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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Chemerin aggravates DSS-induced colitis by suppressing M2 macrophage polarization显示文摘 | Yuli Lin Xuguang Yang Wenjie Yue Xiaofei Xu Bingji Li Linlin Zou Rui He | 2014 | Cellular & Molecular Immunology2014，11，4： | 21 |
| 3 | Sparsity analysis of signals显示文摘在这篇论文,有概括 Gaussian 分发的信号被考虑。一个数学公式被给说明信号的稀少。根据这个公式,拉普拉斯算符信号的措施是 1,并且 Gaussian 信号是 2。给一个信号,与拉普拉斯算符相比信号和 Gaussian 信号,我们能直觉地知道信号怎么稀少经由它的措施。如果没有足够的观察信号,一些例子表明那(例如仅仅三个观察信号) ,一个人能仅仅为足够地稀少的来源信号在坚定的瞎的来源分离(BSS ) 下面完成(例如比拉普拉斯算符信号稀少的大部分) 由这项措施。 | HE Zhaoshui XIE Shengli FU Yuli | 2006 | Progress in Natural Science:Materials International2006，16，8： | 10 |
| 4 | Geometry-dependent springback behaviors of thin-walled tube upon cold bending显示文摘As one kind of key lightweight components with enormous quantities and diversities, the bent tubular parts have attracted in- creasing applications in aerospace, automobile, etc. Thus, how the inevitable springback behaves under different bending specifications should be fully addressed to efficiently achieve the precision forming of various bent tubes. Taking the medium strength thin-walled 6061-T4 Al-alloy tube as the objective, via the deformation theory of plasticity, explicit/implicit FE method and experimental approaches, we explored and clarified the nonlinear springback rules of the tubes and corresponding mechanisms in universal rotary draw bending regarding angular springback and radius growth by deliberately changing the tube diameter D and wall thickness t. The geometry dependent springback behaviors of thin-walled tube upon cold bending are thus revealed: 1) With the increasing of D, the tangent tensile strain increases and the proportional coefficient decreases, which causes the angular springback to decrease, while the radius springback increases due to the larger bending radius. 2) With the increasing of t, the tangent tensile strain decreases and the proportional coefficient increases, resulting in the increase of both angular springback and radius springback. 3) Under the same D/t, the angular springback varies little, while the radius springback increases with the larger diameter D. 4) The D/t can be used as a reasonable nondimensional index to evaluate the springback angle; as to the radius growth, the individual effects of the D and t should be considered. 5) The verification of the above results was conducted by experiments and analytical analysis. | LI Heng YANG He TIAN YuLi LI GuangJun WANG ZhengHua | 2012 | Science China(Technological Sciences)2012，55，12： | 10 |
| 5 | Effects of geometrical parameters on wrinkling of thin-walled rectangular aluminum alloy wave-guide tubes in rotary-draw bending显示文摘Inner flange and side wrinkling often occur in rotary-draw bending process of rectangular aluminum alloy wave-guide tubes, and the distribution and magnitude of wrinkling is related to geometrical parameters of the tubes. In order to study the effects of geometrical parameters on wrinkling of rectangular wave-guide tubes, a 3D-FE model for rotary-draw bending processes of thin-walled rectangular aluminum alloy wave-guide tubes was built based on the platform of ABA-QUS/Explicit, and its reliability was validated by experiments. Simulation and analysis of the influence laws of geometrical parameters on the wave heights of inner flange and side wrinkling were then carried out. The results show that inner flange wrinkling is the main wrinkling way to rectan- gular wave-guide tubes in rotary-draw bending processes, but side wrinkling cannot be neglected because side wrinkling is 2/3 of inner flange wrinkling when b and h are smaller. Inner flange and side wrinkling increase with increasing b and h; the influence of b on side wrinkling is larger than that of h, while both b and h affect inner flange wrinkling greatly. Inner flange and side wrinkling decrease with increasing R/h; the influence of h on inner flange and side wrinkling is larger than that of R. | Tian Shan Liu Yuli Yang He | 2013 | Chinese Journal of Aeronautics2013，26，1： | 8 |
