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| 1 | Totally laparoscopic total gastrectomy using the modified overlap method and conventional open total gastrectomy:A comparative study显示文摘BACKGROUND Although several methods of totally laparoscopic total gastrectomy(TLTG)have been reported.The best anastomosis technique for LTG has not been established.AIM To investigate the effectiveness and surgical outcomes of TLTG using the modified overlap method compared with open total gastrectomy(OTG)using the circular stapled method.METHODS We performed 151 and 131 surgeries using TLTG with the modified overlap method and OTG for gastric cancer between March 2012 and December 2018.Surgical and oncological outcomes were compared between groups using propensity score matching.In addition,we analyzed the risk factors associated with postoperative complications.RESULTS Patients who underwent TLTG were discharged earlier than those who underwent OTG[TLTG(9.62±5.32)vs OTG(13.51±10.67),P<0.05].Time to first flatus and soft diet were significantly shorter in TLTG group.The pain scores at all postoperative periods and administration of opioids were significantly lower in the TLTG group than in the OTG group.No significant difference in early,late and esophagojejunostomy(EJ)-related complications or 5-year recurrence free and overall survival between groups.Multivariate analysis demonstrated that body mass index[odds ratio(OR),1.824;95%confidence interval(CI):1.029-3.234,P=0.040]and American Society of Anaesthesiologists(ASA)score(OR,3.154;95%CI:1.084-9.174,P=0.035)were independent risk factors of early complications.Additionally,age was associated with≥3 Clavien-Dindo classification and EJrelated complications.CONCLUSION Although TLTG with the modified overlap method showed similar complication rate and oncological outcome with OTG,it yields lower pain score,earlier bowel recovery,and discharge.Surgeons should perform total gastrectomy cautiously and delicately in patients with obesity,high ASA scores,and older ages. | Chang Seok Ko Nam Ryong Choi Byung Sik Kim Jeong Hwan Yook Min-Ju Kim Beom Su Kim | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | PRODIGY:多西他赛、奥沙利铂+S-1新辅助化疗联合手术及S-1辅助化疗对比手术及S-1辅助化疗治疗可切除局晚期胃癌的Ⅲ期研究显示文摘局部晚期胃癌(LAGC)的辅助治疗已经发展了20余年,其疗效已经在多项试验中得到证实,但仍缺乏全球性的标准策略。欧美主要采取围手术期化疗(表柔比星、顺铂+氟尿嘧啶);东亚则主要采取术后S-1或卡培他滨+奥沙利铂方案化疗(SOX或CAPOX);部分地区还会在辅助化疗的基础上增加放疗等强化策略提高疗效。有试验研究表明,围手术期多西他赛、奥沙利铂+氟尿嘧啶(FLOT)方案优于表柔比星、顺铂+氟尿嘧啶(ECF)方案;JACCRO GC-07和ARTIST 2试验也表明,对于进展期胃癌患者,SOX、S-1加多西他赛(DS)等强化辅助化疗方案优于标准方案。与欧美的围手术期化疗不同,术前新辅助化疗在韩国乃至亚洲并不是LAGC的标准方案。团队早期的Ⅱ期研究显示,多西他赛、奥沙利铂+S-1(DOS)新辅助化疗在韩国潜在可切除的LAGC患者中耐受性和切除率良好。为了进一步探究新辅助DOS联合手术及S-1辅助化疗(CSC)对比手术后S-1辅助化疗(SC)是否可以改善韩国可切除LAGC患者的预后,该团队设计了PRODIGY研究。 | 高毓(编译) 夏楠(编译) 周福祥(编译) Kang YK Yook JH Park YK | 2022 | 中华医学杂志2022，102，12： | 8 |
| 3 | 细柱五加叶中羽扇豆烷型三萜成分(英文)显示文摘从细柱五加(Acanthopanax gracilistylus W.W.Smith)叶的热MeOH提取液中分离得到了4个lupane型三萜化合物,根据它们的理化性质和波谱数据,鉴定出其化学结构分别为acankoreagenin(1), 3-epi-betulinic acid 28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester(2),acantrifoside A(3)和acankoreoside C(4).其中化合物1是首次从天然植物中分离得到的新化合物,化合物2是首次从五加科植物中分离得到的化合物,且这4个化合物都是第一次从细柱五加中分离得到. | 刘向前 CHANG Seung-Yeup YOOK Chang-soo | 2006 | 兰州大学学报(自然科学版)2006，42，4： | 7 |
| 4 | Cytotoxicity and anti-inflammatory effects of root bark extracts of Acanthopanax henryi显示文摘AIM: To investigate the cytotoxicity, anti-inflammatory activity, and action mechanism of root bark extracts of Acanthopanax henryi. METHOD: The hot methanol extract of the root bark of A. henryi was subjected to XAD-4 column chromatography eluting with a gradient of methanol in water. The cytotoxicity and anti-inflammatory effects of the MeOH fractions were evaluated on the inhibition on lipopolysaccharide(LPS)-induced nitric oxide, prostaglandin E2, interleukin-1β, and interleukin-6 production in RAW 264.7 macrophages. RESULTS: The 80% MeOH fraction was a better inhibitor of LPS-induced NO, PGE2, IL-1β, and IL-6 production, and expression of inducible nitric oxide synthase(iNOS) at the protein levels in a concentration-dependent manner. CONCLUSION: The 80% MeOH fraction of A. henryi root bark has significant anti-inflammatory activity. This provides a pharmacological basis for clinical application for the treatment of inflammation. | KIM Jong-Hwan LIU Xiang-Qian DAI Ling YOOK Chang-Soo LEE Kyung-Tae | 2014 | Chinese Journal of Natural Medicines2014，12，2： | 5 |
