallurgy and Materials2019，26，10： | 5 |
| 7 | Non-occupational lead exposure and hypertension in Pakistani adults显示文摘高血压是最流行的疾病在之一发展;发展中的国家。基于长历史的协会;在铅暴露的底层的血压效果的挑衅性的调查结果研究被执行决定一个协会是否在低血铅集中之间存在;高血压。在这研究,到血压上的铅的低级暴露的效果用原子吸收分光计在 244 个成年人之中被检验。为证明的优秀保证目的引用材料即,动物血 A-13,牛的肝 1577;从国际原子能机构(国际原子能机构) 的棉花纤维素 V-9;NIST (标准技术的国家研究所) 在相同试验性的条件下面被分析。高血压的成年人的吝啬的年龄是 52 年(范围 43 ~ 6 6 ) 。吝啬的价值收缩;心脏舒张的血压是(209 ± 1 1.7 )( 范围 170 ~ 2 50 ) ;(117 ± 2 .9 )( 范围 105 } 140 ) mmHg 分别地。血铅集中从 78 ~ 2 有 139 μ g /L 的一个平均数的 01 μ g /L;165 ~ 4 有在正常的 255 μ g /L 的一个平均数的 97 μ g /L;高血压的成年人分别地。收缩血压的增加随血铅层次的增加是显著地预兆的。身体集体索引(BMI ) ;包括全部的胆固醇的类脂化合物侧面,低密度脂蛋白胆固醇,高密度脂蛋白胆固醇;甘油三酸酯与血压相关。 | RAHMAN Sohaila KHALID Nasir ZAIDI Jamshed Hussain AHMAD Shujaat IQBAL Mohammad Zafar | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，9： | 4 |
| 8 | Robust Neural Control of Discrete Time Uncertain Nonlinear Systems Using Sliding Mode Backpropagation Training Algorithm显示文摘This work deals with robust inverse neural control strategy for a class of single-input single-output(SISO) discrete-time nonlinear system affected by parametric uncertainties. According to the control scheme, in the first step, a direct neural model(DNM)is used to learn the behavior of the system, then, an inverse neural model(INM) is synthesized using a specialized learning technique and cascaded to the uncertain system as a controller. In previous works, the neural models are trained classically by backpropagation(BP) algorithm. In this work, the sliding mode-backpropagation(SM-BP) algorithm, presenting some important properties such as robustness and speedy learning, is investigated. Moreover, four combinations using classical BP and SM-BP are tested to determine the best configuration for the robust control of uncertain nonlinear systems. Two simulation examples are treated to illustrate the effectiveness of the proposed control strategy. | Imen Zaidi Mohamed Chtourou Mohamed Djemel | 2019 | International Journal of Automation and computing2019，16，2： | 4 |
| 9 | The heterogeneity of store-operated calcium entry in melanoma显示文摘Calcium is a key regulator of many physiological processes that are perturbed in cancer, such as migration, proliferation and apoptosis. The proteins STIM and Orai mediate store-operated calcium entry(SOCE), the main pathway for calcium entry in non-excitable cells. Changes in the expression and function of STIM and Orai have been found in a range of cancer types and thus implicated in disease progression. Here we discuss the role of STIM, Orai and the SOCE pathway in the progression of melanoma and explore how the heterogeneous nature of melanoma may explain the lack of consensus in the field regarding the role of SOCE in the progression of this disease. | Robert Hooper M.Raza Zaidi Jonathan Soboloff | 2016 | Science China(Life Sciences)2016，59，8： | 3 |
| 10 | 催产素受体基因敲除对雌激素调节骨密度的影响显示文摘目的:探讨催产素受体基因敲除对雌激素调节骨密度的影响。方法:选取3月龄野生型Oxtr+/+和纯合型Oxtr-/-雌性BABL/c小鼠各20只,随机分成野生型组(WT组)、野生型+雌二醇组(WT+E2组)、野生型去势组(WTOVX组)、野生型去势+雌二醇组(WTOVX+E2组)、纯合型组(KO组)、纯合型+雌二醇组(KO+E2组)、纯合型去势组(KO OVX组)及纯合型去势+雌二醇组(KO OVX+E2组),每组5只。17β-雌二醇皮下注射,每只50μg.d-1,每天1次。实验4周后测量各组小鼠脊柱和股骨的骨密度。结果:与WT组相比较,WT+E2组的骨密度显著增高(P<0.05),WTOVX组的骨密度显著降低(P<0.05),WTOVX+E2组的骨密度差异无统计学意义(P>0.05);与WTOVX组相比较,WTOVX+E2组的骨密度明显增高,差异具有统计学意义(P<0.05);与KO组相比较,KO+E2组、KO OVX组及KO OVX+E2组的骨密度差异均无统计学意义(P>0.05);KO OVX+E2组与KO OVX组相比较,骨密度差异也无统计学意义(P>0.05)。结论:催产素参与调节雌激素的骨合成代谢作用。 | 刘璇 SUN Li ZAIDI Mone 陆祖宏 | 2010 | 东南大学学报(医学版)2010，29，6： | 3 |
