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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Effeet of pioglitazone, a peroxisome proliferator - activated receptor γ agonist, on ischemia reperfusion injury in rats 显示文摘 | Cao ZL Ye P Long CL | 2007 | Pharnacology2007，79，2： | 1 |
| 3 | Advanced glycation end-products activate the reninangiotensinsystem through the RAGE/PI3-K signaling pathwayin podocytes显示文摘 | Cheng CL Tang Y Zheng Z Liu X Ye ZC Wang C Lou TQ | 2012 | Clin Invest Med2012，35，5： | 1 |
| 4 | Administration of interleukin-12 prevents mite Der p1 allergen IgE antibody production and airway eosinophil in an animal model of airway inflamation显示文摘 | Fu CL Ye YL | 1999 | Scand J Immunol1999，49，3： | 1 |
| 5 | Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists显示文摘 | Liu DZ Xie KQ Ji XQ Ye Y Jiang CL Zhu XZ | 2005 | Br J Pharmacol2005，146，4： | 1 |
| 6 | Administration of interleukin- 12 prevents mite Der p1 allergen-IgE antibody production and airway eosinophil infiltration in an animal model of airway inflammation 显示文摘 | Lee YL Fu CL Ye YL | 1999 | Scand J Immunol1999，49，3： | 1 |
| 7 | Reverse correlation between ankle-brachial index and left ventricular hypertrophy in patients on maintenance heamodialysis显示文摘 | Fu WC Ye CY Mei CL | 2006 | Nephrology2006，11，1： | 1 |
| 8 | A new phenolic glycoside from the roots of Lygodium japonicum 显示文摘 | Ye WC Fan CL Zhang LH | 2007 | Fitoterapia2007，78，： | 1 |
| 9 | Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity显示文摘 | Maruyama K Ye CL Woo M | 1991 | Am J Physiol1991，261，： | 1 |
| 10 | Fast-track surgery in gas- trectomy for gastric cancer:a systematic review and meta- analysis 显示文摘 | Yu Z Zhuang CL Ye XZ | 2014 | Langenbecks Arch Surg2014，399，1： | 1 |
| 11 | Fast-track surgeryin gastrectomy for gastric cancer:a systematic reviewand meta-analysis显示文摘 | Yu Z Zhuang CL Ye XZ | 2014 | Langenbecks Arch Surg2014，399，： | 1 |
| 12 | Anti-aging effect of Cordycepssinensis extract 显示文摘 | Ji DB Ye J Li CL | 2009 | Phytotherapy Research2009，23，1： | 1 |
| 13 | Antiaging effect of Cordyceps sinensis extract显示文摘 | Ji DB Ye J Li CL | 2009 | Phytother Res2009，23，1： | 1 |
| 14 | Effect of pioglitazone, a peroxisome proliferator-activated receptor γ agonist, on ischemia reperfusion injury in rats 显示文摘 | Cao ZL Ye P Long CL | 2007 | Pharmacology2007，79，2： | 1 |
| 15 | Flow-injection kinetic spectrophotometric determination of ascorbic acid based on an inhibiting effect显示文摘 | Fan J Ye CL Fang SL | 1999 | Talanta1999，50，4： | 1 |
| 16 | Synthesis and struc- ture-activity relationship of dihydrobenzofuran derivatives as novel human GPRll9 agonists 显示文摘 | YE XY MORALES CL WANG Y | 2014 | Bioorg Med Chem Lett2014，24，11： | 1 |
| 17 | Mechanism underlying en-hantied endothelium-defKindent vasodilatation in thoracic aortaof early stage streptozotocin- induced dial)eti(* niiee 显示文摘 | Shen B Ye CL Ye KH | 2003 | ActaPfmmuicolSin2003，24，5： | 1 |
| 18 | A new nano- sized iron oxide par?ticle with high sensitivity for cellular magnetic resonance imaging显示文摘 | Chen CL Zhang H Ye Q | 2011 | Mol Imaging Bioi2011，13，5： | 1 |
| 19 | Effect of pioglitazone,a peroxisome proliferator-activated receptor γ agonist,on ischemia reperfusion injury in rats显示文摘 | Cao ZL Ye P Long CL | | 0，，02： | 1 |
| 20 | Antiaging effect of Cordyceps sinensis extract 显示文摘 | Ji DB Ye J Li CL | 2009 | Phytotherapy Research2009，23，1： | 1 |
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