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| 1 | Report on Childhood Obesity in China (10): Association of Sleep Duration with Obesity显示文摘Objectives To explore the association of sleep duration with obesity among children in urban areas of China.Methods A total of 6 576 children(3 293 boys and 3 283 girls) aged 7-11 years were randomly selected from 36 primary schools in 6 metropolitan cities in China.A 7-day Physical Activity Recall was used to assess the sleep duration and physical activity level.The height,weight,waist circumference(WC) and percentage of body fat(%BF,as determined by bioelectrical impedance analysis technique) were measured by following the standardized operation procedures.The information on demography,lifestyle and eating habits was collected with a self-administered questionnaire from participants and their parents.Results The average sleep duration per night in the children was 9.7 h with the decreasing trends along with the increase of age(P<0.05).The sleep duration was negatively associated with body mass index(BMI) and WC in both boys and girls after adjustment for confounders(β value-0.23 and-0.82 for boys,-0.24 and-0.91 for girls,respectively,P<0.01).However,no significant association of sleep duration with %BF was found.Children who slept less than 9.0 h per night had a higher risk for overweight and obesity(OR=1.29,95% CI:1.01,1.64) and abdominal obesity(OR=1.38,95% CI:1.04,1.83) as compared with those who slept for 10.0-10.9 h.Conclusions Short sleep duration is associated with obesity.It is important to ensure adequate sleep duration of children and foster their healthy lifestyle at an early stage of life. | MENG Li Ping LIUAi Ling HU Xiao Qi ZHANG Qian DU Song Ming FANG Hong Yun MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 16 |
| 2 | Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury显示文摘In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury(SCI). Currently,however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation(SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations,classification, potential underlying etiology, and currentchallenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed. | Qian Huang Wanru Duan Eellan Sivanesan Shuguang Liu Fei Yang Zhiyong Chen Neil C.Ford Xueming Chen Yun Guan | 2019 | Neuroscience Bulletin2019，35，3： | 13 |
| 3 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 4 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 5 | Fixation of CO_2 by electrocatalytic reduction to synthesis of dimethyl carbonate in ionic liquid using effective silver-coated nanoporous copper composites显示文摘与高表面区域,开的孔和高效率,催化剂在 electrocatalytic 被准备并且第一采用了 CO2 的减小和 dimethyl 碳酸盐(直接数字控制) 的 electrosynthesis。为在离子的液体的 CO2 的 electrocatalytic 减小的电气化学的性质被周期的 voltammogram (CV ) 学习。象 electrocatalytic 性能上的温度,工作潜力和阴极材料一样的各种各样的反应变量的效果也被调查。直接数字控制的 80% 产量在最佳的反应条件下面被获得。 | Xuan Yun Wang Su Qin Liu Ke Long Huang Qiu Ju Feng De Lai Ye Bing Liu Jin Long Liu Guan Hua Jin | 2010 | Chinese Chemical Letters2010，21，8： | 10 |
| 6 | Large-scale real-world radio signal recognition with deep learning显示文摘In the past ten years, many high-quality datasets have been released to support the rapid development of deep learning in the fields of computer vision, voice, and natural language processing. Nowadays, deep learning has become a key research component of the Sixth-Generation wireless systems(6G) with numerous regulatory and defense applications. In order to facilitate the application of deep learning in radio signal recognition, in this work, a large-scale real-world radio signal dataset is created based on a special aeronautical monitoring system-Automatic Dependent Surveillance-Broadcast(ADS-B). This paper makes two main contributions. First, an automatic data collection and labeling system is designed to capture over-the-air ADS-B signals in the open and real-world scenario without human participation. Through data cleaning and sorting, a high-quality dataset of ADS-B signals is created for radio signal recognition. Second, we conduct an in-depth study on the performance of deep learning models using the new dataset, as well as comparison with a recognition benchmark using machine learning and deep learning methods.Finally, we conclude this paper with a discussion of open problems in this area. | Ya TU Yun LIN Haoran ZHA Ju ZHANG Yu WANG Guan GUI Shiwen MAO | 2022 | Chinese Journal of Aeronautics2022，35，9： | 9 |
