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| 1 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 2 | Oxidation behavior of Mo-Si-B alloys at medium-to-high temperatures显示文摘Continuous exploration of high-temperature structural materials is being driven by the needs of gasturbine engines capable of withstanding the high-temperature environment.Relatively low melting points of currently applied superalloys restrain the further improvement of service tempe ratures.With higher melting tempe ratures above 2000℃,Mo-Si-B alloys are regarded as a new generation of ultrahightemperature structural materials.However,oxidation is a concern for the industrial application of Mo-Si-B alloys.Therefore,an in-depth understanding of the oxidation mechanisms may contribute to solving this issue,whereas relevant reviews about their recent advances are lacking.In the current work,a comprehensively systematic review about the oxidation behaviors of Mo-Si-B alloys is described for this purpose. | Kunming Pan Yanping Yang Shizhong Wei Honghui Wu Zhili Dong Yuan Wu Shuize Wang Laiqi Zhang Junping Lin Xinping Mao | 2021 | Journal of Materials Science & Technology2021，，1： | 5 |
| 3 | Influence of Tip End-plate on Noise of Small Axial Fan显示文摘In this work, tip end-plate is used to improve the noise performance of small axial fans. Both numerical simulations and experimental methods were adopted to study the fluid flow and noise level of axial fans. Four modified models and the prototype are simulated. Influences of tip end-plate on static characteristics, internal flow field and noise of small axial fans are analyzed. The results show that on basis of the prototype, the model with the tip end-plate of 2 mm width and changed length achieved best noise performance. The overall sound pressure level of the model with the tip end-plate of 2 mm width and changed length is 2.4 dB less than that of the prototype at the monitoring point in specified far field. It is found that the mechanism of noise reduction is due to the decrease of vorticity variation on the surface of blades caused by the tip end-plate. Compared with the prototype, the static pressure of the model with the tip end-plate of 2 mm width and changed length at design flow rate decreases by 2 Pa and the efficiency decreases by 0.8%. It is concluded that the method of adding tip end-plate to impeller blades has a positive influence on reducing noise, but it may diminish the static characteristics of small axial fan to some extent. | MAO Hongya WANG Yanping LIN Peifeng JIN Yingzi Toshiaki Setoguchi Heuy Dong Kim | 2017 | Journal of Thermal Science2017，26，1： | 4 |
| 4 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 5 | Long-term variation of storm surge-associated waves in the Bohai Sea显示文摘When investigating the long-term variation of wave characteristics as associated with storm surges in the Bohai Sea,the Simulating Waves Nearshore(SWAN)model and Advanced CIRCulation(ADCIRC)model were coupled to simulate 32 storm surges between 1985 and 2014.This simulation was validated by reproducing three actual wave processes,showing that the simulated significant wave height(SWH)and mean wave period agreed well with the actual measurements.In addition,the long-term variations in SWH,pattems in SWH extremes along the Bohai Sea coast,the 100-year retum period SWH extreme distribution,and waves conditional probability distribution were calculated and analyzed.We find that the trend of SWH extremes in most of the coastal stations was negative,among which the largest trend was-0.03 m/a in the western part of Liaodong Bay.From the 100-year return period of the SWH distribution calculated in the Gumbel method,we find that the SWH extremes associated with storm surges decreased gradually from the center of the Bohai Sea to the coast.In addition,the joint probability of wave and surge for the entire Bohai Sea in 100-year return period was determined by the Gumbel logistic method.We therefore,assuming a minimum surge of one meter across the entire Bohai Sea,obtained the spatial SWH distribution.The conclusions of this study are significant for offshore and coastal engineering design. | WANG Yanping LIU Yongling MAO Xinyan CHI Yutao JIANG Wensheng | 2019 | Journal of Oceanology and Limnology2019，37，6： | 2 |
| 6 | A Posteriori Error Estimates of the Galerkin Spectral Methods for Space-Time Fractional Diffusion Equations显示文摘In this paper,an initial boundary value problem of the space-time fractional diffusion equation is studied.Both temporal and spatial directions for this equation are discreted by the Galerkin spectral methods.And then based on the discretization scheme,reliable a posteriori error estimates for the spectral approximation are derived.Some numerical examples are presented to verify the validity and applicability of the derived a posteriori error estimator. | Huasheng Wang Yanping Chen Yunqing Huang Wenting Mao | 2020 | Advances in Applied Mathematics and Mechanics2020，12，1： | 2 |
