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您的检索式：作者名="Yangling Mu"
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| 1 | Neural stem cells:mechanisms and modeling显示文摘In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb.Neurons derived from these stem cells contribute to learning,memory,and the autonomous repair of the brain under pathological conditions.Hence,the physi-ology of adult neural stem cells has become a signifi-cant component of research on synaptic plasticity and neuronal disorders.In addition,the recently developed induced pluripotent stem cell technique provides a powerful tool for researchers engaged in the patho-logical and pharmacological study of neuronal disor-ders.In this review,we briefly summarize the research progress in neural stem cells in the adult brain and in the neuropathological application of the induced pluripotent stem cell technique. | Jun Yao Yangling Mu Fred H.Gage | 2012 | Protein & Cell2012，3，4： | 12 |
| 2 | A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells显示文摘 | Maria C.N. Marchetto Cassiano Carromeu Allan Acab Diana Yu Gene W. Yeo Yangling Mu Gong Chen Fred H. Gage Alysson R. Muotri | 2010 | Cell2010，，4： | 1 |
| 3 | Neural stem cells:mechanisms and modeling显示文摘Erratum to:Protein Cell 2012,3(4):251-261 DOI 10.1007/s13238-012-2033-61.'In the adult brain,neural stem cells have been found in two major niches:the hippocampus and the olfactory bulb'should be changed to:'In the adult brain,neural stem cells have been found in two major niches:the dentate gyrus and the subventricular zone'in the first sentence in the abstract. | Jun Yao Yangling Mu Fred H.Gage | 2012 | Protein & Cell2012，3，7： | 0 |
| 4 | Basal Forebrain Cholinergic Innervation Induces Depression-Like Behaviors Through Ventral Subiculum Hyperactivation显示文摘Malfunction of the ventral subiculum(vSub),the main subregion controlling the output connections from the hippocampus,is associated with major depressive disorder(MDD).Although the vSub receives cholinergic innervation from the medial septum and diagonal band of Broca(MSDB),whether and how the MSDB-to-vSub cholinergic circuit is involved in MDD is elusive.Here,we found that chronic unpredictable mild stress(CUMS)induced depression-like behaviors with hyperactivation of vSub neurons,measured by c-fos staining and whole-cell patch-clamp recording.By retrograde and anterograde tracing,we confirmed the dense MSDB cholinergic innervation of the vSub.In addition,transient restraint stress in CUMS increased the level of ACh in the vSub.Furthermore,chemogenetic stimulation of this MSDB-vSub innervation in ChAT-Cre mice induced hyperactivation of vSub pyramidal neurons along with depression-like behaviors;and local infusion of atropine,a muscarinic receptor antagonist,into the vSub attenuated the depression-like behaviors induced by chemogenetic stimulation of this pathway and CUMS.Together,these findings suggest that activating the MSDB-vSub cholinergic pathway induces hyperactivation of vSub pyramidal neurons and depression-like behaviors,revealing a novel circuit underlying vSub pyramidal neuronal hyperactivation and its associated depression. | Nana Yu Huina Song Guangpin Chu Xu Zhan Bo Liu Yangling Mu Jian-Zhi Wang Yisheng Lu | 2023 | Neuroscience Bulletin2023，39，4： | 0 |
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