| 6 | Quercus yangyiensis sp. nov. from the Late Pliocene of Baoshan, Yunnan and Its Paleoclimatic Significance显示文摘A new Quercus(Fagaceae) morphospecies is described based on well-preserved fossil leaves. The fossils were collected from Yangyi Formation of the Upper Pliocene at the Yangyi coalmine, Baoshan, western Yunnan, China. Details of the microstructure of mesophyll tissue are preserved because lithification of the fossils was not complete. The fossil laminas possess typical characteristics of Quercus sect. Heterobalanus: quite thick and coriaceous cuticle; secondary veins bifurcating near the margin in the middle and top of the leaf; and upper epidermis with adaxial hypodermis. Based on a detailed morphological and anatomical comparison with all living and fossil species of Quercus sect. Heterobalanus, the fossil leaves prove to be different in their sparse and garland-shaped multicellular trichomes on the lower epidermis, and so it is described as a new species Quercus yangyiensis He, Li et Sun sp. nov. The much sparser trichomes of our fossils compare well with those of living Quercus sect. Heterobalanus and indicate a more humid climate during the deposition of the Yangyi Formation in the Late Pliocene. | HE Yuli LI Na WANG Zixi WANG Haofei YANG Guolin XIAO Liang WU Jingyu SUN Bainian | 2014 | Acta Geologica Sinica(English Edition)2014，88，3： | 6 |
| 7 | miR-125b-5p and miR-99a-5p downregulate human γδ T-cell activation and cytotoxicity显示文摘As an important component of innate immunity,human circulatingγδT cells function in rapid responses to infections and tumorigenesis.MicroRNAs(miRNAs)play a critical regulatory role in multiple biological processes and diseases.Therefore,how the functions of circulating humanγδT cells are regulated by miRNAs merits investigation.In this study,we profiled the miRNA expression patterns in human peripheralγδT cells from 21 healthy donors and identified 14 miRNAs that were differentially expressed between peripheralαβT cells andγδT cells.Of the 14 identified genes,7 miRNAs were downregulated,including miR-150-5p,miR-450a-5p,miR-193b-3p,miR-365a-3p,miR-31-5p,miR-125b-5p and miR-99a-5p,whereas the other 7 miRNAs were upregulated,including miR-34a-5p,miR-16-5p,miR-15b-5p,miR-24-3p,miR-22-3p,miR-22-5p and miR-9-5p,inγδT cells compared withαβT cells.In subsequent functional studies,we found that both miR-125b-5p and miR-99a-5p downregulatedγδT cell activation and cytotoxicity to tumor cells.Overexpression of miR-125b-5p or miR-99a-5p inγδT cells inhibitedγδT cell activation and promotedγδT cell apoptosis.Additionally,miR-125b-5p knockdown facilitated the cytotoxicity ofγδT cells toward tumor cells in vitro by increasing degranulation and secretion of IFN-γand TNF-α.Our findings improve the understanding of the regulatory functions of miRNAs inγδT cell activation and cytotoxicity,which has implications for interventional approaches toγδT cell-mediated cancer therapy. | Yuli Zhu Siya Zhang Zinan Li Huaishan Wang Zhen Li Yu Hu Hui Chen Xuan Zhang Lianxian Cui Jianmin Zhang Wei He | 2019 | Cellular & Molecular Immunology2019，16，2： | 5 |
| 8 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 9 | Adaptive blind separation of underdetermined mixtures based on sparse component analysis显示文摘The independence priori is very often used in the conventional blind source sepa-ration (BSS). Naturally, independent component analysis (ICA) is also employed to perform BSS very often. However, ICA is difficult to use in some challenging cases, such as underdetermined BSS or blind separation of dependent sources. Recently, sparse component analysis (SCA) has attained much attention because it is theo- retically available for underdetermined BSS and even for blind dependent source separation sometimes. However, SCA has not been developed very sufficiently. Up to now, there are only few existing algorithms and they are