| 7 | Single-phase Computational Fluid Dynamics Applicability for the Study of Three-dimensional Flow in 5×5 Rod Bundles with Spacer Grids显示文摘Spacer grids play an important role in pressurized water reactor(PWR) fuel assembly in that they have significant influence on the thermal-hydraulic characteristics of the reactor core.But so far,the numerical studies are performed without regarding dimple and spring of spacer grids,just considering mixing vane.Moreover,these studies use k-ε turbulence model without considering the suitability of the other turbulence models upon the different spacer grids flow.A study is carried out to understand the 3-D single-phase flow in AFA-2G 5×5 rod bundles with spacer grids based on numerical method.In order to investigate the suitability of different turbulence models,k-ε model and k-ω model,the influence of different parts of spacer grid on the fluid flow is also predicted.By using second-order upwind scheme,hybrid grids technique,and improved SIMPLEC algorithm,the Reynolds averaged mass conservation and momentum conservation equations are solved,and the pressure and velocity field of flow are obtained.The numerical simulation results are compared with experiment results and the agreement is satisfactory.The simulation results show the influences of the spring,dimple and mixing vane,and the different characteristics of the k-ε model and k-ω model.Comparing with the experiment results,the simulation results suggest that the k-ω model is suitable for the simulation of the rod bundle flow with spacer grids;the spring and dimple are the main causes of the pressure loss in the spacer grid channel.The friction coefficient of the channel with spring and dimple is 1.5 times the coefficient of the channel with the vane.These results are beneficial to enhance the simulation ability of spacer grids flow and optimization design ability of spaces grid. | TIAN Ruifeng MAO Xiaohui GAO Puzhen HUANG Yanping | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 1 |
| 8 | New Quinoxaline-Based Blue Emitters: Molecular Structures, Aggregation-Induced Enhanced Emission Characteristics and OLED Application显示文摘Three new deep blue light emitters,bearing quinoxaline with different substituents(biphenyl/pyrene)at the 1-or 2-position,were synthesized by a Pd-catalysed coupling reaction in high yields,and were fully characterized by 1H/13C NMR spectroscopy,single crystal X-ray diffraction,and high-resolution mass spectrometry(HRMS). | Xiaoyu Mao Fuli Xie Xiaohui Wang Qingsong Wang Zhipeng Qiu Mark R.J.Elsegood Jie Bai Xing Feng Carl Redshaw Yanping Huo Jian-Yong Hu Qing Chen | 2021 | Chinese Journal of Chemistry2021，39，8： | 1 |
| 9 | Characterization of Thauera-dominated hydrogen-oxidizing autotrophie denitrifying microbial communities by using high-throughput sequencing 显示文摘 | MAO Yanping XIA Yu ZHANG Tong | 2013 | Bioresoarce Technology2013，128，： | 1 |
| 10 | A method for repairing the inconsistency of fuzzy preference rela tions显示文摘 | Ma Jian Fan Zhiping Jiang Yanping Mao Jiye Ma Louis | 2006 | Fuzzy Sets and Systems2006，，157： | 1 |
| 11 | Power gen-eration from a biocathode microbial fuel cell biocatalyzedby ferro/manganese-oxidizing bacteria显示文摘 | Mao Yanping Zhang Lehua Li Dongmei | 2010 | ElectrochimicaActa2010，5，5： | 1 |
| 12 | Arabidopsis Profilin Isoforms,PRF1 and PRF2 Show Distinctive Binding Activities and Subcellular Distributions显示文摘Profilin is an actin-binding protein that shows complex effects on the dynamics of the actin cytoskeleton. There are five profilin isoforms in Arabidopsis thaliana L. However, it is still an open question whether these isoforms are functionally different. In the present study, two profilin isoforms from Arabidopsis, PRF1 and PRF2 were fused with green fluorescent protein (GFP) tag and expressed in Escherichia coli and A. thaliana in order to compare their biochemical properties in vitro and their cellular distributions in vivo. Biochemical analysis revealed that fusion proteins of GFP-PRF1 and GFP-PRF2 can bind to poly-L-proline and G-actin showing remarkable differences. GFP-PRF1 has much higher affinities for both poly-L-proline and G-actin compared with GFP-PRF2. Observations of living cells in stable transgenic A. thaliana lines revealed that 35S::GFP-PRF1 formed a filamentous network, while 35S::GFP-PRF2 formed polygonal meshes. Results from the treatment with latrunculin A and a subsequent recovery experiment indicated that filamentous alignment of GFP-PRF1 was likely associated with actin filaments. However, GFP-PRF2 localized to polygonal meshes resembling the endoplasmic reticulum. Our results provide evidence that Arabidopsis profilin isoforms PRF1 and PRF2 have different biochemical affinities for poly-L-proline and G-actin, and show distinctive localizations in living cells. These data suggest that PRF1 and PRF2 are functionally different isoforms. | Feng ang Yanping Jing Zhen ang Tonglin Mao Jozef Samaj Ming Yuan Haiyun Ren | 2009 | Journal of Integrative Plant Biology2009，51，2： | 1 |
| 13 | Development of the high radio frequency power amplifiers for ICRF heating in EAST 显示文摘 | Mao Yuzhou Yuan Shuai Zhao Yanping | 2012 | Fusion Science and Technology2012，61，： | 1 |