| 5 | Changes in annual CO_2 fluxes estimated from inventory data in South Korea显示文摘Using a slightly modified IPCC method, we examined changes in annual fluxes of CO2 and contributions of energy consumption, limestone use, waste combustion, land-use change, and forest growth to the fluxes in South Korea from 1990to 1997. Our method required less data and resulted in a larger estimate of CO2released by industrial processes, comparing with the original IPCC guideline. However, net CO2 emission is not substantially different from the estimates of IPCC and modified methods. Net CO2 emission is intimately related to GDP as Koreaneconomy has heavily relied on energy consumption and industrial activities, which are major sources of CO2. Total efflux of CO2 was estimated to be 63.6 Tg C/ain 1990 and amounted to 112.9 Tg C/a in 1997. Land-use change contributed to annual budget of CO2 in a relatively small portion. Carbon dioxide was sequesteredby forest biomass at the rate of 6.5 Tg C/a in 1990 and 8.5 Tg C/a in 1997. Although CO2 storage in the forests increased, the sink effect was overwhelmed by extensive energy consumption, suggesting that energy-saving strategies will be more effective in reducing CO2 emission in Korea than any other practices. It is presumed that plant uptake of CO2 is underestimated as carbon contained in plant detritus and belowground living biomass were not fully considered. Furthermore, the soil organic carbon stored in forest decomposes in various ways in rugged mountains depending on their conditions, such as slope, aspect and elevation, which could have an effect on decomposition rate and carbon stores in soils. Thus, carbon sequestration of forests deserves further attention. | Lee Dowon Yook Keun Hyung Lee Dongseon Kang Sinkyu Kang Hojeong Lim Jong Hwan Lee Kyeong Hak | 2002 | Science China(Life Sciences)2002，45，z1： | 3 |
| 6 | Metallic stent placement in the palliative treatment of malignant gastroduodenal obstructions: prospective evaluation of results and factors influencing outcome in 213 patients显示文摘 | Jin Hyoung Kim Ho-Young Song Ji Hoon Shin Eugene Choi Tae Won Kim Hwoon-Yong Jung Gin Hyug Lee Sung Koo Lee Myung-Hwan Kim Min-Hee Ryu Yoon-Koo Kang Byung Sik Kim Jeong Hwan Yook | 2007 | Gastrointestinal Endoscopy2007，，2： | 2 |
| 7 | Optimal proximal resection margin distance for gastrectomy in advanced gastric cancer显示文摘BACKGROUND The conventional guidelines to obtain a safe proximal resection margin(PRM)of5-6 cm during advanced gastric cancer(AGC)surgery are still applied by many surgeons across the world.Several recent studies have raised questions regarding the need for such extensive resection,but without reaching consensus.This study was designed to prove that the PRM distance does not affect the prognosis of patients who undergo gastrectomy for AGC.AIM To investigate the influence of the PRM distance on the prognosis of patients who underwent gastrectomy for AGC.METHODS Electronic medical records of 1518 patients who underwent curative gastrectomy for AGC between June 2004 and December 2007 at Asan Medical Center,a tertiary care center in Korea,were reviewed retrospectively for the study.The demographics and clinicopathologic outcomes were compared between patients who underwent surgery with different PRM distances using one-way ANOVA and Fisher’s exact test for continuous and categorical variables,respectively.The influence of PRM on recurrence-free survival and overall survival were analyzed using Kaplan-Meier survival analysis and Cox proportional hazard analysis.RESULTS The median PRM distance was 4.8 cm and 3.5 cm in the distal gastrectomy(DG)and total gastrectomy(TG)groups,respectively.Patient