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| 1 | Differential gene expression between squamous cell carcinoma of esophageus and its normal epithelium; altered pattern of mal,akrlc2, and rablla expression显示文摘AIM: To identify the altered gene expression patterns in squamous cell carcinoma of esophagus (ESCC) in relation to adjacent normal esophageal epithelium. METHODS: Total RNA was extracted using SV total RNA isolation kit from snap frozen tissues of ESCC samples and normal esophageal epithelium far from the tumor. Radio-labeled cDNA were synthesized from equal quantities of total RNAs of tumor and normal tissues using combinations of 24 arbitrary 13-mer primers and three different anchoring oligo-dT primers and separated on sequencing gels. cDNA with considerable different amounts of signals in tumor and normal tissue were reamplified and cloned. Using southern blot, the clones of each band were controlled for false positive results caused by probable heterogeneity of cDNA population with the same size. Clones that confirmed differential expression by slot blot selected for sequencing and northern analysis. Corresponding full-length gene sequences was predicted using human genome project data, related transcripts were translated and used for various protein/motif searches to speculate their probable functions. RESULTS: The 97 genes showed different levels of cDNA in tumor and normal tissues of esophagus. The expression of mal gene was remarkably down. regulated in all 10 surveyed tumor tissues. Akrlc2, a member of the aldoketo reductase 1C family, which is involved in metabolism of sex hormones and xenobiotics, was up-regulated in 8 out of 10 inspected ESCC samples. Rablla, RPL7, and RPL28 showed moderate levels of differential expression. Many other cDNAs remained to further studies. CONCLUSION: The mal gene which is switched-off in all ESCC samples can be considered as a tumor suppressor gene that more studies in its regulation may lead to valuable explanations in ESCC development. Akrlc2 which is upregulated in ESCC probably plays an important role in tumor development of esophagus and may be proposed as a potential molecular target in ESCC treatments. Differential display technique in spite of many disadvantages is still a valuable technique in gene function exploration studies to find new candidates for improved ones like gene chips. | Sakineh Kazemi-Noureini Sergio Colonna-Romano Abed-Ali Ziaee Mohammad-Ali Malboobi Mansour Yazdanbod Parviz Setayeshgar Bruno Maresca | 2004 | World Journal of Gastroenterology2004，10，12： | 4 |
| 2 | Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer显示文摘 | Masoud Sotoudeh Mohammad H. Derakhshan Behnoosh Abedi-Ardakani Mehdi Nouraie Abass Yazdanbod Seyyed Mohammad Tavangar Javad Mikaeli Shahin Merat Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 3 | Effect of Helicobacter pylori eradication in Iranian patients with functional dyspepsia: a prospective, randomized, placebo-controlled trial 显示文摘 | Yazdanbod A Salimian S Habibzadeh S | 2015 | Arch Med Sci2015，11，5： | 1 |
| 4 | High incidence of aclenocarcinoma arising from the right side of the gastric cantia in NW Iran显示文摘 | Derakhshan MH Yazdanbod A | 2004 | Journal List Gut2004，53，9： | 1 |
| 5 | High incidence of adenocarcinoma arising from the right side of the gastric cardia in NM Iran显示文摘 | Derakhshan MH Yazdanbod A Sadjadi AR | | 0，，09： | 1 |
| 6 | Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer显示文摘 | Masoud Sotoudeh Mohammad H. Derakhshan Behnoosh Abedi-Ardakani Mehdi Nouraie Abass Yazdanbod Seyyed Mohammad Tavangar Javad Mikaeli Shahin Merat Reza Malekzadeh | 2008 | Digestive Diseases and Sciences2008，，1： | 1 |
| 7 | Epidemiology of upper gastrointestinal cancers in Iran:A Sub site analysis of 761 cases显示文摘瞄准:在伊朗的三个省定义上面的胃肠的癌症的潜水艇地点分发。方法:学习在伊朗在三个省被执行:Ardabil, Golestan,和德黑兰。在 Arbabil 和 Golestan,数据从胃肠的癌症和本地癌症注册表的唯一的工作分派中心被收集。为德黑兰省,来自二所主要私人医院的数据被使用。从 2000 年 9 月和 2002 年 4 月在时期期间诊断的所有胃、食道的癌症病人在学习被包括。结果:有上面的胃肠的癌症的 761 个病人的一个总数被识别, 314 从 Ardabil, 261 从 Golestan,并且 186 从德黑兰。在德黑兰,癌症的相对的率从上面的食管增加了到远侧的胃。在 Golestan,反向的模式被观察。在 Ardabil,中间的部分(远侧的食管和近似的胃) 最经常被包含。结论:在在学习的三个省的上面的胃肠的癌症的潜水艇地点有可观的变化。我们不能为这个变化提供任何解释。进一步的研究瞄准了解释在上面的胃肠的癌症的潜水艇地点分发的差异可以帮助识别重要风险因素。 | Noushin Taghavi Dariush Nasrollahzadeh Shahin Merat Abbas Yazdanbod Mahshid Hormazdi Masoud Sotoudeh Shahriar Semnani Farhad Eslami Haji-Amin Marjani Saman Fahimi Hooman Khademi Reza Malekzadeh | 2007 | World Journal of Gastroenterology2007，13，40： | 0 |
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