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| 1 | Pyrolysis of oil at high temperatures:Gas potentials,chemical and carbon isotopic signatures显示文摘Although the gas cracked from oil has been believed to be one of the important sources in highly matured marine basins, there are still some debates on its resource potentials and chemical and isotopic compositions. In this study a Cambrian-sourced marine oil sample from the Silurian reservoir of well TZ62 in the central Tarim basin was pyrolyzed using sealed gold tubes with two different pyrolysis schemes: continuous pyrolysis in a closed system and stepwise semi-open pyrolysis. The results show that the maximum weight yield of C1-5 gases occurs at EasyRo=2.3% and the residual gas poten-tial after this maturity is only 43.4 mL/g, about 12% of the yield of 361 mL/g at EasyRo=2.3%. Combined with the results of kinetic modeling, the main stage of gas generation from oil cracking is believed within the EasyRo=1.6%―2.3%. The increase in the volume yield of C1-5 gases at EasyRo>2.3% in a closed system is mainly related to the re-cracking of previously formed C2-5 wet gases, not the direct cracking of oil. The stepwise pyrolysis experiments show that the gas from the cracking of residual oil at EasyRo>2.3% is characterized by very high dryness index (higher than 92%) and heavy methane carbon isotopes ranging from ?28.7‰ to ?26.7‰, which is quite different from the gases from the con-tinuous pyrolysis in a closed system. The kinetic modeling of methane carbon isotope fractionation shows that the carbon isotopes of methane within the main stage of gas generation (EasyRo<2.3%) are far lighter than the carbon isotopes of the precursor oils under a geological heating rate of 2 ℃ /Ma. The above observations and results provide some new clues to the accurate recognition and objective resource evaluation of oil cracking gas in highly mature marine basins. | TIAN Hui XIAO XianMing YANG LiGuo XIAO ZhongYao GUO LiGuo SHEN JiaGui LU YuHong | 2009 | Chinese Science Bulletin2009，54，7： | 12 |
| 2 | Improvement and application of GM(1,1) model based on multivariable dynamic optimization显示文摘For the classical GM(1,1)model,the prediction accuracy is not high,and the optimization of the initial and background values is one-sided.In this paper,the Lagrange mean value theorem is used to construct the background value as a variable related to k.At the same time,the initial value is set as a variable,and the corresponding optimal parameter and the time response formula are determined according to the minimum value of mean relative error(MRE).Combined with the domestic natural gas annual consumption data,the classical model and the improved GM(1,1)model are applied to the calculation and error comparison respectively.It proves that the improved model is better than any other models. | WANG Yuhong LU Jie | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 11 |
| 3 | Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia显示文摘Objective: To investigate the association between the T cell inhibitory receptor programmed death 1(PD-1)and T cell exhaustion status in T cells from patients with de novo acute myeloid leukemia(AML) and AML in complete remission(CR).Methods:Surface expression of PD-1 and the exhaustion and immunosenescence markers CD244 and CD57 on CD3+,CD4+ and CD8+ T cells from peripheral blood samples from 20 newly diagnosed,untreated AML patients and 10 cases with AML in CR was analyzed by flow cytometry.Twenty-three healthy individuals served as control.Results:A significantly higher percentage of PD-1+ cells were found for CD3+ T cells in the de novo AML group compared with healthy controls.In addition,an increased level of PD-1+ CD8+ T cells,but not PD-1+ CD4+,was found for CD3+ T cells in the de novo AML and AML-CR samples.A higher percentage of CD244+ CD4+,CD244+ CD8+,CD57+ CD4+ and CD57+ CD8+ T cells was found in CD3+ T cells in samples from those with de novo AML compared with those from healthy controls.Strong increased PD-1+ CD244+ and PD-1+ CD57+ coexpression was found for CD4+ and CD8+ T cells in the de novo AML group compared with healthy controls.Conclusions:We characterized the major T cell defects,including co-expression of PD-1 and CD244,CD57-exhausted T cells in patients with de novo AML,and found a particular influence on CD8+ T cells,suggesting a poor anti-leukemia immune response in these patients. | Jiaxiong Tan Shaohua Chen Yuhong Lu Danlin Yao Ling Xu Yikai Zhang Lijian Yang Jie Chen Jing Lai Zhi Yu Kanger Zhu Yangqiu Li | 2017 | Chinese Journal of Cancer Research2017，29，5： | 10 |
