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| 1 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 2 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 3 | Historical trends in the anthropogenic heavy metal levels in the tidal flat sediments of Lianyungang, China显示文摘The sedimentation of metals can preserve the historical record of contaminant input from local and regional sources and provide information on the historical changes in regionalwater and sediment quality. We report the 210Pb activities and the heavy metal (Cd, Cr, Cu, Mn, Pb and Zn)depth profiles from sediment cores retrieved in 2010. The mean sedimentation rates of 0.85-1.5 cm/yr aredetermined by 210 Pbdating. The sediments in the tidal flat have recorded heavy metaldeposition and thus allow the establishment of a connection between the temporal evolution of the heavy metal pollution and the historical changes in the economicdevelopment of Lianyungang. The enrichment factors (EF) are calculated to estimate the level of contamination stored in these sediments. The results show that in the studied sites, Cr and Cudisplay low EF values and are mainly from lithogenic origin. For the other studied trace metals, a great variability in the sedimentary record is observed. Significant anthropogenic enrichment over the last 50 years is revealed at the tidal flat that receives fluvial inputs. Zinc is the elementwith the highest EF values, followed by the order of Pb > Cd > Mn > Cu and Cr. The temporal variations of the heavy metals peakduring the late 1980s to the early2000s and show adecreasing trend afterward. The pollution intensity of the tidal flat isdetermined by using EF and thegeo-accumulation index (Igeo ),which show that, based on the Igeo scale, the tidal flat of Haizhou Bay is unpolluted to moderately polluted. | Rui Zhang Fan Zhang Yingjun Ding Jinrong Gao Jing Chen Li Zhou | 2013 | Journal of Environmental Sciences2013，25，7： | 5 |
| 4 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 5 | Research Progress of Grassland Feed-animal Balance at Home and Abroad显示文摘Feed-animal balance is the key technique on the grassland ecosystem management,and attracts widespread attention in the world.Many studies have been conducted by former researchers,and most of their efforts were intended to keep the balance of feed-animal.However,there are still much more issue needed to be studied in details on the face of grassland degeneration and animal husbandry sustainable development.The author analyzed the feed-animal balance research progress,including the concept of stocking rate and its practical management techniques,especially on the stocking rate calculation methods.In addition,the social and economy effects on feed-animal balance were also discussed during the progress of improving the development of pastoral economy.In order to achieve feed-animal balance more effectively,it was concluded that the focus must be shift from only on animal number to the grassland quality,and it's necessary to strengthen market tax control. | Xiaohu MAI Yujuan ZHANG Yingjun ZHANG Shangli SHI Ding HUANG Yajun ZHANG | 2013 | Asian Agricultural Research2013，5，12： | 2 |
| 6 | Transient response of carbon nanotube integrated circuits显示文摘所有的频率反应的速度出版了碳 nanotube (CNT ) 集成电路(IC ) 远离那被预言。CNT IC 的短暂反应通过联合系统地被探索试验性并且模拟方法。互补 field-effect-transistor (联邦货物税) 基于 inverters 在单个半导体的 CNT 上被制作,并且动态反应测量显示它能仅仅以出人意料地低的速度工作,即与 30 s 的大繁殖延期。由于 CNT 联邦货物税的更大的产量抵抗,寄生电容的存在应该导致大部分更大抵抗电容(RC ) 在 Si IC 比那推迟。通过联合模拟和试验性的大小的详细分析,在 CNT 联邦货物税 IC 的实际速度下面拖的几种寄生电容一个一个地被识别,并且他们中的每通过 RC 延期在不同层次限制速度。从测量系统的寄生电容是主导的,这被发现,并且大 RC 延期降低 CNT 联邦货物税逻辑电路的速度到仅仅类似于试验性的结果的几 kHz。各种各样的优化计划被建议并且示威了最小化寄生电容的效果,并且因此改进 CNT IC 的速度。 | Panpan Zhang Yingjun Yang Tian Pei Chenguang Qiu Li Ding Shibo Liang Zhiyong Zhang Lianmao Peng | 2015 | Nano Research2015，8，3： | 2 |
| 7 | Investigation on Inlet Recirculation Characteristics of Double Suction Centrifugal Compressor with Unsymmetrical Inlet显示文摘The inlet recirculation characteristics of double suction centrifugal compressor with unsymmetrical inlet structures were studied in numerical method,mainly focused on three issues including the amounts and differences of the inlet recirculation in different working conditions,the circumferential non-uniform distributions of the inlet recirculation,the recirculation velocity distributions of the upstream slot of the rear impeller.The results show that there are some differences between the recirculation of the front impeller and that of the rear impeller in whole working conditions..In design speed,the recirculation flow rate of the rear impeller is larger than that of the front impeller in the large flow range,but in the small flow range,the recirculation flow rate of the rear impeller is smaller than that of the front impeller.In different working conditions,the recirculation velocity distributions of the front and rear impeller are non-uniform along the circumferential direction and their non-uniform extents are quite different.The circumferential non-uniform extent of the recirculation velocity varies with the working conditions change.The circumferential non-uniform extent of the recirculation velocity of front impeller and its distribution are determined by the static pressure distribution of the front impeller,but that of the rear impeller is decided by the coupling effects of the inlet flow distortion of the rear impeller,the circumferential unsymmetrical distribution of the upstream slot and the asymmetric structure of the volute.In the design flow and small flow conditions,the recirculation velocities at different circumferential positions of the mean line of the upstream slot cross-section of the rear impeller are quite different,and the recirculation velocities distribution forms at both sides of the mean line are different.The recirculation velocity distributions in the cross-section of the upstream slot depend on the static pressure distributions in the intake duct. | YANG Ce WANG Yingjun LAO Dazhong TONG Ding WEI Longyu LIU Yixiong | 2016 | Journal of Thermal Science2016，25，4： | 1 |
