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| 1 | A unified poroviscoelastic model with mesoscopic and microscopic heterogeneities显示文摘The wave-induced fluid flow(WIFF) is considered to be the main cause of dispersion and attenuation of seismic waves in fluid-saturated porous media. Among numerous theories, the mesoscopic and microscopic heterogeneities are considered to be the primary mechanisms causing the WIFF. Furthermore,in most rocks, the mesoscopic and microscopic heterogeneities exist simultaneously and can cause obvious transitions of the fast P-wave velocity, which means it is necessary to consider the influence of the two mechanisms on the dispersion and attenuation simultaneously. Numerous results have shown that the dispersions and attenuations caused by these two mechanisms can be approximated in terms of the Zener model. To combine the two mechanisms into a unified model, we introduce a new generalized Zener model into the Biot poroelasticity theory to obtain a new poroviscoelastic model. Comparisons between the numerical results and two groups of experimental data further confirm the validity of our new model. | Boya Zhang Dinghui Yang Yuanfeng Cheng Yunyin Zhang | 2019 | Science Bulletin2019，64，17： | 9 |
| 2 | A wave propagation model with the Biot and the fractional viscoelastic mechanisms显示文摘Energy loss in porous media containing fluids is typically caused by a variety of dynamic mechanisms.In the Biot theory,energy loss only includes the frictional dissipation between the solid phase and the fluid phase,resulting in underestimation of the dispersion and attenuation of the waves in the low frequency range.To develop a dynamic model that can predict the high dispersion and strong attenuation of waves at the seismic band,we introduce viscoelasticity into the Biot model and use fractional derivatives to describe the viscoelastic mechanism,and finally propose a new wave propagation model.Unlike the Biot model,the proposed model includes the intrinsic dissipation of the solid frame.We investigate the effects of the fractional order parameters on the dispersion and attenuation of the P-and S-waves using several numerical experiments.Furthermore,we use several groups of experimental data from different fluid-saturated rocks to testify the validity of the new model.The results demonstrate that the new model provides more accurate predictions of high dispersion and strong attenuation of different waves in the low frequency range. | Jiaming YANG Dinghui YANG Hongwei HAN Lingyun QIU Yuanfeng CHENG | 2021 | Science China Earth Sciences2021，64，3： | 2 |
| 3 | Adsorption of methylene blue by phoenix tree leaf powder in a fixed-bed column: experiments and prediction of breakthrough curves显示文摘 | Runping Han Yu Wang Xin Zhao Yuanfeng Wang Fuling Xie Junmei Cheng Mingsheng Tang | 2009 | Desalination2009，，1： | 1 |
| 4 | Adsorption of methylene blue by phoenix tree leaf powder in a fixed-bed column: experiments and prediction of breakthrough curves显示文摘 | Runping Han Yu Wang Xin Zhao Yuanfeng Wang Fuling Xie Junmei Cheng Mingsheng Tang | 2009 | Desalination2009，，1： | 1 |
| 5 | POLG Mutations Are Probably Rare in the Han Chinese Population显示文摘Objective Mutations in polymerase gamma gene(POLG)are believed to be an important cause of early and juvenile onset of non-syndromic intractable epilepsy.The aim of this study is to investigate the incidence/prevalence of POLG pathogenic variants in epilespy patients of Han population through sequencing it.Methods Han Chinese patients with seizures prior valproic acid(VPA)exposure at Shanghai Children\Hospital were collected from 2015 to 2019.The clinical diagnosis was based on the 2014 Consensus Statement of Epilepsy by the International League against Epilepsy(ILAE).Blood sampling were performed before VPA treatment.The POLG gene DNA was sequenced by either the first or the next generation sequencing(NGS).The POLG variant burden was illustrated.Liver functions were tested to describe whether they experienced VPA toxicity.Results Ibtally 216 Han Chinese patients were included,aged from 1 month to IS years old,102 were male and 114 were female.The onset age was 1 month old to 13 years old,and the epilepsy course ranged from 2 weeks to about 3 years.VPA treatment was delivered for the generalized or intractable partial seizures at standard dosage.No patient experienced hepatic toxicity following VPA exposure.DNA sequencing data showed no patient had either a homozygous mutation or compound heterozygous mutation of POLG.Single heterozygous mutations of c.1150G>T and p.D384Y were found in 2 patients,and single heterozygous mutation of c.l56_158dupGCA was found in 1 patient.None of these variants showed clinical significance.Conclusions Functional modifying POLG homozygous mutations and compound heterozygous mutations were not detected and VPA toxicity was not seen in the current study.POLG mutation frequency might be rare in Han Chinese,and standard VPA.therapeutic dosage might be safe for Han Chinese patients. | Kunfang Yang Linyi Meng Yuanfeng Zhang Yongchen Yang Hongyi Cheng Zhihu Jiang Hong Zhang Yucai Chen | 2020 | Chinese Medical Sciences Journal2020，35，4： | 0 |
