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| 1 | Persistence and clearance of viral RNA in 2019 novel coronavirus disease rehabilitation patients显示文摘Background:A patient’s infectivity is determined by the presence of the virus in different body fluids,secretions,and excreta.The persistence and clearance of viral RNA from different specimens of patients with 2019 novel coronavirus disease(COVID-19)remain unclear.This study analyzed the clearance time and factors influencing 2019 novel coronavirus(2019-nCoV)RNA in different samples from patients with COVID-19,providing further evidence to improve the management of patients during convalescence.Methods:The clinical data and laboratory test results of convalescent patients with COVID-19 who were admitted to from January 20,2020 to February 10,2020 were collected retrospectively.The reverse transcription polymerase chain reaction(RT-PCR)results for patients’oropharyngeal swab,stool,urine,and serum samples were collected and analyzed.Convalescent patients refer to recovered non-febrile patients without respiratory symptoms who had two successive(minimum 24 h sampling interval)negative RT-PCR results for viral RNA from oropharyngeal swabs.The effects of cluster of differentiation 4(CD4)+T lymphocytes,inflammatory indicators,and glucocorticoid treatment on viral nucleic acid clearance were analyzed.Results:In the 292 confirmed cases,66 patients recovered after treatment and were included in our study.In total,28(42.4%)women and 38 men(57.6%)with a median age of 44.0(34.0-62.0)years were analyzed.After in-hospital treatment,patients’inflammatory indicators decreased with improved clinical condition.The median time from the onset of symptoms to first negative RT-PCR results for oropharyngeal swabs in convalescent patients was 9.5(6.0-11.0)days.By February 10,2020,11 convalescent patients(16.7%)still tested positive for viral RNA from stool specimens and the other 55 patients’stool specimens were negative for 2019-nCoV following a median duration of 11.0(9.0-16.0)days after symptom onset.Among these 55 patients,43 had a longer duration until stool specimens were negative for viral RNA than for throat swabs,with a median delay of 2.0(1.0-4.0)days.Results for only four(6.9%)urine samples were positive for viral nucleic acid out of 58 cases;viral RNA was still present in three patients’urine specimens after throat swabs were negative.Using a multiple linear regression model(F=2.669,P=0.044,and adjusted R2=0.122),the analysis showed that the CD4+T lymphocyte count may help predict the duration of viral RNA detection in patients’stools(t=-2.699,P=0.010).The duration of viral RNA detection from oropharyngeal swabs and fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(15 days vs.8.0 days,respectively;t=2.550,P=0.013)and the duration of viral RNA detection in fecal samples in the glucocorticoid treatment group was longer than that in the non-glucocorticoid treatment group(20 days vs.11 days,respectively;t=4.631,P<0.001).There was no statistically significant difference in inflammatory indicators between patients with positive fecal viral RNA test results and those with negative results(P>0.05).Conclusions:In brief,as the clearance of viral RNA in patients’stools was delayed compared to that in oropharyngeal swabs,it is important to identify viral RNA in feces during convalescence.Because of the delayed clearance of viral RNA in the glucocorticoid treatment group,glucocorticoids are not recommended in the treatment of COVID-19,especially for mild disease.The duration of RNA detection may relate to host cell immunity. | Yun Ling Shui-Bao Xu Yi-Xiao Lin Di Tian Zhao-Qin Zhu Fa-Hui Dai Fan Wu Zhi-Gang Song Wei Huang Jun Chen Bi-Jie Hu Sheng Wang En-Qiang Mao Lei Zhu Wen-Hong Zhang Hong-Zhou Lu | 2020 | Chinese Medical Journal2020，，9： | 58 |
