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| 1 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 2 | Apatite Fission Track Evidence of Uplift Cooling in the Qiangtang Basin and Constraints on the Tibetan Plateau Uplift显示文摘The Qiangtang basin is located in the central Tibetan Plateau. This basin has an important structural position,and further study of its tectonic and thermal histories has great significance for understanding the evolution of the Tibetan Plateau and the hydrocarbon potential of marine carbonates in the basin. This study focuses on low temperature thermochronology and in particular conducted apatite fission track analysis. Under constraints provided by the geological background,the thermal history in different tectonic units is characterized by the degree of annealing of samples,and the timing of major(uplift-erosion related) cooling episodes is inferred. The cooling history in the Qiangtang basin can be divided into two distinct episodes. The first stage is mainly from the late Early Cretaceous to the Late Cretaceous(69.8 Ma to 108.7 Ma),while the second is mainly from the MiddleLate Eocene to the late Miocene(10.3 Ma to 44.4 Ma). The first cooling episode records the uplift of strata in the central Qiangtang basin caused by continued convergent extrusion after the BangongNujiang ocean closed. The second episode can be further divided into three periods,which are respectively 10.3 Ma,22.6–26.1 Ma and 30.8–44.4 Ma. The late Oligocene-early Miocene(22.6–26.1 Ma) is the main cooling period. The distribution and times of the earlier uplift-related cooling show that the effect of extrusion after the collision between Eurasian plate and India plate obviously influenced the Qiangtang basin at 44.4 Ma. The Qiangtang basin underwent compression and started to be uplifted from the middle-late Eocene to the early Oligocene(45.0–30.8 Ma). Subsequently,a large-scale and intensive uplift process occurred during the late Oligocene to early Miocene(26.1–22.6 Ma) and the basin continued to undergo compression and uplift up to the late Miocene(10.3 Ma). Thus,uplift-erosion in the Qiangtang basin was intensive from 44.5 Ma to about 10 Ma. The timing of cooling in the second episode shows that the uplift of the Qiangtang basin was caused by the strong compression after the collision of the Indian plate and Eurasian plate. On the whole,the new apatite fission-track data from the Qiangtang basin show that the Tibetan Plateau started to extrude and uplift during 45–30.8 Ma. The main period of uplift and formation of the Tibetan Plateau took place about 22.6–26.1 Ma,and uplift and extrusion continued until the late Miocene(10.3 Ma). | REN Zhanli CUI Junping LIU Chiyang LI Tiejun CHEN Gang DOU Shuang TIAN Tao LUO Yating | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 11 |
| 3 | Mechanisms of Solidification Structure Improvement of Ultra Pure 17 wt% Cr Ferritic Stainless Steel by Ti,Nb Addition显示文摘The grain structures and the precipitates in the solidification microstructure of the ultra pure 17 wt% Cr ferritic stainless steels with different Ti and/or Nb micro-alloying were investigated both experimentally and theoretically.It was found by the grain structure observation that the addition of Ti or Nb to the steel reduced the grain size (D) and elongation factor (E),and improved the equiaxed grain proportion (P) and globularity factor (ξ).Among the four steels studied,the minimum grain size and maximum equiaxed grain proportion were obtained by jointly adding both Ti and Nb to the steel.The SEM observation indicated that several kinds of precipitations,such as TiN,MC (rich in Nb),Laves phase (Fe2Nb) and so on,formed in the corresponding steels.In addition,the results calculated using the Thermo-Calc software illustrated that TiN precipitates in the liquid at proper Ti and N contents.Meanwhile,the solidification interval (△T) was enlarged by the addition of Ti or Nb,and the effectiveness of Nb was stronger than Ti.Based on the experimental and calculation results,the mechanisms of grain refinement and increment in equiaxed grain proportion were discussed. | Yating Shan Xinghong Luo Xiaoqiang Hu Shi Liu | 2011 | Journal of Materials Science & Technology2011，27，4： | 7 |
