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| 1 | Development of liposomal formulations: From concept to clinical investigations显示文摘Liposome is one of the most successful drug delivery systems applying nanotechnology topotentiate the therapeutic efficacy and reduce toxicities of conventional medicines. Sincethe first doxorubicin-loaded liposome reached the market, numerous researches have beencarried out to develop new liposomal formulations over the past decade and have givenbirth to a series of commercial products. Therapeutic agents, most of which are anti-cancerdrugs, are encapsulated in the aqueous core or lipid bilayers of liposomes to improve theirdelivery to the targeted tissue. There are several liposomal formulations, such as EndoTAG-1 (paclitaxel-loaded cationic liposomes), Lipoplatin (cisplatin-loaded long circulating liposomes) and Stimuvax (a cancer vaccine), showing promising therapeutic value in clinicalstudies. Besides, new designs including environmentally sensitive liposomes, liposomaldrug combinations and liposomal vaccines are now tested in clinical trials. | Yuchen Fan Qiang Zhang | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，2： | 8 |
| 2 | Optimizing the CRISPR/Cas9 system for genome editing in grape by using grape promoters显示文摘The efficacy of the CRISPR/Cas9 system in grapevine(Vitis vinifera L.)has been documented,but the optimization of this system,as well as CRISPR/Cas9-mediated multiplex genome editing,has not been explored in this species.Herein,we identified four VvU3 and VvU6 promoters and two ubiquitin(UBQ)promoters in grapevine and demonstrated that the use of the identified VvU3/U6 and UBQ2 promoters could significantly increase the editing efficiency in grape by improving the expression of sgRNA and Cas9,respectively.Furthermore,we conducted multiplex genome editing using the optimized CRISPR/Cas9 vector that contained the conventional multiple sgRNA expression cassettes or the polycistronic tRNA-sgRNA cassette(PTG)by targeting the sugar-related tonoplastic monosaccharide transporter(TMT)family members TMT1 and TMT2,and the overall editing efficiencies were higher than 10%.The simultaneous editing of TMT1 and TMT2 resulted in reduced sugar levels,which indicated the role of these two genes in sugar accumulation in grapes.Moreover,the activities of the VvU3,VvU6,and UBQ2 promoters in tobacco genome editing were demonstrated by editing the phytoene desaturase(PDS)gene in Nicotiana benthamiana leaves.Our study provides materials for the optimization of the CRISPR/Cas9 system.To our knowledge,our simultaneous editing of the grape TMT family genes TMT1 and TMT2 constitutes the first example of multiplex genome editing in grape.The multiplex editing systems described in this manuscript expand the toolbox of grape genome editing,which would facilitate basic research and molecular breeding in grapevine. | Chong Ren Yanfei Liu Yuchen Guo Wei Duan Peige Fan Shaohua Li Zhenchang Liang | 2021 | Horticulture Research2021，8，1： | 6 |
| 3 | Vertical Distribution Characteristics of PM2.5 Observed by a Mobile Vehicle Lidar in Tianjin, China in 2016显示文摘We present mobile vehicle lidar observations in Tianjin, China during the spring, summer, and winter of 2016. Mobile observations were carried out along the city border road of Tianjin to obtain the vertical distribution characteristics of PM_(2.5). Hygroscopic growth was not considered since relative humidity was less than 60% during the observation experiments. PM_(2.5) profile was obtained with the linear regression equation between the particle extinction coefficient and PM_(2.5) mass concentration. In spring, the vertical distribution of PM_(2.5) exhibited a hierarchical structure. In addition to a layer of particles that gathered near the ground, a portion of particles floated at 0.6–2.5-km height. In summer and winter, the fine particles basically gathered below 1 km near the ground. In spring and summer, the concentration of fine particles in the south was higher than that in the north because of the influence of south wind. In winter, the distribution of fine particles was opposite to that measured during spring and summer. High concentrations of PM_(2.5) were observed in the rural areas of North Tianjin with a maximum of 350 μg m–3 on 13 December2016. It is shown that industrial and ship emissions in spring and summer and coal combustion in winter were the major sources of fine particles that polluted Tianjin. The results provide insights into the mechanisms of haze formation and the effects of meteorological conditions during haze–fog pollution episodes in the Tianjin area. | Lihui LYU Yunsheng DONG Tianshu ZHANG Cheng LIU Wenqing LIU Zhouqing XIE Yan XIANG Yi ZHANG Zhenyi CHEN Guangqiang FAN Leibo ZHANG Yang LIU Yuchen SHI Xiaowen SHU | 2018 | Journal of Meteorological Research2018，32，1： | 5 |
| 4 | mTOR regulates NLRP3 inflammasome activation via reactive oxygen species in murine lupus显示文摘 | Xiaojing Li Xuefang Zhang Yuchen Pan Guoping Shi Jing Ren Hongye Fan Huan Dou Yayi Hou | 2018 | Acta Biochimica et Biophysica Sinica2018，50，9： | 4 |
| 5 | From Brain Science to Artificial Intelligence显示文摘Reviewing the history of the development of artificial intelligence(AI)clearly reveals that brain science has resulted in breakthroughs in AI,such as deep learning.At present,although the developmental trend in AI and its applications has surpassed expectations,an insurmountable gap remains between AI and human intelligence.It is urgent to establish a bridge between brain science and AI research,including a link from brain science to AI,and a connection from knowing the brain to simulating the brain.The first steps toward this goal are to explore the secrets of brain science by studying new brain-imaging technology;to establish a dynamic connection diagram of the brain;and to integrate neuroscience experiments with theory,models,and statistics.Based on these steps,a new generation of AI theory and methods can be studied,and a subversive model and working mode from machine perception and learning to machine thinking and decision-making can be established.This article discusses the opportunities and challenges of adapting brain science to AI. | Jingtao Fan Lu Fang Jiamin Wu Yuchen Guo Qionghai Dai | 2020 | Engineering2020，6，3： | 4 |