| 2 | OsCERK1-Mediated Chitin Perception and Immune Signaling Requires Receptor-like Cytoplasmic Kinase 185 to Activate an MAPK Cascade in Rice显示文摘保存联系病原体的分子的模式(PAMP ) 例如几丁质,被在激活 mitogen 的蛋白质 kinase (MAPK ) 的快速的激活串联的宿主细胞表面和扳机定位的模式识别受体(PRR ) 察觉,它为植物抵抗被要求到病原体。然而,到在植物的 MAPK 激活的从 PAMP 感觉的直接连接仍然保持大部分未知。在这研究,我们发现联系 PRR 的像受体的细胞质的 kinase Oryza sativa RLCK185 播送到通过和 MAPK kinase kinase 的相互作用表明串联的 MAPK 的从 PAMP 受体 OsCERK1 的有免疫力的发信号, OsMAPKKK,它是 MAPK 串联的起始的 kinase。OsRLCK185 交往与并且 phosphorylates OsMAPKKK 的 C 终端规章的领域。phosphomimetic OsRLCK185 和 OsMAPKKK 的 Coexpression 在 Nicotiana benthamiana 叶子激活 MAPK3/6 phosphorylation。而且, OsMAPKKK 交往与并且 phosphorylates OsMKK4,关键 MAPK kinase 那 transduces 几丁质信号。OsMAPKKK 的 Overexpression 增加导致几丁质的 MAPK3/6 激活,而 OsMAPKKK 击倒的妥协导致几丁质的 MAPK3/6 激活和抵抗到米饭强风真菌。一起拿,我们的结果在米饭从房间表面几丁质感觉建议一条发信号 phospho 小径的存在到 MAPK 串联的细胞内部的激活。 | Chao Wang Gang Wang Chi Zhang Pinkuan Zhu Huiling Dai Nan Yu Zuhua He Ling Xu Ertao Wang | 2017 | Molecular Plant2017，10，4： | 27 |
| 3 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 4 | Hf isotopic composition of zircons from the Huashan-Guposhan intrusive complex and their mafic enclaves in northeastern Guangxi:Implication for petrogenesis显示文摘High precision zircon U-Pb dating indicates that main intrusive bodies (Tong'an,Niumiao,Huashan,Lisong),and a mafic microgranular enclave in the Huashan-Guposhan complex were formed at 160-163 Ma.The εHf(t) values of zircons from the Huashan granite vary from -2.8 to +0.3 and those from the Lisong granite vary from -2.3 to +0.3,which are obviously different with those values (+2.6 to +7.4) of the mafic enclaves from the Lisong granite.These Hf isotopic data indicate that the mafic enclaves and host granites were crystallized from different sources of magmas,providing evidence for mafic-felsic magma mixing processes.The highest εHf(t) value of zircons from the mafic enclaves is up to +7.4,indicating that the mafic magma was originated from a relatively depleted mantle source.Studies on regional geology and the contemporaneous mafic and alkaline rocks in this area indicate that the mafic magma was not originated from reworking of basaltic juvenile crust,but from partial melting of the mantle.However,it remains to be resolved whether the mafic magma was derived from partial melting of the asthenosphere or the lithospheric mantle.The Huashan granite and the Lisong granite were formed from hybrid magma of mantle-derived and crust-derived magmas,and the mafic enclaves are considered as remains of mantle-derived magma during mixing processes.The εHf(t) values of zircons from the Niumiao diorite vary from -1.1 to +2.1,and those from the Tong'an quartz monzonite vary from -1.7 to +1.7.These values are lower than those from the mafic enclaves,suggesting that the diorite and monzonite were formed from different source-derived magmas with the mafic enclaves.The εHf(t) values for the Niumiao diorite and the Tong'an monzonite are only slightly higher than those for the Hushan granite and the Lisong granite.Abundant mafic enclaves also occur in the Niumiao diorite and in the Tong'an monzonite.Thus,we suggest that the Niumiao diorite and the Tong'an monzonite were probably also formed from the same hybrid magma as the granites but come through less degree of fractional crystallization and crustal contamination.The strong mantle-derived and crust-derived magma mixing caused by an intense crustal extension and thinning in the Mid-Late Jurassic may be the major mechanism for generating the diorites and granites in southeastern Hunan and northeastern Guangxi belt in South China. | ZHAO KuiDong JIANG ShaoYong ZHU JinChu LI Liang DAI BaoZhang JIANG YaoHui LING HongFei | 2010 | Chinese Science Bulletin2010，55，6： | 24 |
| 5 | Transduction of Fas gene or Bcl-2 antisense RNA sensitizes cultured drug resistant gastric cancer cells to chemotherapeutic drugs显示文摘INTRODUCTIONChemotherapyisoneofthemajormethodsintumortreatment,butitoftendoesnotworkduetomultidrugresistance(MDR).Recentstudi... | XIAO Bing, SHI Yong Quan, ZHAO Yan Qiu, YOU Han, WANG Zuo You, LIU Xian Ling, YIN Fang, QIAO Tai Dong and FAN Dai Ming | 1998 | World Journal of Gastroenterology1998，4，5： | 24 |
