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| 1 | Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta显示文摘胎盘为成功的怀孕和胎儿和怀孕女人的健康是关键的。然而,人的 trophoblast 系怎么被调整,包括胎盘的房间的分类,子类型糟糕被理解。这里,我们在排序的胎盘的房间上执行了定序的单个房间的 RNA (RNA-seq ) 从第一三个月并且秒三个月人胎盘。已知的 cytotrophoblast 房间(CTB ) 的房间的新子类型, extravillous trophoblast 房间(EVT ) , Hofbauer 房间,和间充质的 stromal 房间被识别, cell-type-specific 基因签名被定义。机能上地,这研究揭示了人的胎盘的许多以前未知的功能。尤其是, 102 多肽荷尔蒙基因被发现被胎盘的房间的各种各样的子类型表示,它在调整母亲的生理学的胎儿的生长和改编到怀孕建议建筑群和这些荷尔蒙的重要角色。这些结果在单个房间的分辨率记录人的胎盘的 trophoblast 区别并且因此在怀孕的早阶段期间推进我们人的胎座式的理解。 | Yawei Liu Xiaoying Fan Rui Wang Xiaoyin Lu Yan-Li Dang Huiying Wang Hai-Yan Lin Cheng Zhu Hao Ge James C. Cross Hongmei Wang | 2018 | Cell Research2018，28，8： | 15 |
| 2 | Processes of coastal ecosystem carbon sequestration and approaches for increasing carbon sink显示文摘The oceans are the largest carbon pools on Earth, and play the role of a 'buffer' in climate change. Blue carbon, the carbon(mainly organic carbon) captured by marine ecosystems, is one of the important mechanisms of marine carbon storage.Blue carbon was initially recognized only in the form of visible coastal plant carbon sequestration. In fact, microorganisms(phytoplankton, bacteria, archaea, viruses, and protozoa), which did not receive much attention in the past, account for more than 90% of the total marine biomass and are the main contributors to blue carbon. Chinese coastal seas, equivalent to 1/3 of China's total land area, have a huge carbon sink potential needing urgently research and development. In this paper, we focus on the processes and mechanisms of coastal ocean's carbon sequestration and the approaches for increasing that sequestration. We discuss the structures of coastal ecosystems, the processes of carbon cycle, and the mechanisms of carbon sequestration. Using the evolution of coastal ocean's carbon sinks in sedimentary records over geologic times, we also discuss the possible effects of natural processes and anthropogenic activities on marine carbon sinks. Finally, we discuss the prospect of using carbon sequestration engineering for increasing coastal ocean's carbon storage capacity. | ZHANG Yao ZHAO MeiXun CUI Qiu FAN Wei QI JiaGuo CHEN Ying ZHANG YongYu GAO KunShan FAN JingFeng WANG GuangYi YAN ChongLing LU HaoLiang LUO YaWei ZHANG ZiLian ZHENG Qiang XIAO Wei JIAO NianZhi | 2017 | Science China Earth Sciences2017，60，5： | 6 |
| 3 | Influence of carbon sources on nutrient removal in A2/O-MBRs: Availability assessment of internal carbon source显示文摘Both internal carbon source and some external carbon sources were used to improve the nutrient removal in Anaerobic-Anoxic-Oxic-Membrane Bioreactor(A^2/O-MBRs), and their technical and cost analysis was investigated. The experimental results showed that the nutrient removals were improved by all the carbon source additions. The total nitrogen and phosphorus removal efficiency were higher in the experiments with external carbon source additions than that with internal carbon source addition. It was found that pathways of nitrogen and phosphorus transform were different dependent on different carbon source additions by the mass balance analysis. With external carbon source addition, the simultaneous nitrification and denitrification occurred in aerobic zone, and the P-uptake in aerobic phase was evident. Therefore, with addition of C-MHP(internal carbon source produced from sludge pretreatment by microwave-H_2O_2 process), the denitrification and phosphorus-uptake in anoxic zone was notable. Cost analysis showed that the unit nitrogen removal costs were 57.13 CNY/kgN of C-acetate addition and 54.48 CNY/kgN of C-MHP addition, respectively. The results indicated that the C-MHP has a good technical and economic feasibility to substitute external carbon sources partially for nutrient removal. | Rongle Xu Yaobo Fan Yuansong Wei Yawei Wang Nan Luo Min Yang Xing Yuan Rong Yu | 2016 | Journal of Environmental Sciences2016，28，10： | 6 |
