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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Water Requirements and Irrigation Scheduling of Spring Maize Using GIS and CropWat Model in Beijing-Tianjin-Hebei Region显示文摘Due to the over use of available water resources, it has become very important to define appropriate strategies for planning and management of irrigated farmland. In this paper, Beijing-Tianjin-Hebei (Jing-Jin-Ji) region was chosen as the case study area for its special political and economic status and its severe water problem. To achieve effective planning, the information about crop water requirements, irrigation withdrawals, soil types and climatic conditions were obtained in the study area. In the meantime, a GIS method was adopted, which extends the capabilities of the crop models to a regional level. The main objectives of the study are: 1) to estimate the spatial distribution of the evapotranspiration of spring maize; 2) to estimate climatic water deficit; 3) to estimate the yield reduction of spring maize under different rainfed and irrigated conditions. Based on the water deficit analysis, recommended supplemental irrigation schedule was developed using CropWat model. Compared to the rainfed control, the two or three times of supplemental water irrigated to spring maize at the right time reduced the loss of yield, under different scenarios. | FENG Zhiming LIU Dengwei ZHANG Yuehong | 2007 | Chinese Geographical Science2007，17，1： | 18 |
| 3 | Comparative study of microRNA profiling in keloid fibroblast and annotation of differential expressed microRNAs显示文摘蟹状肿是由于皮损害的异常愈合成长的像肿瘤的皮疤,没有有效 treatment.The 分子的机制位于 \O 下面蟹状肿致病仍然大部分未知。在这研究,我们比较了表示在导出蟹状肿的成纤维细胞和正常成纤维细胞之间介绍的 microRNA (miRNA )( 包括胎儿、成年的真皮的成纤维细胞) 由 miRNA microarray 分析。我们发现在导出蟹状肿的成纤维细胞的 miRNA 侧面与在 normalfibroblasts 的那些是不同的。九 miRNAs 是表示其六在蟹状肿成纤维细胞(KF ) 是显著地起来调整的差别,包括 miR-152, miR-23b-3p, miR-31-5p, miR-320c, miR-30a-5p,和 hsv1-miR-H7,并且其三是调整 significantlydown 的包括 miR-4328, miR-145-5p,和 miR-143-3p。差别的功能的注解表示了他们在为疤创伤愈合重要的几条发信号的小径被充实的 miRNA targetsrevealed。在结论,我们 demonstratethat miRNA 表示侧面在 KF 被改变与相比可以为探索蟹状肿的致病在胎儿、成年的真皮的成纤维细胞,和 expressionprofile 提供有用线索。miRNAs 可能部分由影响相关的几条发信号的小径使创伤愈合留下疤痕贡献 etiologyof 蟹状肿。 | Chao Li Yuehong Bai Hua Liu Xuemei Zuo Haichang Yao Yiming Xu Manlin Cao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 15 |
| 4 | Reflective chiral meta-holography: multiplexing holograms for circularly polarized waves显示文摘By allowing almost arbitrary distributions of amplitude and phase of electromagnetic waves to be generated by a layer of sub-wavelength-size unit cells,metasurfaces have given rise to the field of meta-holography.However,holography with circularly polarized waves remains complicated as the achiral building blocks of existing meta-holograms inevitably contribute to holographic images generated by both left-handed and right-handed waves.Here we demonstrate how planar chirality enables the fully independent realization of high-efficiency meta-holograms for one circular polarization or the other.Such circular-polarization-selective meta-holograms are based on chiral building blocks that reflect either left-handed or right-handed circularly polarized waves with an orientation-dependent phase.Using terahertz waves,we experimentally demonstrate that this allows the straightforward design of reflective phase meta-holograms,where the use of alternating structures of opposite handedness yields independent holographic images for circularly polarized waves of opposite handedness with negligible polarization cross-talk. | Qiu Wang Eric Plum Quanlong Yang Xueqian Zhang Quan Xu Yuehong Xu Jiaguang Han Weili Zhang | 2018 | Light(Science & Applications)2018，7，1： | 15 |