| 7 | Downward continuation of airborne geomagnetic data based on two iterative regularization methods in the frequency domain显示文摘Downward continuation is a key step in processing airborne geomagnetic data. However,downward continuation is a typically ill-posed problem because its computation is unstable; thus, regularization methods are needed to realize effective continuation. According to the Poisson integral plane approximate relationship between observation and continuation data, the computation formulae combined with the fast Fourier transform(FFT)algorithm are transformed to a frequency domain for accelerating the computational speed. The iterative Tikhonov regularization method and the iterative Landweber regularization method are used in this paper to overcome instability and improve the precision of the results. The availability of these two iterative regularization methods in the frequency domain is validated by simulated geomagnetic data, and the continuation results show good precision. | Liu Xiaogang Li Yingchun Xiao Yun Guan Bin | 2015 | Geodesy and Geodynamics2015，6，1： | 8 |
| 8 | 脊髓损伤后胫骨前肌运动单位数目测定的意义显示文摘目的:建立健康成人胫骨前肌运动单位的正常值并探讨其在脊髓损伤(spinalcordinjury,SCI)研究中的意义。方法:采用改良多点刺激技术对45例健康成人(20~59岁35例,≥60岁10例)和20例SCI患者(伤后1~6个月,亚急性期组10例;伤后1年以上,慢性期组10例)进行胫骨前肌运动单位数目测定,并随访观察SCI患者胫骨前肌运动单位数目的变化情况。结果:45例健康成人胫骨前肌运动单位数目为188±20个,不同年龄组、性别间无显著性差异(P>0.05)。SCI亚急性期组初测胫骨前肌运动单位数目平均为40±33个,随访1个月时为71±37个,随访3个月时为116±41个,三次检查间均有显著性差异(P<0.01);SCI慢性期组初测时胫骨前肌运动单位数目平均为173±29个,与正常值无明显差异,随访3个月时为177±34个,与初测时无明显变化(P>0.05)。结论:胫骨前肌运动单位数目在SCI后不同时间发生不同变化,测量其数目变化可能有助于对SCI的诊断、治疗和预后的定量评估。 | 熊国星 张军卫 洪毅 Yun Guan 关骅 | 2008 | 中国脊柱脊髓杂志2008，18，6： | 8 |
| 9 | Translational Research in Oncology Research & Development and Its Impact on Early Development in China: report of the 5th Annual Meeting of the US Chinese Anti-Cancer Association (USCACA) at 2013 AACR Annual Meeting显示文摘In April 2013, the US Chinese Anti-Cancer Association (USCACA) held its 5th annual meeting in conjunction with the American Association for Cancer Research (AACR) 2013 Annual Meeting in Washington DC. The USCACA executive committee reported activities and programs and highlighted the partnership and collaboration between USCACA and other major organizations. The key initiatives and programs of USCACA included 1) USCACA-TIGM Esophageal Cancer Program that funds translational research of esophageal cancer prevention and treatment at the Xinxiang Medical University in Henan province, China; 2) the USCACA-NFCR-AFCR Scholarship Program, which has supported 10 young outstanding Chinese cancer researchers and will award 4 fellowships at the Guangzhou International Symposium on Oncology in November this year; 3) USCACA-Hengrui Training Program for Early Phase Clinical Research, which has supported the training of a Chinese scholar at two major cancer centers in the US; and 4) USCACA has continued its partnership with the Chinese Journal of Cancer, which has reached significant international impact. | Lingjie Guan Yun Dai Roger Luo | 2013 | Chinese Journal of Cancer2013，32，7： | 6 |
| 10 | Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment显示文摘 | Hong-YangWang Ya-Li Zhao Qiong Liu Hu Yuan Yun Gao Lan Lan Da-Yong Wang Jing Guan Qiu-Ju Wang | 2015 | Chinese Medical Journal2015，，24： | 6 |
| 11 | Investigating the Effectiveness of Road-related Mitigation Measures under Semi-controlled Conditions:A Case Study on Asian Amphibians显示文摘Road traffic is the main factor causing the decline in amphibian populations worldwide. The proper design of an amphibian tunnel is one of the most efficient measures to mitigate the negative impacts of road traffic on amphibians. However, no study has investigated the effectiveness of amphibian tunnels under semi-controlled conditions in Asian amphibians. Here, we selected two representative amphibian species, the Chinese brown frog, Rana chensinensis, and the Asiatic toad, Bufo gargarizans, which suffer the most severe road mortality along the roads in Northeast China. We placed experimental arrays of culverts of various sizes(diameters of 1.5, 1, and 0.5 m for circular culverts; side lengths of 1.5, 1, and 0.5 m for box culverts), and substrate type(soil, concrete, and metal) to examine the preferences of both species during the migratory season between May and September in 2016 and 2017. The results revealed that the Chinese brown frog preferred mid-and large-sized culverts as well as soil culverts. We concluded that culverts with a side length ≥ 1 m, lined with soil, and accompanied by a ≥ 0.4 m high guide drift fence and ≤ 45° gradient on the roadside ditch wall would best facilitate road crossings for both species and likely for other amphibian species in Northeast China. | Yun WANG Jiayu LAN Hongping ZHOU Lei GUAN Yudi WANG Yongshun HAN Jiapeng QU Syed Asifullah SHAH Yaping KONG | 2019 | Asian Herpetological Research2019，10，1： | 4 |