| 14 | Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinoma显示文摘Metastasis and recurrence account for 95%of deaths from nasopharyngeal carcinoma(NPC).Cancer stem cells(CSCs)are regarded as one of the main reasons for tumor cell resistance to clinical therapy,and cancer metastasis or recurrence,while little is known about CSCs in NPC.The present study uncovers a subpopulation of cells labeled as CD45 EPCAM PROCR4 in NPC biopsy samples that exhibit stem cell-like characteristics.A relatively low number of these cells initiate xenograft tumors in mice. | Panpan Zhang Qiuping He Yaqin Wang Guanqun Zhou Yupei Chen Linglong Tang Yuan Zhang Xiaohong Hong Yanping Mao Qingmei He Xiaojing Yang Na Liu Jun Ma | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 0 |
| 15 | Computer-aided engineering of CRISPR-Cas proteins for enhanced human genome editing显示文摘Dear editor.The remarkably diversified CRISPR-Cas systems in nature have provided unlimited valuable resources to develop genome editing tools that are revolutionizing the fields of biotechnology and medicine.However,due to their microbial origin,the activity of most naturally occurring CRISPR-Cas nucleases is relatively poor in mammalian cells(Ran et al.,2015).Thus,improving the mammalian genome editing efficiency becomes the priority for harnessing more CRISPRCas systems for widespread applications.Rational protein engineering serves as a powerful approach to enhance the catalytic activity of enzymes.Whereas,this approach largely relies on proteinic three-dimension(3D)structure information as guide for design.The fact is that of the large numbers of the CRISPR-Cas systems discovered in recent years,only a small number of them with the 3D structures were reported.To bypass this limitation,here,we report an efficient and simple strategy for rational engineering of Cas nucleases without the need of 3D structure information and successfully optimized nucleases from Cas9 and Cas12 families. | Yangcan Chen Yanping Hu Shengqiu Luo Xinge Wang Bangwei Mao Yi Chen Jing Xu Zhikun Li Qi Zhou Wei Li | 2023 | Science China(Life Sciences)2023，66，4： | 0 |
| 16 | More endemic birds occur in regions with stable climate, more plant species and high altitudinal range in China显示文摘Background:Geographical distribution of endemic species and its multiple scale drivers are an important topic in biodiversity conservation,because these species are especially vulnerable to climate change and habitat degradation,and therefore have high conservation priority.Here,for the first time,we simultaneously linked glacial-interglacial climate change,contemporary climate,plant species richness and altitudinal range with endemic bird distribution in China.Methods:Ordinary least squares models and simultaneous autoregressive models were used to assess the associations between endemic bird richness,endemic bird ratio and each explanatory variable.Structural Equation Models were also performed to test the direct and indirect effects of these variables on endemic bird richness and endemic bird ratio.Results:Higher endemic bird richness and endemic bird ratio occurred in regions with stable glacial-interglacial temperature,i.e.,southwest China.Plant species richness and altitudinal range were also positively correlated with endemic bird richness and endemic bird ratio.Glacial-interglacial temperature change,contemporary precipitation,plant species richness and altitudinal range were all included in the best combination of variables for endemic bird richness.Importantly,glacial-interglacial temperature change had strong direct effects on both endemic bird richness and endemic bird ratio,while plant species richness only had a direct effect on endemic bird richness.Conclusions:Our results indicate that endemic birds in China concentrate in southwest regions where there are stable glacial-interglacial temperature,more plant species and larger altitudinal range.Notably,while stable climate has strong direct effects on both endemic bird richness and endemic bird ratio,plant species may affect endemic bird richness through its effect on overall bird species richness.Importantly,the recent anthropogenic activities have also significantly intensified in this region,which would pose huge challenge for biodiversity conservation in China. | Gang Feng Xiongwei Huang Lingfeng Mao Na Wang Xueting Yang Yanping Wang | 2020 | Avian Research2020，11，2： | 0 |
| 17 | Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells显示文摘Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment.We tested the potential effect of apigenin,a natural flavonoid with anticancer,anti-inflammatory,and antioxidant activities,on neomycin-induced ototoxicity in cochlear hair cells in vitro.Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation of reactive oxygen species upon neomycin injury.Further evidence suggested that the nuclear factor erythroid 2-related factor 2(Nrf2)signaling pathway was activated by apigenin treatment.Disruption of the Nrf2 axis abolished the effects of apigenin on the alleviation of oxidative stress and subsequent apoptosis of hair cells.This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying mechanism. | Gaogan Jia Huanyu Mao Yanping Zhang Yusu Ni Yan Chen | 2022 | Frontiers of Medicine2022，16，4： | 0 |
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