| 6 | Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations显示文摘Uncommon epidermal growth factor receptor(EGFR) mutations account for 10% 20% of all EGFR mutations in non-small-cell lung cancer(NSCLC). The uncommon EGFR-mutated NSCLC is associated with poor clinical outcomes and generally achieved unsatisfactory effects to the current therapies using standard EGFR-tyrosine kinase inhibitors(TKIs), including afatinib and osimertinib. Therefore, it is necessary to develop more novel EGFR-TKIs to treat uncommon EGFR-mutated NSCLC.Aumolertinib is a third-generation EGFR-TKI approved in China for treating advanced NSCLC with common EGFR mutations. However, it remains unclear whether aumolertinib is effective in uncommon EGFR-mutated NSCLC. In this work, the in vitro anticancer activity of aumolertinib was investigated in engineered Ba/F3 cells and patient-derived cells bearing diverse uncommon EGFR mutations. Aumolertinib was shown to be more potent in inhibiting the viability of various uncommon EGFR-mutated cell lines than those with wild-type EGFR. And in vivo, aumolertinib could also significantly inhibit tumor growth in two mouse allograft models(V769-D770insASV and L861Q mutations) and a patientderived xenografts model(H773-V774insNPH mutation). Importantly, aumolertinib exerts responses against tumors in advanced NSCLC patients with uncommon EGFR mutations. These results suggest that aumolertinib has the potential as a promising therapeutic candidate for the treatment of uncommon EGFR-mutated NSCLC. | Chen Shi Cong Zhang Zhiwen Fu Jinmei Liu Yuanfeng Zhou Bao Cheng Cong Wang Shijun Li Yu Zhang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 7 | Characteristics of snow cover distribution along railway subgrade and the protective effect of snow fences显示文摘Railways built in cold,snowy,and lightly populated areas are subjected to wind and snow disasters.In this study,we selected a snow hazard prevention and control section of the Altay–Zhundong Railway in Xinjiang Uygur Autonomous Region of China as the research object.We investigated the deposited snowfall variation characteristics on the two sides and in the embankment pavement area of snow fences with different porosities,fence heights,and arrangement distances using single-factor tests and orthogonal tests based on global atmospheric reanalysis climate data,field survey data,and a multi-phase flow analysis model.The results showed significant differences in the characteristics of snow cover distribution and snow cover thickness between the embankment and the cutting in the absence of snow protection measures.The maximum snow cover thickness of the embankment pavement decreased by 12.6%relative to the cutting pavement.The snow cover thickness of the embankment exhibited an increasing trend from windward shoulder to leeward shoulder,whereas the snow cover thickness of the cutting presented a declining trend from windward shoulder to leeward toe.In the collaborative prevention and control of snow fences and embankments,the three factors can be ranked in terms of their sensitivity to deposited snowfall within the influence scope of snow fences as follows:fence height>arrangement distance>porosity.At the same time,fence height yielded a significant relationship for the influence scope of snow fences(P<0.05).The three factors can also be ranked in terms of their sensitivity to deposited snowfall on the pavement as follows:porosity>fence height>arrangement distance.For the embankment protection of the Altay–Zhundong Railway against wind and snow,snow fence with a porosity of 75%,a fence height of 4.8 m,and an arrangement distance from the embankment of 60 m produced the best snow control effect.By revealing the characteristics of snow cover distribution along railway subgrade and the protective effect of snow fences,this study provides valuable references for the engineering applications of railway construction in areas prone to wind and snow disasters. | LEI Jia CHENG Jianjun GAO Li MA Benteng AN Yuanfeng DONG Hongguang | 2023 | Journal of Arid Land2023，15，8： | 0 |
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