| 6 | Effects of multimodal fast-track surgery on liver transplantation outcomes显示文摘BACKGROUND:Fast-track surgery and enhanced recovery after surgery have been applied to many surgical procedures;however,data on fast-track surgery and enhanced recovery after surgery following liver transplantation is limited.This study aimed to conduct a prospective study to determine the effects of fast-track surgery on prognosis after liver transplantation.METHODS:This was a prospective,single-blinded,randomized study.One hundred twenty-eight patients undergoing liver transplantation were selected for the fast-track(FT group,n=54) or conventional process(NFT group,n=74).The primary endpoints were intensive care unit(ICU) stay and hospital stay.The secondary endpoints were as follows:operative time,anhepatic phase time,intraoperative blood loss,intraoperative blood transfusion volume,postoperative complications,readmission rate,and postoperative mortality.RESULTS:There was no significant difference in preoperative demographics between the two groups.The median ICU stay was 2 days(range 1-7 days) in the FT group and 5 days(range 3-12 days) in the NFT group(P<0.01).Furthermore,the hospital stay was also significantly reduced in the FT group(P<0.01).The operative time,anhepatic phase time,intraoperative blood loss,and intraoperative blood transfusion volume were decreased in the FT group compared with the NFT group(P<0.05).Based on Spearman correlation analysis,the ICU stay and hospital stay may be positively correlated with operative time,anhepatic phase time and intraoperative blood loss.There were no differences in the incidence of postoperative complications,readmissions,and postoperative mortality between the two groups.CONCLUSION:Fast-track procedures effectively reduce the ICU stay and hospital stay without adversely affecting prognosis.This study demonstrated that fast-track protocols are safe and feasible in liver transplantation. | Jian-Hua Rao Feng Zhang Hao Lu Xin-Zheng Dai Chuan-Yong Zhang Xiao-Feng Qian Xue-Hao Wang Ling Lu | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 23 |
| 7 | Characteristics of sewage sludge and distribution of heavy metal in plants with amendment of sewage sludge显示文摘In order to better understand land application of sewage sludge, the characterization of heavy metals and organic pollutants were investigated in three different sewage sludges in Shanghai City, China. It was found that the total concentrations of Cd in all of sewage sludge and total concentrations of Zn in Jinshan sewage sludge, as well as those of Zn, Cu, and Ni in Taopu sludge are higher than Chinese regulation limit of pollutants for sludge to be used in agriculture. Leachability of Hg in all of studied samples and that of Cd in Taopu sewage sludge exceed the limit values of waste solid extraction standard in China legislation. Based on the characteristics for three kinds of sewage sludge, a pot experiment was conducted to investigate the effect of soil amended with Quyang sewage sludge on the accumulation of heavy metal by Begonia semperflorens-hybr; Ophiopogon japonicus (L.F.) Ker-Gaw; Loropetalum chindense-var. rubrum; Dendranthema morifolium; Viola tricolor; Antirrhinum majus; Buxus radicans Sieb; Viburnum macrocephalum; Osmanthus fragrans Lour; Cinnamomum camphora siebold and Ligustrum lucidum ait. Results showed that 8 species of plant survived in the amended soil, and moreover they flourished as well as those cultivated in the control soil. The heavy metal concentration in plants varied with species, As, Pb, Cd and Cr concentration being the highest in the four herbaceous species studied, particularly in the roots of D. morifolium. These plants, however, did not show accumulator of As, Pb, Cd and Cr. The highest concentration of Ni and Hg was found in the roots of D. morifolium, followed by the leaves of B. semperflorens-hybr. Levels of Zn and Cu were much higher in D. morifolium than in the other plant species. D. morifolium accumulated Ni, Hg, Cu and Zn, which may contribute to the decrease of heavy metal contents in the amended soil. Treatment with sewage sludge did not significantly affect the uptake of heavy metals by the L. chindense-var. rubrum, however, it significantly affected the uptake of heavy metals by D. morifolium. | DAI Jia-yin CHEN Ling ZHAO Jian-fu MA Na | 2006 | Journal of Environmental Sciences2006，18，6： | 18 |
