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| 1 | Assessment of Point and Nonpoint Sources Pollution in Songhua River Basin,Northeast China by Using Revised Water Quality Model显示文摘Individual participation of pollutants in the pollution load should be estimated even if roughly for the appropriate environmental management of a river basin.It is difficult to identify the sources and to quantify the load, especially in modeling nonpoint source.In this study a revised model was established by integrating point and nonpoint sources into one-dimensional Streeter-Phelps(S-P) model on the basis of real-time hydrologic data and surface water quality monitoring data in the Jilin Reach of the Songhua River Basin.Chemical oxygen demand(COD) and ammonia nitrogen(NH 3-N) loads were estimated.Results showed that COD loads of point source and nonpoint source were 134 958 t/yr and 86 209 t/yr, accounting for 61.02% and 38.98% of total loads, respectively.NH 3-N loads of point source and nonpoint source were 16 739 t/yr and 14 272 t/yr, accounting for 53.98% and 46.02%, respectively.Point source pollution was stronger than nonpoint source pollution in the study area at present.The water quality of upstream was better than that of downstream of the rivers and cities.It is indispensable to treat industrial wastewater and municipal sewage out of point sources, to adopt the best management practices to control diffuse pollutants from agricultural land and urban surface runoff in improving water quality of the Songhua River Basin.The revised S-P model can be successfully used to identify pollution source and quantify point source and nonpoint source loads by calibrating and validating. | YANG Yuhong YAN Baixing SHEN Wanbin | 2010 | Chinese Geographical Science2010，20，1： | 13 |
| 2 | Compound Zhebei granules combined with chemotherapy for the treatment of refractory acute leukemia: a randomized clinical trial显示文摘OBJECTIVE: To observe the effect of compound Zhebei granules(CZBG) with chemotherapy in the treatment of refractory acute leukemia.METHODS: In this multicenter, double-blind, placebo-controlled clinical trial, we used a central(online) randomization system to assign 235 patients to two treatment groups. A total of 118 patients received chemotherapy combined with CZBG(4 g,twice daily) and 117 patients received chemotherapy plus placebo. The clinical efficacy was evaluated at the end of one chemotherapeutic cycle.RESULTS: In the full analysis set, in which deaths due to disease progression were regarded as inefficacy, the rates of complete remission(CR) and partial remission(CR + PR) were 32.35% and 50.00%,respectively, for the chemotherapy combined with CZBG group, and 23.08% and 35.58%, respectively,for the chemotherapy plus placebo group. There was a statistically significant difference between the two groups according to a ysis set(PPχ2test(P < 0.05). In the per protocol analS), the CR(33.67%),CR+PR(52.04%) response rates for the chemotherapy plus CZBG group were significantly different from the response rates of the control group(CR:24.24% and CR+PR: 37.37%), respectively(P < 0.05).CONCLUSION: CZBG plus chemotherapy can improve the clinical remission rate of refractory acute leukemia after one just one therapeutic cycle. | Hou Li Yang Shulian Yang Wenhua Zhou Yuhong Liu Feng Yang Hongyong Sun Weizheng Li Dongyun Xu Yamei Chen Xinyi | 2016 | Journal of Traditional Chinese Medicine2016，36，5： | 13 |
| 3 | Pyrolysis of oil at high temperatures:Gas potentials,chemical and carbon isotopic signatures显示文摘Although the gas cracked from oil has been believed to be one of the important sources in highly matured marine basins, there are still some debates on its resource potentials and chemical and isotopic compositions. In this study a Cambrian-sourced marine oil sample from the Silurian reservoir of well TZ62 in the central Tarim basin was pyrolyzed using sealed gold tubes with two different pyrolysis schemes: continuous pyrolysis in a closed system and stepwise semi-open pyrolysis. The results show that the maximum weight yield of C1-5 