| 12 | In situ SIMS oxygen isotope analyses: Evidence for the formation of aluminum-rich chondrules from ordinary chondrites显示文摘Aluminum-rich chondrules(ARCs),which share mineralogic and chemical properties with both Ca,Al-rich inclusions(CAIs)and ferromagnesian chondrules,play an important role in revealing their temporal and petrogenetic relationships.In this work,seven ARCs were found in three ordinary chondrites GRV 022410(H4),GRV 052722(H3.7)and Julesburg(L3.6).They contain bulk Al2O3~17%-33%and exhibit igneous textures composed of olivine,high-and low-Ca pyroxene,plagioclase,spinel and glass.In situ SIMS analyses show that ARCs have oxygen isotopic compositions(δ18O=–6.1‰–7.1‰;δ17O=–4.5‰–5.1‰)close to ferromagnesian chondrules but far more depleted in 16O than CAIs(δ18O=-40‰;δ17O=-40‰).Most ARCs plot close to the terrestrial mass fractionation(TF)line,and a few between the TF and carbonaceous chondrite anhydrous mixing(CCAM)lines.Plagioclase,nepheline and glass suffered O-isotopic exchanges during the metamorphism processes in the parent body.Spinel,olivine and pyroxene represent the primary O-isotopic compositions of ARCs,and define a fitted line with a slope of^0.7±0.1.Compared with the results of previous studies,shallower slope as well as more depleted16O compositions further demonstrates that ARCs in ordinary chondrites are not a simple mixing product of ferromagnesian chondrules and CAIs.Instead,they probably experienced higher-degree oxygen isotope exchange with a 16O-poor nebular gas reservoir during multiple melting episodes. | JIANG Yun HSU WeiBiao GUAN YunBin WANG Ying | 2015 | Science China Earth Sciences2015，58，10： | 4 |
| 13 | Single and Combined Effects of As (Ⅲ) and Acetochlor on Phosphatase Activity in Soil显示文摘The actions and interactions of acetochlor and As on the soil phosphatase activity were investigated after 1, 3, 6, 10, 15, 30 and 60 d of exposure under control conditions. The soils were exposed to various concentrations of acetochlor and As individually and simultaneously. The results showed that acetochlor, As only, and combined pollution all clearly inhibited soil phosphatase activity. The maximum inhibition ratios of soil phosphatase activity by acetochlor, As only and combined pollution were 36.44, 74.12 and 61.29%, respectively. Two kinetic models, ν=c/(1+bi) (model 1) and ν=c(1+ai)/(l+bi) (model 2), were used to describe the relationship between the concentrations of As and acetochlor and the activity of soil phosphatase. The semi-effect dose (ED 50 ) values induced by As and acetochlor stress based on the inhibition of soil phosphatase were 18.1 and 33.11 mg kg-1, respectively, according to calculation by model 1. The interactive effect of acetochlor with As on soil phosphatase primarily consisted of significant antagonism effects at the higher concentrations tested. The step regression results show that the toxicity order was As (III)>acetochlor>As (III)×acetochlor throughout the incubation period. | ZHANG Yun ZHANG Feng ZHANG Guan-cai GUAN Lian-zhu | 2013 | Journal of Integrative Agriculture2013，12，6： | 4 |
| 14 | Numerical Study of the Intensity Correlation between Secondary Flow and Heat Transfer of Circle Tube-Finned Heat Exchanger with Vortex Generators显示文摘The application of vortex generators in tube-finned heat exchangers is very universal.The vortex generators can generate secondary flow,and as we all know secondary flow can obviously strengthen heat transfer.To use vortex generators much more efficiently in the circle tube-finned heat exchangers,the intensity correlation study between secondary flow and heat transfer is needed.22 different structures of circle tube-finned heat exchangers were numerically studied,including the plain fin cases and the cases with