| 11 | Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori -infected gastric epithelial cells显示文摘 | Syed Faisal Zaidi Jibran Sualeh Muhammad Saeeda Shahryar Khan Usmanghani Anwarul-Hassan Gilani Wasim Jafri Toshiro Sugiyama | 2012 | Journal of Ethnopharmacology2012，，1： | 3 |
| 12 | Diagnostically untypable hepatitis C virus variants:It is time to resolve the problem显示文摘Pakistan is a low income country with more than 10million hepatitis C virus(HCV)infections and the burden is on continuous raise.Accurate viral genotyping is very critical for proper treatment of the infected individuals as the sustained virological response of the standard antiviral interferon therapy is genotype dependent.We observed at our diagnostic center that15.6%of HCV patient’s samples were not genotypeable by using Ohno et al method.The genotyped samples showed that 3a(68.3%)is the major prevalent genotype in Pakistan followed by 2a(10.3%),3b(2.6%),1b(1.5%),2b(1.2%)and 1a(0.5%).Presence of large number of untypable HCV variants in the current study highlights an important issue of health care setup in Pakistan.Untypable HCV cases create difficulties in treatment of these patients.The problem of routine diagnostics setup of Pakistan should be addressed on priority basis to facilitate the medical professionals in patient’s treatment and to help in achieving the maximum sustained virological response. | Muhammad Sohail Afzal Muhammad Yousaf Khan Muhammad Ammar Sadia Anjum Najm us Sahar Sadaf Zaidi | 2014 | World Journal of Gastroenterology2014，20，46： | 2 |
| 13 | Generation of wavelength-independent subwavelength Bessel beams using metasurfaces显示文摘Bessel beams are of great interest due to their unique non-diffractive properties.Using a conical prism or an objective paired with an annular aperture are two typical approaches for generating zeroth-order Bessel beams.However,the former approach has a limited numerical aperture(NA),and the latter suffers from low efficiency,as most of the incident light is blocked by the aperture.Furthermore,an additional phase-modulating element is needed to generate higher-order Bessel beams,which in turn adds complexity and bulkiness to the system.We overcome these problems using dielectric metasurfaces to realize meta-axicons with additional functionalities not achievable with conventional means.We demonstrate meta-axicons with high NA up to 0.9 capable of generating Bessel beams with full width at half maximum about as small as~λ/3(λ=405 nm).Importantly,these Bessel beams have transverse intensity profiles independent of wavelength across the visible spectrum.These meta-axicons can enable advanced research and applications related to Bessel beams,such as laser fabrication,imaging and optical manipulation. | Wei Ting Chen Mohammadreza Khorasaninejad Alexander Y.Zhu Jaewon Oh Robert C.Devlin Aun Zaidi Federico Capasso | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 14 | Significance of Bacillus subtilis strain SJ-101 as a bioinoculant for concurrent plant growth promotion and nickel accumulation in Brassica juncea显示文摘 | Sabina Zaidi Saima Usmani Braj Raj Singh Javed Musarrat | 2006 | Chemosphere2006，，6： | 2 |