| 4 | Quantitative climatic reconstruction of the Last Glacial Maximum in China显示文摘Quantitative paleoclimatic reconstruction is crucial for understanding the operation and evolution of the global climate system.For example,a quantitative paleoclimatic reconstruction for the Last Glacial Maximum(18±2 ka14C,LGM)is fundamental to understanding the evolution of Earth’s climate during the last glacial-interglacial cycle.Previous quantitative palaeoclimate reconstructions in China are generally based on statistical comparison of modern pollen assemblages and modern climate data.These methods are based on the premise that vegetation-climate interactions remain the same through time,and implicitly assume that the interactions are independent of changes in seasonality and atmospheric CO2concentration.However,these assumptions may not always be valid,which may affect the reconstructions.Here,we present the results of a quantitative study of the LGM climate of China based on an improved inverse vegetation model which incorporates physiological processes combined with a new China Quaternary Pollen Database.The results indicate that during the LGM,mean annual temperature(ANNT),mean temperature of the coldest month(MTCO)and mean temperature of the warmest month in China were lower by^5.6±0.8,~11.0±1.6 and^2.6±0.9°C,respectively,compared to today,and that the changes in ANNT were mainly due to the decrease of MTCO.The ANNT decrease in southern China was^5.5±0.5°C.Mean annual precipitation was lower by^46.3±17.8 mm compared to today and was especially low in northern China(~51.2±21.4 mm)due to the decrease in summer rainfall.Comparison of our results with recent outputs from paleoclimatic modelling reveals that while the latter are broadly consistent with our estimated changes in mean annual climatic parameters,there are substantial differences in the seasonal climatic parameters.Our results highlight the crucial importance of developing seasonal simulation on paleoclimatic models,as well as the need to improve the quality of paleoclimatic reconstructions based on proxy records from geological archives. | Haibin WU Qin LI Yanyan YU Aizhi SUN Yating LIN Wenqi JIANG Yunli LUO | 2019 | Science China Earth Sciences2019，62，8： | 3 |
| 5 | Reagent elution combined with positive pressure filtration:A zero-discharge method for cyanide tailings remediation显示文摘At present, the cyanide gold extraction process is still the main technology for gold production. Generated cyanide tailings containing highly toxic substances exhibit potential environmental risks. These tailings are in urgent need of purification treatment, especially after being classified as hazardous waste. In this study, the impacts of elution methods, operating time, tailings/water ratios, reagent types on the elution rates of cyanide were investigated. Furthermore, the composite elution method developed in this research was extended for engineering. Results showed that the optimum elution conditions were determined to be: stirring elution, tailings/water ratio( M/V;1:1) and operating time(10-20 min). Besides, 4 reagents(sodium dodecyl benzene sulfonate, cyclodextrin, sodium silicate and calcium hydroxide) were selected from four categories of 21 reagents for further composite elution. The cyanide elution rate was the highest(90.7% ±0.1%) while the molar ratio of these 4 reagents was 5:2:2:1. Moreover, the combination of reagent elution and positive pressure filtration improved the elution efficiency of cyanide(92.6% ±0.8%). And the cyanide content in the toxic leaching solution was lower than the standard value(5.0 mg/L). Furthermore, the composite elution method developed in this study was also extended for engineering. The concentration of cyanide in the leachate was < 5.0 mg/L, and was stable during 189 days of detection. Notably, the effluent can be reused directly, or reused after further treatment. The zero discharge of effluents and solid wastes was realized in the processes. The above results provided supports for the engineering treatment of cyanide tailings. | Qiang Liu Yating Luo Jiyan Shi | 2022 | Journal of Environmental Sciences2022，34，3： | 1 |
| 6 | Investigating the Changes in Air Pollutant Emissions over the Beijing-Tianjin-Hebei Region in February from 2014 to 2019 through an Inverse Emission Method显示文摘In recent years,China has implemented several measures to improve air quality.The Beijing-Tianjin-Hebei(BTH)region is one area that has suffered from the most serious air pollution in China and has undergone huge changes in air quality in the past few years.How to scientifically assess these change processes remain the key issue in further improving the air quality over this region in the future.To evaluate the changes in major air pollutant emissions over this region,this paper employs ensemble Kalman filtering(EnKF)for integrating the national ground monitoring pollutant observation data and the Nested Air Quality Prediction Modeling System(NAQPMS)simulation data to inversely estimate the emission rates of SO_(2),NOX,CO,and primary PM_(2.5)over BTH region in February from 2014 to 2019.The results show that SO_(2),NOX,CO,and primary PM_(2.5)emissions in the BTH region decreased in February from 2014 to 2019 by 83%,37%,41%,and 42%,while decreases in Beijing during this period were 86%,67%,59%,and 65%,respectively.Compared with the prior