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| 1 | MicroRNA-24 promotes pancreatic beta cells toward dedifferentiation to avoid endoplasmic reticulum stress-induced apoptosis显示文摘Current research indicates that beta cell loss in type 2 diabetes may be attributed to beta cell dedifferentiation rather than apoptosis;however,the mechanisms by which this occurs remain poorly understood.Our previous study demonstrated that elevation of microRNA-24(miR-24)in a diabetic setting caused beta cell dysfunction and replicative deficiency.In this study,we focused on the role of miR-24 in beta cell apoptosis and dedifferentiation under endoplasmic reticulum(ER)stress conditions.We found that miR-24 overabundance protected beta cells from thapsigargin-induced apoptosis at the cost of accelerating the impairment of glucosestimulated insulin secretion(GSIS)and enhancing the presence of dedifferentiation markers.Ingenuity?Pathway Analysis(IPA)revealed that elevation of miR-24 had an inhibitory effect on XBP1 and ATF4,which are downstream effectors of two key branches of ER stress,by inhibiting its direct target,Irela.Notably,elevated miR-24 initiated another pathway that targeted Mafa and decreased GSIS function in surviving beta cells,thus guiding their dedifferentiation under ER stress conditions.Our results demonstrated that the elevated miR-24,to the utmost extent,preserves beta cell mass by inhibiting apoptosis and inducing dedifFerentiation.This study not only provides a novel mechanism by which miR-24 dominates beta cell turnover under persistent metabolic stress but also offers a therapeutic consideration for treating diabetes by inducing dedifferentiated beta cells to re-differentiation. | Yunxia Zhu Yi Sun Yuncai Zhou Yan Zhang Tao Zhang Yating Li Weiyan You Xiaoai Chang Li Yuan Xiao Han | 2019 | Journal of Molecular Cell Biology2019，11，9： | 9 |
| 2 | Tandem catalysis in electrochemical CO_(2) reduction reaction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)is an attractive pathway for closing the anthropogenic carbon cycle and storing intermittent renewable energy by converting CO_(2) to valuable chemicals and fuels.The production of highly reduced carbon compounds beyond CO and formate,such as hydrocarbon and oxygenate products with higher energy density,is particularly desirable for practical applications.However,the productivity towards highly reduced chemicals is typically limited by high overpotential and poor selectivity due to the multiple electron-proton transfer steps.Tandem catalysis,which is extensively utilized by nature for producing biological macromolecules with multiple enzymes via coupled reaction steps,represents a promising strategy for enhancing the CO_(2)RR performance.Improving the efficiency of CO_(2)RR via tandem catalysis has recently emerged as an exciting research frontier and achieved significant advances.Here we describe the general principles and also considerations for designing tandem catalysis for CO_(2)RR.Recent advances in constructing tandem catalysts,mainly including bimetallic alloy nanostructures,bimetallic heterostructures,bimetallic core-shell nanostructures,bimetallic mixture catalysts,metal-metal organic framework(MOF)and metal-metallic complexes,metal-nonmetal hybrid nanomaterials and copper-free hybrid nanomaterials for boosting the CO_(2)RR performance are systematically summarized.The study of tandem catalysis for CO_(2)RR is still at the early stage,and future research challenges and opportunities are also discussed. | Yating Zhu Xiaoya Cui Huiling Liu Zhenguo Guo Yanfeng Dang Zhanxi Fan Zhicheng Zhang Wenping Hu | 2021 | Nano Research2021，14，12： | 5 |
| 3 | Direct site-specific treatment of skin cancer using doxorubicin-loaded nanofibrous membranes显示文摘Doxorubicin(DOX) is widely used in cancer therapy. However, its application is sometimes limited by its adverse cardiotoxicity and delivery pathways. In our study, we prepared a topical implantable delivery device for controlled drug release and site-specific treatment. The core region consisted of poly(lactic co-glycolic acid) and poly-caprolactone, whereas the shell region was composed of cross-linked gelatin.DOX was enclosed in the core region of a core-shell nanofiber obtained by electrospinning. This implantable delivery device was implanted on the top of the melanoma in a mouse model, which had shown a DOX-controlled release profile with sustained and sufficient local concentration against melanoma growth in mice with negligible side effects. Compared with the traditional intravenous administration,the implantable device allows precisely localized treatment and therefore can reduce the dose, decrease the injection frequency, and ensure antitumor efficacy associated with lower side effects to normal tissues. Using a coaxial electrospinning process, it is promising to deliver different hydrophobic or hydrophilic drugs for direct tumor site-specific therapy without large systemic doses and minimized systemic toxicity. | Mengyu Guo Guoqiang Zhou Zhu Liu Jing Liu Jinglong Tang Yating Xiao Wenshi Xu Ying Liu Chunying Chen | 2018 | Science Bulletin2018，63，2： | 4 |
