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| 1 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 2 | An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease显示文摘Background:With the rising global prevalence of fatty liver disease related to metabolic dysfunction,the association of this common liver condition with chronic kidney disease(CKD)has become increasingly evident.In 2020,the more inclusive term metabolic dysfunction-associated fatty liver disease(MAFLD)was proposed to replace the term non-alcoholic fatty liver disease(NAFLD).The observed association between MAFLD and CKD and our understanding that CKD can be a consequence of underlying metabolic dysfunction support the notion that individuals with MAFLD are at higher risk of having and developing CKD compared with those without MAFLD.However,to date,there is no appropriate guidance on CKD in individuals with MAFLD.Furthermore,there has been little attention paid to the link between MAFLD and CKD in the Nephrology community.Methods and Results:Using a Delphi-based approach,a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on some of the open research questions regarding the link between MAFLD and CKD.Conclusions:This Delphi-based consensus statement provided guidance on the epidemiology,mechanisms,management and treatment of MAFLD and CKD,as well as the relationship between the severity of MAFLD and risk of CKD,which establish a framework for the early prevention and management of these two common and interconnected diseases. | Dan-Qin Sun Giovanni Targher Christopher D.Byrne David C.Wheeler Vincent Wai-Sun Wong Jian-Gao Fan Herbert Tilg Wei-Jie Yuan Christoph Wanner Xin Gao Michelle T.Long Mehmet Kanbay Mindie H.Nguyen Sankar D.Navaneethan Yusuf Yilmaz Yuli Huang Rino A.Gani Pierluigi Marzuillo Jérôme Boursier Huijie Zhang Chan-Young Jung Jin Chai Luca Valenti George Papatheodoridis Giovanni Musso Yu-Jun Wong Mohamed El-Kassas Nahum Méndez-Sánchez Silvia Sookoian Michael Pavlides Ajay Duseja Adriaan G.Holleboom Junping Shi Wah-Kheong Chan Yasser Fouad Junwei Yang Sombat Treeprasertsuk Helena Cortez-Pinto Masahide Hamaguchi Manuel Romero-Gomez Mamun Al Mahtab Ponsiano Ocama Atsushi Nakajima Chunsun Dai Mohammed Eslam Lai Wei Jacob George Ming-Hua Zheng | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 1 |
| 3 | Effect of additives on formation of natural gas hydrate 显示文摘 | ZHANG Chunsun FAN Shuanshi LIANG Deqing | 2004 | Fuel2004，83，16： | 1 |
| 4 | Effect of Additives on Formation of Natural Gas Hydrate 显示文摘 | ZHANG Chunsun FAN Shuanshi LIANG Deqing | 2004 | Fuel2004，83，16： | 1 |
| 5 | Identification of novel miRNAs in mouse embryonic stem cells and reprogrammed pluripotent cells显示文摘MicroRNAs(miRNAs)are a class of endogenous small RNAs that regulate target gene expression at the posr-transcriptional level.miRNAs play an important role in almost all physiological activities including the processes of embryonic stem cell(ESC)pluripotency maintenanee and differentiation,as well as induced pluripotent stem cell(iPSC)reprogramming.In this study,we identified eight novel miRNAs by mining the deep sequencing dataset from mouse ESCs and three kinds of reprogrammed pluripotent cells.Most of them are con served at least in Murinae animals.Seven of them are derived from gene introns.We further showed that miR-novel-41 is a mirtron that derives from the intron of Man2cl,a protein-coding gene.Mirtrons are a kind of special non-canonical miRNAs encoded in introns.Their precursors are not processed by Drosha but generated by intron splicing. | Botao Zhao Chunsun Fan Youxin Jin | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 0 |
| 6 | miR-290 contributes to the low abundance of cyclin D1 protein in mouse embryonic stem cells显示文摘老鼠 miR-290 簇 miRNAs 在早胚胎和胚胎的细菌房间明确地被表示。这些 miRNAs 戏在 pluripotency 和自强的维护的关键角色。这里,我们证明 Cyclin D1 是 miR-290 簇 miRNAs 的直接目标基因。在在 pluripotent 和 non-pluripotent 房间,以及在区分 CGR8 房间的 Cyclin D1 蛋白质和 miR-290 簇 miRNAs 的表示之间的否定关系被观察。miR-290 簇 miRNAs 的抑制能在 G1 阶段逮捕房间并且在 CGR8 老鼠干细胞减慢房间增长。因为 miR-290 簇 miRNAs 是最主导的 stem-cell-specific miRNAs,我们的结果在老鼠为 Cyclin D1 的缺席揭示了一个重要原因胚胎的干细胞。 | Zizhen Gong Detao Wang Shaoliang Zhu Yuqing Xia Chunsun Fan Botao Zhao Youxin Jin | 2017 | Acta Biochimica et Biophysica Sinica2017，49，7： | 0 |
| 7 | Identification of differentially expressed miRNAs in mouse spinal cord development显示文摘MicroRNAs (miRNAs ) 是 22 nt 的非编码的、规章的小 RNA 的一个班。这些小 RNA 在各种各样的重要生物过程起关键作用,这被含有。在开发期间,某 miRNAs 明确地在单个纸巾并且在特别发展阶段被表示。许多 miRNAs 表演在中央神经系统的发展的不同表示模式,包括针的绳索。在这研究,我们首先在鼠标的开发报导了 miRNAs 表达式针的绳索。差别表示了 miRNAs 在胚胎(白天 13.5 ) 并且新生的老鼠针的绳索被识别。差别的预言的目标基因表示了 miRNAs 服从于基因本体论和 KEGG 小径分析,并且几条紧张的发展相关的小径被充实暗示这些 miRNAs 可以涉及调整老鼠的这些小径针的绳索开发。 | Botao Zhao Menggui Huang Yanyan Bai Chunsun Fan Yi Fan Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 0 |
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