emission inventory,the inversion emission inventory reduces the uncertainty of multi-pollutant simulation in the BTH region,with simulated root mean square errors of the monthly average concentrations of SO_(2),NOX,PM_(2.5),and CO reduced by 41%,30%,31%,and 22%,respectively.The average uncertainties of SO_(2),NOX,PM_(2.5),and CO inversion emissions in2014-19 are±14.03%yr^(-1),±28.91%yr^(-1),±126.15%yr^(-1),and±43.58%yr^(-1).Compared with the uncertainty of MEIC emission,the uncertainties of all species changed by+2%yr^(-1),-2%yr^(-1),-26%yr^(-1),and-4%yr^(-1),respectively.The spatial distribution results illustrate that air pollutant emissions are mainly distributed over the eastern and southern BTH regions.The spatial gap between the inversion emissions and MEIC emissions was further closed in 2019 compared to 2014.The results of this paper can provide a new reference for assessing changes in air pollution emissions over the BTH region in recent years and validating a bottom-up emission inventory. | Xuechun LUO Xiao TANG Haoyue WANG Lei KONG Huangjian WU Weiguo WANG Yating SONG Hongyan LUO Yao WANG Jiang ZHU Zifa WANG | 2023 | Advances in Atmospheric Sciences2023，40，4： | 1 |
| 7 | Service outage based power andrate allocation for parallel fading channels显示文摘 | LUO J YATES R SPASOJEVIC P | 2005 | IEEE Transactions onInformation Theory2005，51，7： | 1 |
| 8 | The Impact of the Numbers of Monitoring Stations on the National and Regional Air Quality Assessment in China During 2013-18显示文摘China national air quality monitoring network has become the core data source for air quality assessment and management in China.However,during network construction,the significant change in numbers of monitoring sites with time is easily ignored,which brings uncertainty to air quality assessments.This study aims to analyze the impact of change in numbers of stations on national and regional air quality assessments in China during 2013-18.The results indicate that the change in numbers of stations has different impacts on fine particulate matter(PM_(2.5))and ozone concentration assessments.The increasing number of sites makes the estimated national and regional PM_(2.5) concentration slightly lower by 0.6−2.2μg m^(−3) and 1.4−6.0μg m^(−3) respectively from 2013 to 2018.The main reason is that over time,the monitoring network expands from the urban centers to the suburban areas with low population densities and pollutant emissions.For ozone,the increasing number of stations affects the long-term trends of the estimated concentration,especially the national trends,which changed from a slight upward trend to a downward trend in 2014−15.Besides,the impact of the increasing number of sites on ozone assessment exhibits a seasonal difference at the 0.05 significance level in that the added sites make the estimated concentration higher in winter and lower in summer.These results suggest that the change in numbers of monitoring sites is an important uncertainty factor in national and regional air quality assessments,that needs to be considered in long-term concentration assessment,trend analysis,and trend driving force analysis. | Hongyan LUO Xiao TANG Huangjian WU Lei KONG Qian WU Kai CAO Yating SONG Xuechun LUO Yao WANG Jiang ZHU Zifa WANG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 1 |
| 9 | Mapping of individual sensory nerve axons from digits to spinal cord with the transparent embedding solvent system显示文摘Achieving uniform optical resolution for a large tissue sample is a major challenge for deep imaging.For conventional tissue clearing methods,loss of resolution and quality in deep regions is inevitable due to limited transparency.Here we describe the Transparent Embedding Solvent System(TESOS)method,which combines tissue clearing,transparent embedding,sectioning and block-face imaging.We used TESOS to acquire volumetric images of uniform resolution for an adult mouse whole-body sample.The TESOS method is highly versatile and can be combined with different microscopy systems to achieve uniformly high resolution.With a light sheet microscope,we imaged the whole body of an adult mouse,including skin,at a uniform 0.8×0.8×3.5μm^(3) voxel resolution within 120 h.With a confocal microscope and a 40×/1.3 numerical aperture objective,we achieved a uniform sub-micron resolution in the whole sample to reveal a complete projection of individual nerve axons within the central or peripheral nervous system.Furthermore,TESOS allowed the first mesoscale connectome mapping of individual sensory neuron axons spanning 5 cm from adult mouse digits to the spinal cord at a uniform sub-micron resolution. | Yating Yi Youqi Li Shiwen Zhang Yi Men Yuhong Wang Dian Jing Jiayi Ding Qingjie Zhu Zexi Chen Xingjun Chen Jun-Liszt Li Yilong Wang Jun Wang Hanchuan Peng Li Zhang Wenjing Luo Jian Q.Feng Yongwen He Woo-Ping Ge Hu Zhao | 2024 | Cell Research2024，34，2： | 0 |