| 5 | Electromagnetism and Absorptivity of the Modified Micro-coiled Chiral Carbon Fibers显示文摘微卷的 chiral 碳纤维被 nano-Ni 修改。X 光检查衍射(XRD ) 和扫描电子显微镜学(SEM ) 被用来比较作文和形态学未修改并且修改纤维。结果显示出那电磁参数修改与那些不同未修改。在由 nano-Ni 的修正以后,微卷的 chiral 碳纤维减少了介电常数和电的损失。渗透和修改的碳纤维的磁性的损失未修改的变得比那些大。而且,未修改的 chiral 碳纤维进的修正与在内的磁性的核心象就一样把空电的线圈正在变成修改那些。修饰词加强 chiral 碳纤维的生气极化并且让介电常数和渗透接近改进匹配的表演并且提高涂层的被吸收的对方。在 6-18 GHz 的范围,涂层的反射率是 6-8 dB,带宽是 12 GHz。涂层的区域密度在 3 kg/m2 下面。 | Zheng Tianliang Wang Yuehong Zheng Kuangyu Li Qian Tao Ye | 2007 | Chinese Journal of Aeronautics2007，20，6： | 10 |
| 6 | Terahertz spoof surface-plasmon-polariton subwavelength waveguide显示文摘Surface plasmon polaritons(SPPs) with the features of subwavelength confinement and strong enhancements have sparked enormous interest. However, in the terahertz regime, due to the perfect conductivities of most metals, it is hard to realize the strong confinement of SPPs, even though the propagation loss could be sufficiently low. One main approach to circumvent this problem is to exploit spoof SPPs, which are expected to exhibit useful subwavelength confinement and relative low propagation loss at terahertz frequencies. Here we report the design,fabrication, and characterization of terahertz spoof SPP waveguides based on corrugated metal surfaces. The various waveguide components, including a straight waveguide, an S-bend waveguide, a Y-splitter, and a directional coupler, were experimentally demonstrated using scanning near-field terahertz microscopy. The proposed waveguide indeed enables propagation, bending, splitting, and coupling of terahertz SPPs and thus paves a new way for the development of flexible and compact plasmonic circuits operating at terahertz frequencies. | YING ZHANG YUEHONG XU CHUNXIU TIAN QUAN XU XUEQIAN ZHANG YANFENG LI XIXIANG ZHANG JIAGUANG HAN WEILI ZHANG | 2018 | Photonics Research2018，9，1： | 9 |
| 7 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 8 | Prognostic value and nomograms of proximal margin distance in gastric cancer with radical distal gastrectomy显示文摘Objective:The proximal margin(PM)distance for distal gastrectomy(DG)of gastric cancer(GC)remains controversial.This study investigated the prognostic value of PM distance for survival outcomes,and aimed to combine clinicopathologic variables associated with survival outcomes after DG with different PM distance for GC into a prediction nomogram.Methods:Patients who underwent radical DG from June 2004 to June 2014 at Department of General Surgery,Nanfang Hospital,Southern Medical University were included.The first endpoints of the prognostic value of PM distance(assessed in 0.5 cm increments)for disease-free survival(DFS)and overall survival(OS)were assessed.Multivariate analysis by Cox proportional hazards regression was performed using the training set,and the nomogram was constructed,patients were chronologically assigned to the training set for dates from June 1,2004 to January 30,2012(n=493)and to the validation set from February 1,2012 to June 30,2014(n=211).Results:Among 704 patients with p TNM stage I,p TNM stage II,T1-2,T3-4,N0,differentiated type,tumor size≤5.0 cm,a PM of(2.1-5.0)cm vs.PM≤2.0 cm showed a statistically significant difference in DFS and OS,while a PM>5.0 cm was not associated with any further improvement in DFS and OS vs.a PM of 2.1-5.0 cm.In patients with p TNM stage III,N1,N2-3,undifferentiated type,tumor size>5.0 cm,the PM distance was not significantly correlated with DFS and OS between patients with a PM of(2.1-5.0)cm and a PM≤2 cm,or between patients with a PM>5.0 cm and a PM of(2.1-5.0)cm,so there were no significant differences across the three PM groups.In the training set,the C-indexes of DFS and OS,were 0.721 and 0.735,respectively,and in the validation set,the C-indexes of DFS and OS,were 0.752 and 0.751,respectively.Conclusions:It is necessary to obtain not less than 2.0 cm of PM distance in early-stage disease,while PM distance was not associated with long-term survival in later and more aggressive stages of disease because more advanced GC is a systemic disease.Different types of patients should be considered for removal of an individualized PM distance intra-operatively.We developed a universally applicable prediction model for accurately determining the 1-year,3-year and 5-year DFS and OS of GC patients according to their preoperative clinicopathologic characteristics and PM distance. | Jun Luo Yuming Jiang Xinhua Chen Yuehong Chen Jhang Lopsang Gurung Tingyu Mou Liying Zhao Guoqing Lyu Tuanjie Li Guoxin Li Jiang Yu | 2020 | Chinese Journal of Cancer Research2020，32，2： | 8 |