| 8 | MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancercell proliferation by directly targeting HMGA2显示文摘 | Huading Zhou Weijie Guo Yingjun Zhao Yifei Wang Ruopeng Zha Jie Ding Linhui Liang Jun Hu Hao Shen Zongyou Chen Baobing Yin Baojin Ma | 2014 | International Journal of Oncology2014，，6： | 1 |
| 9 | Development and Impacts of the Sierra Leone-China Laboratory for Parasitic Diseases Testing and Surveillance显示文摘BACKGROUND The Republic of Sierra Leone is located on the west coast of Africa,bordering Guinea and Liberia,with a population of 7.8 million in 2019(1).It has a tropical monsoon climate,with high temperatures and plentiful precipitation.As one of the least developed countries in the world(2),Sierra Leone has long struggled with poor health outcomes with a life expectancy at birth of 59 for male and 61 for female,and high maternal and neonatal mortality,threatened by infectious diseases such as malaria,tuberculosis,typhoid fever,cholera,and Lassa fever(3). | Lei Duan Lili Wang Shenning Lu Bei Wang Yanbing Li Qiuli Xu Lulu Huang Wei Ding Yingjun Qian Hongmei Li Xuejiao Ma Duoquan Wang Yayi Guan Xiaochun Wang Ning Xiao Xiao-nong Zhou | 2021 | China CDC weekly2021，3，15： | 1 |
| 10 | The Identification and Geological Significance of Fault Buried in the Gasikule Salt Lake in China based on the Multi-source Remote Sensing Data显示文摘The salinity of the salt lake is an important factor to evaluate whether it contains some mineral resources or not,the fault buried in the salt lake could control the abundance of the salinity.Therefore,it is of great geological importance to identify the fault buried in the salt lake.Taking the Gasikule Salt Lake in China for example,the paper established a new method to identify the fault buried in the salt lake based on the multi-source remote sensing data including Landsat TM,SPOT-5 and ASTER data.It includes the acquisition and selection of the multi-source remote sensing data,data preprocessing,lake waterfront extraction,spectrum extraction of brine with different salinity,salinity index construction,salinity separation,analysis of the abnormal salinity and identification of the fault buried in salt lake,temperature inversion of brine and the fault verification.As a result,the study identified an important fault buried in the east of the Gasikule Salt Lake that controls the highest salinity abnormal.Because the level of the salinity is positively correlated to the mineral abundance,the result provides the important reference to identify the water body rich in mineral resources in the salt lake. | WANG Junhu ZHAO Yingjun WU Ding LU Donghua | 2021 | Acta Geologica Sinica(English Edition)2021，95，3： | 1 |
| 11 | 2 - 9 Observation of Collective and Non-collective Excitations in 127I显示文摘 | Ding Bing Zhang Yuhu Zhou Xiaohong Wang Haixia Li Guangshun Zhou Houbing Ma Yingjun Y. Sasakiz K. Yamada H. Ohshima S. Yokose M. Ishizuka T. Komatsubara K. Furuno Xu Furong Dong Guoxiang | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 12 | Carbon nanotube network film-based ring oscillators with sub l O-ns propagation time and their applications in radio-frequency signal transmission显示文摘 | Yingjun Yang Li Ding Hengjia Chen Jie Han Zhiyong Zhang Lian-Mao Peng | 2018 | Nano Research2018，11，1： | 0 |
| 13 | Over-correction of curvature causes the non-surgical curvature loss in one- and two-level anterior cervical discectomy and fusion显示文摘To the Editor:Cervical disc degenerative disease(CDDD)is a common clinical spinal disease,which has a great impact on the quality of life of middle-aged and elderly patients.[1,2]Although it is challenged by advanced surgical techniques,anterior cervical discectomy and fusion(ACDF)is still the best choice for most patients with CDDD.[3,4]In most cases,the focus of ACDF surgery is“decompression.”However,for patients with preoperatively poor curvature,in addition to the decompression of the nerve to relieve symptoms,it is also vital to improve the cervical curvature. | Yingjun Guo Hao Liu Yang Meng Chen Ding Ying Hong Beiyu Wang | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 14 | Correction to:Potentiating CD8^(+)T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Figure 1.LDLR deficiency hinders the antitumor activity of CD8^(+)T cells.(A)Transcriptional level of genes involved in cholesterol transport in naïve CD8^(+)T cells,CTLs and CD8^(+)TILs(isolated at Day3 or Day7 post CTLs adoptive transfer),(n=4).(B)LDLR expression level on CTLs and CD8^(+)TILs(isolated at Day3 post CTLs adoptive transfer),(n=4). | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2022 | Protein & Cell2022，13，9： | 0 |
| 15 | A New High-spin Level Scheme of 128I显示文摘 | Wang Hai xia Zhang Yuhu Ding Bing Zhou Xiaohong Liu Minliang Zhang Ningtao Ma Yingjun Y. Sasakiz K. Yamada H. Ohshima S. Yokose M. Ishizuka T. Komatsubara K. Furuno | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
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