| 8 | Spatial variability of soil organic carbon in the forestlands of northeast China显示文摘Soil organic carbon(SOC) is an effective indicator of soil fertility and productivity, and it varies spatially and temporally in relation to other soil properties. Spatial variability of SOC in the forestlands of northeast China was characterized using geostatistics. Soil samples at the depths of 0?20 cm, 20?40 cm and 40?60 cm were collected from sixty-three temporary plots to evaluate SOC concentration and density(SOCD) and other soil properties. We analyzed correlations between SOC and soil properties. Soil organic carbon concentrations were high. The total amount of C stored in soil(0?60 cm) was 16.23 kg·m-2 with the highest SOCD of 7.98 kg?m-2 in topsoil. Soil properties in most cases differed by horizon, suggesting different processes and effects in each horizon. Soil organic carbon had positive relationships with total N, P and K as well as readily available K, but did not show a significant positive correlation with available P. Spatial factors including elevation, slope and aspect affected SOC distribution. Soil organic carbon at 0?60 cm had strong spatial autocorrelation with nugget/sill ratio of 5.7%, and moderate structured dependence was found at 0?20 cm, which indicated the existence of a highly developed spatial structure. Spatial distributionsof SOC concentration and SOCD were estimated using regression-kriging, with higher prediction accuracy than ordinary kriging. The fractal dimension of SOC indicated the preferential pattern of SOC distribution, with the greatest spatial heterogeneity and strongest spatial dependence in the northeast-southwest direction. | Ling Liu Haiyan Wang Wei Dai Xiangdong Lei Xiaojuan Yang Xu Li | 2014 | Journal of Forestry Research2014，25，4： | 11 |
| 9 | Characterization and evaluation of rice blast resistance of Chinese indica hybrid rice parental lines显示文摘The development of resistant varieties and hybrid combinations has been the most effective and economical strategy to control blast disease caused by Magnaporthe oryzae.However, the distribution of major R genes and blast resistance characterization in hybrid rice parents has not been well investigated, resulting in their limited use in hybrid rice blast-resistance breeding. In the present study, 88 elite indica hybrid rice parental lines were evaluated with 30 isolates of M. oryzae collected from the main planting area of indica hybrid rice in China and were characterized for the presence of 11 major resistance genes using molecular markers. The pathogenicity assays showed that four types of hybrid rice parent line showed some resistance to M. oryzae. However, the proportions of highly resistant lines and the mean resistance frequency(RF) varied among the four types, with resistance in decreasing order shown by three-line restorer lines, three-line maintainer lines, two-line sterile lines, and two-line restorer lines. All 88 hybrid rice parental lines carried more than one R gene, but none carried the R genes Pi1 and Pi2. Although Pid3 and Pi9 were present only in three-line restorer lines and Pigm only in three-line maintainer lines, the remaining six R genes(Pib, Pid2, Pi5, Pia, Pi54, and Pita) were present in the four types of hybrid rice parent with significantly different distribution frequencies. The correlation between R genes and resistance reactions was investigated. The results are expected to provide useful information for rational utilization of major R genes in hybrid rice breeding programs. | Yunyu Wu Ling Yu Ning Xiao Zhengyuan Dai Yuhong Li Cunhong Pan Xiaoxiang Zhang Guangqing Liu Aihong Li | 2017 | The Crop Journal2017，5，6： | 10 |
| 10 | Occurrence of Aflatoxin B_(1),deoxynivalenol and zearalenone in feeds in China during 2018-2020显示文摘Background:The current study was conducted to investigate the individual and combined occurrence of aflatoxin B_(1)(AFB_(1)),deoxynivalenol(DON)and zearalenone(ZEN)in feeds from various Provinces of China during 2018 to 2020.A total of 3,507 feed samples,including 2,090 feed ingredients and 1,417 complete feed samples,were collected from different areas of China for mycotoxins analysis.Results:The individual contamination of AFB_(1),DON and ZEN were present in more than 81.9%,96.4% and 96.9% of feed samples,respectively,with average concentration