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| 1 | Effects of Tetrandrine on Apoptosis and Radiosensitivity of Nasopharyngeal Carcinoma Cell Line CNE显示文摘Tetrandrine 被知道然而,几乎不施加反肿瘤效果在鼻咽的癌房间上对它的效果被知道。在这研究,我们在鼻咽的癌房间线 CNE 测试了导致 tetrandrine 的 apoptosis 和放射敏感度并且调查了可能的机制。用流动 cytometry 和 DNA 电气泳动,我们发现 tetrandrine 能导致房间 apoptosis.Further , Bcl-2 mRNA 的水平减少了,盒子 mRNA 由使用反向的抄写聚合酶链 reaction.X-ray-induced G2 在 tetrandrine 的增加以后增加了,这被显示出拘捕被处理与 tetrandrine 废除,是由流动 cytometry 和有丝分裂的索引检测了。cyclinBl 蛋白质的累积和 Cdc2 tyrosine-15 和 Cdc25C serine-216 phosphorylation 的抑制在用蛋白质印迹分析与 tetrandrine 对待的照耀的房间被检测。总起来说,这些结果证明 tetrandrine 能导致 apoptosis 并且在 CNE 房间废除导致放射的 G2 拘捕。 | Xinchen SUN Ruizhi XU Yuxia DENG Hongyan CHENG Jun M Jiazhong JI Yingfeng ZHOU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，11： | 13 |
| 2 | XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer显示文摘DNA 修理能力(DRC ) 向基于铂的化疗与癌症房间的敏感被相关。我们假设那在 DNA 的基因多型性修理基因 XPA (干皮病 pigmentosum 组 A )和 XPG (干皮病 pigmentosum 组 G )( ERCC5 ,切除修理跨互补的组 5 ),它在 DNA 修理效率导致内部个人的差别,可以在先进非小的房间肺癌症( NSCLC )预言临床的反应到铂代理人病人。在这研究,我们发现 XPA A23G 多型性的 A G 变化显著地增加了反应到基于铂的化疗。在 XPG His46His 的多型性与减少的治疗回答被联系,但是不是统计上重要的。 | Jifeng Feng Xinchen Sun Ning Sun Shukui Qin Fan Li Hongyan Cheng Baoan Chen YuanDong Cao Jun Ma Lu Cheng Zuhong Lu Jiazhong Ji Yingfeng Zhou | 2009 | Acta Biochimica et Biophysica Sinica2009，41，5： | 8 |
| 3 | Microwave propagation in air drilling显示文摘This paper examines the feasibility in air drilling of transmitting down-hole signals by using microwaves. Firstly the basic theory of microwave propagation in the drill-pipe or casing was studied, including power loss, cutoff wavelength, and dust scattering. Theoretical analysis indicates that the microwave propagation distance in a Ф214mm casing can easily reach 5,000 m. When the effect of dust particles is taken into account, the propagation distance decreases to 2,000 m. We conducted both laboratory experiments and field tests in casings commonly used in oilfields. The field tests show that the effective propagation distance of microwave in the casing is about 1,300 m. The experimental results do not match well with theoretical prediction, but are acceptable. In future commercial applications, by applying multiple relay amplifiers, the microwave propagation distance could be long enough for most drilling wells. | Meng Xiaofeng Chen Yijian Zhou Jing Meng Yingfeng | 2010 | Petroleum Science2010，7，3： | 4 |
| 4 | TRANSVERSE VIBRATION CHARACTERISTICS OF VISCOELASTIC RECTANGULAR PLATE WITH CRACK显示文摘Based on the two-dimensional viscoelastic differential constitutive relation and the thin plate theory,the differential equations of motion of the viscoelastic plate with an all-over part-through crack are established and the expression of additional rotation induced by the crack is derived.The complex eigenvalua equations of the viscoelastic plate with crack are derived by the differential quadrature method,and theδmethod is used at the crack continuity conditions.Dimensionless complex frequencies of a crack viscoelastic plate with four edges simply supported,two opposite edges simply supported and other two edges clamped are calculated.The effects of the crack parameter,the aspect ratio and dimensionless delay time of the material on the transverse vibration of the viscoelastic plate are analyzed. | WANG Yan WANG Zhongmin ZHOU Yingfeng | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 2 |
| 5 | Properties of New Mullite-SiC Bricks for CDQ Shafts显示文摘Currently the service life of CDQ shafts in China is mainly restricted by the properties of the inclined flue bricks.In this work,based on the systematic analysis of the damage mechanism of inclined flue refractories,high performance mullite-SiC bricks were developed.The bricks were produced by corundum,andalusite,SiC and other high purity raw materials.Metal silicon and alumina ultra micropowder were added to form dispersion multi-phase structure,fortifying the matrix and improving the microstructure.The products have excellent properties such as low porosity,high density,good wear resistance,high refractoriness under load,and good thermal shock resistance.The products can replace the ordinary mullite-SiC bricks and obtain a good service life. | MA Shulong WEI Yingfeng WANG Zhifeng MA Fei XIA Wenbin ZHOU Xiaowei | 2017 | China's Refractories2017，26，1： | 2 |