gases occurs at EasyRo=2.3% and the residual gas poten-tial after this maturity is only 43.4 mL/g, about 12% of the yield of 361 mL/g at EasyRo=2.3%. Combined with the results of kinetic modeling, the main stage of gas generation from oil cracking is believed within the EasyRo=1.6%―2.3%. The increase in the volume yield of C1-5 gases at EasyRo>2.3% in a closed system is mainly related to the re-cracking of previously formed C2-5 wet gases, not the direct cracking of oil. The stepwise pyrolysis experiments show that the gas from the cracking of residual oil at EasyRo>2.3% is characterized by very high dryness index (higher than 92%) and heavy methane carbon isotopes ranging from ?28.7‰ to ?26.7‰, which is quite different from the gases from the con-tinuous pyrolysis in a closed system. The kinetic modeling of methane carbon isotope fractionation shows that the carbon isotopes of methane within the main stage of gas generation (EasyRo<2.3%) are far lighter than the carbon isotopes of the precursor oils under a geological heating rate of 2 ℃ /Ma. The above observations and results provide some new clues to the accurate recognition and objective resource evaluation of oil cracking gas in highly mature marine basins. | TIAN Hui XIAO XianMing YANG LiGuo XIAO ZhongYao GUO LiGuo SHEN JiaGui LU YuHong | 2009 | Chinese Science Bulletin2009，54，7： | 12 |
| 4 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 5 | Comparison analysis between haplo identical stem cell transplantation and matched sibling donor stem cell transplantation for high-risk acute myeloid leukemia in first complete remission显示文摘In order to compare the effect between haploidentical(HID) stem cell transplantation(HSCT) and matched sibling donor(MSD)stem cell transplantation for high-risk acute myeloid leukemia(AML) in first complete remission status(CR1), we retrospectively studied 170 cases who received stem cell transplantation from Jan 2008 to Jul 2015 in Peking University People's Hospital. We divided all cases into MSD group(43 cases) and HID(127 cases) group. Patients in HID and MSD group displayed similar baseline characteristics except for age distribution. There were no statistic differences for overall survival(OS), cumulative incidence of relapse, leukemia free survival(LFS), transplantation related mortality(TRM) between HID and MSD group. The 3-year OS, LFS for all patients was 63.9% and 59.7% respectively. Multivariate analysis showed that grade III-IV acute graft versus host disease(aGVHD) was an independent risk factor for treatment related mortality(HR=8.134, 95% CI:3.210–20.611, P<0.001), monosomy/complex chromosomal karyotype and white blood cell count more than 50×109 L-1 were two independent factors for relapse(HR=1.533, 95% CI: 1.040–2.260, P=0.031)(HR=1.004, 95% CI: 1.001–1.008, P=0.015).Grade III-IV aGVHD was an independent factor for mortality(HR=3.184, 95% CI: 1.718–5.902, P<0.001). These results demonstrated some risk factors for high-risk AML leukemia transplantation and indicated for AML patients in CR1 status, haplo stem cell transplantation could have the same therapeutic effect as MSD transplantation. | Yang Liu Xiaojun Huang Qian Fei Lanping Xu Xiaohui Zhang Kaiyan Liu Yuhong Chen Huan Chen Yu Wang | 2019 | Science China(Life Sciences)2019，62，5： | 9 |
| 6 | Self-Assembled Silane Film and Silver Nanoparticles Coating on Magnesium Alloys for Corrosion Resistance and Antibacterial Applications显示文摘Contamination resulting from microbial adhesion on magnesium alloys is very common in many applications.Self-assembly technology was employed to prepare an antibacterial composite coating by fixing silver nanoparticles(AgNPs)onto the surface of magnesium alloys.The AgNPs were immobilized on the surface of3-aminopropyltrimethoxysilane(APTMS)-modified magnesium alloy AZ31(APTMS/Mg)through electrostatic inter-attraction between partially protonated amino groups and negatively charged citrate-capped AgNPs,resulting in the AgNPs attached APTMS/Mg(AgNPs/APTMS/Mg)substrate.The prepared Ag colloid and functionalized AZ31 alloy were characterized