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| 1 | MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition显示文摘MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection assay.Moreover, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target. | guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
| 2 | MiR-214 inhibits cell growth in hepatocellular carcinoma through suppression of β-catenin显示文摘 | Xiaojun Wang Ji Chen Feng Li Yanting Lin Xiaoping Zhang Zhongwei Lv Jiaji Jiang | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 3 | Effectiveness of contrast-enhanced ultrasound in the classification and emergency management of abdominal trauma显示文摘 | Faqin Lv Yanting Ning Xuan Zhou Yukun Luo Tong Liang Yongkang Nie Tanshi Li Jie Tang | 2014 | European Radiology2014，，： | 1 |
| 4 | Characterization of Mechanical Properties of Waste Slurry Modified by Recycled Sand and Cement显示文摘In order to study the modification effect of recycled sand on cement reinforced waste slurry(CWS),triaxial test,scanning electron microscope test and X-ray diffraction test were carried out.The mechanical test of recycled sand and cement reinforced waste slurry(RCWS)shows that the deviatoric stress–strain curve of RCWS samples changes from hardening type to softening type with the increase of recycled sand content;the peak stress increases with the increase of recycled sand content;recycled sand can enhance the shear strength of CWS by increasing both cohesion and internal friction angle.The microscopic test shows that recycled sand can improve the structural compactness by cementing with hydrated calcium silicate and can reduce the void ratio and orientation index of RCWS samples.Finally,the mathematical model between shear strength parameters and void ratio is established.The research shows that adding an appropriate amount of recycled sand and cement has a good modification effect on waste slurry.This is an effective method to treat two kinds of construction wastes:construction waste slurry and waste concrete. | Beifeng Lv Na Li Haibo Kang Yanting Wu Ben Li Wei Wang | 2022 | Journal of Renewable Materials2022，10，10： | 0 |
| 5 | Toward a unified information framework for cell atlas assembly显示文摘Cells are the basic structural and functional unit of the human body.Virtually all cells of a human body possess the same genome,but they exhibit colorful heterogeneities in phenotypes and functions.The heterogeneities include rich paerns and variabilities in the transcriptomic,epigenomic and proteomic features of the cells.Building an atlas of human cells with the biomolecular properties of all cell types in all organs is essential for understanding the human body;and will provide a fundamental reference for studies on human health and diseases. | Sijie Chen Yanting Luo Haoxiang Gao Fanhong Li Jiaqi Li Yixin Chen Renke You Hairong Lv Kui Hua Rui Jiang Xuegong Zhang | 2022 | National Science Review2022，9，3： | 0 |
| 6 | Purification and characterization of a salt-tolerant cellulase from the mangrove oyster, Crassostrea rivularis显示文摘有 pH 抵抗和高盐忍耐的宽范围的绗维素酶在红树属植物森林里从牡蛎 Crassostrea rivularis 生活的消化的腺被孤立。作为 CrCel 说出的 27 kDa 绗维素酶被净化由从在非减少的钠 dodecylsufate-polyacrylamide 胶化电气泳动以后的胶化的阴离子交换层析和抽取的 40.6 褶层。净化的绗维素酶的特定的活动是对 carboxymethyl 纤维素 CMC 的 23.4 U/mg。CrCel 的 N 终端氨基酸顺序决心是 NQKCQANSRV。CrCel 最好水解 -1,4-glucosidic 向木聚糖在纤维素材料和显示降级活动的非结晶的部分结合。K m 和 V 为 CMC 的 CrCel 的最大 价值决心是 2.1% 汵瑡潩 ? 景 ? 剄′獵湩 ? 浳污 ? 湩整晲牥湩 ? 乒 ? 楳乒 ? 灡牰慯档 ? 潢桴漠 ? 桴?散汬洠杩慲潴祲愠摮椠癮獡癩?桰湥瑯灹獥眠牥?楳湧晩捩湡汴?瑡整畮瑡摥眠敨?潣灭牡摥眠瑩?桴?潣瑮潲? | Tianchen An Zhu Dong Junchen Lv Yujun Liu Manchuriga Wang ShuangshuangWei Yanting Song Yingxia Zhang Shiming Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 0 |
| 7 | In-house or Outsourcing R&D?Manufacturer Technology Strategy in the Presence of Market Follower Encroachment显示文摘Facing the threat of market follower encroachment,this paper constructs game theoretical models based on different channel structures and market structures,investigates following manufacturer's encroachment strategy and technology strategies,and discusses the impact of following manufacturer's strategy on quality decisions.The results show that encroachment always improves consumer surplus by slashing prices when leading manufacturer adopts in-house R&D(IRD);otherwise,it results in lower consumer surplus with mild competition if leading manufacturer is at a technological disadvantage.Furthermore,the technology strategies of following manufacturer are related to their R&D capabilities.The superior one is outsourcing R&D(ORD)for the manufacturers when their R&D capability is weak,otherwise,IRD is optimal.In a word,the leading manufacturer always prefers IRD under certain conditions,while the following manufacturer always prefers ORD.In addition,encroachment restrains quality innovative motivation under fixed or quality-sensitive R&D costs,but can improve quality level when consumers have a higher reference dependency for quality;meanwhile,the following manufacturer adopting ORD is always beneficial to quality improvement. | Chunyu Li Cuihua Zhang Yanting Li Ruxia Lv | 2022 | Journal of Systems Science and Systems Engineering2022，31，1： | 0 |
| 8 | Bio-inspired Polyimine Copolymers: Facial Integration with High Content Variability and Extremal Transitions of Mechanical Properties显示文摘自然 composites 启发了在某些机械表演上完成了改进的各种各样的 biomimetic composites 的制造。此处,最近的进展在 polyimine 化学启用的一条面部途径被开发了从二 polyimines 制作启发简历的 hard-soft-integrated 共聚物(即 PI-H 和 PI-S ) 与坚硬微分。有完整范围的可变性(0 wt%-100 wt%) 的 PI-S 内容的启发简历的共聚物上的多重机械性质的随后的评估为磨擦系数,影响力量和张力的 moduli 揭示了 extremal 转变。更有趣地,最小向应用负担的变化系数显示出的磨擦削尖抵抗变丑的回答,然而并非为改变的滑动加速在决定难软的综合共聚物的最佳的防摩作文建议负担的一个更重要的角色。这些趋势被扫描穿的标本的电子显微镜学进一步支持了。一起这些结果证明了完整范围的 extremal 转变为 hard-soft-integrated 共聚物在多重机械性质上存在,为许多应用程序提供珍贵卓见给合成聚合物的设计和制造。这里构画出的基于 polyimine 的途径也负担得起一个方便方法在 0 wt%-100 wt% 的完整的范围以内在共聚物调节二个部件的比率,启用有高内容可变性的快集成。 | Si Zhang Yanting Lv Long Zheng Jiayi Li Song Liang Zhenning Liu Luquan Ren | 2017 | Journal of Bionic Engineering2017，14，1： | 0 |
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