| 10 | Design, synthesis, molecular modeling, and biological evaluation of acrylamide derivatives as potent inhibitors of human dihydroorotate dehydrogenase for the treatment of rheumatoid arthritis显示文摘Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis(RA), psoriasis and multiple sclerosis(MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structureeactivity relationship(SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar range.Further structure optimization revealed that an acrylamide with small hydrophobic groups(Me, Cl or Br)at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53-55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic(PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner. | Fanxun Zeng Shiliang Li Guantian Yang Yating Luo Tiantian Qi Yingfan Liang Tingyuan Yang Letian Zhang Rui Wang Lili Zhu Honglin Li Xiaoyong Xu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 0 |
| 11 | Silica Modulation of Raney Nickel Catalysts for Selective Hydrogenation显示文摘Selective hydrogenation over earth-abundant metal catalysts is challenging but particularly valuable for practical applications in heterogeneous catalysis.Herein,we demonstrate that the catalytic selectivity of the commercial Raney nickel catalyst can be greatly tuned by modulation of the nickel surface by silica.Using quinoline hydrogenation as a model,we show that the silica-modified Raney nickel catalysts exhibit good activity,excellent selectivity,and long stability,whereas the undesired over-hydrogenation reactions are effectively hindered.In contrast,the pristine Raney nickel catalyst shows inferior selectivity for the targeted product.Mechanistic studies confirm a positive role of silica to facilitate the desorption of 1,2,3,4-tetrahydroquinoline from the catalyst surface,thus enhancing the product selectivity. | Yating Lv Hai Wang Huixin Wu Qingsong Luo Liang Wang Feng-Shou Xiao | 2023 | Precision Chemistry2023，1，5： | 0 |
| 12 | Topological materials for full-vector elastic waves显示文摘Elastic wave manipulation is important in a wide variety of applications,including information processing in small elastic devices and noise control in large solid structures.The recent emergence of topological materials has opened new avenues for modulating elastic waves in solids.However,because of the full-vector feature and the complicated couplings of the longitudinal and transverse components of elastic waves,manipulating elastic waves is generally difficult compared with manipulating acoustic waves(scalar waves) and electromagnetic waves(vectorial waves but transverse only).To date,topological materials,including insulators and semimetals,have been used for acoustic and electromagnetic waves.Although topological materials with elastic waves have also been reported,the observed topological edge modes lie on the domain wall.A natural question arises:Is there an elastic metamaterial with topological edge modes on its own boundary?Here,we report a 3D metal-printed bilayer metamaterial that topologically insulates elastic waves.By introducing chiral interlayer couplings,the spin-orbit couplings for elastic waves are induced,which give rise to nontrivial topological properties.Helical edge states with vortex features were demonstrated on the boundary of the single topological phase.We further show a heterostructure of the metamaterial that exhibits tunable edge transport.Our findings could be used in devices based on elastic waves in solids. | Ying Wu Jiuyang Lu Xueqin Huang Yating Yang Li Luo Linyun Yang Feng Li Weiyin Deng Zhengyou Liu | 2023 | National Science Review2023，10，5： | 0 |
| 13 | Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization显示文摘Due to their broad functional plasticity,myeloid cells contribute to both liver injury and recovery during acetaminophen overdose-induced acute liver injury(APAP-ALI).A comprehensive understanding of cellular diversity and intercellular crosstalk is essential to elucidate the mechanisms and to develop therapeutic strategies for APAP-ALI treatment.Here,we identified the function of IFN-I in the myeloid compartment during APAP-ALI.Utilizing single-cell RNA sequencing,we characterized the cellular atlas and dynamic progression of liver CD11b+cells post APAP-ALI in WT and STAT2 T403A mice,which was further validated by immunofluorescence staining,bulk RNA-seq,and functional experiments in vitro and in vivo.We identified IFN-I-dependent transcriptional programs in a three-way communication pathway that involved IFN-I synthesis in intermediate restorative macrophages,leading to CSF-1 production in aging neutrophils that ultimately enabled Trem2+restorative macrophage maturation,contributing to efficient liver repair.Overall,we uncovered the heterogeneity of hepatic myeloid cells in APAP-ALI at single-cell resolution and the therapeutic potential of IFN-I in the treatment of APAP-ALI. | Qiaoling Song Shyamasree Datta Xue Liang Xiaohan Xu Paul Pavicic Xiaonan Zhang Yuanyuan Zhao Shan Liu Jun Zhao Yuting Xu Jing Xu Lihong Wu Zhihua Wu Minghui Zhang Zhan Zhao Chunhua Lin Yuxin Wang Peng Han Peng Jiang Yating Qin Wei Li Yingying Zhang Yonglun Luo Ganes Sen George R.Stark Chenyang Zhao Thomas Hamilton Jinbo Yang | 2023 | Cellular & Molecular Immunology2023，20，2： | 0 |