ranges of AFB_(1) between 1.2-27.4μg/kg,DON between 458.0-1,925.4μg/kg and ZEN between 48.1-326.8μg/kg.Notably,0.9%,0.5% and 0.1% of feed ingredients,and 1.2-12.8%,0.9-2.9% and 0-8.9% of complete feeds for pigs,poultry and ruminants with AFB_(1),ZEN and DON that exceeded China’s safety standards,respectively.Moreover,more than 81.5%of feed ingredients and 95.7% of complete feeds were co-contaminated with various combinations of these mycotoxins.Conclusion:This study indicates that the feeds in China were universally contaminated with AFB_(1),DON and ZEN during the past 3 years.These findings highlight the significance of monitoring mycotoxin contaminant levels in the domestic animal feed,and the importance of carrying out feed administration and remediation strategies for mycotoxin control. | Ling Zhao Lei Zhang Zijian Xu Xingda Liu Liyuan Chen Jiefan Dai Niel Alexander Karrow Lvhui Sun | 2022 | Journal of Animal Science and Biotechnology2022，13，1： | 10 |
| 11 | A novel anticancer property of Lycium barbarum polysaccharide in triggering ferroptosis of breast cancer cells显示文摘Breast cancer is one of the most malignant tumors and is associated with high mortality rates among women.Lycium barbarum polysaccharide(LBP)is an extract from the fruits of the traditional Chinese herb,L.barbarum.LBP is a promising anticancer drug,due to its high activity and low toxicity.Although it has anticancer properties,its mechanisms of action have not been fully established.Ferroptosis,which is a novel anticancer strategy,is a cell death mechanism that relies on iron-dependent lipid reactive oxygen species(ROS)accumulation.In this study,human breast cancer cells(Michigan Cancer Foundation-7(MCF-7)and MD Anderson-Metastatic Breast-231(MDA-MB-231))were treated with LBP.LBP inhibited their viability and proliferation in association with high levels of ferroptosis.Therefore,we aimed to ascertain whether LBP reduced cell viability through ferroptosis.We found that the structure and function of mitochondria,lipid peroxidation,and expression of solute carrier family 7 member 11(SLC7 A11,also known as x CT,the light-chain subunit of cystine/glutamate antiporter system X_(c)^(-))and glutathione peroxidase 4(GPX4)were altered by LBP.Moreover,the ferroptosis inhibitor,Ferrostatin-1(Fer-1),rescued LBP-induced ferroptosis-associated events including reduced cell viability and glutathione(GSH)production,accumulation of intracellular free divalent iron ions and malondialdehyde(MDA),and down-regulation of the expression of x CT and GPX4.Erastin(x CT inhibitor)and RSL3(GPX4 inhibitor)inhibited the expression of x CT and GPX4,respectively,which was lower after the co-treatment of LBP with Erastin and RSL3.These results suggest that LBP effectively prevents breast cancer cell proliferation and promotes ferroptosis via the x CT/GPX4 pathway.Therefore,LBP exhibits novel anticancer properties by triggering ferroptosis,and may be a potential therapeutic option for breast cancer. | Xing DU Jingjing ZHANG Ling LIU Bo XU Hang HAN Wenjie DAI Xiuying PEI Xufeng FU Shaozhang HOU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 10 |
| 12 | Invited review:Remediation strategies for mycotoxin control in feed显示文摘Mycotoxins are secondary metabolites of different species of fungi.Aflatoxin B1(AFB1),deoxynivalenol(DON),zearalenone(ZEN)and fumonisin B1(FB1)are the main mycotoxins contaminating animal feedstuffs.These mycotoxins can primarily induce hepatotoxicity,immunotoxicity,neurotoxicity and nephrotoxicity,consequently cause adverse effects on the health and performance of animals.Therefore,physical,chemical,biological and nutritional regulation approaches have been developed as primary strategies for the decontamination and detoxification of these mycotoxins in the feed industry.Meanwhile,each of these techniques has its drawbacks,including inefficient,costly,or impractically applied on large scale.This review summarized the advantages and disadvantages of the different remediation strategies,as well as updates of the research progress of these strategies for AFB1,DON,ZEN and FB1 control in the feed industry. | Meng Liu Ling Zhao Guoxin Gong Lei Zhang Lei Shi Jiefan Dai Yanming Han Yuanyuan Wu Mahmoud Mohamed Khalil Lvhui Sun | 2022 | Journal of Animal Science and Biotechnology2022，13，4： | 8 |