| 9 | Enhanced Power Allocation Scheme in Ultra-Dense Small Cell Network显示文摘A feasible design of ultra-dense Small cell network involves an effective solution to the interference coordination especially in cell edge. In this paper, we propose a channel state and interference aware power allocation scheme(PAG) as an enhanced solution to improve the system performance, especially for the cell-edge users. Cournot model in Non-cooperative game is employed for power adjustment in Small cell clusters to increase cell-edge users' throughput by considering the power limitation and interference coordination. Additionally, we take iterative Water Filling scheme as a comparison to clarify that the PAG scheme has struck a favorable balance between system efficiency and fairness. Simulation results show that the proposed scheme contributes to the enhancement of edge users' throughput and cells' coverage. Moreover, the scheme is observed to show a stronger adaptability in denser Small cell networks. | GAO Yuehong CHENG Lei ZHANG Xin ZHU Yajun ZHANG Yunfei | 2016 | China Communications2016，13，2： | 8 |
| 10 | Experimental and Numerical Investigation of Enhancement of Heat and Mass Transfer in Adsorbent Beds显示文摘ExperimentalandNumericalInvestigationofEnhancementofHeatandMassTransferinAdsorbentBedsLiuZhenyan;FuZhuman;GeXinshi;SuYuehong;... | Liu Zhenyan Fu Zhuman Ge Xinshi Su Yuehong Wang Yongtang (Department of Thermal Science and Energy Engineering, University of Science and Technology of China,Hefei, Anhui, 230026, China) | 1994 | Journal of Thermal Science1994，3，3： | 7 |
| 11 | Family-level leaf nitrogen and phosphorus stoichiometry of global terrestrial plants显示文摘Leaf nitrogen(N) and phosphorus(P) concentrations are critical for photosynthesis, growth, reproduction and other ecological processes of plants. Previous studies on large-scale biogeographic patterns of leaf N and P stoichiometric relationships were mostly conducted using data pooled across taxa, while family/genus-level analyses are rarely reported. Here, we examined global patterns of family-specific leaf N and P stoichiometry using a global data set of 12,716 paired leaf N and P records which includes 204 families, 1,305 genera, and 3,420 species. After determining the minimum size of samples(i.e., 35 records), we analyzed leaf N and P concentrations, N:P ratios and N^P scaling relationships of plants for 62 families with 11,440 records. The numeric values of leaf N and P stoichiometry varied significantly across families and showed diverse trends along gradients of mean annual temperature(MAT) and mean annual precipitation(MAP). The leaf N and P concentrations and N:P ratios of 62 families ranged from 6.11 to 30.30 mg g–1, 0.27 to 2.17 mg g–1, and 10.20 to 35.40, respectively. Approximately 1/3–1/2 of the families(22–35 of 62) showed a decrease in leaf N and P concentrations and N:P ratios with increasing MAT or MAP, while the remainder either did not show a significant trend or presented the opposite pattern. Family-specific leaf N^P scaling exponents did not converge to a certain empirical value, with a range of 0.307–0.991 for 54 out of 62 families which indicated a significant N^P scaling relationship. Our results for the first time revealed large variation in the family-level leaf N and P stoichiometry of global terrestrial plants and that the stoichiometric relationships for at least one-third of the families were not consistent with the global trends reported previously. The numeric values of the family-specific leaf N and P stoichiometry documented in the current study provide critical synthetic parameters for biogeographic modeling and for further studies on the physiological and ecological mechanisms underlying the nutrient use strategies of plants from different phylogenetic taxa. | Di Tian Zhengbing Yan Suhui Ma Yuehong Ding Yongkai Luo Yahan Chen Enzai Du Wenxuan Han Emoke Dalma Kovacs Haihua Shen Huifeng Hu Jens Kattge Bernhard Schmid Jingyun Fang | 2019 | Science China(Life Sciences)2019，62，8： | 7 |
