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| 1 | Neither Multiple Tumors Nor Portal Hypertension Are Surgical Contraindications for Hepatocellular Carcinoma显示文摘 | Takeaki Ishizawa Kiyoshi Hasegawa Taku Aoki Michiro Takahashi Yosuke Inoue Keiji Sano Hiroshi Imamura Yasuhiko Sugawara Norihiro Kokudo Masatoshi Makuuchi | 2008 | Gastroenterology2008，，7： | 7 |
| 2 | Risk factors of post‐operative recurrence and adequate surgical approach to improve long‐term outcomes of hepatocellular carcinoma显示文摘 | Junichi Shindoh Kiyoshi Hasegawa Yosuke Inoue Takeaki Ishizawa Rihito Nagata Taku Aoki Yoshihiro Sakamoto Yasuhiko Sugawara Masatoshi Makuuchi Norihiro Kokudo | 2012 | HPB2012，，1： | 2 |
| 3 | Is there any difference in survival according to the portal tumor thrombectomy method in patients with hepatocellular carcinoma?显示文摘 | Yosuke Inoue Kiyoshi Hasegawa Takeaki Ishizawa Taku Aoki Keiji Sano Yoshifumi Beck Hiroshi Imamura Yasuhiko Sugawara Norihiro Kokudo Masatoshi Makuuchi | 2009 | Surgery2009，，1： | 1 |
| 4 | Neither Multiple Tumors Nor Portal Hypertension Are Surgical Contraindications for Hepatocellular Carcinoma显示文摘 | Takeaki Ishizawa Kiyoshi Hasegawa Taku Aoki Michiro Takahashi Yosuke Inoue Keiji Sano Hiroshi Imamura Yasuhiko Sugawara Norihiro Kokudo Masatoshi Makuuchi | 2008 | Gastroenterology2008，，7： | 1 |
| 5 | Intra-operative freehand real-time elastography for small focal liver lesions: “Visual palpation” for non-palpable tumors显示文摘 | Yosuke Inoue Michiro Takahashi Junichi Arita Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Masatoshi Makuuchi Norihiro Kokudo | 2010 | Surgery2010，，5： | 1 |
| 6 | Stereotactic body radiotherapy for small hepatocellular carcinoma: A retrospective outcome analysis in 185 patients显示文摘 | Naoko Sanuki Atsuya Takeda Yohei Oku Tomikazu Mizuno Yosuke Aoki Takahisa Eriguchi Shogo Iwabuchi Etsuo Kunieda | 2014 | Acta Oncologica2014，，3： | 1 |
| 7 | New closure technique for large mucosal defects after endoscopic submucosal dissection of colorectal tumors (with video)显示文摘 | Yosuke Otake Yutaka Saito Taku Sakamoto Takaya Aoki Takeshi Nakajima Naoya Toyoshima Takahisa Matsuda Hiroyuki Ono | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 8 | Immunosuppreesant PC490(Triptolide) inhibits T-cell intedeukin-2 expreaaion at the level of Putine-box/Nuclear factor of activated T-cell and NF-kB transcriptional activation显示文摘 | Qiu DM Zhao GH Yosuke Aoki | 1999 | J Bid Chem1999，274，13： | 1 |
| 9 | Stereotactic body radiotherapy for small hepatocellular carcinoma: A retrospective outcome analysis in 185 patients显示文摘 | Naoko Sanuki Atsuya Takeda Yohei Oku Tomikazu Mizuno Yosuke Aoki Takahisa Eriguchi Shogo Iwabuchi Etsuo Kunieda | 2014 | Acta Oncologica2014，，3： | 1 |
| 10 | Physical multimorbidity patterns and depressive symptoms:a nationwide cross-sectional study in Japan显示文摘Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of studies.However,whether patterns of chronic physical conditions have comparatively different associations with depressive symptoms remains unclear.This study aimed to investigate the associations of physical multimorbidity patterns with depressive symptoms.Design This study was designed as a nationwide cross-sectional survey in Japan.setting General sample of the Japanese population.Participants Adult Japanese residents were selected by a quota sampling method.Data were analysed from 1788 residents who reported one or more chronic health conditions.results Among four physical multimorbidity patterns:cardiovascular-renal metabolic(CRM),skeletal-articular digestive(SAD),respiratory-dermal(RDE)and malignant-digestive urologic(MDU),multivariable logistic regression analyses revealed that the RDE pattern showed the strongest association with depressive symptoms(aOR=1.68,95%CI:1.21 to 2.31 for the pattern score highest quartile,compared with the lowest quartile),followed by SAD and MDU patterns(aOR=1.41,95%CI:1.01 to 1.98 for the SAD pattern score highest quartile;1.41,95%CI:1.01 to 1.96 for the MDU pattern score highest quartile,compared with the lowest quartile).In contrast,the CRM pattern score was not significantly associated with depressive symptoms(aOR=1.31,95%CI:0.90 to 1.89 for the pattern score highest quartile,compared with the lowest quartile).Conclusions Physical multimorbidity patterns have different associations with depressive symptoms.Among these patterns,patients with the RDE pattern may be at a higher risk for developing depressive symptoms.This study reinforces the evidence that cluster pattern of chronic health conditions is a useful measure for clinical management of multimorbidity as it is differently associated with mental health status,which is one of the crucial outcomes for multimorbid patients. | Takuya Aoki Yosuke Yamamoto Sayaka Shimizu Shunichi Fukuhara | 2020 | Family Medicine and Community Health2020，8，1： | 1 |
