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| 1 | Detection of dietary plant-based small RNAs in animals显示文摘 | Jian Yang Lisa M Farmer Abia AA Agyekum Kendal D Hirschi | 2015 | Cell Research2015，25，4： | 9 |
| 2 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 3 | VDR基因敲除鼠一氧化氮合酶和内皮素-1基因的表达显示文摘目的探讨维生素D受体(VDR)基因敲除鼠血压变化以及与血压水平密切相关的内皮型一氧化氮合酶、内皮素-1基因在主动脉的表达情况,了解维生素D、维生素D受体与血压的联系及可能机制。方法小鼠血压采用动脉血管插管法直接测定,主动脉内皮型一氧化氮合酶、内皮素-1基因表达采用实时定量聚合酶链式反应检测。结果内皮型一氧化氮合酶、内皮素-1基因均能在野生型正常鼠及维生素D受体基因敲除鼠主动脉表达。与野生型正常鼠比较,纯合子维生素D受体基因敲除鼠收缩压、舒张压明显升高,主动脉内皮型一氧化氮合酶基因表达明显下调,内皮素-1基因表达明显上调(P均<0.05),杂合子维生素D受体基因敲除鼠收缩压、舒张压及主动脉内皮型一氧化氮合酶、内皮素-1基因表达则无明显改变(P均>0.05)。相关性研究发现主动脉内皮型一氧化氮合酶基因表达水平与收缩压、舒张压水平呈负相关,与收缩压、舒张压水平呈正相关(P均<0.05)。结论纯合子维生素D受体基因敲除鼠存在与血压密切相关的主动脉内皮型一氧化氮合酶、内皮素-1基因表达水平明显异常。 | 向伟 蒋湘玲 符生苗 Wei Zheng Uskokovic M Jian Kong YC Li | 2005 | 中国热带医学2005，5，5： | 7 |
| 4 | Hollow mesoporous titania microsphere with low shell thickness/diameter ratio and high photocatalysis显示文摘 | Jianing Liu Gaowen Zhang Wei Ao Kan Yang Shaoxian Peng Christel Müller-Goymann | 2012 | Applied Surface Science2012，，20： | 2 |
| 5 | Current knowledge and future directions of TLR and NOD signaling in sepsis显示文摘The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack of normal immune homeostatic functions and excessive production of proinflammatory cytokines, which leads to multi-organ failure. The Toll-like receptor(TLR) family, one of whose members was initially discovered in Drosophila, performs an important role in the recognition of microbial pathogens. These pattern recognition receptors(PRRs), upon sensing invading microorganisms, activate intracellular signal transduction pathways. NOD signaling is also involved in the recognition of bacteria and acts synergistically with the TLR family in initiating an efficient immune response for the eradication of invading microbial pathogens. TLRs and NOD1/NOD2 respond to different pathogenassociated molecular patterns(PAMPs). Modulation of both TLR and NOD signaling is an area of research that has prompted much excitement and debate as a therapeutic strategy in the management of sepsis. Molecules targeting TLR and NOD signaling pathways exist but regrettably thus far none have proven efficacy from clinical trials. | Niamh M Foley Jian Wang H Paul Redmond Jiang-Huai Wang | 2014 | Journal of Medical Colleges of PLA(China)2014，29，4： | 2 |
| 6 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 7 | Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers显示文摘在 enhancers 和倡导者之间的远程的染色质相互作用为在哺乳动物和另外的 metazoans 的许多发展地控制的基因的抄写是必要的。当前,把远侧的 enhancers 连接到他们的特定的目标倡导者的准确机制尚待充分被阐明。这里,我们证明 4 monomethylation (H3K4me1 )(MLL3/4 ) 和 histone methyltransferases MLL3 和 MLL4 玩的提高特定的 histone H3 离氨酸在这个过程的一个活跃角色。我们在区分老鼠表明那胚胎的干细胞,在 enhancers 的 H3K4me1 的 MLL3/4-dependent 免职与染色质相互作用的增加的层次相关,而这 histone 修正的损失在区别期间在基因激活导致染色质相互作用和缺点的减少的层次。H3K4me1 便于 Cohesin 建筑群的招募,染色质组织的一个已知的管理者到在 vitro 并且在 vivo 的染色质,提供潜在的机制让 MLL3/4 支持在 enhancers 和倡导者之间的染色质相互作用。一起拿,我们的结果在在哺乳动物的房间在 enhancers 安排远程的染色质相互作用为 MLL3/4-dependent H3K4me1 支持一个角色。 | Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren | 2018 | Cell Research2018，28，2： | 2 |
| 8 | (A) 显示文摘 | Cao Huai xin Xu zong ben Zhang Jian hua Matrix-trace on C^*- algebra M | 2002 | Linear Algebra and its Applications2002，，345： | 1 |
| 9 | Propping through Related Party Transactions 显示文摘 | Jian M T J Wong | 2010 | Review of Accounting Studies2010，15，： | 1 |
| 10 | Association of dis- tinct double-stranded RNAs with enhanced or diminished viru- lence in Rhizoctonia solani infecting potato 显示文摘 | Jian J H Lakshman D K Tavantzis S M | 1997 | Molecular Plant-Microbe Interactions1997，10，8： | 1 |
| 11 | High throughput sequencing reveals a complex pattern of dynamic interrelationships among human Tcell subsets显示文摘 | Wang C Catherine M Jian H | 2010 | Prec Nail Acad Sei U S A2010，107，4： | 1 |
| 12 | Propping and tunneling through related party transactions显示文摘 | Jian M Wong T J | 2010 | Review of Accounting Studies2010，15，： | 1 |
| 13 | Role of growth factors in acute lung injury induced by paraquat in a rat mode显示文摘 | Jian X Li M Zhang Y Ruan Y Guo G Sui H | 2010 | Hum Exp Toxicol2010，4，： | 1 |
| 14 | Trends in regional inequality in China显示文摘 | Jian T Sachs J D Warner A M | 1996 | China Economic Review1996，7，1： | 1 |
| 15 | An audit of technological innovation capabilities in Chinese firms: Some empirical findings in Beijing, China 显示文摘 | Richard C M Yam Jian Cheng Guan Kit Fai Pun | 2004 | Research Policy2004，33，： | 1 |
| 16 | Uptake system of silicon in different plant species 显示文摘 | MITANI N JIAN F M | 2005 | Journal of Experimental Botany2005，56，414： | 1 |
| 17 | Human esophageal carci- nomas frequently express the tumor-rejection antigens of blAGE genes显示文摘 | Hiroshi I Masaki M Jian L | 1995 | Int J Cancer1995，63，4： | 1 |
| 18 | Induction of c-fos protein by patterned visual stimulation in central visual pathways of the rat显示文摘 | MONTERO V M JIAN S | 1995 | Brain Res1995，690，2： | 1 |
| 19 | Effect of taurine in rat milk on the growth of offspring显示文摘 | Hu Jian M | 2000 | J Vet Med Sci2000，7，62： | 1 |
| 20 | A compara- tive study of growth performance and antioxidant sta- tus of rabbits when fed with or without chestnut tan- nins under high ambient temperature 显示文摘 | LIU H W XIAO F D JIAN M T | 2011 | Animal Feed Science and Technology2011，164，： | 1 |
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