| 6 | Synthesis and ordered aggregation in water of a blue light-emitting PEO-PHP-PEO triblock oligomer显示文摘A novel blue light-emitting coil-rod-coil triblock oligomer, PEO-PHP-PEO, which consists of para-hexaphenyl (PHP) as the rigid rod and poly(ethylene oxide) (PEO, M w = 750) as the flexible coil, has been synthesized. It is the first soluble poly(para-phenylene) molecule containing no lateral substituent, which can dissolve not only in organic solvents such as chloroform and THF, but also in water. The critical micelle concentration (CMC) of PEO-PHP-PEO in water is 5.25×10-4 mol·L-1 and the surface tension at CMC, 鉉MC, is 61.29 mN·m-1. The absorption peak of the molecularly dissolved PEO-PHP-PEO in water is centered at 323 nm and the fluorescence spectrum has a maximum at 432 nm and shows the vibronic fine structure typical of molecular dissolution. The photoluminescence spectrum of the aggregate solution is similar to that of the PHP polycrystal film, indicating that the ordered packing of PHP block has taken place due to a combination of hydrophobic interaction and p-p stacking. The oligomer self-assembles into cotton-like nanofibers with diameter of about 20 nm in 5.0×10-3 mol·L-1 aqueous solution. | HE Haifeng, CAO Hongqing, WAN Xinhua, TU Yingfeng, CHEN Xiaofang & ZHOU Qifeng Department of Polymer Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Correspondence should be addressed to Wan Xinhua (e-mail: xhwan@pku.edu.cn) | 2003 | Chinese Science Bulletin2003，48，15： | 2 |
| 7 | GAdriven part e-manufacturing scheduling via an online e-service platform显示文摘 | ZHANG Yingfeng JIANG Pingyu ZHOU Guanghui | 2003 | Journal of Integrated Manufacturing Systems2003，15，7： | 1 |
| 8 | Mechanism study and molecular design in controlled/“living” radical polymerization显示文摘This tutorial review summarizes recent progress in the research field of controlled/'living' radical polymerization (CLRP) from Soochow University.The present paper gives a broad overview of the mechanism study and molecular design in CLRP.The mechanism study in CLRP aided by microwave,initiated by γ-radiation at low temperature,mediated by iron,in reversible addition-fragmentation chain transfer (RAFT) polymerization and the mechanism transfer between different CLRP processes are reviewed and summarized.The molecular design in CLRP,especially in RAFT polymerization for mechanism study,and in achieving tailor-made functional polymers is studied and discussed in the later part. | TU YingFeng,CHENG ZhenPing,ZHANG ZhengBiao,ZHU Jian,ZHANG Wei,ZHOU NianChen,NI PeiHong & ZHU XiuLin College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123,China | 2010 | Science China Chemistry2010，53，8： | 1 |
| 9 | AN ADAPTIVE COLOR PLANE INTERPOLATION METHOD BASED ON EDGE DETECTION显示文摘In this letter, an adaptive interpolation algorithm based on edge detection is proposed. With this algorithm, all the missing green values can be reconstructed in Bayer pattern image by using edge detection interpolation method. Reconstructed images composed of green pixels are classified according to the high frequency components in image, and the threshold T needed for all kinds of green images in the edge detection is determined through experiments. The edge detection is carried out based on the one Dimensional (1D) gradient operator. If the gradient value is greater than T, this pixel is located on the edge; otherwise the pixel is in the smooth area of the image. Finally, the simple bilinear interpolation is used for the smooth area while the Laplacian interpolation with the second-order correction term is adopted to reconstruct the other red/blue values on the edge. This algorithm resolves effectively the conflicts between reconstructing high quality color image and reducing computational complexity, and thus largely enhances the processing speed for the reconstructed color image. | Cheng Yongqiang Xie Keming Zhou Yingfeng Liu Yanlong | 2007 | Journal of Electronics(China)2007，24，2： | 1 |