| 4 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 5 | The effectiveness of bisulfite-activated permanganate technology to enhance the coagulation efficiency of Microcystis aeruginosa显示文摘The effects of bisulfite-activated permanganate technology(PM/BS)as a pre-oxidation process on enhancing Microcystis aeruginosa(M.aeruginosa)removal by post coagulation were investigated.The results demonstrated that pretreatment with PM/BS process effectively promoted the algae removal by coagulation with Al2(SO4)3 as the coagulant and this phenomenon was more obvious with the increase of water hardness.Compared to the sole coagulation,PM/BS pre-oxidation combing with coagulation could neutralize the zeta potential of algal cells effectively,decrease the algal cell size,and lead to the formation of more compact flocs due to the in-situ generated Mn02.The effect of oxidant dosages on algal organic matter(AOM)was also studied and no obvious release of macromolecular substances was observed with the dosage of KMn04 increasing from 3.0 mg/L to 7.0 mg/L,suggesting the integrity of algal cells at a high KMn04 dosage.Moreover,PM/BS pre-oxidation could lead to the decrease of most analyzed disinfection by-products(DBPs)at a Al2(SO4)3 dosage of 40.0 mg/L.The algae removal efficiency was also significantly enhanced by PM/BS pre-oxidation in the test using real algae-laden water.This study indicated that PM/BS process might be a potential assistant technology for algae removal by subsequent coagulation. | Yating Zhu Jinfeng Ling Lei Li Xiaohong Guan | 2020 | Chinese Chemical Letters2020，31，6： | 3 |
| 6 | Genetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel显示文摘Due to the virtues of no stutter peaks,low rates of mutation,and short amplicon sizes,insertion/deletion(InDei)polymorphism is an indispensable tool for analyzing degraded DNA samples from crime scenes for human identifications(Wang et al.,2021).Herein,a self-developed panel of 43 InDei loci constructed previously by our group was utilized to evaluate the genetic diversities and explore the genetic background of the Han Chinese from Beijing(HCB)including 301 random healthy individuals. | Congying ZHAO Jinlong YANG Hui XU Shuyan MEI Yating FANG Qiong LAN Yajun DENG Bofeng ZHU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 2 |
| 7 | A full-process intelligent trial system for smart court显示文摘In constructing a smart court,to provide intelligent assistance for achieving more efficient,fair,and explainable trial proceedings,we propose a full-process intelligent trial system(FITS).In the proposed FITS,we introduce essential tasks for constructing a smart court,including information extraction,evidence classification,question generation,dialogue summarization,judgment prediction,and judgment document generation.Specifically,the preliminary work involves extracting elements from legal texts to assist the judge in identifying the gist of the case efficiently.With the extracted attributes,we can justify each piece of evidence’s validity by establishing its consistency across all evidence.During the trial process,we design an automatic questioning robot to assist the judge in presiding over the trial.It consists of a finite state machine representing procedural questioning and a deep learning model for generating factual questions by encoding the context of utterance in a court debate.Furthermore,FITS summarizes the controversy focuses that arise from a court debate in real time,constructed under a multi-task learning framework,and generates a summarized trial transcript in the dialogue inspectional summarization(DIS)module.To support the judge in making a decision,we adopt first-order logic to express legal knowledge and embed it in deep neural networks(DNNs)to predict judgments.Finally,we propose an attentional and counterfactual natural language generation(AC-NLG)to generate the court’s judgment. | Bin WEI Kun KUANG Changlong SUN Jun FENG Yating ZHANG Xinli ZHU Jianghong ZHOU Yinsheng ZHAI Fei WU | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，2： | 2 |