by ultraviolet-visible(UV-vis)spectroscopy,Fourier transform infrared(FTIR)spectroscopy,scanning electron microscopy(SEM),and electrochemical methods.Finally,the bactericidal activity of AgNPs/APTMS/Mg substrate against Escherichia coli was assessed by the inhibition zone.The results demonstrated that Si-O-Si covalent bonds existed on the substrate with the formation of inorganic Si-O-Mg bonds.AgNPs were immobilized and well-dispersed,forming a uniform submonolayer on the silane film in two dimensions.The AgNPs/APTMS-pretreated AZ31 alloys exhibited better corrosion resistance and excellent antibacterial performance. | Rongchang ZENG Lijun LIU Shuoqi LI Yuhong ZOU Fen ZHANG Yanan YANG Hongzhi CUI En-hou HAN | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，6： | 8 |
| 7 | Extreme precipitation events in East China and associated moisture transport pathways显示文摘Interannual variation of summer precipitation in East China, and frequency of rainstorms during the monsoon season from 1961 to 2010, are analyzed in this study. It is found that the two variables show opposite trends on a decadal time scale: frequency of rainstorms increases significantly after the 1990 s, while summer precipitation in East China decreases during the same period. Analysis of the spatial distribution of summer rainstorm frequency from 1961 to 2010 indicates that it decreases from the southeast to the northwest at the east edge of the large-scale topography associated with the plateaus. Spatial distribution of rainstorms with daily rainfall greater than 50 mm is characterized by a 'high in the southeast and low in the northwest' pattern, similar to the staircase distribution of the topography. However, the spatial distribution of variation in both summer precipitation and frequency of extreme rainstorms under global warming differs significantly from the three-step staircase topography. It is shown that moisture characteristics of summer precipitation and extreme rainstorms during the monsoon season in East China, including moisture transport pathways, moist flow pattern, and spatial structure of the merging area of moist flows, differ significantly. Areas of frequent rainstorms include the Yangtze River Valley and South China. Column-integrated moisture transport and its spatial structure could be summarized as a 'merging' of three branches of intense moist flows from low and middle latitude oceans, and 'convergence' of column-integrated moisture fluxes. The merging area for moist flow associated with rainstorms in the high frequency region is located slightly to the south of the monsoonal precipitation or non-rainstorm precipitation, with significantly strong moisture convergence. In addition, the summer moist flow pattern in East China has a great influence on the frequency of extreme rainstorms. Moisture flux vectors in the region of frequent rainstorms correspond to vortical flow pattern. A comparison of moisture flux vectors associated with non-rainstorms and rainstorms indicates that the moist vortex associated with rainstorms is smaller in size and located to the south of the precipitation maximum, while the moist vortex associated with non-rainstorms is larger and located to the north. It is shown that column-integrated moist transport vortices and the structure of moist flux convergence have significant impacts on the north-south oscillation of frequent rainstorm areas in East China, which is synchronized with the maximum vorticity of moisture transport and the minimum of convergence on the decadal time scale. Synthesis of moisture transport pathways and related circulation impacts leads to a conceptual model of moisture flow associated with rainstorms. | ZHAO Yang XU XiangDe ZHAO TianLiang XU HongXiong MAO Fei SUN Han WANG YuHong | 2016 | Science China Earth Sciences2016，59，9： | 8 |