| 4 | Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process显示文摘Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process remains unclear and needs to be further investigated.In this study, we aimed to evaluate the effects of exosomes on rabies virus infection. OptiPrep^(TM) density gradient centrifugation was used to isolate exosomes from rabies virus-infected cell culture supernatants. A rabies virus G protein enzyme-linked immunosorbent assay and acetylcholinesterase activity assays were performed to verify the centrifugation fractions. Exosomes were then characterized using transmission electron microscopy and Western blotting. Our results showed that rabies virus infection increased the release of exosomes. Treatment with GW4869 and si-Rab27 a, two exosomal secretion inhibitors, inhibited exosome release. Furthermore, the inhibitors reduced the levels of extracellular and intracellular viral RNA. These data indicated that exosomes may participate in the viral infection process. Moreover, our results establish a basis for future research into the roles of exosomes in rabies virus infection and as potential targets for developing new antiviral strategies. | Jingyu Wang Fan Wu Chuntian Liu Wenwen Dai Yawei Teng Weiheng Su Wei Kong Feng Gao Linjun Cai Ali Hou Chunlai Jiang | 2019 | Virologica Sinica2019，34，1： | 3 |
| 5 | Ultralight and ordered lamellar polyimide-based graphene foams with efficient broadband electromagnetic absorption显示文摘The development of high-performance microwave absorption materials with strong absorption capacity and broad bandwidth is highly desirable in the field of electromagnetic pollution protection.Herein,ultralight polyimide-based graphene foam with ordered lamellar structure is precisely designed and controllably constructed by bidirectional freezing process.More lamellar interfaces formed inside the foam per unit volume effectively facilitate the layer-by-layer dissipation for the vertical incident electromagnetic waves,thereby endowing the foam with efficient broadband electromagnetic absorption performance.More importantly,electromagnetic absorption performance can be controllably adjusted by optimizing impedance distribution and microstructure of skeletons.As a result,the optimized foam with an ultralow density of 9.10 mg/cm^(3)presents a minimum reflection loss value of-61.29 dB at 9.25 GHz and an effective absorption bandwidth of 5.51 GHz(7.06-12.57 GHz,covering the whole X band) when the thickness is 4.75 mm. | Yawei Zhang Shuangshuang Li Xinwei Tang Wei Fan Qianqian Lan Le Li Piming Ma Weifu Dong Zicheng Wang Tianxi Liu | 2022 | Journal of Materials Science & Technology2022，，7： | 3 |
| 6 | Rare-earth based materials:an effective toolbox for brain imaging,therapy,monitoring and neuromodulation显示文摘Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties, superior magnetism, and high X-ray absorption abilities, enabling high-resolution imaging of the brain through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. In addition, rare-earth based materials can be used to detect, treat, and regulate of brain diseases through fine modulation of their structures and functions. Importantly, rare-earth based materials coupled with biomolecules such as antibodies, peptides, and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein, this review highlights the rational design and application of rare-earth based materials in brain imaging, therapy, monitoring, and neuromodulation. Furthermore, the development prospect of rare-earth based materials is briefly introduced. | Zheng Wei Yawei Liu Bo Li Jingjing Li Shuang Lu Xiwen Xing Kai Liu Fan Wang Hongjie Zhang | 2022 | Light(Science & Applications)2022，11，8： | 3 |
| 7 | Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers显示文摘 | Chen Wu Yuanyuan Xie Feng Gao Yanan Wang Yawei Guo Huanna Tian Yanshuang Li Wufang Fan | 2013 | Gene2013，，1： | 2 |