| 11 | Acoustic Radiation Force Impulse Imaging of the Pancreas for Estimation of Pathologic Fibrosis and Risk of Postoperative Pancreatic Fistula显示文摘 | Nobuhiro Harada Takeaki Ishizawa Yosuke Inoue Taku Aoki Yoshihiro Sakamoto Kiyoshi Hasegawa Yasuhiko Sugawara Mariko Tanaka Masashi Fukayama Norihiro Kokudo | 2014 | Journal of the American College of Surgeons2014，，5： | 1 |
| 12 | Neither Multiple Tumors Nor Portal Hypertension Are Surgical Contraindications for Hepatocellular Carcinoma显示文摘 | Takeaki Ishizawa Kiyoshi Hasegawa Taku Aoki Michiro Takahashi Yosuke Inoue Keiji Sano Hiroshi Imamura Yasuhiko Sugawara Norihiro Kokudo Masatoshi Makuuchi | 2008 | Gastroenterology2008，，7： | 1 |
| 13 | Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer显示文摘BACKGROUND Gastric cancers can be categorized into diffuse-and intestinal-type cancers based on the Lauren histopathological classification.These two subtypes show distinct differences in metastasis frequency,treatment application,and prognosis.Therefore,accurately assessing the Lauren classification before treatment is crucial.However,studies on the gastritis endoscopy-based Kyoto classification have recently shown that endoscopic diagnosis has improved.AIM To investigate patient characteristics including endoscopic gastritis associated with diffuse-and intestinal-type gastric cancers in Helicobacter pylori(H.pylori)-infected patients.METHODS Patients who underwent esophagogastroduodenoscopy at the Toyoshima Endoscopy Clinic were enrolled.The Kyoto classification included atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness.The effects of age,sex,and Kyoto classification score on gastric cancer according to the Lauren classification were analyzed.We developed the Lauren predictive background score based on the coefficients of a logistic regression model using variables independently associated with the Lauren classification.Area under the receiver operative characteristic curve and diagnostic accuracy of this score were examined.RESULTS A total of 499 H.pylori-infected patients(49.6%males;average age:54.9 years)were enrolled;132 patients with gastric cancer(39 diffuse-and 93 intestinal-type cancers)and 367 cancer-free controls were eligible.Gastric cancer was independently associated with age≥65 years,high atrophy score,high intestinal metaplasia score,and low nodularity score when compared to the control.Factors independently associated with intestinal-type cancer were age≥65 years(coefficient:1.98),male sex(coefficient:1.02),high intestinal metaplasia score(coefficient:0.68),and low enlarged folds score(coefficient:-1.31)when compared to diffuse-type cancer.The Lauren predictive background score was defined as the sum of+2(age≥65 years),+1(male sex),+1(endoscopic intestinal metaplasia),and-1(endoscopic enlarged folds)points.Area under the receiver operative characteristic curve of the Lauren predictive background score was 0.828 for predicting intestinal-type cancer.With a cut-off value of+2,the sensitivity,specificity,and accuracy of the Lauren predictive background score were 81.7%,71.8%,and 78.8%,respectively.CONCLUSION Patient backgrounds,such as age,sex,endoscopic intestinal metaplasia,and endoscopic enlarged folds are useful for predicting the Lauren type of gastric cancer. | Osamu Toyoshima Toshihiro Nishizawa Shuntaro Yoshida Tomonori Aoki Fumiko Nagura Kosuke Sakitani Yosuke Tsuji Hayato Nakagawa Hidekazu Suzuki Kazuhiko Koike | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，5： | 1 |
| 14 | Immunosuppressant PG490(Triptolide)inhibits T-cell interleukin-2 expression at the level of Purine-box/Nuclear factor of activated T-cell and NF-kB transcriptional activation显示文摘 | Qiu DM Zhao GH Yosuke Aoki | 1999 | J Biol Chem1999，274，13： | 1 |
| 15 | Risk factors of post‐operative recurrence and adequate surgical approach to improve long‐term outcomes of hepatocellular carcinoma显示文摘 | Junichi Shindoh Kiyoshi Hasegawa Yosuke Inoue Takeaki Ishizawa Rihito Nagata Taku Aoki Yoshihiro Sakamoto Yasuhiko Sugawara Masatoshi Makuuchi Norihiro Kokudo | 2012 | HPB2012，，1： | 1 |
| 16 | Neither Multiple Tumors Nor Portal Hypertension Are Surgical Contraindications for Hepatocellular Carcinoma显示文摘 | Takeaki Ishizawa Kiyoshi Hasegawa Taku Aoki Michiro Takahashi Yosuke Inoue Keiji Sano Hiroshi Imamura Yasuhiko Sugawara Norihiro Kokudo Masatoshi Makuuchi | 2008 | Gastroenterology2008，，7： | 1 |
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