|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 2 | Th17 cells and IL-17 are involved in the disruption of vulnerable plaques triggered by short-term combination stimulation in apolipoprotein E-knockout mice显示文摘可观的证据显示那种类型 1 个 T 助手(Th1 )- 并且当时,调停 Th17 的有免疫力的回答支持动脉粥样硬化患者匾的形成那 CD4 + CD25 + 规章的 T 房间(Tregs ) 有的 Foxp3 + 保护的效果。然而,因为令人满意的匾破裂模型的缺乏,在匾破裂遗体的多样的 CD4 + 淋巴细胞子集的功能糟糕理解。这里,我们在颈动脉动脉上用一本高脂肪的食谱和领子放置建立了动脉粥样硬化患者匾破裂的一个鼠科的模型,并且在 apolipoprotein 电子大美人与 lipopolysaccharide, phenylephrine 注射和寒冷的联合由短期的刺激触发了匾破裂(ApoE −/−) 老鼠。我们由 PCR,流动 cytometry, ELISA 和 immunohistochemistry 调查了在 Th1 房间, Th17 房间和 Tregs 和匾破裂之间的协会。总共, 75 %(18/24 ) 脆弱的匾,而是没有稳定的匾,显示出的破裂特征。Th17 房间的比例在处理以后在 splenocytes 之中被增加,但是在 Th1 房间和 Tregs 的层次的变化不与破裂有关。而且,处理在浆液并且在匾破裂的区域导致了 interleukin-17 (IL-17 ) 的高水平。在 vitro, IL-17 增加了 apoptosis 的水平,与匾破裂联系的一个主要因素,在有教养的鼠科的脉管的光滑的肌肉房间。Th17 房间和 IL-17 可以涉及短期的刺激在 ApoE −/− 老鼠。 | Tian Ma Qi Gao Faliang Zhu Chun Guo Qun Wang Fei Gao Lining Zhang | 2013 | Cellular & Molecular Immunology2013，10，4： | 9 |
| 3 | 在由巨噬细胞并且从而的增加的 IL-10 表示的规划房间死亡 4 结果的缺乏在 hyperlipidemic 鼠标稀释动脉粥样硬化显示文摘(Pdcd4 ) 规划房间死亡 4 是抄写和翻译和肿瘤 suppressor 的一个最新定义的禁止者。最近的研究建议了 Pdcd4 可以也涉及一些煽动性的疾病。然而,它在动脉粥样硬化的角色,动脉的墙的长期的发炎,尚待被调查。这里,我们发现在老鼠的那 Pdcd4 缺乏在巨噬细胞增加了 IL-10 的表示并且减少在 T 房间的 IL-17 的表示面对在 vitro 并且在高导致脂肪的动脉粥样硬化患者匾的一个联系动脉粥样硬化的激发器。重要地,击倒 Pdcd4 在喂的 Apoe −/− 老鼠在动脉粥样硬化患者损害导致了减少一本高胖的食谱。这效果能被与抵销的抗体堵住 IL-10 然而并非由外长的 IL-17 的申请部分颠倒。进一步机械学的研究表明 Pdcd4 否定地以一种 ERK1/2 依赖、 p38 依赖的方式调整了 IL-10 的表示。这些结果证明那 Pdcd4 缺乏通过反煽动性的 cytokine IL-10 的 upregulation 部分地在 hyperlipidemic 老鼠稀释动脉粥样硬化。这显示内长的 Pdcd4 支持动脉粥样硬化因此与动脉粥样硬化为病人代表一个潜在的治疗学的目标。 | Yang Jiang Qi Gao Liyang Wang Chun Guo Faliang Zhu Bo Wang Qun Wang Fei Gao Youhai Chen Lining Zhang | 2016 | Cellular & Molecular Immunology2016，13，4： | 8 |
| 4 | High throughput online sequential extraction of natural rare earth elements and determination by mass spectrometry显示文摘At the beginning of rare earth industry,several days are normally required for characterization of rare earth elements(REEs)fractionation in ore samples.Herein,rapid fractionation analysis of 15 REEs and accompanied metal(Fe,Mn,etc.)in ore samples has been achieved within 1 h using ICP-MS with a homemade device for online sequential solvent extraction.As a result,five fractionations for REEs occurrences,i.e.,water soluble,exchangeable,reducible,oxidizable and crystalline,have been identified,offering chemical insights which not only reveal the formation mechanism of REEs ores but also show great implications for guiding the exploitation and separation of REEs.In comparison with conventional methods,the present approach significantly shortened the analysis time(1 h vs.~80 h)and reduced the sample consumption(1.0 mg vs.5.0 g)with high recovery(>95%),providing a useful platform for the rapid quantitative fractionation analysis of REEs in complexed samples such as ore and fossils. | Jiaquan Xu Faliang Li Fei Xia Tenggao Zhu Debo Wu Konstantin Chingin Huanwen Chen | 2021 | Science China Chemistry2021，64，4： | 3 |