| 8 | U-Pb Zircon Age, Geochemical, and Sr-Nd-Pb Isotopic Constraints on the Age and Origin of Mafic Dykes from Eastern Shandong Province, Eastern China显示文摘U-Pb 锆石年龄, geochemical,和从东方山东省的 mafic 女同性恋的 Sr-Nd-Pb 同位素的数据,东方中国此处被报导。激光脱离诱导地联合了从调查 mafic 女同性恋的二件样品的 U-Pb 锆石分析产出一致年龄从 121.9 妈的血浆团 spectrometry (LA-ICP-MS )?????? 猠潨桳湯瑩捩吗? | LIU Shen HU Ruizhong FENG Caixia GAO Shan FENG Guangying LAI Shaocong QI Youqiang Ian M. COULSON YANG Yuhong YANG Chaogui TANG Liang | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 7 |
| 9 | Variation of Antarctic seal population in response to human activities in the 20th century显示文摘A sediment core was collected from the Fildes Peninsula of Antarctica, which contained numerous seal hairs and was identified to be seal excrement deposition. By analyzing its total organic carbon (TOC) and concentrations of bio-elements, the seal population changes of the past century were reconstructed. The variation of seal population in the last century on the Fildes Peninsula is primarily controlled by human activities. The sealing industry in the early 20th century caused the dramatic decline of seal popula-tion. The protection of the Antarctic seals since the 1960s and the reduced seal's competition with whales for prey resources due to whaling lead to the recovery of seal population and make the high level of the seal population sustainable. | YANG QiChao SUN LiGuang KONG DeMing HUANG Tao WANG YuHong | 2010 | Chinese Science Bulletin2010，55，11： | 7 |
| 10 | Genome-wide identification of OSCA gene family and their potential function in the regulation of dehydration and salt stress in Gossypium hirsutum显示文摘Background:Cotton(Gossypium hirsutum) provides the largest natural fiber for the textile manufacturing industries,but its production is on the decline due to the effects of salinity.Soil salt-alkalization leads to damage in cotton growth and a decrease in yields.Hyperosmolality-gated calcium-permeable channels(OSCA) have been found to be involved in the detection of extracellular changes which trigger an increase in cytosolic free calcium concentration.Hyperosmolality-induced calcium ion increases have been widely speculated to be playing a role in osmosensing in plants.However,the molecular nature of the corresponding calcium ion channels remains unclearly.In this research work,we describe the OSCA genes and their putative function in osmosensing in plants by carrying out genomewide identification,characterization and functional analysis of the significantly up-regulated OSCA gene,GhOSCA1.1 through reverse genetics.Result:A total of 35,21 and 22 OSCA genes were identified in G.hirsutum,G.arboreum,and G.raimondii genomes,respectively,and were classified into four different clades according to their gene structure and phylogenetic relationship.Gene and protein structure analysis indicated that 35 GhOSCA genes contained a conserved RSN17 TM(PF02714) domain.Moreover,the cis-regulatory element analysis indicated that the OSCA genes were involved in response to abiotic stress.Furthermore,the knockdown of one of the highly up-regulated genes,GhOSCA1.1 showed that the virus-induced gene silenced(VIGS) plants were highly sensitive to dehydration and salinity stresses compared with the none VIGS plants as evident with higher concentration levels of oxidant enzymes compared with the antioxidant enzymes on the leaves of the stressed plants.Conclusion:This study provides the first systematic analysis of the OSCA gene family and will be important for understanding the putative functions of the proteins encoded by the OSCA genes in cotton.These results provide a new insight of defense responses in general and lay the foundation for further investigation of the molecular role played by the OSCA genes,thereby providing suitable approaches to improve crop performance under salinity and drought stress conditions. | YANG Xiu XU Yanchao YANG Fangfang MAGWANGA Richard Odongo CAI Xiaoyan WANG Xingxing WANG Yuhong HOU Yuqing WANG Kunbo LIU Fang ZHOU Zhongli | 2019 | Journal of Cotton Research2019，2，2： | 7 |