| 14 | A novel method for objectively, rapidly and accurately evaluating burn depth via near infrared spectroscopy显示文摘The accurate and objective evaluation of burn depth is a significant challenge in burn wound care.Herein,we used near infrared spectroscopy(NIRS)technology to measure the different depth of thermal burns in ex vivo porcine models.Based on the intensity of the spectral signals and the diffuse reflection theory,we extracted the optical parameters involved in functional(total hemoglobin andwater content)and structural(tissue scattered size and scattered particles)features that reflect the changes in burn depth.Next,we applied support vector regression to construct a model including the optical property parameters and the burn depth.Finally,we histologically verified the burn depth data collected via NIRS.The results showed that our inversion model could achieve an average relative error of about 7.63%,while the NIRS technology diagnostic accuracy was in the range of 50μm.For the first time,this novel technique provides physicians with real-time burn depth information objectively and accurately. | Meifang Yin Yongming Li Yongquan Luo Mingzhou Yuan Ubaldo Armato Ilaria Dal Prà Lijun Zhang Dayong Zhang Yating Wei Guang Yang Lixian Huang Pin Wang Jun Wu | 2021 | Burns & Trauma2021，9，1： | 0 |
| 15 | Microbially-mediated formation of Ca-Fe carbonates during dissimilatory ferrihydrite reduction:Implications for the origin of sedimentary ankerite显示文摘The origin of sedimentary dolomite has become a long-standing problem in the Earth Sciences.Some carbonate minerals like ankerite have the same crystal structure as dolomite,hence their genesis may provide clues to help solving the dolomite problem.The purpose of this study was to probe whether microbial activity can be involved in the formation of ankerite.Bio-carbonation experiments associated with microbial iron reduction were performed in batch systems with various concentrations of Ca^(2+)(0–20 mmol/L),with a marine iron-reducing bacterium Shewanella piezotolerans WP3 as the reaction mediator,and with lactate and ferrihydrite as the respective electron donor and acceptor.Our biomineralization data showed that Ca-amendments expedited microbially-mediated ferrihydrite reduction by enhancing the adhesion between WP3 cells and ferrihydrite particles.After bioreduction,siderite occurred as the principal secondary mineral in the Ca-free systems.Instead,Ca-Fe carbonates were formed when Ca^(2+)ions were present.The CaCO_(3) content of microbially-induced Ca-Fe carbonates was positively correlated with the initial Ca2+concentration.The Ca-Fe carbonate phase produced in the 20 mmol/L Ca-amended biosystems had a chemical formula of Ca_(0.8)Fe_(1.2)(CO_(3))_(2),which is close to the theoretical composition of ankerite.This ankeritelike phase was nanometric in size and spherical,Ca-Fe disordered,and structurally defective.Our simulated diagenesis experiments further demonstrated that the resulting ankerite-like phase could be converted into ordered ankerite under hydrothermal conditions.We introduced the term“proto-ankerite”to define the Ca-Fe phases that possess near-ankerite stoichiometry but disordered cation arrangement.On the basis of the present study,we proposed herein that microbial activity is an important contributor to the genesis of sedimentary ankerite by providing the metastable Ca-Fe carbonate precursors. | Deng LIU Jinpeng CAO Shanshan YANG Yating YIN Pengcong WANG Dominic PAPINEAU Hongmei WANG Xuan QIU Genming LUO Zongmin ZHU Fengping WANG | 2024 | Science China Earth Sciences2024，67，1： | 0 |