| 8 | Antibacterial Effects of Chinese Herbal Medicines against Streptococcus iniae in Oreochromis niloticus显示文摘In this study,the antibacterial effects of Chinese herbal medicines against Streptococcus iniae in Oreochromis niloticus were investigated by drug sensitivity test. The results indicated that Streptococcus iniae was extremely sensitive to Galla Chinensis,Fructus Hippophae and Fructus Mume,highly sensitive to Sappan Lignum,Pericarpium Granati,Folium Eucalypti and Radix Scutellariae,moderately sensitive to Rhizoma Coptidis,Radix et Rhizoma Rhei,Flos Caryophyllata,Cortex phellodendri and Rabdosia serra( Maxim.) Hara,and insensitive to Herba Portulacae,Herba Houttuyniae,Polygonum hydropiper L.,Herba Menthae,Radix Glycyrrhizae,Pericarpium Citri Reticulatae,Herba Andrographitis and Rhizoma Acori Tatarinowii. Chinese medicinal herbs which Streptococcus iniae was extremely sensitive or moderately sensitive to were selected and prepared into three Chinese herbal medicine formulae for medicated bath of Oreochromis niloticus infected artificially with Streptococcus iniae. The results showed that medicated bath elicited therapeutic effects on infected Oreochromis niloticus. Formula II exhibited the best therapeutic effect with an effective percentage of 90%. | Guisheng GAO Yanying ZHANG Yongmei SU Qiumei SHI Guangping GAO Yating BAI Hongsheng HAN Jianxin ZHU Qingchun SONG Guanglian REN | 2016 | Agricultural Biotechnology2016，5，1： | 2 |
| 9 | Set potential regulation reveals additional oxidation peaks of Geobacter sulfurreducens anodic biofilms 显示文摘 | Zhu X Yates MD Logan BE | 2012 | Electrochem Commun2012，22，： | 1 |
| 10 | Research on the ef- ficiency of querying historical data with the spatio-time data integration method 显示文摘 | Fan Yating Yang Jianyu Zhu Dehai | 2011 | Mathematical and Computer Model- ling2011，54，3： | 1 |
| 11 | Occurrence and distribution of phthalate esters in riverine sediments from the Pearl River Delta region, South China显示文摘 | Hong Liu Kunyan Cui Feng Zeng Lixuan Chen Yating Cheng Huiru Li Shuocong Li Xi Zhou Fang Zhu Gangfeng Ouyang Tiangang Luan Zunxiang Zeng | 2014 | Marine Pollution Bulletin2014，，： | 1 |
| 12 | Investigating the Changes in Air Pollutant Emissions over the Beijing-Tianjin-Hebei Region in February from 2014 to 2019 through an Inverse Emission Method显示文摘In recent years,China has implemented several measures to improve air quality.The Beijing-Tianjin-Hebei(BTH)region is one area that has suffered from the most serious air pollution in China and has undergone huge changes in air quality in the past few years.How to scientifically assess these change processes remain the key issue in further improving the air quality over this region in the future.To evaluate the changes in major air pollutant emissions over this region,this paper employs ensemble Kalman filtering(EnKF)for integrating the national ground monitoring pollutant observation data and the Nested Air Quality Prediction Modeling System(NAQPMS)simulation data to inversely estimate the emission rates of SO_(2),NOX,CO,and primary PM_(2.5)over BTH region in February from 2014 to 2019.The results show that SO_(2),NOX,CO,and primary PM_(2.5)emissions in the BTH region decreased in February from 2014 to 2019 by 83%,37%,41%,and 42%,while decreases in Beijing during this period were 86%,67%,59%,and 65%,respectively.Compared with the prior emission inventory,the inversion emission inventory reduces the uncertainty of multi-pollutant simulation in the BTH region,with simulated root mean square errors of the monthly average concentrations of SO_(2),NOX,PM_(2.5),and CO reduced by 41%,30%,31%,and 22%,respectively.The average uncertainties of SO_(2),NOX,PM_(2.5),and CO inversion emissions in2014-19 are±14.03%yr^(-1),±28.91%yr^(-1),±126.15%yr^(-1),and±43.58%yr^(-1).Compared with the uncertainty of MEIC emission,the uncertainties of all species changed by+2%yr^(-1),-2%yr^(-1),-26%yr^(-1),and-4%yr^(-1),respectively.The spatial distribution results illustrate that air pollutant emissions are mainly distributed over the eastern and southern BTH regions.The spatial gap between the inversion emissions and MEIC emissions was further closed in 2019 compared to 2014.The results of this paper can provide a new reference for assessing changes in air pollution emissions over the BTH region in recent years and validating a bottom-up emission inventory. | Xuechun LUO Xiao TANG Haoyue WANG Lei KONG Huangjian WU Weiguo WANG Yating SONG Hongyan LUO Yao WANG Jiang ZHU Zifa WANG | 2023 | Advances in Atmospheric Sciences2023，40，4： | 1 |
| 13 | Set potential regulation reveals additional oxidation peaks of Geobacter sulfurreducens anodic biofilms显示文摘 | Xiuping Zhu Matthew D. Yates Bruce E. Logan | 2012 | Electrochemistry Communications2012，，： | 1 |
| 14 | Probability judgment accuracy: China, Japan, and the United States显示文摘 | Yates J F Zhu Y Ronis D L Wang D-F Shinotsuka H &Toda M | 1989 | Organizational Behavior and Human Decision Processes1989，43，： | 1 |
