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| 1 | Research on the Relationship between Molecular Activity of Additives and Lubricating Performance of Aluminum Rolling Oil显示文摘In this paper,an ab initio,local density functional(LDF)method was used to explore the relationship between the molecular properties of additives and the lubricating performance of aluminum rolling oil.The structural properties of butyl stearate,dodecanol,docosanol,and methyl dodecanoate were studied according to the density functional theory.The calculated data showed that the atoms in or around the functional groups might be likely the reacting sites.Because of the different functional groups and structure of ester and alcohol,two types of complex additives,dodecanol and butyl stearate,methyl dodecanoate and butyl stearate,respectively,were chosen for studying their tribological properties and performing aluminum cold rolling experiments.The test results agreed with the calculated results very well.The complex ester,viz.methyl dodecanoate and butyl stearate,had the best lubricating performance with a friction coefficient of 0.084 1 and a permissive-rolling thickness of 0.040 mm as compared with that of dodecanol-butyl stearate-base oil formulation. | Xia Lei Sun Jianlin Zeng Yingfeng Zhang Min Duan Qinghua | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，3： | 6 |
| 2 | Study on Surface Adsorption and Inhibition Behavior of Corrosion Inhibitors Contained in Copper Foil Rolling Oil显示文摘Adsorption and inhibition behavior of 2,5-bis(ethyldisulfanyl)-1,3,4-thiadiazole(DMTDA) and N-((6-methyl-1H-benzo[d][1,2,3]triazol-1-yl)methyl)-N-octyloctan-1-amine(EAMBA) as corrosion inhibitors contained in copper foil rolling oil have been investigated using gravimetric and electrochemical techniques. Meanwhile, scanning electron microscopy(SEM) and energy dispersive spectrometer(EDS) have been employed to observe the surface topography and analyze the components on copper foil. The results show that the rolling oil containing DMTDA and EAMBA can significantly decrease the dissolution rate and increase the inhibition efficiency of samples, especially in the case of best compounded rolling oil system. The SEM and EDS investigations also confirmed that the protection of the copper foil surface is achieved by strong adsorption of the molecules which can prevent copper from being corroded easily. Reactivity descriptors of the corrosion inhibitors have been calculated by the density functional theory(DFT) and the reactivity has been analyzed through the molecular orbital and Fukui indices. Active sites of inhibitor are mainly concentrated on the ring and the polar functional groups, and in the meanwhile, the distribution is helpful to form coordination and backbonding among molecules and then to form stable adsorption on the metal surface. And this work provides theoretical evidence for the selection of corrosion inhibitors contained in copper foil rolling oil. | Xiong Sang Sun Jianlin Jiang Wei Xu Yang Zeng Yingfeng Xia Lei | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，1： | 3 |
| 3 | Excellent light-capture capability of trilobal SiNW for ultra-high JSC in single-nanowire solar cells显示文摘Single-.nanowire solar cells with a unique light-concentration property are expected to exceed the Shockley-Queisser limit.The architecture of single nanowire is an important factor to regulate its optical performance.We designed a trilobal silicon nanowire(SiNW)with two cquivalent scales that possesses superior light-absorption efficiency in the whole wavelength range and shows good tolerance for incident angle.The electric field distribution in this geometry is concentrated in the blade with small equivalent scale and pivot with large equivalent scale,respectively,in the short wavelength range and long wavelength range.Corresponding good light absorption of trilobal SiNW in the two wavelength ranges leads to stronger total light absorption capacity than that of cylindrical SiNW.Trilobal single nanowire solar cells can obtain a short-circuit current density(JSC)of 647 mA·cm^2,which provides a new choice for designing single nanowire with excellent light-capture capability. | ZHONGLIANG GAO GUILU Lin YUPENG ZHENG NA SANG YINGFENG LI LEI CHEN MEICHENG LI | 2020 | Photonics Research2020，8，6： | 2 |
| 4 | Effect of site-directed PEGylation of trichosanthin on its biological activity, immunogenicity, and pharmacokinetics显示文摘 | Qunxing An Yingfeng Lei Ning Jia Xianqing Zhang Yinlan Bai Jing Yi Rui Chen Aijun Xia Jing Yang Sanhua Wei Xiaodong Cheng Ailing Fan Shijie Mu Zhikai Xu | 2007 | Biomolecular Engineering2007，，6： | 1 |
| 5 | Mapping the antigenic determinants and reducing the immunogenicity of trichosanthin by site-directed mutagenesis显示文摘 | Qunxing An Sanhua Wei Shijie Mu Xianqing Zhang Yingfeng Lei Wei Zhang Ning Jia Xiaodong Cheng Ailing Fan Zhidong Li Zhikai Xu | 2006 | Journal of Biomedical Science2006，，5： | 1 |