| 10 | Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients显示文摘 | Xinchen Sun Fan Li Ning Sun Qin Shukui Chen Baoan Feng Jifeng Cheng Lu Lu Zuhong Cheng Hongyan Cao YuanDong Ji Jiazhong Zhou Yingfeng | 2008 | Lung Cancer2008，，2： | 1 |
| 11 | Seizures in posterior reversible encephalopathy syndrome:blood pressure management in normotensive patients显示文摘Posterior reversible encephalopathy syndrome(PRES)is a rare clinical disease that refers to the subcortical vasogenic edema involving bilateral parieto-occipital regions,with a usually reversible syndrome when causes are eliminated or controlled.Hypertension or blood pressure fluctuations are most common causes of PRES,but other contributors like chemotherapy and autoimmune disorders have also been reported.PRES has rapid onset of symptoms.Therefore,it is of major importance to determine whether blood pressure management plays an important role in prognosis.We presented two PRES patients who developed non-convulsive seizure but had normal baseline blood pressure at the time of presence of cause.The diagnosis of PRES was made by neurologists.The patients had no history of seizure or hypertension,but during the disease course they presented with temporal elevation of blood pressure with different durations.The second patients without instant blood pressure control developed residual symptoms of seizure at 90-and 120-day follow-up.Although the exact pathophysiology of PRES remains to be fully understood,primary and secondary prolonged blood pressure fluctuations may be associated with the prognosis of this syndrome.Early blood pressure management would be critical to favorable outcome. | Lu Lu Weixi Xiong Yingying Zhang Yingfeng Xiao Dong Zhou | 2021 | Acta Epileptologica2021，3，1： | 0 |
| 12 | Force Spectrum of Single CsgA Nanofiber Reveal Surprising Properties显示文摘CsgA protein monomers consist of aβ-helix of five repeat units possessing several conservative residues and thus,inherently fibrillate.CsgA protein monomers could self-assemble into hierarchical nanofiber structure cross multiple scales after expression and secretion by E.Coli cells.Previous researches show that CsgA nanofibers could provide adhesion,stiffness,and mechanical homogeneity for the biofilms,host cells’fibronectin binding for internalization,or protection against phage attack.CsgA nanofibers have obtained various applications in material science and synthetic biology.To illustrate,CsgA nanofibers have characteristics of intrinsic hierarchical structures across multiple scales,robustness in harsh environments and programmable functionality via biological tools.Studying the force spectrum or mechanical properties of the nanofiber can provide fundamental information of self-assembly process and ultra-stability in extreme conditions.Single molecule techniques such as atomic force microscopy,optical tweezers,and magnetic tweezers have been widely applied to study proteins.In these studies,proteins are usually chemically conjugated or genetically constructed to have a tag such as histidine,cysteine or biotin.Genetic engineering requires modification of the plasmids encoding the specific protein,and also involve special protein expression and purification.Such study needs collaboration from multi-disciplinary.It normally studies one protein at a time which gives out clear signal but lacks throughput and efficiency.Here we have established a simple method to measure all kinds of proteins without labels.The carboxyl terminus of a protein is attached to the amine group on a magnetic bead,and the amine terminus of the protein is attached to glutaraldehyde on the glass slide.Then we used magnetic tweezers to manipulate and stretched the bead and protein.Extension versus rotation relation was used to identify a single protein or protein fibril.The fiber under tension is also observed by Scanning Electronic Microcopy which convinces that single CsgA-His fibril is linked to a microbead.The peak of diameter distribution is around 15 nm.The fracture of fibers was observed in real time on SEM.Force-extension curves of single fibers are obtained in real time.The force-extension curves generally agree with the worm like