| 13 | Two new epimeric pairs of iridoid from mangrove plant Scyphiphora hydrophyllacea显示文摘iridoid scyphiphin A1 (1a ) 的二新 epimeric 对, A2 (1b ) 和 scyphiphin B1 (2a ) , B2 (2b ) 从 Scyphiphora hydrophyllacea Gaertn 被孤立。F。他们的结构被分光镜的方法阐明。scyphiphin B1 和 scyphiphin B2 的混合由 MTT 方法在 vitro 对人的 hepatoma SMMC-7721 房间线显示出中等 cytotoxicity。 | Yan Bo Zeng Wen Li Mei You Xing Zhao Ling Zhuang Kui Hong Hao Fu Dai | 2007 | Chinese Chemical Letters2007，18，12： | 8 |
| 14 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 15 | Nanostructured lipid carrier based topical gel of Ganoderma Triterpenoids for frostbite treatment显示文摘The objective of this study was to prepare nanostructured lipid carrier(NLC)-based topical gel of Ganoderma Triterpenoids(GTs) and evaluate their effects on frostbite treatment. GT-NLCs was prepared by the high pressure homogenization method and then characterized by morphology and analyses of particle size, zeta potential, entrapment efficiency(EE), and drug loading(DL). The NLCs was suitably gelled for skin permeation studies in vitro and pharmacodynamic evaluation in vivo, compared with the GT emulgel. The GT-NLC remained within the colloidal range and was uniformly dispersed after suitably gelled by carbopol preparation. Transmission electron microscopy(TEM) study showed GT-NLCs was spherical in shape. The EE(%) and DL(%) could reach up to(81.84 ± 0.60)% and(2.13 ± 0.12)%, respectively. The result of X-ray diffractograms(XRD) showed that GTs were in an amorphous state in the NLC-gel. In vitro permeation studies through rat skin indicated that the amount of GTs permeated through skin of GT-NLCs after 24 h was higher than that of GT emulsion, and GT-NLCs increased the accumulative amounts of GTs in epidermis 7.76 times greater than GT emulsion. GT-NLC-gel was found to possess superior therapeutic effect for frostbite, compared with the GT emulgel. The NLC based topical gel of GTs could improve-their therapeutic effect for frostbite. | SHEN Cheng-Ying DAI Ling SHEN Bao-De ZHOU Xu BAI Jin-Xia XU He LV Qing-Yuan HAN Jin YUAN Hai-Long | 2015 | Chinese Journal of Natural Medicines2015，13，6： | 6 |
| 16 | Diagnosis related group grouping study of senile cataract patients based on E-CHAID algorithm显示文摘AIM: To figure out the contributed factors of the hospitalization expenses of senile cataract patients(HECP) and build up an area-specified senile cataract diagnosis related group(DRG) of Shanghai thereby formulating the reference range of HECP and providing scientific basis for the fair use and supervision of the health care insurance fund.METHODS: The data was collected from the first page of the medical records of 22 097 hospitalized patients from tertiary hospitals in Shanghai from 2010 to 2012 whose major diagnosis were senile cataract. Firstly, we analyzed the influence factors of HECP using univariate and multivariate analysis. DRG grouping was conducted according to the exhaustive Chi-squared automatic interaction detector(E-CHAID) model, using HECP as target variable. Finally we evaluated the grouping results using non-parametric test such as Kruskal-Wallis H test, RIV, CV, etc.RESULTS: The 6 DRGs were established as well as criterion of HECP, using age, sex, type of surgery and whether complications/comorbidities occurred as the key variables of classification node of senile cataract cases.CONCLUSION: The grouping of senile cataract cases based on E-CHAID algorithm is reasonable. And the criterion of HECP based on DRG can provide a feasible way of management in the fair use and supervision of medical insurance fund. | AiJing Luo Wei-Fu Chang Zi-Rui Xin Hao Ling Jun-Jie Li Ping-Ping Dai Xuan-Tong Deng Lei Zhang Shao-Gang Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 6 |