| 8 | Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling显示文摘Myocardial hypertrophy is a major pathological and physiological process during heart failure.Glucagon-like peptide 1(GLP-1)is a glucagon incretin hormone released from the gut endocrine L-cells that has protective effects on various cardiovascular diseases,in eluding hyperte nsion,atherosclerosis,and myocardial hypertrophy.However,the protective mechanisms of GLP-1 in myocardial hypertrophy remain unclear.Here,we showed that the GLP-1 agonist liraglutide and dipeptidyl peptidase 4 inhibitor alogliptin decreased heart weight and cardiac muscle cell volume in spontaneously hypertensive rats(SHR).In H9C2 cell hypertensive models induced by angiotensin II,GLP-1 treatment reduced myocardial cell volume,inhibited the expressions of atrial natriuretie peptide,brain/B-type natriuretic peptide,p-myosin heavy chain,RhoA,and ROCK2,and decreased MLC and MYPT1 phosphorylation.When H9C2 cells were treated with H89,a PKA inhibitor,the inhibitory effect of GLP-1 disappeared,while the inhibitory role was enhaneed under the treatment of Y-27632,a ROCK2 inhibitor.These results suggested that GLP-1 might reverse myocardial hypertrophy through the PKA/RhoA/ROCK2 signaling pathway. | Shaohua Fan Qianfeng Xiong Xin Zhang Lihui Zhang Yawei Shi | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
| 9 | Tripartite entangled state,tripartite entangled Wigner operator and their generalization to an n-mode case显示文摘For entangled three particles one should treat their wave function as a whole.There is no physical meaning talking about the wave function(or Wigner function) for any one of the tripartite,and therefore considering the entangled Wigner function(Wigner operator) is of necessity.In this paper,we introduce a pair of mutually conjugate tripartite entangled state representations for defining the Wigner operator of entangled tripartite.Its marginal distributions and the Wigner function of the three-mode squeezed vacuum state are presented.Deriving wave function from its corresponding tripartite entangled Wigner function is also discussed.Moreover,through establishing the n-mode entangled state representation,we introduce the n-mode entangled Wigner operator,which would be more generally useful in quantum physics. | L CuiHong GU DanDan FAN HongYi WANG YaWei | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，9： | 2 |
| 10 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 11 | Application of high-speed counter-current chromatography coupled with high performance liquid chromatography for the separation and purification of Quercetin-3-O-sambubioside from the leaves of Nelumbo nucifera显示文摘Quercetin-3-O-sambubioside[Quercetin-3-O-β-D-xylopyranosyl(1→2)-β-D-glucopyranoside]was separated and purified by semi-preparative high-speed counter-current chromatography(HSCCC)with a twophase-solvent system composed of ethyl acetate-nbutanol-water(4∶1∶5,v/v)from the leaves of Nelumbo nucifera(Lotus).A total of 5.0 mg of the targeted compound with a purity of 98.6%as determined by high performance liquid chromatography(HPLC)was obtained from 100 mg of the crude extract cleaned up by AB-8 macroporous resin in a one-step separation.Quercetin-3-O-sambubioside was a novel flavonoid glycoside from the leaves of Nelumbo nucifera,and its chemical structure was identified by means of ESI-MS,1D NMR and 2D NMR. | Shengguo DENG Zeyuan DENG Yawei FAN Jing LI Rong LIU Dongmei XIONG | 2009 | Frontiers of Chemical Science and Engineering2009，3，4： | 1 |
| 12 | Microstntctures and mechani- cal properties of A1203-C refractories with silicon additive using different carbon sources 显示文摘 | Fan Haibing Li Yawei Sang Shaobai | 2011 | Mater Sci Eng A2011，528，78： | 1 |
| 13 | Glucagon-like peptide-1 attenuates cardiac hypertrophy via the AngII/AT1R/ACE2 and AMPK/mTOR/p70S6K pathways显示文摘Glucagon-like peptide-1(GLP-1),a novel type of glucose-lowering agent,has been reported to exert cardioprotective effects.However,the cardioprotective mechanism of GLP-1 on spontaneous hypertension-induced cardiac hypertrophy has not been fully elucidated.In this study,we revealed that liraglutide or alogliptin treatment ameliorated spontaneous hypertension-induced cardiac hypertrophy,as evidenced by decreased levels of cardiac hypertrophic markers(atrial natriuretic peptide,brain natriuretic peptide,andβ-myosin heavy chain),as well as systolic blood pressure,diastolic blood pressure,mean arterial pressure,and histological changes.Both drugs significantly reduced the levels of angiotensin II(AngII)and AngII type 1 receptor(AT1R)and upregulated