维普期刊资源整合服务平台（V6.5）

115篇 您的检索式：作者名="Yu T Cheng"

选中清除导出查看参考文献查看引证文献引用追踪共6页首页上一页第1页下一页末页 /6 跳转

	题名	作者	年代	出处	被引量
1	Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones.	Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang	2020	World Journal of Gastroenterology2020，26，47：	3
2	The microstrueture and phase equilibrium of new high performance high - entropy alloys 显示文摘	Ker - Chang Hsieh Cheng - Fu Yu Wen - Tai Hsieh Wei - Ren Chiang Jin Son Ku Jiun -Hui Lai Chin -Pan T Chih Chao Yang	2008	Journal of Alloys and Compounds2008，，8：	1
3	Benefits of information sharing with supply chain partnerships 显示文摘	Yu Z Yan H Cheng T C	2001	Industrial Management & Data System2001，101，3：	1
4	OsREC8 is essential for chromatid cohesion and metaphase I monopolar orientation in rice meiosis 显示文摘	Shao T Tang D Wang K J Wang M Che L X Qin B X Yu H X Li M Gu M H Cheng Z K	2011	Plant Physiology2011，156，3：	1
5	Modeling the benefits of information sharing-based partnerships in a two-level supply chain显示文摘	Yu Z Yan H Cheng T C E	2002	Journal of the Operational Research Society2002，53，4：	1
6	Fluorine ions-media-ted morphology control of Ti02 with enhanced pho-tocatalytic activity 显示文摘	Lu K Cheng B Yu T G	2012	J Phys Chem2012，14，16：	1
7	Broad -spectrum resistance to different geographic strains of Papaya ringspot virus in coat protein gene transgenic papaya显示文摘	Bau H J Cheng Y H Yu T A	2003	Phytopathology2003，93，1：	1
8	Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin显示文摘	Cheng T S Hsiao Y L Lin C C Yu C T Hsu C M Chang M S Lee C I Huang C Y Howng S		0，，04：	1
9	查看详情显示文摘	Wang N Huang D ZhangJ Cheng J Yu T Zhang H Bi S		0，，46：	1
10	Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention显示文摘	Chien C T Yu H J Cheng Y J	2000	J Physiol2000，526，2：	1
11	Field evaluation of transgenic papaya lines carrying the coat protein gene of Papaya ringspot virus in Taiwan显示文摘	Bau H J Cheng Y H Yu T A	2004	Plant Dis2004，88，6：	1
12	The function of porcine PPARγanddietary fish oil effect on the expression of lipid and glucose metabolism re-lated genes显示文摘	YU Y H WU S C CHENG W T	2011	J Nutr Biochem2011，22，2：	1
13	An analysis of chemical composition of different rain types in ' Minnan Golden Triangle' region in the southeastern coast of China 显示文摘	Yu S C Gao C T Cheng Z M	1998	Atmospheric Research1998，48，：	1
14	Reduction in renal haemodynamics by exaggerated vesicovascular reflex in rats with acute urinary retention显示文摘	CHIEN C T YU H J CHENG Y J	2000	J Physiol2000，526，2：	1
15	Cu2O-decorated Cd S Nanostructures for High Efficiency Visible Light Driven Hydrogen Production显示文摘	Cheng W Y Yu T H Chao K J	2013	International Journal of Hydrogen Energy2013，38，23：	1
16	Efficient rooting for establishment of papaya plantets by micropropagation显示文摘	Yu T A Yeh S D Cheng Y H	2000	Plant Cell Tissue and Organ Culture2000，61，1：	1
17	Stretchable batteries with self-similar serpentine interconnects and integrated wireless re- charging systems 显示文摘	Xu S Zhang Y H Cho J Lee J W Huang X Jia L Fan J A Su Y W Su J Zhang H Cheng H Lu B Yu C J Chuang C Kim T I Song T Shigeta K Kang S Dagdeviren C Petrov I Braun P V Huang Y Paik U Rogers J A		Nature Communications0，4，：	1
18	Scheduling jobs with release dates and deadlines on a batching processing machine显示文摘	Cheng T C E Liu Z H Yu W C	2001	IIE Transactions2001，33，8：	1
19	T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells显示文摘	Cheng G Yu A Malek T R	2011	Immunol Rev2011，241，1：	1
20	Thesequence and de novo assembly of the giant panda genome显示文摘	LI R FAN W TIAN G ZHU H HE L CAI J HUANG Q CAIQ LI B BAI Y ZHANG Z ZHANG Y WANG W LI J WEI F LI H JIAN M LI J ZHANG Z NIELSEN R LI D GU W YANG Z XUAN Z RYDER OA LEUNG FC ZHOU Y CAO J SUN X FU Y FANG X GUO X WANG B HOU R SHEN F MU B NI P LIN R QIAN W WANG G YU C NIE W WANGJ WU Z LIANG H MIN J WU Q CHENG S RUAN J WANGM SHI Z WEN M LIU B REN X ZHENG H DONG D COOKK SHAN G ZHANG H KOSIOL C XIE X LU Z ZHENG H LI Y STEINER CC LAM TT LIN S ZHANG Q LI G TIAN J GONG T LIU H ZHANG D FANG L YE C ZHANG J HU W XU A REN Y ZHANG G BRUFORD MW LI Q MA L GUOY AN N HU Y ZHENG Y SHI Y LI Z LIU Q CHEN Y ZHAO J QU N ZHAO S TIAN F WANG X WANG H XU L LIU X VINAR T WANG Y LAM TW YIU SM LIU S ZHANGH LI D HUANG Y WANG X YANG G JIANG Z WANG J QIN N LI L LI J BOLUND L KRISTIANSEN K WONG GK OLSON M ZHANG X LI S YANG H WANG J WANG J	2010	Na-ture2010，463，：	1

返回顶部每页显示：

共6页首页上一页第1页下一页末页 /6 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示