also not perfect as well in practice. For example, although Lewicki-Sejnowski’s natural gradient for SCA is superior to K-mean clustering, it is just an approximation without rigorously theo- retical basis. To overcome these problems, a new natural gradient formula is pro- posed in this paper. This formula is derived directly from the cost function of SCA through matrix theory. Mathematically, it is more rigorous. In addition, a new and robust adaptive BSS algorithm is developed based on the new natural gradient. Simulations illustrate that this natural gradient formula is more robust and reliable than Lewicki-Sejnowski’s gradient. | YANG ZuYuan HE ZhaoShui XIE ShengLi FU YuLi | 2008 | Science in China(Series F)2008，51，4： | 3 |
| 10 | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development显示文摘Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune response.Furthermore,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response.Based on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers.In the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic effects.The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest.For example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion.Furthermore,many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers.Therefore,it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs.In this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs. | Yuli Wang Xingyan Zhang Yuyan Wang Wenjing Zhao Huling Li Lixing Zhang Xinping Li Tiejun Zhang Hongbing Zhang He Huang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 11 | Performance Assessment and Outlook of China's Emission-Trading Scheme显示文摘 | Dabo Guan Yuli Shan Zhu Liu Kebin He | 2016 | Engineering2016，2，4： | 3 |
| 12 | Thermo-mechanical fatigue behavior of nickel-base powder metallurgy superalloy FGH96 under tension-tension loading显示文摘Thermo-mechanical fatigue(TMF) behavior of FGH96,a nickel-base powder metallurgy superalloy,has been studied under tension-tension loading at the temperature range from 550 to 720 ℃.The results show that TMF fracture mode is intergranular for the in-phase(IP),but transgranular cleavage-like for the out-of-phase(OP) samples.The total content of Al,Ti and Nb in the γ phases for the IP or OP samples and the partitioning ratio of γ /γ in these elements for the IP samples are relatively higher at the lower strain amplitude,which is consistent with the case of the γ size that is larger at the lower strain amplitude,the lattice parameter misfit is negative and the absolute value is lower at the lower strain amplitude that is correlative with the change of the γ morphology.The deformation at the lower strain amplitude is mainly dominated by the dislocation lines and dislocation pairs in the matrix channels,at the higher strain amplitude dominated by the large numbers of superlattice stacking faults within the γ phases. | Yuli GU Yuhuai HE Shiyu QU Guodong ZHANG Fei ZHENG Chunhu TAO | 2010 | Acta Metallurgica Sinica(English Letters)2010，23，2： | 2 |
| 13 | A novel framework of multi-channel acoustic echo cancellation显示文摘通常,多信道的声学的回响取消(原子能委员会) 由估计本地房间的推动回答达到目标。通常,然而,常规原子能委员会方法没有唯一的答案。由于输入信号的强壮的关联,常规方法与许多劣势。克服这问题,一个新框架基于 SIMO 在这篇论文被建议(单个输入多重输出) 盲目 deconvolution。在新框架下面,我们由识别远空间的推动回答并且避免常规方法的劣势达到目标。 | HE Zhaoshui XIE Shengli FU Yuli | 2006 | Progress in Natural Science:Materials International2006，16，9： | 2 |
| 14 | Dynamic changes and convergence of China's regional green productivity:A dynamic spatial econometric analysis显示文摘Low-carbon economic development is at the heart of the post-pandemic green recovery scheme worldwide.It requires economic recovery without compromising on the environment,implying a critical role that green productivity plays in achieving the carbon neutrality goal.Green productivity measures the quality of economic growth with consideration for energy consumption and environmental pollution.This study employs the slacks-based measure directional distance function(SBM-DDF)approach and the