the levels of AngII type 2 receptor(AT2R)and angiotensin-converting enzyme 2(ACE2),as indicated by a reduced AT1R/AT2R ratio.Simultaneously,treatment with liraglutide or alogliptin significantly increased GLP-1 receptor expression and adenosine monophosphate-activated protein kinase(AMPK)phosphorylation and downregulated the phosphorylation of mammalian target of rapamycin(mTOR),p70 ribosomal S6 protein kinase,and eukaryotic translation initiation factor 4E binding protein 1 in spontaneous hypertension rats.Furthermore,our data demonstrated that the AMPK inhibitor compound C or mTOR activator MHY1485 inhibited the anti-hypertrophic effect of GLP-1.In summary,our study suggests that liraglutide or alogliptin protects the heart against cardiac hypertrophy by regulating the expression of AngII/AT1R/ACE2 and activating the AMPK/mTOR pathway,and GLP-1 agonist can be used in the treatment of patients with cardiac hypertrophy. | Jing Wang Shaohua Fan Qianfeng Xiong Yu Niu Xin Zhang Junnan Qin Yawei Shi Lihui Zhang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 1 |
| 14 | Microstmctures and mechani- cal properties of A12 03 -C refractories with silicon additive using dif- ferent carbon sources 显示文摘 | Fan Haibing Li Yawei Sang Shaobai | 2011 | Mater Sci Eng A2011，528，78： | 1 |
| 15 | Microstructures and mechanical properties of A12 03 - ZrO2 - C refractories using silicon, microsilica or their combination as additive 显示文摘 | Fan Haibing Li Yawei Huang Yupeng | 2012 | Mater Sci Eng A2012，545，： | 1 |
| 16 | Interleukin 6 protects H<sub>2</sub>O<sub>2</sub>‐induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation显示文摘 | Yuhua Jia Fenghua Zhou Peng Deng Qin Fan Chunhua Li Yawei Liu Xiuqiong Fu Yingchun Zhou Xin Xu Xuegang Sun | 2012 | Cell Biochem Funct2012，，5： | 1 |
| 17 | Introduction of porous structure:A feasible and promising method for improving thermoelectric performance of Bi_2Te_3 based bulks显示文摘The porous p-type Bi_(0.4)Sb_(1.6)Te_3 bulks containing irregularly and randomly oriented pores were obtained by artificially controlling the relative density of sintered samples during resistance pressing sintering process. It is demonstrated that the thermoelectric performances are significantly affected by the porous structure, especially for the electrical and thermal conductivity due to the enhanced carrier scattering and phonon scattering. The increasing porosity resulted in the obvious decrease in electrical and thermal conductivity, and little change in Seebeck coefficients. It is encouraging that the reduction of thermal conductivity can compensate for the deterioration of electrical performance, leading to the enhancement in thermoelectric figure of merit(ZT). The maximum ZT value of 1.0 was obtained for the sample with a relative density of 90% at 333 K. Unfortunately, the increase in porosity also brought in obvious degradations in Vickers hardness from 51.71 to 27.74 HV. It is worth mentioning that although the Vickers hardness of the sample with a relative density of 90% decreased to 40.12 HV, it was still about twice as high as that of the zone melting sample(21.25 HV). To summarize, introducing pores structure into bulks properly not only enhances the ZT value of Bi_2Te_3 based alloys, but also reduces the use of raw materials and saves production cost. | Jie Hu Xi’An Fan Chengpeng Jiang Bo Feng Qiusheng Xiang Guangqiang Li Zhu He Yawei Li | 2018 | Journal of Materials Science & Technology2018，34，12： | 1 |
| 18 | Microstructures and mechanical properties of Al2O3-C refractories with silicon additive using different carbon sources显示文摘 | Fan Haibing Li Yawei Sang Shaobai | 2011 | Mater Sci Eng A2011，528，78： | 1 |
| 19 | Atypical mismatch negativity in response to emotional voices in people with autism spectrum conditions显示文摘 | Yang-Teng FAN Yawei CHENG | 2014 | PLoS One2014，9，10： | 1 |
| 20 | Isolation and pu-rification of three flavonoid glycosides from the leavea of Nelumbo nu-cifera (Lotus) by high-speed counter-current chromatography 显示文摘 | DENG Shengguo DENG Zeyuan FAN Yawei | 2009 | JChromatogr B2009，877，： | 1 |
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