| 12 | 体育馆运动人体热舒适性的改进模型与实验调查显示文摘体育馆空调环境不仅会影响人体的运动效果、运动成绩,对于体育馆空调节能也有重要意义。相比于运动人员的热舒适性,传统的空调设计往往更多地关注观众的热舒适性。运动人体具有新陈代谢率大,衣着少,排汗量大以及呼吸急促的特点,传统的基于Fanger模型的人体热舒适性评价指标难以准确预测运动人体的热舒适性。本文针对运动人体提出了衣着覆盖率的概念,对Fanger模型中的辐射、体表扩散的模型进行适当的修正,并探讨了修正模型与Fanger模型计算结果差异。同时,采用环境测试仪和问卷调查对某高校体育馆内篮球训练类、健美操训练类和羽毛球健身类运动人体进行了大量实验调查,并将实验结果与两种模型计算结果进行对比和偏差分析,研究结果表明,修改模型PMV计算结果低于Fanger模型且更接近实测结果,这表明对于运动人体,适宜的场馆环境温度可以比采用Fanger模型得到的传统的空调温度更高,对于空调节能具有重要意义。 | 季泰 袁伟琪 杨剑 季浏 Yuehong Su Saffa Riffat | 2017 | 建筑热能通风空调2017，36，5： | 6 |
| 13 | Preparation and characterization of 3-aminopropyl-triethoxysilane grafted montmorillonite and acid-activated montmorillonite显示文摘3-aminopropyltriethoxysilane grafted montmorillonites were synthesized with montmorillonite, acidactivated montmorillonites and 3-aminopropyltriethoxysilane in ethanol-water mixture. The resulting products were investigated using Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TG). XRD patterns demonstrated that silane was intercalated into the montmorillonite gallery, indicated by increasing basal spacings. These intercalated silanes probably adopt bilayer arrangement models within the montmorillonite and acid-activated montmorillonites interlayer spaces. TG and DTG curves indicate that acidification results in a decrease of the thermal stability of the resultant montmorillonites. Silane grafting leads to a surface property transformation of montmorillonite from hydrophilicity to lipophilicity and an increase of the thermal stability of the condensed silanes. | SHEN Wei HE HongPing ZHU JianXi YUAN Peng MA YueHong LIANG XiaoLiang | 2009 | Chinese Science Bulletin2009，54，2： | 6 |
| 14 | S-wave velocity structure beneath Changbaishan volcano inferred from receiver function显示文摘The S wave velocity structure in Changbaishan volcanic region was obtained from teleseismic receiver func-tion modeling. The results show that there exist distinct low velocity layers in crust in volcano area. Beneath WQD station near to the Tianchi caldera the low velocity layer at 8 km depth is 20 km thick with the lowest S-wave velocity about 2.2 km/s. At EDO station located 50 km north of Tianchi caldera,no obvious crustal low velocity layer is detected. In the volcanic re-gion,the thickness of crustal low velocity layer is greater and the lowest velocity is more obvious with the distance shorter to the caldera. It indicates the existence of the high temperature material or magma reservoir in crust near the Tianchi caldera. The receiver functions and inversion result from different back azimuths at CBS permanent seismic station show that the thickness of near surface low velocity layer and Moho depth change with directions. The near surface low velocity layer is obviously thicker in south direction. The Moho depth shows slight uplifting in the direction of the caldera located. We con-sider that the special near surface velocity structure is the main cause of relatively lower prominent frequency of volcanic earthquake waveforms recorded by CBS station. The slight uplifting of Moho beneath Tianchi caldera indicates there is a material exchanging channel between upper mantle and magma reservoir in crust. | Jianping Wu Yuehong Ming Lihua Fang Weilai Wang | 2009 | Earthquake Science2009，22，4： | 6 |