| 6 | PET probes beyond ^(18)F-FDG显示文摘During the past several decades,positron emission tomography(PET) has been one of the rapidly growing areas of medical imaging;particularly,its applications in routine oncological practice have been widely recognized.At present,^(18)F-fluorodeoxyglucose(^(18)F-FDG) is the most broadly used PET probe.However,^(18)F-FDG also suffers many limitations.Thus,scientists and clinicians are greatly interested in exploring and developing new PET imaging probes with high affinity and specificity.In this review,we briefly summarize the representative PET probes beyond ^(18)F-FDG that are available for patients imaging in three major clinical areas(oncology,neurology and cardiology),and we also discuss the feasibility and trends in developing new PET probes for personalized medicine. | Lei Jiang Yingfeng Tu Hongcheng Shi Zhen Cheng | 2014 | The Journal of Biomedical Research2014，28，6： | 0 |
| 7 | Research progress in improving the performance of PEDOT:PSS/Microand Nano-textured Si heterojunction for hybrid solar cells显示文摘Silicon-based hybrid solar cells(HSCs),especially PEDOT:PSS/Si HSC,have attracted the interest of researchers because they combine the advantages of organic and inorganic materials.A high quality PEDOT:PSS/Si heterojunction is the key to the good performance of PEDOT:PSS/Si HSC.However,as generally requisite to enhance light absorption for HSCs,Si Micro/Nano structures will reduce the interface contact quality between PEDOT:PSS and Si surface.The inferior interface contact quality will limit the separation efficiency of the photogenerated carriers.In this paper,we summarize the research progress in improving the interface contact between Si Micro/Nano structures and PEDOT:PSS film from three aspects:the optimization of Si Micro/Nano structures aimed to improve the fluid properties of PEDOT:PSS solution,the material modification of PEDOT:PSS and interface modification with the purpose to enlarge the heterojunction area and improve the electrical contact,and the specific deposition process of PEDOT:PSS solution developed to achieve the high filling rate of PEDOT:PSS on Si Micro/Nano structures.The insight of this paper is helpful for the preparation of high-quality heterojunction,which is vitally important for the development of high efficiency PEDOT:PSS/Si HSCs. | Guilu Lin Zhongliang Gao Ting Gao Yongcong Chen Qi Geng Yingfeng Li Lei Chen Meicheng Li | 2021 | Journal of Materiomics2021，7，5： | 0 |
| 8 | A technique for enhancing tight oil recovery by multi-field reconstruction and combined displacement and imbibition显示文摘A seepage-geomechanical coupled embedded fracture flow model has been established for multi-field coupled simulation in tight oil reservoirs,revealing the patterns of change in pressure field,seepage field,and stress field after long-term water injection in tight oil reservoirs.Based on this,a technique for enhanced oil recovery(EOR)combining multi-field reconstruction and combination of displacement and imbibition in tight oil reservoirs has been proposed.The study shows that after long-term water flooding for tight oil development,the pressure diffusion range is limited,making it difficult to establish an effective displacement system.The variation in geostress exhibits diversity,with the change in horizontal minimum principal stress being greater than that in horizontal maximum principal stress,and the variation around the injection wells being more significant than that around the production wells.The deflection of geostress direction around injection wells is also large.The technology for EOR through multi-field reconstruction and combination of displacement and imbibition employs water injection wells converted to production and large-scale fracturing techniques to restructure the artificial fracture network system.Through a full lifecycle energy replenishment method of pre-fracturing energy supplementation,energy increase during fracturing,well soaking for energy storage,and combination of displacement and imbibition,it effectively addresses the issue of easy channeling of the injection medium and difficult energy replenishment after large-scale fracturing.By intensifying the imbibition effect through the coordination of multiple wells,it reconstructs the combined system of displacement and imbibition under a complex fracture network,transitioning from avoiding fractures to utilizing them,thereby improving microscopic sweep and oil displacement efficiencies.Field application in Block Yuan 284 of the Huaqing Oilfield in the Ordos Basin has demonstrated that this technology increases the recovery factor by 12 percentage points,enabling large scale and efficient development of tight oil. | LEI Zhengdong WANG Zhengmao MU Lijun PENG Huanhuan LI Xin BAI Xiaohu TAO Zhen LI Hongchang PENG Yingfeng | 2024 | Petroleum Exploration and Development2024，51，1： | 0 |