| 11 | Extraction of penicillin G by aqueous two-phase system of [Bmim]BF_(4)/NaH_(2)PO_(4)显示文摘A novel approach for the extraction of penicil-lin G by aqueous two-phase system comprised of hydrophilic ionic liquid [Bmim]BF4 (1-butyl-3- methylimidazolium tetra-fluoroborate) and NaH2PO4 is reported. The effects of some important parameters involving the concentration of NaH2PO4, the concentration of penicillin G, the amount of [Bmim]BF4 on the formation of aqueous two-phase system and the extraction yield of penicillin were investigated. The primary result shows that the ATPS can take advantage of penicillin concentrated in upper phase at higher pH value for penicillin extraction from its aqueous solution without emul-sification. | LIU Qingfen HU Xuesheng WANG Yuhong YANG Ping XIA Hansong YU Jiang LIU Huizhou | 2005 | Chinese Science Bulletin2005，50，15： | 6 |
| 12 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 13 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 14 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 15 | Effects of acrous gramineus and its component, alpha-asarone, on apoptosis of hippocampal neurons after seizure in immature rats显示文摘BACKGROUND: α-asarone and acrous gramineus have been shown to play a necessary function in enhancing the reactivity and convulsant threshold to electric stimulation of immature rats. They have also been shown to effectively suppress epileptic seizures induced by pentylenetetrazol in young rats. However, the mechanisms for these roles have been still unclear. OBJECTIVE: To observe the effects in immature rats of acrous gramineus and α-asarone on apoptosis of hippocampal neurons after epileptic seizure at the protein level, and to analyze the mechanism for these effects. DESIGN: A randomized controlled animal experiment. SETTINGS: Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, Norman Bethune Medical School of Jilin University; Department of Internal Medicine, Children's Hospital of Changchun City; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University. MATERIALS: Fifty 3-week old Wistar rats, 34-40 g, irrespective of gender, were provided by Gaoxin Research Center of Medical Animal Experiment, Changchun. The animals were treated according to the animal ethical standards. The following chemicals were used for this study: acrous gramineus powders or infusion (Batch No. 0307113, Tianjiang Medicine Company Limited, Jiangyin), α-asarone tablets (Batch No. 030219, Tianwei Pharmaceutical Factory, Shenyang), and phenobarbital sodium tablets (Batch No. 020608, Xinya Medicine Company Limited, Shanghai). The animals were divided into five groups randomly. First, ten rats were chosen as the normal controls. The remaining rats were treated with i.p. injections of pentylenetetrazol to stimulate an epileptic model. METHODS: The experiments were performed at the Neurological Laboratory of the First Hospital of Jilin University between October and December 2004. The rats were treated with i.p. injections of pentylenetetrazol (60 mg/kg) to establish an epileptic model. According to Racine' s standard, animals that reached stage 4 and 5 were chosen and randomly divided into 4 groups: model group, phenobarbital sodium, acrous gramineus, and α-asarone group. The normal control group was treated with an i.p. injection of physiological saline (0.5 mL). After modeling, the model groups were intragastrically administrated 0.5 mL saline. The phenobarbital sodium, acrous gramineus, and α -asarone groups were intragastrically administrated 18 mg/kg/d phenobarbital sodium, 2 350 mg/kg/d acrous gramineus and 29 mg/kg/d α -asarone, respectively. The course of treatment was twice a day for 7 days. The normal group received intragastric administration of 0.5 mL saline at the same time. The rats were sacrificed and brain sections were prepared for light microscopy and electron microscopy. MAIN OUTCOME MEASURES: ① Pathological changes of CA1 and CA3 hippocampal region neurons were observed by light microscopy and electronic microscopy. ② Neuronal apoptosis in the CA1 and CA3 region was measured by TUNEL staining. ③ Bcl-2 and Bax expression in CA1 and CA3 region neurons was detected by immunohistochemistry and a ratio of Bcl-2/Bax was calculated. RESULTS: All 50 immature rats were included in the final analysis. ① Pathological changes of CA1 and CA3 region