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| 1 | Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy显示文摘AIM: To evaluate the implication of substitutions in the hepatitis C virus (HCV) non-structural 5A (NS5A) protein in the resistance of HCV during mono-interferon (IFN) or combined IFN-ribavirin (IFN-R) therapy. Although NS5A has been reported to interact with the HCV RNA- dependent RNA polymerase, NS5B, as well as with many cellular proteins, the function of NS5A in the life cycle of HCV remains unclear. METHODS: HCV quasispecies were studied by clon- ing and sequencing of sequential isolates from patients infected by HCV genotype 1b. Patients were treated by IFN-α2b for 3 mo followed by IFN-α2b alone or com- bined IFN-R therapy for 9 additional months. Patients were categorized intro two groups based on their re- sponse to the treatments: 7 with sustained virological re- sponse (SVR) (quasispecies = 150) and 3 non-respond- ers (NR) to IFN-R (quasispecies = 106). RESULTS: Prior to treatment, SVR patients displayed a lower complexity of quasispecies than NR patients. Most patients had a decrease in the complexity of quasispe- cies during therapy. Analysis of amino acids substitu- tions showed that the degree of the complexity of the interferon sensitivity-determining region (ISDR) and the V3 domain of NS5A protein was able to discriminate thetwo groups of patients. Moreover, SVR patients displayed more variability in the NS5A region than NR patients. CONCLUSION: These results suggest that detailed mo- lecular analysis of the NS5A region may be important for understanding its function in IFN response during HCV 1b infection. | Pascal Veillon Christopher Payan Hélène Le Guillou-Guillemette Catherine Gaudy Franoise Lunel | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 3 | Pulmonary fibrosis correlates with outcome in the adult respiratory dis- tress syndrome显示文摘 | Martin C Papazian L Payan M J | 1995 | Chest1995，107，1： | 1 |
| 4 | Comparative evaluation of the total hepatitis C virus core antigen, branched-DNA, and amplicor monitor assays in determining viremia for patients with chronic hepatitis C during interferon plus ribavirin combination therapy 显示文摘 | VEILLON P PAYAN C PICCHIO G | 2003 | J Clin Microbiol2003，41，： | 1 |
| 5 | Patient specific finite el- ement model of the face soft tissues for computer-assisted maxillofacial surgery 显示文摘 | Chabanas M Luboz V Payan Y | 2003 | Med Image Anal2003，7，2： | 1 |
| 6 | Biomechanical models to simulate consequences of maxillofacial surgery显示文摘 | Payan Y Chabanas M Pelorson X | 2002 | C R Biol2002，325，4： | 1 |
| 7 | Alterations in human leukocyte function induced by ingestion of eicosapentaenoic acid显示文摘 | Payan DG Wong MYS Chernov-Rogan T | 1986 | J Clin Immunol1986，6，： | 1 |
| 8 | Stability and structural analysis of α-amylase from the antarctic psychrophile Alteromonas haloplanctis A23显示文摘 | Feller G Payan F Theys M | 1994 | Eur J Biochem1994，，222： | 1 |
| 9 | How should salinity influence fish growth? 显示文摘 | Boeuf G Payan P | 2001 | Comparative Biochemistry and Physiology-Part C: Toxicology & Pharmacology2001，130，4： | 1 |
| 10 | Stability and structural analysis of α-amylase from the Antarctic psychrophile Alteromonas haloplanctis A23显示文摘 | Feller G Payan F Theys F | 1994 | European Journal of Biochemistry1994，222，： | 1 |
| 11 | Influence of manufacturing tolerances on the electro- motive force in permanent-magnet motors 显示文摘 | SIMON - SEMPERE V BURGOS - PAYAN M CERQUIDES - BUENO J R | 2013 | IEEE Transactions on Magnetics2013，49，11： | 1 |
| 12 | Group connectivity of graphs-a nonhomogeneous analogue of nowhere-zero flow properties 显示文摘 | JAEGER F LINIAL N PAYAN C | 1992 | J Combinatorial Theory:Ser B1992，56，： | 1 |
| 13 | In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study显示文摘 | J.J.M. van de Sandt J.A. van Burgsteden S. Cage P.L. Carmichael I. Dick S. Kenyon G. Korinth F. Larese J.C. Limasset W.J.M. Maas L. Montomoli J.B. Nielsen J.-P. Payan E. Robinson P. Sartorelli K.H. Schaller S.C. Wilkinson F.M. Williams | 2004 | Regulatory Toxicology and Pharmacology2004，，3： | 1 |
| 14 | High interaction alginate - hyaluronate associations by hyaluronate deacetylation for the preparation of effident biomaterials显示文摘 | Oerther S Maurin A Payan E Hubert P I.apicque F Presle N etal | | 0，，： | 1 |
| 15 | Changes in physical and chemical properties of a dental palladium-silver alloy during metal-porcelain bonding显示文摘 | Payan J Moya GE Meyer JM | 1986 | J Oral Rehabil1986，13，4： | 1 |
| 16 | A property on edge-disjoint spanning trees 显示文摘 | LAI Hongjian LAI Hongyuan PAYAN C | 1996 | European J Combin1996，17，： | 1 |
| 17 | Layer by layer buildup of polysaccharide films: physical chemistry and cellular adhesion aspects 显示文摘 | Richert L Lavalle P Payan E Shu XZ Prestwish GD Stohz J-F Schaaf P Voegel JC Picart C | 2004 | Langmuir2004，20，： | 1 |
| 18 | Synthesis of V-V sequences with a 2D biomechanical tongue model controlled by the Equilibrium Point Hypothesis显示文摘 | Yohan Payan Pascal Perrier | 1997 | Speech Communication . 1997 (2-3)1997，，2： | 1 |
| 19 | Geometric optimization of radiative enclosures using PSO algorithm显示文摘 | Farahmand A Payan S Hosseini Sarvari S M | 2012 | International Journal of Thermal Sciences2012，60，1： | 1 |
| 20 | Comparison of linearand non-linear soft tissue models with post-operative CT scan inmaxillofacial surgery显示文摘 | Chabanas M Payan Y Marecaux C | 2004 | Int Symp Med Simul2004，3078，： | 1 |
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