| 5 | Structure and Electrochemical Properties of A_2B_7-Type La-Mg-Ni Hydrogen Storage Alloys显示文摘Investigation of alloy structure shows that La 2-x MgxNi7(x=0.3~0.8) alloys are mainly composed of Ce2Ni7-type, Gd2Co7-type and PuNi3-type phase. The influence of Mg content in alloys on the phase structure is great, resulting in a linear decrease of the unit cell parameters of main phases and increase of hydrogen absorption/desorption plateau as Mg content increases. Electrochemical measurements show that as the Mg content increases, the discharge capacity of alloy electrodes first increases and then decreases. The cyclic stability presents a deteriorative trend, La 1.4 Mg 0.6 Ni7 alloy electrode exhibits the maximum electrochemical discharge capacity (378 mAh·g -1 ), and the La 1.6 Mg 0.4 Ni7 alloy electrode shows the best cyclic stability (S 270 =81%). The high rate dischargeability increases with the increase of Mg content. When the Mg content (x) is lower than 0.5, the rate-determining step of the electrode reaction is the diffusion of hydrogen in bulk. When the Mg content (x) is higher than 0.5, the control progress of the electrode reaction is converted to charge-transfer on the alloy surface. | Zhang Faliang Luo Yongchun Zhang Yongchao Deng Anqiang Kang Long Chen Jianhong | 2006 | Journal of Rare Earths2006，24，5： | 2 |
| 6 | Guest selectivity in the supramolecular host networks fabricated by van der Waals force and hydrogen bond显示文摘Here, the structural transformations of H4ETTC induced by coronene (COR) and selective adsorption behaviors of COR in different templates were investigated by seanning tunnelling microscope (STM). It was discovered that the assembled architecture of H4ETTC at the HOPG/ heptanoic acid interface depended on the concentration of COR, and the clusters of COR were obtained in the kagome nanoporous network of H4ETTC molecules at a high concentration of COR solution. In addition, COR clusters can also be formed in the hexagonal porous structure of hexaphenylbenzene (HPB) molecules modified by alkyl chains at the HOPG/heptanoic acid interface. When both H4ETTC and HPB assembly structures, based on hydrogen bonding and van der Waals force respectively, were selected as the host templates, COR showed selectivity for HPB template to form HPB/COR hexagonal host-guest architecture. Density functional theory (DFT) calculations were also performed to disclose the mechanisms involved. | Xuan Peng Yanfang Geng Min Zhang Faliang Cheng Linxiu Cheng Ke Deng Qingdao Zeng | 2019 | Nano Research2019，12，3： | 2 |
| 7 | ANALYSIS OF THE LARGE DEFLECTION DYNAMIC PLASTIC RESPONSE OF SIMPLY-SUPPORTED CIRCULAR PLATES BY THE“MEMBRANE FACTOR METHOD”显示文摘Based on energy equilibrium,a new procedure called the Membrane Factor Method is devel-oped to analyze the dynamic plastic response of plates with deflections in the range where both bending mo-ments and membrane forces are important.The final deflection of a simply -supported circular rigid-plasticplate loaded by a uniformly distributed impulse is obtained.In comparison with other approximate solutions,the present results are found to be simpler and in better agreement with the corresponding experimental valuesreoorded by Florence. | Yu Tongxi (1) Chen Faliang (1) | 1990 | Acta Mechanica Sinica1990，6，4： | 2 |