hippocampal neurons: there were different pathological changes in all groups other than the normal control group. The number of damaged neurons in the model group was highest. The phenobarbital sodium, acrous gramineus, and α-asarone group exhibited different degrees of improvement. ② Neuronal apoptosis in the CA1 and CA3 regions: there were less TUNEL-positive cells in the CA1 and CA3 regions in the normal control group. One week after PTZ-induced seizure, numerous TUNEL-positive cells were detected in the CA1 and CA3 regions in the remaining four groups. There was a significant difference between the normal control group and the remaining four groups (t = 12.089-19.162, P < 0.01). The number of TUNEL-positive cells was less in the phenobarbital sodium, acrous gramineus, and α-asarone groupscompared to the model group (t = 4.707-6.268, P < 0.01). ③Bcl-2 and Bax expression of neurons in the CA1 and CA3 regions: The number of Bcl-2- and Bax-positive cells was less in the normal control group. The Bax-positive cells exhibited a normal shape and had large round nuclei that were predominant. One week after PTZ-induced epilepsy, the number of Bcl-2- and Bax-positive cells in the CA1 and CA2 regions was significantly increased in the remaining four groups compared to the normal control group (t = 11.606-27.042, P < 0.01). The Bax-positive cells exhibited a reduced size and nuclear pyknosis was predominant. However, there was no significant difference among the four groups (P > 0.05). The number of Bcl-2-positive cells in the phenobarbital sodium, acrous gramineus, and α -asarone groups were significantly increased compared to the model group (t = 4.051-6.404, P < 0.01). However, the number of Bax-positive cells was not significantly different among the four groups. The ratio of Bcl-2 to Bax expression was approximately 6.0 in the normal controls, 0.7 in the model group, and 1.0 in the remaining three groups. CONCLUSION: Acrous gramineus and α-asarone increased Bcl-2 expression and decreased Bax expression, and also reduced the number of apoptotic hippocampal neurons during PTZ-induced epileptic seizures in immature rats. | Libin Yang Shulei Li Yanzhi Huang Jianmin Liang Yuhong Wang | 2008 | Neural Regeneration Research2008，3，1： | 4 |
| 16 | Human Health Risk Assessment Model of Organic Pollution in Groundwater:Shijiazhuang Industrial Zone显示文摘在这研究,一个基于风险的管理模型被开发并且适用于一个工业地区。模特儿由美国环境保护机构和汉被在在半衰期煮并且删除相关参数以后增加不稳定的有机化合物(VOC ) 的剩余比率一直在改进求婚了。用这个改进模型,一个综合过程被用来在学习区域估计人的健康风险水平。与水质量分析相比,结果强调在风险层次和水保护上为决策使用一条综合途径的重要性。这研究的结果表明了那:(1 ) 与在中国(GB 38382002 ) 和美国的国家的主要喝酒水规定的这些可允许的水平标准相比,居民的日常生活没被地下水在这个区域影响了(除了 HB34 和 HB36 的相对的坏水质量) ;(2 ) 所有地下水样品的典型检测器官的沾染物是氯仿,碳四氯化物, trichloroethylene 和 tetrachloroethene,并且污染来源主要是由初步的调查的工业来源;(3 ) 至于地下水,所有样品的 non-carcinogenic 风险价值不超过 1.0 的可允许的水平, carcinogenic 风险价值比对 1.00E-04 的 1.00E-06 的可允许的水平相对低;(4 ) 喝 trichloroethylene 和 tetrachloroethylene 的水小径主要贡献在学习区域增加居民的健康风险;(5 ) 以 non-carcinogenic,风险和 carcinogenic 冒险,为喝水小径的健康风险顺序和真皮的接触小径:喝的水小径 > 真皮的接触小径。 | YANG Mei FEI Yuhong JU Yiwen LI Huaqi | 2011 | Acta Geologica Sinica(English Edition)2011，85，6： | 4 |
| 17 | Effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on excisional wound healing in a rat's model显示文摘OBJEVTIVE: To investigate the effects of extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) on the excisional wound healing in a rat's model.METHODS: Rats were performed a surgical lesion with a 2.0 cm resected tissue in the dorsal fascia.Following, animals were randomly divided into model group, YNB group and APE group those were respectively treated with saline, 1 mg/mL of Yunnan Baiyao and 1 mg/mL of Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) extracts. Wound contractions in days 0, 3, 7, 14 and 21 were calculated by an image analyzer. Histological analysis was analyzed using hematoxilin and eosin.Levels of tumor necrosis factor-2(IL-2), IL-4, IL-10, transformαin(TNF-g growα), interleukinth factor-1(TGF-nd basic fibroblast growth factor(bFββ1) a-GF) were determined by real-time quantitative PCR.RESULTS: Compared with that of YNB group and APE