| 15 | TOOL PATH PLANNING USING VORONOI DIAGRAM AND THREE STACKS显示文摘Based on the object oriented data structure of Voronoi diagram, the algorithm of the trimmed offset generating and the optimal too l path planning of the pocket machining for multiply connected polygonal domains are studied. The intersection state transition rule is improved in this algorithm. The intersection is between the trimmed offsets and Voronoi polygon. On this basis, the trimmed offset generating and the optimal tool path planning are mad e with three stacks(I stack, C stack and P stack)in different monotonous pouches of Voronoi diagram. At the same time, a merging method of Voronoi diagram an d offsets generating for multiply connected polygonal domains is also presented. The above algorithms have been implemented in NC machining successfully, and the efficiency is fully verified. | Fu Zhuang,Liu Chengliang,Yin Yuehong,Cao Qixin,Ma Peixun (Research Institute of Robotics, Shanghai Jiaotong University) Wang Shuguo (Harbin Institute of Technology) | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 5 |
| 16 | Collective mechanism of molecular motors and a dynamic mechanical model for sarcomere显示文摘A non-equilibrium statistical method is used to study the collective characteristics of myosin II motors in a sarcomere during its contraction. By means of Fokker-Planck equation of molecular motors, we present a dynamic mechanical model for the sarcomere in skeletal muscle. This model has been solved with a numerical algorithm based on experimental chemical transition rates. The influences of ATP concentration and load on probability density, contraction velocity and maximum active force are discussed respectively. It is shown that contraction velocity and maximum isometric active force increase with the increasing ATP concentration and become constant when the ATP concentration reaches equilibrium saturation. Contraction velocity reduces gradually as the load force increases. We also find that active force begins to increase then decrease with the increasing length of sarcomere, and has a maximum value at the optimal length that all myosin motors can attach to actin filament. Our results are in good agreement with the Hill muscle model. | YIN YueHong GUO Zhao | 2011 | Science China(Technological Sciences)2011，54，8： | 5 |
| 17 | Comparative pharmacokinetics of tetramethylpyrazine phosphate in rat plasma and extracellular fluid of brain after intranasal,intragastric and intravenous administration显示文摘The purpose of this study was to compare the pharmacokinetic profiles of tetramethylpyrazine phosphate(TMPP)in plasma and extracellular fluid of the cerebral cortex of rats via three delivery routes:intranasal(i.n.),intragastric(i.g.)and intravenous(i.v.)administration.After i.n.,i.g.and i.v.administration of a single-dose at 10 mg/kg,cerebral cortex dialysates and plasma samples drawn from the carotid artery were collected at timed intervals.The concentration of TMPP in the samples was analyzed by HPLC.The area under the concentration-time curve(AUC)and the ratio of the AUCbrain to the AUCplasma(drug targeting efficiency,DTE)was calculated to evaluate the brain targeting efficiency of the drug via these different routes of administration.After i.n.administration,TMPP was rapidly absorbed to reach its peak plasma concentration within 5 min and showed a delayed uptake into cerebral cortex(t_(max)=15 min).The ratio of the AUCbrain dialysates value between i.n.route and i.v.injection was 0.68,which was greater than that obtained after i.g.administration(0.43).The systemic bioavailability obtained with i.n.administration was greater than that obtained by the i.g.route(86.33%vs.50.39%),whereas the DTE of the nasal route was 78.89%,close to that of oral administration(85.69%).These results indicate that TMPP is rapidly absorbed from the nasal mucosa into the systemic circulation,and then crosses the blood-brain barrier(BBB)to reach the cerebral cortex.Intranasal administration of TMPP could be a promising alternative to intravenous and oral approaches. | Dongmei Meng Haoyang Lu Shanshan Huang Minyan Wei Pingtian Ding Xianglin Xiao Yuehong Xu Chuanbin Wu | 2014 | Acta Pharmaceutica Sinica B2014，4，1： | 5 |