chain model.The persistence lengths from the fitting are from 0.9 to 49.8 nm.The elongation ratio increases gradually with force until reaches a plateau.The maximum elongation ratio of 78 nanofibers were made into an elongation ratio distribution diagram,more than half of CsgA-His nanofibers has an elongation ratio from 0 to 2,some are distributed in 2~10,and a few are distributed in 10~18.The maximum elongation ratio of CsgA-His nanofibers is 17.1,indicating that the fibril’s flexibility is much higher than DNA or silk fiber.For forces less than 20 pN,the extension was reversible.With a 42.1 pN holding force,the extension jumped in steps of from 30 to 365 nm and was irreversible.At the scale tested,the jumps corresponded to the unfolding of multiple beta sheets in the fiber.Work for CsgA-His nanofibers during stretching increase with the normalized strain fractions.The experimental data agree with a theoretical prediction for a single CsgA protein from a SMD calculation.Therefore,our results provide key information for the understandings of CsgA protein nanofiber assembly and biofilm robustness. | Jingqi Lv Yingfeng Li Kai Zhou Pei Guo Ke Ding Quan Long Yang Liu Qi Wang Chao Zhong Botao Xiao | 2019 | 医用生物力学2019，34，A01： | 0 |
| 13 | Comparative study on brain pharmacokinetics of Buyang Huanwu Decoction in normal and cerebral ischemia rats using brain microdialysis combined with LC-MS/MS显示文摘Objective To conduct a comparative study on the brain pharmacokinetics of seven ingredients(i.e.senkyunolide A,ferulic acid,formononetin,calycosin,ononin,calycosin-O-β-D-glucopyranoside,and paeoniflorin),which were the compounds of Buyang Huanwu Decoction(BHD),in normal and cerebral ischemia rats administrated intragastrically with BHD.Methods The samples of normal and permanent middle cerebral artery occlusion(pMCAO)rats were collected by using brain microdialysis technique.The concentrations of seven ingredients were determined by the HPLC-MS/MS method.After the BHD were administrated intragastrically to the rats for seven consecutive days,brain microdialysis probes were inserted into the hippocampus of rats,and then the brain microdialysates were collected at 20 min time intervals for 5 h.The separation of the seven ingredients and internal standard(IS)was carried out on an ACQUITY UPLC BEH C18(2.1 mm×100 mm,1.7μm)chromatographic column,using a mobile phase consisting of acetonitrile(containing 0.1%formic acid)and water(containing 0.1%formic acid)for gradient elution within 13 min.The ionization was conducted using an ESI source in positive ion mode.Multiple reaction monitoring mode was used for quantification of ingredients in BHD.Results Linearity,accuracy,precision,matrix effect and stability of LC-MS/MS method were all satisfactory,successfully applied to compare the pharmacokinetics of the analytes between normal and model rats after intragastric administration of BHD.Compared with the normal group,the model group after the administration of the BHD showed that T1/2 of formononetin and ononin were longer,and except for calycosin-O-β-D-glucopyranoside(P<0.01),there was no significant difference between the normal group and the model group.The C_(max) of senkyunolide A and calycosin of model group were increased,while the T_(max) of senkyunolide A was decreased,and except for the T_(max) of PF,the differences between the two groups were statistically significant(P<0.01).Conclusion The LC-MS/MS method combined with microdialysis was successfully applied to the comparative study of brain pharmacokinetics of seven ingredients in BHD.After intragastric administration of BHD,there were differences in the pharmacokinetics of seven ingredients in the brain hippocampus between normal rats and model rats,probably related to the characteristics of the ingredients and the effects of cerebral ischemia on the absorption and distribution of the ingredients. | Wanyi Liu Keqi Zeng Xin Zhou Yingfeng Zhang Cong Nie | 2022 | Chinese Herbal Medicines2022，14，4： | 0 |