gtoup, the skin of rats showed poor re-modeling and re-epithelization characterized by a significant decrease of neovascularization, epithelialization and fibroblast in the model group. In the APE group, levels of TNF-α-and IL-2 were significantly down-regulated and IL4 and IL-10 significantly upregulated in contrasted with that of model group.In addition, levels of TGF-roup were significantly iβ1 and bFGF in the APE gnduced compared with that of model group.CONCLUSION: The results suggest that the extracts from Chuanwu(Aconitum Carmichaelii) and Banxia(Rhizoma Pinelliae) promote wound healing in the rats, which is associated with enhancing antiinflammatory ability and inducing fibroblast formation. | Xia Xichao Ma Yuhong Wang Fuan Zheng Xinhua Liu Yang Zhang Junfeng Cui Juan Shi Bingqin Li Hongwen Liu Rongzhi Zhang Yaping Cheng Zhaofei Han Xiaolong | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 18 | A Model of Debris Flow Forecast Based on the Water-Soil Coupling Mechanism显示文摘Debris flow forecast is an important means of disaster mitigation. However, the accuracy of the statistics-based debris flow forecast is unsatisfied while the mechanism-based forecast is unavailable at the watershed scale because most of existing researches on the initiation mechanism of debris flow took a single slope as the main object. In order to solve this problem, this paper developed a model of debris flow forecast based on the water-soil coupling mechanism at the watershed scale. In this model, the runoff and the instable soil caused by the rainfall in a watershed is estimated by the distributed hydrological model(GBHM) and an instable identification model of the unsaturated soil. Because the debris flow is a special fluid composed of soil and water and has a bigger density, the density estimated by the runoff and instable soil mass in a watershed under the action of a rainfall is employed as a key factor to identify the formation probability of debris flow in the forecast model. The Jiangjia Gulley, a typical debris flow valley with a several debris flow events each year, is selected as a case study watershed to test this forecast model of debris flow. According the observation data of Dongchuan Debris Flow Observation and Research Station, CAS located in Jiangjia Gulley, there were 4 debris flow events in 2006. The test results show that the accuracy of the model is satisfied. | Shaojie Zhang Hongjuan Yang Fangqiang Wei Yuhong Jiang Dunlong Liu | 2014 | Journal of Earth Science2014，25，4： | 4 |
| 19 | TOWARDS MORE EFFECTIVE PRONUNCIATION TEACHING显示文摘While pronunciation instruction is going through somerevolutionary change in the international TESL field,mostteachers in China still keep to the traditional approach,which isbelieved to give priority to the wrong aspects of pronunciation.This paper aims to help teachers update theoretical knowledgeand beliefs about pronunciation teaching and,through areasonable integration of various findings,search for ways toimprove the effectiveness of pronunciation teaching at thetertiary level in China. | Yang Yuhong Suzhou Railway Teachers’College | 2001 | Chinese Journal of Applied Linguistics2001，24，2： | 4 |
| 20 | Effects of acrous gramimeus and its main component alpha-asarone on the reactivity and convulsive threshold of immature rats to electric stimulation显示文摘BACKGROUND: The traditional Chinese medicine acrous gramimeus is the dry rhizome of Acrous gramimeus Soland, a kind of Araceae familial perennial herb, which has a sedation action, anticonvulsant and antiepileptic effect. Its effective component has not been known yet, and α-asarone, the major component of the volatile oil extracted from acrous gramineus, has been supposed to play a necessary role in it. OBJECTIVE: To explore the effects of acrous gramimeu and α-asarone on the reactivity and convulsive threshold to electric stimulation in immature rats, furthermore, attempt to definitize the anticonvulsant effect of αasarone. DESIGN: A randomized controlled study. SETTINGS: Department of Pediatrics, First Hospital of Jilin