| 15 | Development of Non-enzymatic Cholesterol Electrochemical Sensor Based on Polyindole/Tungsten Carbide Nanocomposite显示文摘Non-enzymatic electrochemical sensor was developed for estimation of low-level cholesterol.Polyindole/tungsten carbide(PIN/WC)nanocomposite was synthesized and used as an electroactive material to develop low-cost modified stainless steel plate electrode(SSPE).Surface morphology of developed electrode was characterized by scanning electron microscopy.Electrochemical behavior of cholesterol was investigated through electron impedance spectroscopy,potentiodynamic polarization and cyclic voltammetry in 1-M KOH electrolytic solution.The quantification of cholesterol was studied by square wave voltammetry and differential pulse voltammetry.The calibration plots between the cholesterol concentration and peak current were in linear relation with limit of detection of 1.23×10^(−6) mol L^(−1).The overall result reveals that developed PIN/WC/SSPE electrode has excellent performance for trace-level cholesterol estimation and can be further employed for cholesterol monitoring in blood serum samples. | Shubham Sharma Preeti Joshi Sameena Mehtab Md.Ghulam Haider Zaidi Kavita Singhal Tanveer Irshad Siddiqi | 2020 | Journal of Analysis and Testing2020，4，1： | 2 |
| 16 | Incorporation of layered tin(Ⅳ) phosphate in graphene framework for high performance lithium-sulfur batteries显示文摘To anchor the polysulfide and enhance the conversion kinetics of polysulfide to disulfide/sulfide is critical for improving the performance of lithium-sulfur battery.For this purpose,the graphene-supported tin(Ⅳ) phosphate(Sn(HPO_4)_2·H_2 O,SnP) composites(SnP-G) are employed as the novel sulfur hosts in this work.When compared to the graphene-sulfur and carbon-sulfur composites,the SnP-G-sulfur composites exhibit much better cycling performance at 1.0 C over 800 cycles.Meanwhile,the pouch cell fabricated with the SnP-G-sulfur cathodes also exhibits excellent performance with an initial capacity of1266.6 mAh g^(-1)(S) and capacity retention of 76.9% after 100 cycles at 0.1 C.The adsorption tests,density functional theory(DFT) calculations in combination with physical cha racterizations and electrochemical measurements provide insights into the mechanism of capture-accelerated conversion mechanism of polysulfide at the surface of SnP.DFT calculations indicate that the Li-O bond formed between Li atom(from Li_2 S_n,n=1,2,4,6,8) and O atom(from PO_3-OH in SnP) is the main reason for the strong interactions between Li_2 S_n and SnP.As a result,SnP can effectively restrain the shuttle effect and improving the cycling performance of Li-S cell.In addition,by employing the climbing-image nudged elastic band(ciNEB) methods,the energy barrier for lithium sulfide decomposition(charging reaction) on SnP is proved to decrease significantly compared to that on graphene.It can be concluded that SnP is an effective sulfur hosts acting as dual-functional accelerators for the conversion reactions of polysulfude to sulfide(discharging reaction) as well as polysulfide to sulfur(charging reaction). | Haifeng Yuan Na Zhang Leiwu Tian Lei Xu Qinjun Shao Syed Danish Ali Zaidi Jianping Xiao Jian Chen | 2021 | Journal of Energy Chemistry2021，30，2： | 2 |
| 17 | Osteoclast function and its control显示文摘 | Pazianas M Shakar VS | 1993 | Exp Physiol1993，78，6： | 1 |
| 18 | Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites显示文摘 | Zaidi SK Sullivan AJ van Wijnen AJ | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 19 | Catalytic conversion of methanol to gasoline range hydrocarbons显示文摘 | Zaidi H A Pant K K | 2004 | Catalysis Today2004，96，： | 1 |
| 20 | Sulfonated polyether ether ketone based composite polymer electrolyte membranes显示文摘 | Mikhailenko SD Zaidi SMJ Kaliaguine S | 2001 | Catalysis Today2001，67，： | 1 |
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