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| 1 | Epithelial ovarian cancer:An overview显示文摘Ovarian cancer is the second most common gyneco-logical cancer and the leading cause of death in the United States. In this article we review the diagnosis and current management of epithelial ovarian cancer which accounts for over 95 percent of the ovarian malignancies. We will present various theories about the potential origin of ovarian malignancies. We will discuss the genetic anomalies and syndromes that may cause ovarian cancers with emphasis on Breast cancer type 1/2 mutations. The pathology and pathogenesis of ovarian carcinoma will also be presented. Lastly, we provide a comprehensive overview of treatment strategies and staging of ovarian cancer, conclusions and future directions. | Arpita Desai Jingyao Xu Kartik Aysola Yunlong Qin Chika Okoli Ravipati Hariprasad Ugorji Chinemerem Candace Gates Avinash Reddy Omar Danner Geary Franklin Anachebe Ngozi Guilherme Cantuaria Karan Singh William Grizzle Charles Landen Edward E Partridge Valerie Montgomery Rice E Shyam P Reddy Veena N Rao | 2014 | World Journal of Translational Medicine2014，3，1： | 10 |
| 2 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 3 | Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin显示文摘 | Yan-li LIU Hai-ming LIN Rong ZOU Jun-chao WU Rong HAN Laurence N RAYMOND Paul F REID Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，2： | 6 |
| 4 | Development and characterization of monoclonal antibody specific to nuclear protein of avian influenza virus type A 显示文摘 | LI N QIN A J SHAO H X | 2008 | Agricuhural Science & Technology2008，9，1： | 1 |
| 5 | Soft lithography for micro-and nanoscale patterning显示文摘 | Qin D Xia Y N Whitesides G M | 2010 | Nature Protocols2010，5，3： | 1 |
| 6 | Differential profile of genes expressed in hemocytes ofwhite spot syndrome virus-resistant shrimp(Penaeus japonicus)by combi-ning suppression subtractive hybridization and differential hybridization显示文摘 | HE N QIN Q XU X | 2005 | Antiviral Res2005，66，1： | 1 |
| 7 | Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes 显示文摘 | Qin Y Timothy E Graham N M | 2005 | Nature2005，436，： | 1 |
| 8 | Adjoint-based optimization of a BWB shape with shock control bumps显示文摘 | Qin N Wong W S Le Moigne A | 2007 | Aeronautical Journal2007，1117，111： | 1 |
| 9 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 10 | Study of the synthesis and C12 gas-sensing properties of nanometer HNO3 -doped SnO2显示文摘 | Wang X B Qin N Lou T J | | 0，，： | 1 |
| 11 | The growth and metastasis of human hepatocellular carcinoma xenografts are inhibited by small interfering RNA targeting to the subunit ATP6L of proton pump显示文摘 | Qin W Li J Tan N | 2005 | Cancer Res2005，65，15： | 1 |
| 12 | Ontogenetic development of digestive enzymes in yellowtail kingfish Seriola lalandi larvae 显示文摘 | Chen B N Qin J G Kumar M S | 2006 | Aquaculture2006，260，： | 1 |
| 13 | Experimental realization of second harmonic generation in a fibonacei optical superlatfice of LiTaOs 显示文摘 | ZHU S N ZHU Y Y QIN Y Q | 1997 | Phys Rev Lett1997，78，14： | 1 |
| 14 | Differential evolution algorithm with strategy adaptation for global numerical optimization显示文摘 | Qin A K Huang V L Suganthan P N | 2009 | IEEE Transactions on Evolutionary Computation2009，13，2： | 1 |
| 15 | Aerodynamic con siderations of blended wing body aircraft显示文摘 | Qin N Vavalle A Le Moigne A | 2004 | Progress in Aerospace Sciences2004，40，6： | 1 |
| 16 | Systemic administration of insulin - like growth factor (IGF) - binding protein - 4 ( IGFBP - 4 ) increases bone formation parameters in mice by increasing IGF bioavailability via an IG- FBP - 4 protease - dependent mechanism 显示文摘 | Miyakoshi N Qin X Kasukawa YJ | 2001 | Endocrinology2001，142，6： | 1 |
| 17 | Evolutionary extreme learning machine显示文摘 | ZHU Qin-yu QIN A K Suganthan P N | 2005 | Pattern Recognition2005，38，2： | 1 |
| 18 | Comprehensivelearning particle swarm optimizer for global optimization of multimodalfunctions显示文摘 | LIANG J J QIN A K SUGANTHAN P N ei al | 2006 | IEEE Trans on Evolutionary Computation2006，10，3： | 1 |
| 19 | Comprehensive learning particle swarm optimizer for global optimization of multimodal functions显示文摘 | Liang J J Qin A K Suganthan P N | 2006 | IEEE Trans on Evolutionary Computation2006，10，3： | 1 |
| 20 | Differen- tial evolution algorithm with strategy adaptation for global numerical optimization 显示文摘 | QIN A K HUANG V L SUGANTHAN P N | 2009 | Evolutionary Compu- tation IEEE Transactions on2009，13，2： | 1 |
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