| 6 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 7 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 8 | Native point defects and oxygen migration of rare earth zirconate and stannate pyrochlores显示文摘Various excellent properties of rare earth zirconate and stannate pyrochlores are close related with their native point defects.First-principles calculations are performed to systematically investigate the point defect mechanism and the oxygen diffusion behavior of A_(2)B_(2)O_(7)(A=La,Ce,Pr,Nd,Pm,Sm,Eu,Gd;B=Zr,Sn).The possible defect complexes and their associated reactions under stoichiometric and nonstoichiometric conditions are explored.The O Frenkel pairs are the most stable defect structure in stoichiometric zirconates,whereas the cation antisite defects are the predominant one in stoichiometric stannates.In the case of BO_(2) excess zirconates and stannates,the BA cation antisite defect with the A vacancy and/or the oxygen interstitial is energetically favorable,whereas the ABantisite defect together with the oxygen vacancy and/or the A interstitial is preferable under the A_(2)O_(3) excess condition.Meanwhile,the maximum point defect concentrations of zirconates are much higher than those of stannates.Furthermore,the oxygen migration barriers are similar in these compounds,ranging in 0.68 eV–0.80 eV.The predicted point defects and oxygen diffusion mechanisms play the critical role in their engineering applications and are expected to guide the future property improvement of pyrochlores through the control of point defects and/or composition. | Juanli Zhao Yuchen Liu Yun Fan Wei Zhang Chengguan Zhang Guang Yang Hongfei Chen Bin Liu | 2021 | Journal of Materials Science & Technology2021，，14： | 2 |
| 9 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 10 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 11 | Long-term Seismic Performance of Reinforced Concrete Bridges Under Steel Reinforcement Corrosion Due to Chloride Attack显示文摘 | Ou Yuchen Fan Hongda Nguyen Dang Nguyen | 2013 | Earthquake Engng Struct Dyn2013，42，14： | 1 |
| 12 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 13 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 14 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 15 | Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘 | Di Li Lijun Song Yuchen Fan Xia Li Yingjie Li Jie Chen Faliang Zhu Chun Guo Yongyu Shi Lining Zhang | 2009 | Clinical Immunology2009，，： | 1 |
| 16 | Optical Design and Stray Light Analysis of the Space Infrared Optical System显示文摘This article describes a novel configuration design for a re-imaging off-axis catadioptric space infrared optical system,and in order to satisfy the signal noise ratio requirements of the system,the stray light of the system is necessary to analyze and restrain. The optical system with a focal length of 1 200 mm,an entrance pupil diameter of 600 mm,an F-number of 2,a field of view of 3°× 0. 15°,a working wave band of 8 μm-10 μm,and the image quality of the optical system almost approach to diffraction limits in all field of view.Then the mathematical models of stray light are built,and the suppressive structure is established to eliminate the effect of stray light. Finally,TraceP ro is used to analyze and simulate stray light with and without the suppressive structure,and also get the results of the PST curves. The results indicate that appropriate optical system and suppressive structure can highly reduce the stray light of the space infrared optical system. | Yuchen Zhao Yanjun Xu Changzheng Chen Fan Zhang Jianyue Ren | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，1： | 1 |
| 17 | Down-regulation of TIPE2 Mrna expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘 | Di Li Lijun Song Yuchen Fan | 2009 | Clinical Immunology2009，133，2： | 1 |
| 18 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 19 | Targeting the brain with PEG–PLGA nanoparticles modified with phage-displayed peptides显示文摘 | Jingwei Li Liang Feng Li Fan Yuan Zha Liangran Guo Qizhi Zhang Jun Chen Zhiqing Pang Yuchen Wang Xinguo Jiang Victor C. Yang Longping Wen | 2011 | Biomaterials2011，，21： | 1 |
| 20 | Impact of chlorites on the wettability of tight oil sandstone reservoirs in the Upper Triassic Yanchang Formation,Ordos Basin,China显示文摘Wettability is an essential property of reservoirs that is of great importance for enhancing oil recovery(EOR)and oil migration.The wettability of reservoirs is generally believed to be strongly affected by mineral compositions but it is not always the case.An integrated study of petrography and wettability was carried out to determine the impact of chlorite minerals on the wettability of the sandstone reservoirs in the Upper Triassic Yanchang Formation.Chlorites are found to be commonly present in the reservoir sandstones as detrital grains,rim-shaped cements,and biotite-chloritized forms with the pore peripheries being largely coated by chlorite,which is the main mineral in direct contact with pores.At pore scale,the wetting state of chlorites can either be oil-wet or water-wet in the tight sandstone reservoirs depending on wettability alteration by oil charge.Chlorites in contact with pores occupy a large of proportions of oil-wet pore walls and are crucial for the formation of oil-wetting state of reservoir sandstones.At core scale,the contents of chlorites in direct contact with pores do not correlate well with the AmottHarvey index due to other factors such as heterogeneity,oil-bearing degrees of samples. | Zhongnan WANG Xiaorong LUO Keyu LIU Yuchen FAN Xiangzeng WANG | 2021 | Science China Earth Sciences2021，64，6： | 1 |
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