| 16 | Nuclear localization of human MEIOB requires its NLS in the OB domain and interaction with SPATA22显示文摘MEIOB is a vital protein in meiotic homologous recombination and plays an indispensable role in human gametogenesis.In mammals,MEIOB and its partner SPATA22 form a heterodimer,ensuring their effective localization on single-strand DNA(ssDNA)and proper synapsis processes.Mutations in human MEIOB(hMEIOB)cause human infertility attributed to the failure of its interaction with human SPATA22(hSPATA22)and ssDNA binding.However,the detailed mechanism is still unclear.In our study,truncated or full-length hMEIOB and hSPATA22 are traced by fused expression with fluorescent proteins(i.e.,copGFP or mCherry),and the live cell imaging system is used to observe the expression and localization of the proteins.When transfected alone,hMEIOB accumulates in the cytoplasm.Interestingly,a covered NLS in the OB domain of hMEIOB is identified,which can be exposed by hSPATA22 and is necessary for the nuclear localization of hMEIOB.When hSPATA22 loses its hMEIOB interacting domain or NLS,the nuclear localization of hMEIOB is aborted.Collectively,our results prove that the NLS in the OB domain of hMEIOB and interaction with hSPATA22 are required for hMEIOB nuclear localization. | Yating Xu Zhen Chen Panfeng Wu Wei Qu Hanqing Shi Muyang Cheng Yumin Xu Tingyu Jin Cong Liu Cong Liu Yi Li Mengcheng Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 17 | The Analysis of Clinical Features of Systemic Lupus Erythematosus (SLE) in Children显示文摘Objective:Observe the clinical characteristics of children with SLE,namely,to observe the symptoms and laboratory examinations,such as blood routine,blood lipid,immunoglobulin,complement,autoantibodies,serum 25(OH)D and other indicators,and to explore the clinical characteristics,the difference and the significance of vitamin D supplements between male and female SLE patients in children respectively.Methods:We enrolled 64 cases of SLE patients in children who were admitted into the department of pediatrics and rheumatology of the third affiliated hospital of sun yat-sen university in guangzhou from May 1,2011 to February 1,2019,They were analyzed retrospectively,adoptingΧ²test for statistical analysis.Results:64 cases of SLE in children,which included 10 cases of male and 54 cases of female.Clinical manifestations:facial skin rash in 48 patients(75%),fever in 38 cases(59.4%),arthritis in 28 cases(43.8%),oral ulcer in 18 cases(28.1%),serositis in13 cases(20.3%),and the sun allergy in 9 cases(14.1%),the damage of central nervous system in 7 cases(10.9%).Laboratory examination:30 cases of leukopenia(46.9%),anemia in 30 cases(46.9%),thrombocytopenia in 12 cases(18.8%),hematuria in 18 cases(28.1%),proteinuria in 33 cases(51.2%),6 patients with renal impairment(9.4%),antinuclear antibody positive in 63 cases(98.4%),anti-double-stranded DNA(dsDNA)antibody positive in 48 cases(75%),anti SSA antibody positive in 44 cases(68.7%),SSB antibody positive in 33 cases(51.6%),Sm antibody positive in 40 cases(62.5%),nucleosome antibody positive in 28 cases(43.8%).Among these children,male SLE patients were higher than female children with SLE in the damage of kidney,Sm antibodies and resisting nucleosome antibody positive rates(Χ²=4.451,8.336,6.803,P<0.05),the female children with SLE was higher than male SLE Children in the anti-SSB antibody positive rate(Χ²=4.945,P<0.05).In 64 cases of SLE children,which included 52 cases were lower than the normal level of serum 25(OH)D measurements,12 cases were in the normal lower limit of serum 25(OH)D measurements,at the same time,the female SLE.Patients was higher than male children with SLE in the reduce rate of serum 25(OH)D(Χ²=8.351,P<0.05).Conclusion:Male SLE patients which appeared damage of kidney easier than female patients,the proteinuria was the most common in the damage of kidney.Resistance to Sm antibodies which was the risk factor of renal injury with higher incidence in male children with SLE;Anti nucleosome antibody which was the risk factor for the disease activity in male children with SLE were higher than female children with SLE.It was estimated that the risk of Sjogren’s syndrome appeared in female with SLE were higher than that in male SLE children.In this retrospective study,the serum 25(OH)D levels were significantly lower in children with SLE,and vitamin D supplementation was required. | Ying Liang Pingping Zhang Huiqin Chen Xiangqin Luo Yesheng Ling Yating Li Ou Jin Qian Kong Fenhua Chen Yikun Mou | 2020 | Journal of Clinical and Nursing Research2020，4，5： | 0 |
| 18 | CircUCP2 promotes the tumor progression of non-small cell lungcancer through the miR-149/UCP2 pathway显示文摘Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the functions of circRNAs in NSCLC remain unclear.To study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues.RNA was isolated and used for circRNA sequencing.Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and migration.How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms.We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues.circUCP2 promoted the proliferation and metastasis of NSCLC cells.circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2.The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC. | WEI DU FANG YIN YATING ZHONG MINJIE LUO ZHEN WANG PENG LIN QING LIU HAN YANG | 2023 | Oncology Research2023，31，6： | 0 |
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