vortex generators.In addition,the influence of fin spacing,transverse and longitudinal tube pitch,heights and attack angle of vortex generators,positions of vortex generators and shape of vortex generators on heat transfer and fluid flow are studied,too.The non-dimensional parameter Se is applied to quantify the secondary flow intensity.The results show that Se can describe the secondary flow intensity very well.There is very close corresponding relationship between overall averaged Nu and volumetrically averaged Se for all the researched cases and the relational expression is obtained.However,there is no one-to-one correlation not only between Re and f but also between volumetrically averaged Se and f for all the studied cases. | Yong Guan Wanling Hu Yun Zhang Kewei Song Liangbi Wang | 2020 | Computer Modeling in Engineering & Sciences2020，，4： | 3 |
| 15 | Rapid intelligent evaluation method and technology for determining engineering rock mass quality显示文摘The evaluation of engineering rock mass quality is fundamental work for the engineering activities of rock mass.The increasing scale of rock mass engineering necessitates higher intelligence,timeliness,and accuracy in engineering rock mass quality evaluation.As the core aspects of engineering rock mass quality evaluation,the structural characteristics,mechanical characteristics,and quality classification of rock mass have been innovated in recent years.The non-contact measurement technology for rock mass structure and rapid interpretation of rock mass structure information enables the intelligent extraction and analysis of rock mass structure parameters.The modular backpack laboratory system of rock mechanics provides an effective means to acquire rock mechanical parameters on-site conveniently.The theory of statistical mechanics of rock mass(SMRM)integrates various factors such as the rock mass properties,geological environment,and engineering disturbance,providing a theoretical basis for accurately evaluating the weakening and anisotropy of rock mass.The cloud computing platform established based on SMRM can provide technical support for the rapid calculation of rock mass parameters and instant evaluation of the rock mass quality.The development of intelligent evaluation method and technology is altering the conventional technical state of qualitative and semi-quantitative evaluation of engineering rock mass quality,supporting the realization of rock mass engineering construction with intellectualization and informatization. | Faquan Wu Jie Wu Han Bao Zhongxi Bai Lei Qiao Fang Zhang Bo Li Fuan Si Lei Yu Shenggong Guan Peng Sha Deheng Kong Zhenzhong Dai Kun Chen Yun Tian Changqing Liu | 2023 | Rock Mechanics Bulletin2023，2，2： | 3 |
| 16 | Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs显示文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology. | LEI Qun XU Yun CAI Bo GUAN Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu | 2022 | Petroleum Exploration and Development2022，49，1： | 3 |
| 17 | Optimizational production of phenyllactic acid by a Lactobacillus buchneri strain via uniform design with overlay sampling methodology显示文摘A Lactobacillus buchneri GBS3 strain isolated from the traditional Chinese pickles was used for the production of 3-phenyllactic acid(PLA), an important compound with antimicrobial activities against a wide species of grampositive and gram-negative bacteria and some fungi. The growth performance of this strain in the de Man, Rogosa and Sharpe(MRS) medium, the production of metabolites of valuable organic acids, and the biosynthesis of PLA using this strain as the whole-cell biocatalyst and phenylpyruvic acid(PPA) as the precursor, were investigated experimentally. The uniform design method with overlay sampling was developed for the optimization of the biotransformation conditions. The results showed that although it produced naturally lactic acid with the maximum concentration of 1.84 g·L^(-1) and PLA with the concentration of 0.015 g·L^(-1) after 66 to 72 h cultivation in MRS broth by fermentation, the present strain displayed an effective utilization ability by transforming PPA to PLA. By the uniform design method with overlay sampling for the design and optimization of transformation conditions, a maximum yield of 10.93 g·L^(-1) PLA with the mole conversion ratio of 83.07% from PPA to PLA was achieved