| 15 | Microbial communitycomposition is unaffected by anode potential 显示文摘 | Zhu X Yates M D Hatzell M C | 2014 | Environmental Science & Technology2014，48，2： | 1 |
| 16 | The Impact of the Numbers of Monitoring Stations on the National and Regional Air Quality Assessment in China During 2013-18显示文摘China national air quality monitoring network has become the core data source for air quality assessment and management in China.However,during network construction,the significant change in numbers of monitoring sites with time is easily ignored,which brings uncertainty to air quality assessments.This study aims to analyze the impact of change in numbers of stations on national and regional air quality assessments in China during 2013-18.The results indicate that the change in numbers of stations has different impacts on fine particulate matter(PM_(2.5))and ozone concentration assessments.The increasing number of sites makes the estimated national and regional PM_(2.5) concentration slightly lower by 0.6−2.2μg m^(−3) and 1.4−6.0μg m^(−3) respectively from 2013 to 2018.The main reason is that over time,the monitoring network expands from the urban centers to the suburban areas with low population densities and pollutant emissions.For ozone,the increasing number of stations affects the long-term trends of the estimated concentration,especially the national trends,which changed from a slight upward trend to a downward trend in 2014−15.Besides,the impact of the increasing number of sites on ozone assessment exhibits a seasonal difference at the 0.05 significance level in that the added sites make the estimated concentration higher in winter and lower in summer.These results suggest that the change in numbers of monitoring sites is an important uncertainty factor in national and regional air quality assessments,that needs to be considered in long-term concentration assessment,trend analysis,and trend driving force analysis. | Hongyan LUO Xiao TANG Huangjian WU Lei KONG Qian WU Kai CAO Yating SONG Xuechun LUO Yao WANG Jiang ZHU Zifa WANG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 1 |
| 17 | Microbial community composition is unaffected by anode potential显示文摘 | Zhu X P Yates M D Hatzell M C | 2014 | Environmental Science & Technology2014，48，2： | 1 |
| 18 | Probability Judgment Accuracy: China, Japan and the United States 显示文摘 | Yates J F Zhu Y Ronis D L | 1989 | Organization Behavior and Human Decision Processes1989，43，2： | 1 |
| 19 | Impact of θ-burst stimulation on memory mechanism:modeling study显示文摘The information stored in working memory can be transformed into the system of long-term memory due to the long-term potential(LTP) mechanism. The θ-burst stimulation(TBS) can be used as an LTP induction protocol in some experiments,but it has not been used in the models related to memory. In this work, an improved Camperi-Wang(C-W) model with the Ca2+subsystem-induced bistability is adopted,and the TBS is simulated to be the initial stimuli of this model. With the evolution of the effects of the stimuli properties such as the cycle, the amplitude, and the duty ration on the memory mechanism of this model, the TBS can be adopted to activate working memory models and produce long-term memory. The study helps to propose the relationship between working memory and long-term memory, which lays a theoretical basis for the study of the neural mechanism of long-term memory. | Yating ZHU Rubin WANG Yihong WANG | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，3： | 1 |
| 20 | An interpretation of the genetic polymorphism and population genetic background of Ankang Han population via a novel InDel panel显示文摘In this research,genotyping data of 43 InDel loci in 311 Han individuals in Ankang City,Shaanxi Province,China were detected using a self-developed five-dye multiplex amplification panel.The allelic frequencies and forensic parameters of all InDel loci were calculated.The combined power of discrimination and probability of exclusion values were 0.99999999999999999882739 and 0.999887424,respectively,which demonstrated that this 43-InDel panel was powerful for individual identifications in Ankang Han population.Moreover,genetic distances,pairwise F_(ST)values,principal component analyses,phylogenetic trees and STRUCTURE analyses were performed to investigate the genetic affinities between Ankang Han and reference groups.Population genetic investigations indicated that Ankang Han population had a close genetic relationship with Southern Han population compared with other reference groups. | Wei Cui Xiaoye Jin Yating Fang Qiong Lan Jiangwei Lan Man Chen Shuyan Mei Tong Xie Bofeng Zhu | 2022 | Forensic Sciences Research2022，7，4： | 0 |
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