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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Ovaian cancer in the elderly 显示文摘 | yancik R Ries LG Yates JW | 2001 | Am J Obstet Gynecol2001，169，4： | 1 |
| 3 | The biological impact of mass-spectrometry-based proteomics 显示文摘 | Cravatt B F Simon G M Yates J R 3rd | 2007 | Nature2007，450，7172： | 1 |
| 4 | Primary structure of Gamma-bungarotoxin, a new postsynaptic neurotoxin from venom of Bungarus multicinctus 显示文摘 | Aird S D Womble G C Yates J R | 1999 | Toxicon1999，37，4： | 1 |
| 5 | Peptide mass maps: a highly informative approach to protein identification 显示文摘 | YATES J R SPEICHER S GRIFFIN P R | 1993 | Anal Biochem1993，214，2： | 1 |
| 6 | Parlay X Web Services显示文摘 | LOFTHOUSE H YATES M J STRETCH R | 2004 | BT Technology Journal2004，22，1： | 1 |
| 7 | Effect of Surface Tarp on Emissions and Distribution of Drip-applied Fumigants显示文摘 | PAPIERNIK S K YATES S R DUNGAN R S | 2004 | Environ Sci Technol2004，38，16： | 1 |
| 8 | Relativistic nuclear magnetic resonance chemical shifts of heavy nuclei with pseudopotentials and the zeroth-order regular approximation显示文摘 | Yates J R Pickard C J Payne M C | 2003 | J Chem Phys2003，118，13： | 1 |
| 9 | Serum anti-Mullerian hormone and FSH prediction of live birth and extremes of response in stimulated eyeles*implications {or individualization of therapy显示文摘 | Nelson SM Yates RW Fleming R | 2007 | Hum Reprod2007，22，： | 1 |
| 10 | An analytical solution for one-dimensional transport in heterogeneous porous media显示文摘 | Yates S R | 1990 | Water Resources Research1990，26，10： | 1 |
| 11 | Initial/final state selection of the spin polarization in electron tunneling across an epitaxial Fe/GaA(OOI) interface显示文摘 | KUREBAYASHI H STEINMULLER S J LALOE J B TRYPINIOTIS T EASTON S IONESCU A YATES J R BLAND J A C | 2007 | Appl Phys Lett2007，91，10： | 1 |
| 12 | Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease 显示文摘 | Celli B R Locantore N Yates J | 2012 | American journal of respiratory and critical care medicine2012，185，10： | 1 |
| 13 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 14 | A catalytic loop within Pseudomonas aerugi nosa exotoxin A modulates its transferase activity显示文摘 | Yates S P Merrill A R | 2001 | J Biol Chem2001，276，35： | 1 |
| 15 | Persistence of maternal antibodies against Mycoplasma agassizii in desert tortoise hatchlings显示文摘 | SCHUMACHER I M ROSTAL D C YATES R A | 1999 | Am J Vet Res1999，60，： | 1 |
| 16 | Use of pseudo-cross variograms and eokriging to improve estimates of soil solute concentrations显示文摘 | Zhang R Shouse P Yates S | 1997 | Soil Science Society of America Journal1997，61，5： | 1 |
| 17 | Stochastic power control for cellular radio systems 显示文摘 | SENNUR U YATES R D | 1998 | IEEE Trans on Communication1998，46，6： | 1 |
| 18 | Estimating soil water content using cokriging显示文摘 | Yates S R Warrick A W | 1987 | Soil Science Society of America Journal1987，51，： | 1 |
| 19 | A 'high-pressure' electron spectrometer for surface studies 显示文摘 | Joyner R W Roberts M W Yates K | 1979 | Surface Science1979，87，： | 1 |
| 20 | Quantifying crack tip displacement fields with DIC显示文摘 | YATES J R ZANGANEH M TAI Y H | 2010 | Engineering Fracture Mechanics2010，77，11： | 1 |
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