under the optimized condition, i.e., 20 g·L^(-1) glucose, 270 g·L^(-1) cells, 13 g·L^(-1) PPA, pH 8.0 and the reaction time of 15 h, indicating that Lactobacillus buchneri GBS3 was an interesting strain for the biosynthesis of PLA via the microbial transformation. The prediction of PLA yield under different conditions was achieved successfully based on the limited information of only a small number of experiments by the uniform design with overlay sampling. Therefore, the present methodology is effective and helpful for the optimization of the biosynthesis processes of PLA. | Jintao Guan Chaofei Han Yixin Guan Songhong Zhang Junxian Yun Shanjing Yao | 2019 | Chinese Journal of Chemical Engineering2019，27，2： | 3 |
| 18 | The Single-active-part Structure of the UHVDC Converter Transformer with the UHVAC Power Grid显示文摘The studied sending-terminal’s UHVDC converter transformer with the UHVAC grid is currently one of the largest-capacity converter transformers,which is characterized by strong support for the large-scale grid power delivering out,strengthening grid’s fault tolerance and backup capability,improving grid operation’s flexibility and security,lowering the short-circuit currents.The proposed single-active-part converter transformer structure is well-designed,including the single-phase five-leg iron core,the special winding arrangement,the special structure of the spacers and angle rings,and so on,which is a smaller footprint,easier to install and test on site,but is more challenging in the structural design due to the critical railway transportation limitations on aspects of both size and weight.The feasibility of the proposed structure schema is verified by a series of tests,concerning the wave process,the short circuit force,the temperature field,the main insulation,and so on.Among them,the main insulation’s electric fields at the import positions are verified to be reasonable,including the AC impressed voltage test,the DC impressed voltage test,and the polarity reversal test.It shows that the proposed single-active-part design scheme is practicable and conductive to manufacture and application for the UHV large-capacity converter transformers. | Yun Liu Guangfan Li Lan Guan Zhi Li | 2017 | CSEE Journal of Power and Energy Systems2017，3，3： | 2 |
| 19 | Early Miocene Paleoaltitude of the Tuotuohe Basin,Central-Northern Tibetan Plateau and its Tectonic Implications显示文摘Reconstruction of the paleoaltitude history of the Tibetan Plateau is critical for understanding the linkage between tectonics and its effect on regional and global climate change.Presently,most of the paleoaltitude studies are concentrated on the southern and southeastern part of the Tibetan Plateau,and few studies have been conducted in the central-northern part.In this paper we focused on the Wudaoliang Formation in the Tuotuohe Basin,central to northern Tibetan Plateau,to reconstruct paleoaltitude based on carbonate oxygen isotopes.The carbonate samples are primary or have experienced an early stage of digenesis.Based on the thermodynamic and empirical model results,the paleoaltitude of the Wudaoliang Formation is found to be around 2700–3260 m(average of 2980±280 m)in the early Miocene(~24 Ma).Integrating paleoaltitude results from Wudaoliang Basin and our results,we conclude that crustal shortening and tectonic activity were strong during the late Eocene to late Oligocene-early Miocene and relatively weak during the early Miocene in the central-northern Tibetan Plateau. | LI Leyi CHANG Hong GUAN Chong LIU Weiguo CAO Yunning | 2020 | Acta Geologica Sinica(English Edition)2020，94，5： | 2 |
| 20 | Synthesis of the major isomers of Aprepitant and Fosaprepitant显示文摘The synthesis of two isomers of Aprepitant(APT)and three isomers of Fosaprepitant(FPT),crucial components for quality control in manufacturing,is described.Herein,three chiral centers in the isomers of Aprepitant are established in high yield by induced crystallization and chiral reduction.Additionally,the isomers of Aprepitant are utilized to synthesize the isomers of Fosaprepitant with the same stereochemistry.All the target compounds were confrmed by elemental analyses,IR,NMR and MS data analysis. | Wei-Li Wan Yun He Mei Guan Xiao-Long Li Xu Cheng Yong Wu | 2013 | Chinese Chemical Letters2013，24，12： | 2 |
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