University; Department of Histology and Embryology, School of Basic Medical Sciences of Jilin University; Department of Neurology, First Clinical Hospital affiliated to Harbin Medical University; Department of Internal Medicine, Children’s Hospital of Changchun City. MATERIALS: Seventy 3-week immature Wistar rats (either males or females) of 34-40 g were used. Acrous gramimeu (1 g/bag, the content of α-asarone was 0.046 26%-0.070 16%) with the batch number of 0307113 was provided by Tianjiang Medicine Company Limited, Jiangyin City. α-asarone tablet (60 mg per tablet) with the batch number of 030219 was provided by Tianwei Pharmaceutical Factory, Shenyang City. α-asarone injectable preparation (2 mL per piece) with the batch number of 030105 was provided by Shuanghe Medicine Limited Company, Beijing City. METHODS: The experiments were carried out in the Neurological Laboratory of the First Hospital of Jilin University between August and October in 2004. ① The 70 rats were randomly divided into intragastric subset and intraperitoneal subset. The intragastric subset included four groups of control, phenobarbital sodium, acrous gramimeu and α-asarone; the intraperitoneal subset included three groups of control, phenobarbital sodium and α-asarone. There were 10 rats per group. ② In the intragastric subset, different group was treated with saline (1 mL for each time, phenobarbital sodium (18 mg/kg per day), acrous gramineu (2 350 mg/kg per day) and α-asarone (29 mg/kg per day) respectively twice every day for 5 days. In the intraperitoneal subset, different group was treated with saline (0.5 mL), phenobarbital sodium (29 mg/kg) and α-asarone (2.9 mg/kg) respectively. ③ Before and after administration for 5 days in the intragastric subset as well as before and after administration for about 1 hour in the intraperitoneal subset respectively, the rats were given electric stimulation with the NIHOM KOMDEM multifunctional electrophysiological recorder, and the reactivity and convulsive threshold to electric stimulation of the rats were recorded. MAIN OUTCOME MEASURES: The reactivity and convulsive threshold to electric stimulation in immature rats were compared. RESULTS: All the rats were involved in the analysis of results. ① Results for intragastric administration: Before intragastric administration, there were no obvious differences in the reactivity and convulsive threshold to electric stimulation among the groups (P > 0.05). After intragastric administration for 5 days, the reactivity and convulsive threshold to the electric stimulation had no obvious changes in the control group, but those were significantly higher than before administration in the drug administration groups (t=3.317-7.401, P < 0.01), which were also obviously higher than those in the control group (t=3.027-8.941, P < 0.01), and those in the acrous gramimeu group and α-asarone group were not markedly different from those in the phenobarbital sodium group. ② Results for intraperitoneal injection: Before intraperitoneal injection, the reactivity and convulsive threshold to the electric stimulation had no obvious differences among the groups. After the intraperitoneal injection for 1 hour, the reactivity and convulsive threshold to the electric stimulation had no obvious change in the control group, but those were significantly higher than before administration in the drug administration groups (P < 0.01), which were also obviously higher than those in the control group (t=6.211-7.237, P < 0.01; t=4.085-5.633, P < 0.05), and there was no marked difference between α-asarone group and phenobarbital sodium group (P > 0.05). CONCLUSION: ① As effective anticonvulsants, both acrous gramineu and α-asarone can enhance the reactivity and convulsive threshold of immature rats to electric stimulation. ② As one of the major effective components against convulsion of acrous gramineu, α-asarone is equivalent to phenobarbital sodium. | Libin Yang Shulei Li Yuhong Wang Yanzhi Huang | 2006 | Neural Regeneration Research2006，1，1： | 3 |
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