| 8 | La-Mg-Ni ternary hydrogen storage alloys with Ce2Ni7- type and Gd2 CoT-type structure as negative electrodes for Ni/MH batteries 显示文摘 | Zhang Faliang Luo Yongchun Chen Jiangping | 2007 | Journal of Alloys and Compounds2007，430，： | 1 |
| 9 | Preparation of titanium nitride ultrafine powders by sol-gel and microwave carbothermal reduction nitridation methods显示文摘 | Zhang Haijun Li Faliang Jia Quanli | 2009 | Ceramics International2009，35，： | 1 |
| 10 | Effect of Co content on the structure and electrochemical properties of La 1.5 Mg 0.5 Ni 7? x Co x ( x =0, 1.2, 1.8) hydrogen storage alloys显示文摘 | Faliang Zhang Yongchun Luo Kai Sun Dahui Wang Ruxu Yan Long Kang Jianhong Chen | 2006 | Journal of Alloys and Compounds2006，，1： | 1 |
| 11 | The large deflection dy-namic plastic response of rectangular plates显示文摘 | YU Tongxi CHEN Faliang | | 0，，04： | 1 |
| 12 | Recent Progress of Carbon Nanotubes Reinforced MgO-C and Al_2O_3-C Refractories显示文摘Carbon nanotubes( CNTs) have been extensively studied over the last two decades since they possess excellent properties. CNTs have been considered as new promising reinforcements for carbon containing refractories( CCRs). Current research progress of the CNT-reinforced MgO- C and Al2O3- C refractories was summarized in this mini-review,and the CNT-reinforced CCRs possess remarkable mechanical properties and superior thermal shock resistance compared to CCRs without CNTs. | WANG Junkai DENG Xiangong LI Faliang ZHANG Haijun ZHANG Shaowei | 2014 | China's Refractories2014，23，4： | 1 |
| 13 | La-Mg-Ni ternary hydrogen storage alloys with Ce2Ni7-type and Gd2Co7-type structure as negative electrodes for Ni/MH batteries显示文摘 | Faliang Zhang Yongchun Luo Jiangping Chen | 2007 | J Alloys Comp2007，430，： | 1 |
| 14 | 显示文摘 | Zhang Faliang | 2005 | J Power Sources2005，150，： | 1 |
| 15 | IL-17 induces apoptosis of vascular endothelial cells-a potential mechanism for human acute coronary syndrome显示文摘 | Faliang Zhu Qun Wang Chun Guo | 2011 | Clinical Immunology2011，141，： | 1 |
| 16 | Study of the suitable water-saving technique model based on fuzzy neural network for Wannian County Original Research Article显示文摘 | Huang Binbin Gui Faliang Zhang Xiaohui | 2011 | Procedia Engineering2011，，15： | 1 |
| 17 | 显示文摘 | Zhang Faliang Luo Yongchun Chen Jiangping | 2005 | Journal of Power Sources2005，150，4： | 1 |
| 18 | Fast face detection algorithm based on improved skin-color model显示文摘 | Chen Zhenxue Liu Chengyun Chang Faliang | 2013 | Arabian Journal for Science and Engineering2013，38，3： | 1 |
| 19 | Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘 | Di Li Lijun Song Yuchen Fan Xia Li Yingjie Li Jie Chen Faliang Zhu Chun Guo Yongyu Shi Lining Zhang | 2009 | Clinical Immunology2009，，： | 1 |
| 20 | 显示文摘 | Zhang Faliang Luo Yongchun Chen Jiangping | | J Power sources0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员