| 9 | The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed;many more still need an answer显示文摘Crimean-Congo hemorrhagic fever virus(CCHFV)is regarded as one of the most deadly viruses,with mortality of up to 40%.Currently,no licensed vaccine with validated efficacy against CCHFV is available.CCHFV uses Gn and Gc glycoproteins to bind and penetrate the cell,like other bunyaviruses(Hulswit et al.,2021).Thus,the desired vaccines are needed,to elicit a potent neutralizing antibody(NAb)response to counteract this process. | Wei Ye Chuantao Ye Yongliang Hu Yangchao Dong Yingfeng Lei Fanglin Zhang | 2022 | Virologica Sinica2022，37，4： | 0 |
| 10 | Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells during JEV Infection显示文摘Japanese encephalitis virus(JEV) is a leading cause of viral encephalitis in endemic regions of Asia. The neurotropism of JEV and its high-efficiency replication in neurons are the key events for pathogenesis. Revealing the interplay between virus and host cells in metabolic facet is of great importance both for unraveling the pathogenesis mechanisms and providing novel antiviral targets. This study took advantage of the integration analysis of metabolomics and transcriptomics to depict the metabolic profiles of neurons during the early stage of JEV infection. Increased glycolysis and its branched pentose phosphate pathway(PPP) flux and impaired oxidative phosphorylation(OXPHOS) in glucose utilization,and the catabolic patterns of lipid metabolism were created to facilitate the biosynthesis of precursors needed for JEV replication in neurons. Pharmacological inhibitions of both glycolysis pathway and PPP in neurons suggested its indispensable role in maintaining the optimal propagation of JEV. In addition, analysis of metabolomic-transcriptomic regulatory network showed the pivotal biological function of lipid metabolism during JEV infection. Several pro-inflammatory lipid metabolites were significantly up-regulated and might partially be responsible for the progression of encephalitis.These unique metabolic reprogramming features might give deeper insight into JEV infected neurons and provide promising antiviral approaches targeting metabolism. | Mengyuan Li Jiali Yang Chuantao Ye Peiyu Bian Xiaofei Yang Haijun Zhang Chuanyu Luo Zhifeng Xue Yingfeng Lei Jianqi Lian | 2021 | Virologica Sinica2021，36，6： | 0 |
| 11 | Correction to: Integrated Metabolomics and Transcriptomics Analyses Reveal Metabolic Landscape in Neuronal Cells During JEV Infection显示文摘Correction to:Virologica Sinica http://gffzzd3cc09b8251d45dfsobq9x59uvqk66ou5.ffgz.tsg.suse.edu.cn/10.1007/s12250-021-00445-0 In the original version of this article,one image in Fig.4 was accidently duplicated during figure layout and the dilution rate was mislabeled. | Mengyuan Li Jiali Yang Chuantao Ye Peiyu Bian Xiaofei Yang Haijun Zhang Chuanyu Luo Zhifeng Xue Yingfeng Lei Jianqi Lian | 2021 | Virologica Sinica2021，36，6： | 0 |
| 12 | RIPK3 promotes hantaviral replication by restricting JAK-STAT signaling without triggering necroptosis显示文摘Hantaan virus(HTNV)is a rodent-borne virus that causes hemorrhagic fever with renal syndrome(HFRS),resulting in a high mortality rate of 15%.Interferons(IFNs)play a critical role in the anti-hantaviral immune response,and IFN pretreatment efficiently restricts HTNV infection by triggering the expression of a series of IFNstimulated genes(ISGs)through the Janus kinase-signal transducer and activator of transcription 1(JAK-STAT)pathway.However,the tremendous amount of IFNs produced during late infection could not restrain HTNV replication,and the mechanism remains unclear.Here,we demonstrated that receptor-interacting protein kinase 3(RIPK3),a crucial molecule that mediates necroptosis,was activated by HTNV and contributed to hantavirus evasion of IFN responses by inhibiting STAT1 phosphorylation.RNA-seq analysis revealed the upregulation of multiple cell death-related genes after HTNV infection,with RIPK3 identified as a key modulator of viral replication.RIPK3 ablation significantly enhanced ISGs expression and restrained HTNV replication,without affecting the expression of pattern recognition receptors(PRRs)or the production of type I IFNs.Conversely,exogenously expressed RIPK3 compromised the host's antiviral response and facilitated HTNV replication.RIPK3^(-/-)mice also maintained a robust ability to clear HTNV with enhanced innate immune responses.Mechanistically,we found that RIPK3 could bind STAT1 and inhibit STAT1 phosphorylation dependent on the protein kinase domain(PKD)of RIPK3 but not its kinase activity.Overall,these observations demonstrated a noncanonical function of RIPK3 during viral infection and have elucidated a novel host innate immunity evasion strategy utilized by HTNV. | Yue Si Haijun Zhang Ziqing Zhou Xudong Zhu Yongheng Yang He Liu Liang Zhang Linfeng Cheng Kerong Wang Wei Ye Xin Lv Xijing Zhang Wugang Hou Gang Zhao Yingfeng Lei Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，5： | 0 |