| 18 | Bioelectrochemical control mechanism with variable-frequency regulation for skeletal muscle contraction-Biomechanics of skeletal muscle based on the working mechanism of myosin motors(Ⅱ)显示文摘This paper presents a bioelectrochemical model for the activation of action potentials on sarcolemma and variation of Ca2+ concentration in sarcomeres of skeletal muscle fibers.The control mechanism of muscle contraction generated by collective motion of molecular motors is elucidated from the perspective of variable-frequency regulation,and action potential with variable frequency is proposed as the control signal to directly regulate Ca2+ concentration and indirectly control isometric tension.Furthermore,the transfer function between stimulation frequency and Ca2+ concentration is deduced,and the frequency domain properties of muscle contraction are analyzed.Moreover the conception of 'electro-muscular time constant' is defined to denote the minimum delay time from electric stimulation to muscle contraction.Finally,the experimental research aiming at the relation between tension and stimulation frequency of action potential is implemented to verify the proposed variable-frequency control mechanism,whose effectiveness is proved by good consistence between experimental and theoretical results. | YIN YueHong CHEN Xing | 2012 | Science China(Technological Sciences)2012，55，8： | 5 |
| 19 | Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility:a meta-analysis显示文摘Expression of estrogen receptors is correlated with breast cancer risk,but inconsistent results have been reported.To clarify potential estrogen receptor(ESR)-related breast cancer risk,we analyzed genetic variants of ESR1 in association with breast cancer susceptibility.We performed a meta-analysis to investigate the association between rs2234693,rs1801132,and rs2046210(single nucleotide polymorphisms of ESR1),and breast cancer risk.Our analysis included 44 case-control studies.For rs2234693,the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype.For rs2046210,the AA,GA,or GA + GG genotype had a much higher risk compared to the GG genotype.No significant association was found for the rs 1801132 polymorphism with breast cancer risk.This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk.The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity. | Xu Hu Linfei Jiang Chenhui Tang Yuehong Ju Li Jiu Yongyue Wei Li Guo Yang Zhao | 2017 | The Journal of Biomedical Research2017，31，3： | 4 |
| 20 | A dynamic model of skeletal muscle based on collective behavior of myosin motors-Biomechanics of skeletal muscle based on working mechanism of myosin motors(I)显示文摘A dynamic model of skeletal muscle is developed to describe its activation kinetics and contraction dynamics based on the collective working mechanism of myosin II motors with a statistical mechanics method.According to the structure of sarcomeres arranged in series and in parallel,the mechanical properties of skeletal muscle are studied.This model reveals the relations between action potential and muscle characteristics.It is shown that calcium concentration in sarcoplasmic(SP) increases linearly with the increasing stimulation frequency and gradually reaches saturation.Active force and contraction velocity follow the trend of calcium concentration and reach a peak value at the maximum stimulation frequency.Contraction velocity is inversely proportional to the load while the contraction power increases to maximum and then reduces to zero with the increasing load.These properties are consistent with published physiological experimental results of skeletal muscle. | GUO Zhao YIN YueHong | 2012 | Science China(Technological Sciences)2012，55，6： | 4 |
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