Malmquist-Luenberger(ML)index to calculate green productivity and its components of 30 provinces in China between 2001 and 2018.Using a spatial panel data model,we empirically analyzed the conditionalβ-convergence of China's green productivity.We found that overall,since 2001,China's green productivity has demonstrated a continuous upward trend.When taking into account spatial factors,China's green productivity demonstrates a significant conditionalβ-convergence.In terms of regional effects,the results indicate that the green productivity of the eastern and western regions demonstrates club convergence,implying a more balanced green economic development.Moreover,the convergence rate of China's green productivity increases with the addition of environmental regulation variable,and so the corresponding convergence time decreases.It indicates that environmental regulations help to facilitate the convergence of China's green productivity,narrowing the gap between the regional green economic development.The findings provide guideline for achieving a low-carbon development and carbon neutrality from a regional green productivity perspective. | Xu-Quan ZHAI Rui XUE Bin HE Dong YANG Xiang-Yu PEI Xian LI Yuli SHAN | 2022 | Advances in Climate Change Research2022，13，2： | 2 |
| 15 | Prediction of Grain Size for Blade Precision Forging Process under Thermo-Mechanical Coupling显示文摘Blade precision forging is a high temperature and large plastic deformation process. Interaction of deformation andheat conduction results in producing large temperature unevenness inside the billet. The unevenness has a greateffect on the mechanical property and microstructure of the forged blade. However, internal quality of the blade isdecided by its microstructure, it is necessary to conduct a research on the microstructure of the blade forging process.Taking a blade with a tenon as an object, its precision forging process is simulated and analyzed using a 3D coupledthermo-mechanical FEM code. And based on the prediction model of Ti-6Al-4V presented by the predecessor, astudy of the evolution of grain size in the forging process is made. The distribution characteristics of grain size intypical sections are obtained under various deformation degrees. This study may provide a base for designing theblade forging process and working out its parameters. | He YANG Yuli LIU Wang CAI Mei ZHAN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 2 |
| 16 | Effects of Process Parameters on the Temperature Field in Ti-6Al-4V Alloy Blade Precision Forging Process显示文摘片精确前进是高温度和大塑料变丑过程。进程参数在营舍在温度分发上有大效果,那么在这篇论文,由拿有象一个对象的雄榫的 Ti-6AI-4V 合金片,在伪造进程的精确的温度分发上的进程参数的影响用 3Dcoupled 被调查thermo机械女性(有限元素方法)代码由作者发展了。获得的结果说明那:(1 ) 温度分发的坡度与增加变丑度增加;(2 ) 与增加营舍的起始的温度,高温度的地区变得更大,并且温度分发的坡度几乎没有任何增加;(3 ) 磨擦因素在温度地的分发上有小效果;(4 ) 与增加上面死速度,当在营舍的温度坡度减少时,营舍的温度增加。结果对在伪造 Ti 合金片的过程的精确的过程参数的设计和优化有用。 | Yuli LIU He YANG Tao GAO Mei ZHAN | 2006 | Journal of Materials Science & Technology2006，22，4： | 2 |
| 17 | Enantioselective NiH-Catalyzed Reductive Hydrofunctionalization of Alkenes显示文摘Enantioselective NiH-catalyzed reductive hydrofunctionalization of olefins has attracted much attention in recent years.Using simple chiral ligands,a wide array of functionalized olefins and electrophiles can undergo diverse transformations to afford hydrofunctionalized products,regio-and enantioselectively.These processes avoid the prior preparation of organometallic reagents,and can construct a stereogenic center at a carbon originating either from the olefin or from the electrophile.This review discusses the background,major progress and mechanistic investigations in this reaction. | Yuli He Jian Chen Xiaoli Jiang Shaolin Zhu | 2022 | Chinese Journal of Chemistry2022，40，5： | 1 |