| 13 | Development of the expressed immunoglobulinμchain repertoire during maturation of mice B cells显示文摘In the bone marrow and spleen,the developing B cell populations undergo both negative and positive selections to shape their B cell receptor repertoire.To gain insight into the shift of the immunoglobulin heavy(IgH)chain repertoire during B cell development,we undertook large scale Igμchain repertoire analysis of pre-B,immature B and spleen B cell populations.We found that the majority of VH gene segments,VH families,JH and D gene segments,were observed to have significantly different usage frequencies when three B cell populations were compared,but the usage profile of the VH,D,and JH genes between different B cell populations showed high correlations.In both productive and nonproductive rearrangements,the length of CDRH3 shortened significantly on average when B cells entered the periphery.However,the CDRH3 length distribution of nonproductive rearrangements did not follow a Gaussian distribution,but decreased successively in the order 3n–2,3n–1 and 3n,suggesting a direct correlation between mRNA stability and CDRH3 length patterns of nonproductive rearrangements.Further analysis of the individual components comprising CDRH3 of productive rearrangements indicated that the decrease in CDRH3 length was largely due to the reduction of N addition at the 5′and 3′junctions.Moreover,with development,the amino acid content of CDRH3 progressed toward fewer positively charged and nonpolar residues but more polar residues.All these data indicated that the expressed Igμchain repertoire,especially the repertoire of CDRH3,was fine-tuned when B cells passed through several checkpoints of selection during the process of maturation. | Jingwen LIANG Yingfeng LUO Yi SUN Meng LEI Bing ZHANG Songnian HU Yaofeng ZHAO | 2014 | Frontiers of Agricultural Science and Engineering2014，1，3： | 0 |
| 14 | Multiple virus sorting based on aptamer-modified microspheres in a TSAW device显示文摘Due to the overlapping epidemiology and clinical manifestations of flaviviruses,differential diagnosis of these viral diseases is complicated,and the results are unreliable.There is perpetual demand for a simplified,sensitive,rapid and inexpensive assay with less cross-reactivity.The ability to sort distinct virus particles from a mixture of biological samples is crucial for improving the sensitivity of diagnoses.Therefore,we developed a sorting system for the subsequent differential diagnosis of dengue and tick-borne encephalitis in the early stage.We employed aptamer-modified polystyrene(PS)microspheres with different diameters to specifically capture dengue virus(DENV)and tick-borne encephalitis virus(TBEV),and utilized a traveling surface acoustic wave(TSAW)device to accomplish microsphere sorting according to particle size.The captured viruses were then characterized by laser scanning confocal microscopy(LSCM),field emission scanning electron microscopy(FE-SEM)and reverse transcription-polymerase chain reaction(RT‒PCR).The characterization results indicated that the acoustic sorting process was effective and damage-free for subsequent analysis.Furthermore,the strategy can be utilized for sample pretreatment in the differential diagnosis of viral diseases. | Xianglian Liu Xuan Chen Yangchao Dong Chuanyu Zhang Xiaoli Qu Yingfeng Lei Zhuangde Jiang Xueyong Wei | 2023 | Microsystems & Nanoengineering2023，9，3： | 0 |
| 15 | STING strengthens host anti-hantaviral immunity through an interferon-independent pathway显示文摘Hantaan virus(HTNV),the prototype virus of hantavirus,could escape innate immunity by restraining type I interferon(IFN)responses.It is largely unknown whether there existed other efficient anti-hantaviral tactics in host cells.Here,we demonstrate that the stimulator of interferon genes(STING)strengthens the host IFNindependent anti-hantaviral immunity.HTNV infection activates RIG-I through IRE1-XBP 1-mediated ER stress,which further facilitates the subcellular translocation and activation of STING.During this process,STING triggers cellular autophagy by interacting with Rab7A,thus restricting viral replication.To note,the anti-hantaviral effects of STING are independent of canonical IFN signaling.Additionally,neither application of the pharmacological antagonist nor the agonist targeting STING could improve the outcomes of nude mice post HTNV challenge in vivo.However,the administration of plasmids exogenously expressing the mutant C-terminal tail(ΔCTT)STING,which would not trigger the type I IFN responses,protected the nude mice from lethal HTNV infection.In summary,our research revealed a novel antiviral pathway through the RIG-I-STING-autophagy pathway,which offered novel therapeutic strategies against hantavirus infection. | Kerong Wang Jian Zhang Yongheng Yang Yue Si Ziqing Zhou Xudong Zhu Sushan Wu He Liu Hui Zhang Liang Zhang Linfeng Cheng Wei Ye Xin Lv Yingfeng Lei Xijing Zhang Shilin Cheng Lixin Shen Fanglin Zhang Hongwei Ma | 2023 | Virologica Sinica2023，38，4： | 0 |
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