cohorts in the DG and TG groups were subdivided into different groups according to the PRM distance;≤1.0 cm,1.1-3.0 cm,3.1-5.0 cm and>5.0 cm.The DG and TG groups showed nostatistical difference in recurrence rate(23.5%vs 30.6%vs 24.0%vs 24.7%,P=0.765)or local recurrence rate(5.9%vs 6.5%vs 8.4%vs 6.2%,P=0.727)according to the distance of PRM.In both groups,Kalpan-Meier analysis showed no statistical difference in recurrence-free survival(P=0.467 in DG group;P=0.155 in TG group)or overall survival(P=0.503 in DG group;P=0.155 in TG group)according to the PRM distance.Multivariate analysis using Cox proportional hazard model revealed that in both groups,there was no significant difference in recurrence-free survival according to the PRM distance.CONCLUSION The distance of PRM is not a prognostic factor for patients who undergo curative gastrectomy for AGC. | Amy Kim Beom Su Kim Jeong Hwan Yook Byung Sik Kim | 2020 | World Journal of Gastroenterology2020，26，18： | 2 |
| 8 | EMR versus gastrectomy for intramucosal gastric cancer: comparison of long-term outcomes显示文摘 | Kwi-Sook Choi Hwoon-Yong Jung Kee Don Choi Gin Hyug Lee Ho June Song Do Hoon Kim Jeong Hoon Lee Mi-Young Kim Byung Sik Kim Sung Tae Oh Jeong Hwan Yook Se Jin Jang Sung-Cheol Yun Seon Ok Kim Jin-Ho Kim | 2011 | Gastrointestinal Endoscopy2011，，5： | 2 |
| 9 | Experimental investigation of submicron and ultrafine soot particle removal by tree leaves显示文摘 | Hee-Jae Hwang Se-Jin Yook Kang-Ho Ahn | 2011 | Atmospheric Environment2011，，38： | 2 |
| 10 | Laparoscopic Gastrectomy in Patients With Previous Gastrectomy for Gastric Cancer: A Report of 17 Cases显示文摘 | Hee Sung Kim Beom Su Kim In Seob Lee Sol Lee Jeoung Hwan Yook Byung Sik Kim | 2014 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2014，，2： | 2 |
| 11 | Signet ring cell type and other histologic types: differing clinical course and prognosis in T1 gastric cancer显示文摘 | Beom Su. Kim Seong Tae Oh Jeong Hwan Yook Byug Sik Kim | 2013 | Surgery2013，，： | 2 |
| 12 | 消防员职业紧张及其与心肺功能、动脉僵硬度、心率变异性和睡眠质量的关联显示文摘消防工作具有突发性、高危性、紧张性和高负荷性等特点,消防员比其他职业人群更易暴露于物理、化学、心理等职业健康危险因素,引发机体出现生理、心理和行为的变化,高度紧张的工作状态导致消防员发生心血管疾病风险增加。本研究采用方便抽样的方法,于2016年11月、2017年12月在韩国首尔全民健身中心选择40~50岁男性消防员705名。 | 王瑾(编译) Yook YS. | 2020 | 中华预防医学杂志2020，54，11： | 2 |
| 13 | A design methodology for distributed control systems to optimize performance in the presence of time delays显示文摘 | Yook J K Tilbury D M Soparkar N R | 2001 | Iht J Control2001，74，1： | 1 |
| 14 | Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone:A randomized controlled trial显示文摘 | Cho S J Yook K Kim B | 2011 | Prog Neu- ropsychopharmacol Biol Psyehiatry2011，35，1： | 1 |
| 15 | Fabrication and efficiency improvement of soluble blue phosphorescent organic light-emitting diodes u- sing a multilayer structure based on an alcohol-soluble blue phosphorescent emitting layer 显示文摘 | YOOK K S JANG S E JEON S O | 2010 | Adv Mater2010，22，： | 1 |
| 16 | Comparison of early outcomes of intracorporeal and extracorporeal gastroduodenostomy after laparoscopic distal gastrectomy for gastric cancer显示文摘 | KIM B S YOOK J H CHOI Y B | 2011 | J Laparoendosc Adv Surg Tech A2011，21，5： | 1 |
| 17 | Influence of obesity on early surgical outcomes of laparoscopic-assisted gastrectomy in gastric cancer显示文摘 | Kim MG Yook JH Kim KC | 2011 | Surg Laparosc Endosc Percutan Tech2011，21，3： | 1 |
| 18 | Phenylcarbazole-based phosphine oxide host materials for high efficiency in deep blue phosphorescent or- ganic light-emitting diodes 显示文摘 | JEON S O YOOK K S JOO C W | 2009 | Adv Funct Mater2009，19，22： | 1 |
| 19 | Comparison of early outcomes of intracorporeal and extracorporeal gastroduodenostomy after laparoscopic distal gastrectomy for gastric cancer 显示文摘 | Kim BS Yook JH Choi YB | 2011 | J Laparo- endosc Adv Surg Tech A2011，21，5： | 1 |
| 20 | Effects of calcium phosphate ceramic bone graft materials on permanent teeth eruption in beagles 显示文摘 | LINTON J L SOHN B W YOOK I I | 2002 | Cleft Palate Craniofac J2002，9，2： | 1 |
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