| 18 | Biomolecular Preservation of Miocene Fossil Liquidambar from Tiantai,China and Clarkia,USA:Implications for Palaeoenvironmental Study显示文摘Biomolecular characteristics of fossil Liquidambar from the Miocene Shengxian Formation, Tiantai, Zhejiang province in eastern China and Miocene Clarkia sediment, Idaho, U.S.A., are obtained by means of Pyrolysis-Gas chromatography-Mass spectrometry analysis(Py-GC-MS). Their modern equivalent(Liquidambar formosana) collected from Nanjing, eastern China, is also analyzed for comparison. The total ion chromatograms(TIC) of modern L. formosana leaves shows abundant pyrolysates of lignin, polysaccharide, aliphatic acid, and amino acid. However, only one polysaccharide molecule, i.e., levoglucosan, is retained in fossil Liquidambar leaves from the two Miocene sites with the Tiantai specimen possessing higher intensity. As expected, some lignin pyrolysates including benzene, phenol, guaiacol, vinylphenol and their derivatives, are detected in Miocene Tiantai L. miosinica. However, the lignin components with large molecular weight other than benzene and phenol compounds, are absent in Miocene Clarkia L. pachyphyllum. Abundant pristene and homologous series of n-alk-1-ene/n-alkane pairs with a long retention time are shown in pyrograms of both Tiantai and Clarkia fossils. Based upon our Py-GC-MS data, the molecular preservation in these Liquidambar leaf samples can be ranked as the following(from high to low quality respectively): modern sample >Tiantai sample >Clarkia sample. Vinyl phenol, an important compound, is present in modern and Tiantai Liquidambar leaves, while absent in Clarkia sample, implying that vinyl phenol may be sourced from lignin for Liquidambar leaves. Our data support the hypothesis of in situ polymerization for the origin of long-chain homologous series of n-alk-1-ene/nalkane pairs as leaf alteration products. Our data have implications of the impact of leaf degradation toward biases for palaeoenvironmental reconstruction using stable carbon isotope of fossil plants, and suggest the importance of evaluating molecular preservation of fossil leaf tissues prior to the application of carbon isotope compositions of fossil leaves. | XIAO Liang YANG Hong HE Yuli HE Wenlong LI Xiangchuan GUO Junfeng HUI Kaixuan | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 19 | Primary ocular natural K- iller/T-Cell lymphomas:cllnicopathologic features and diagnosis显示文摘 | Yuli Yang Qingli Luo Weiming He | 2007 | Ophthalmologica2007，221，3： | 1 |
| 20 | Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α显示文摘Acute kidney injury(AKI)is a common clinical complication associated with high mortality in patients.Immune cells and cytokines have recently been described to play essential roles in AKI pathogenesis.Plasmacytoid dendritic cells(pDCs)are a unique DC subset that specializes in type Ⅰ interferon(IFN)production.Here,we showed that pDCs rapidly infiltrated the kidney in response to AKI and contributed to kidney damage by producing IFN-α.Deletion of pDCs using DTR^(BDCA2) transgenic(Tg)mice suppressed cisplatin-induced AKI,accompanied by marked reductions in proinflammatory cytokine production,immune cell infiltration and apoptosis in the kidney.In contrast,adoptive transfer of pDCs during AKI exacerbated kidney damage.We further identified IFN-α as the key factor that mediated the functions of pDCs during AKI,as IFN-α neutralization significantly attenuated kidney injury.Furthermore,IFN-α produced by pDCs directly induced the apoptosis of renal tubular epithelial cells(TECs)in vitro.In addition,our data demonstrated that apoptotic TECs induced the activation of pDCs,which was inhibited in the presence of an apoptosis inhibitor.Furthermore,similar deleterious effects of pDCs were observed in an ischemia reperfusion(IR)-induced AKI model.Clinically,increased expression of IFN-α in kidney biopsies was observed in kidney transplants with AKI.Taken together,the results of our study reveal that pDCs play a detrimental role in AKI via IFN-α. | Bo Deng Yuli Lin Yusheng Chen Shuai Ma Qian Cai Wenji Wang Bingji Li Tingyan Liu Peihui Zhou Rui He Feng Ding | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
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