| 17 | On Universally Left-stability of ε-Isometry显示文摘LetX,Y be two real Banach spaces andε≥0.A map f:X→Y is said to be a standardε-isometry if|f(x)f(y)x y|≤εfor all x,y∈X and with f(0)=0.We say that a pair of Banach spaces(X,Y)is stable if there existsγ>0 such that,for every suchεand every standardε-isometry f:X→Y,there is a bounded linear operator T:L(f)≡spanf(X)→X so that T f(x)x≤γεfor all x∈X.X(Y)is said to be universally left-stable if(X,Y)is always stable for every Y(X).In this paper,we show that if a dual Banach space X is universally left-stable,then it is isometric to a complemented w-closed subspace of∞(Γ)for some setΓ,hence,an injective space;and that a Banach space is universally left-stable if and only if it is a cardinality injective space;and universally left-stability spaces are invariant. | Ling Xin BAO Li Xin CHENG Qing Jin CHENG Duan Xu DAI | 2013 | Acta Mathematica Sinica,English Series2013，29，11： | 6 |
| 18 | Adhesion Characteristics of a Novel Synthetic Polydimethylsiloxane for Bionic Adhesive Pads显示文摘 | Qingsong He Min Yu Yang Li Xinlong Chen Hao Zhang Ling Gong Zhendong Dai | 2014 | Journal of Bionic Engineering2014，11，3： | 6 |
| 19 | Catalytic removal of phenol from gas streams by perovskite-type catalysts显示文摘Three perovskite-type catalysts prepared by citric acid method are applied to remove phenol from gas streams with the total flow rate of 300 mL/min, corresponding to a GHSV of10,000/hr. LaMnO_3 catalyst is first prepared and further partially substituted with Sr and Cu to prepare La_(0.8)Sr_(0.2)MnO_3 and La_(0.8)Sr_(0.2)Mn_(0.8)Cu_(0.2)O_3, and catalytic activities and fundamental characteristics of these three catalysts are compared. The results show that phenol removal efficiency achieved with La_(0.8)Sr_(0.2)Mn_(0.8)Cu_(0.2)O_3 reaches 100% with the operating temperature of 200°C and the rate of mineralization at 300°C is up to 100%, while the phenol removal efficiencies achieved with La_(0.8)Sr_(0.2)MnO_3 and LaMnO_3 are up to 100% with the operating temperature of 300°C and 400°C, respectively. X-ray photoelectron spectroscopy(XPS) analysis shows that the addition of Sr and Cu increases the lattice oxygen of La_(0.8)Sr_(0.2)Mn_(0.8)Cu_(0.2)O_3, and further increases mobility or availability of lattice oxygen. The results indicate that La_(0.8)Sr_(0.2)Mn_(0.8)Cu_(0.2)O_3 has the best activity for phenol removal among three catalysts prepared and the catalytic activity of phenol oxidation is enhanced by the introduction of Sr and Cu into LaMnO_3. Apparent activation energy of 48 k J/mol is calculated by Mars–Van Krevelen Model for phenol oxidation with La_(0.8)Sr_(0.2)Mn_(0.8)Cu_(0.2)O_3 as catalyst. | Dai Ling Chen Kuan Lun Pan Moo Been Chang | 2017 | Journal of Environmental Sciences2017，29，6： | 5 |
| 20 | Recent advances and perspectives on vanadium-and manganese-based cathode materials for aqueous zinc ion batteries显示文摘The growing demand for energy storage has inspired researchers’exploration of advanced batteries.Aqueous zinc ion batteries(ZIBs)are promising secondary chemical battery system that can be selected and pursued.Rechargeable ZIBs possess merits of high security,low cost,environmental friendliness,and competitive performance,and they are received a lot of attention.However,the development of suitable zinc ion intercalation-type cathode materials is still a big challenge,resulting in failing to meet the commercial needs of ZIBs.Both vanadium-based and manganese-based compounds are representative of the most advanced and most widely used rechargeable ZIBs electrodes.The valence state of vanadium is+2~+5,which can realize multi-electron transfer in the redox reaction and has a high specific capacity.Most of the manganese-based compounds have tunnel structure or three-dimensional space frame,with enough space to accommodate zinc ions.In order to understand the energy storage mechanism and electrochemical performance of these two materials,a specialized review focusing on state-of-the-art developments is needed.This review offers access for researchers to keep abreast of the research progress of cathode materials for ZIBs.The latest advanced researches in vanadium-based and manganese-based cathode materials applied in aqueous ZIBs are highlighted.This article will provide useful guidance for future studies on cathode materials and aqueous ZIBs. | Na Liu Bin Li Zhangxing He Lei Dai Haiyan Wang Ling Wang | 2021 | Journal of Energy Chemistry2021，30，8： | 5 |
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