| 14 | RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis显示文摘Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)pathway.However,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains unclear.Here,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 phosphorylation.RNA-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral replication.RIPK3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I IFNs.Conversely,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV replication.RIPK3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune responses.Mechanistically,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase activity.Overall,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV. | Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，5： | 0 |
| 15 | Studies on Stability and Moisture Retention of Urea and Its Derivatives显示文摘The effect of triethyl citrate(TEC)on the stability of cream preparations containing urea or hydroxyethyl urea along with their moisturizing effect on skin was investigated.The results showed that creams incorporating urea or hydroxyethyl urea led to increase in pH value after a long-term and high-temperature storage.pH change in the latter one was relatively smaller.With the addition of TEC,the elevated pH of the formula system was suppressed.In the situation of stable formula,the higher the TEC added,the more significant inhibition effect on the pH change was observed.In the moisture retention test in vivo,compared to 27.19%moisture rate in negative control,cream preparations containing 5%urea or 5%hydroxyethyl urea had remarkable moisturizing effect,which were all higher than 52%.The latter one was relatively more prominent.There is no significant effect on moisturizing effect for product with TEC additive. | Lv Yingfeng Lv Wanqi Zhou Jingmin | 2023 | China Detergent & Cosmetics2023，8，3： | 0 |
| 16 | Differential expression profile of circular RNAs in mouse peritoneum with peritoneal fibrosis and the potential regulatory role of novel_circ_0007527显示文摘CircRNAs,a novel type of endogenous non-coding RNAs(ncRNAs),are typically produced by back-splicing from exons of protein-coding genes,which are characterized by a covalently closed structure with neither 5'to 3'polarity nor a poly(A)tail.'On the one hand,circRNAs are involved in the regulation of a variety of important biological processes,such as apoptosis,proliferation,migration,and inflammatory responses.'On the other hand,the relationship between circRNAs and several fibrotic diseases has been reported.2 However. | Yingfeng Shi Yan Hu Hui Chen Jinqing Li Min Tao Xun Zhou Qin Zhong Andong Qiu Shougang Zhuang Na Liu | 2024 | Genes & Diseases2024，11，3： | 0 |
| 17 | STING strengthens host anti-hantaviral immunity through an interferon-independent pathway显示文摘Hantaan virus(HTNV),the prototype virus of hantavirus,could escape innate immunity by restraining type I interferon(IFN)responses.It is largely unknown whether there existed other efficient anti-hantaviral tactics in host cells.Here,we demonstrate that the stimulator of interferon genes(STING)strengthens the host IFNindependent anti-hantaviral immunity.HTNV infection activates RIG-I through IRE1-XBP 1-mediated ER stress,which further facilitates the subcellular translocation and activation of STING.During this process,STING triggers cellular autophagy by interacting with Rab7A,thus restricting viral replication.To note,the anti-hantaviral effects of STING are independent of canonical IFN signaling.Additionally,neither application of the pharmacological antagonist nor the agonist targeting STING could improve the outcomes of nude mice post HTNV challenge in vivo.However,the administration of plasmids exogenously expressing the mutant C-terminal tail(ΔCTT)STING,which would not trigger the type I IFN responses,protected the nude mice from lethal HTNV infection.In summary,our research revealed a novel antiviral pathway through the RIG-I-STING-autophagy pathway,which offered novel therapeutic strategies against hantavirus infection. | Kerong Wang Jian Zhang Yongheng Yang Yue Si Ziqing Zhou Xudong Zhu Sushan Wu He Liu Hui Zhang Liang Zhang Linfeng Cheng Wei Ye Xin Lv Yingfeng Lei Xijing Zhang Shilin Cheng Lixin Shen Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，4： | 0 |
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