| 4 | The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells显示文摘Neogambogic 酸(NGA ) ,在 garcinia 的活跃成分,能在 anticancer 效果禁止一些稳固的肿瘤和结果的生长。我们假设那 NGA 可能为人的乳癌房间线 MCF-7 房间的增长的抑制负责。在 vitro 调查它的 anticancer 机制, MCF-7 房间与 NGA 的各种各样的集中被对待。试金显示出的 MTT (甲基 thiazolyl tetrazolum ) 的结果有 NGA 的那治疗显著地以一种剂量依赖者方式减少了 MCF-7 房间的增长。NGA 能增加 anti-apoptotic 蛋白质 Bcl-2 的表示由 mitochondrial transmembrane 损坏伴随了的 apoptosis 相关的蛋白质 FasL, caspase-3, caspase-8, caspase-9,和 Bax 和减少的表示。MCF-7 房间上的 NGA 的 antiproliferative 效果由于 Fas/FasL 和细胞色素 C 小径的 G0/G1 拘捕,增加的 apoptosis 和激活。这些结果提供重要卓见进 NGA 通过损害乳癌房间的增长的细胞、分子的机制。 | Keming Wang Yuhong Tang Ming Sun Binbin Lu Hongqin Zhu Ou Ji Qun Shen | 2011 | Acta Biochimica et Biophysica Sinica2011，43，9： | 9 |
| 5 | Geochemical characteristics and accumulation of marine oil and gas around Halahatang depression,Tarim Basin,China显示文摘There exists a petroleum system rich of oil and gas around Halahatang depression,where the oil and gas possess obvious local distinctions of properties in different parts.The research proved that the discovered crude oil and natural gas in the region derived mainly from O2+3 source rock,and the differences of its properties were controlled by the oil and gas filling intensity.The comprehensive study result shows the oil and gas reservoirs of the region mainly underwent three important accumulation phases:late Caledonian-Early Hercynian epoch,late Hercynian epoch,and Yanshan-Himalayan epoch. In the first phase,the oil and gas derived mostly from Cambrian source rock,which formed the primary ancient oil reservoirs,then suffered strong degradation and remained a great quantity of pyrobitumen in the high position of Tabei uplift in the present.In the second phase,the O2+3 source rock of Manjia'er depression started its generation of hydrocarbon,which accumulated in the high position of Tabei uplift afterwards,and then biodegradated to heavy oil in the late Hercynian epoch.In the last phase,the O2+3 source rock of southern Halahatang depression and margin of Manjia'er depression started its peak of generating liquid hydrocarbon,which mostly accumulated in the trap formed before the Indo-China and Yanshan epoch,and in somewhere the heavy oil suffered dilutions in various degrees or serious gas invading,to lead to obvious crude oil divergence. | LU YuHong,XIAO ZhongYao,GU QiaoYuan&ZHANG QiuCha Research Institute of Exploration and Development,Tarim Oilfield Company,PetroChina,Korla 841000,China | 2008 | Science China Earth Sciences2008，51，S1： | 7 |
| 6 | The origin and distribution of natural gas in the frontal uplift area of the Kuqa depression,Tarim Basin显示文摘The frontal uplift of the Kuqa depression is an important oil and gas producing area. In this study, the distribution and origin of natural gas were discussed based on natural gas components and isotope data. The main components of natural gas were hydrocarbons with relatively high contents of C2+ component. Most gases were derived from terrestrial source rocks, and some came from marine rocks. The contents of non-hydrocarbon gases were high in the central part of the frontal uplift area and low in the two terminals. The distribution of oil composition was similar to that of natural gas, which was mainly controlled by the types of source rocks. Dry coefficient and maturity of natural gas in the frontal uplift were lower than those of gas in the Kelasu tectonic belt of the Kuqa depression, which was mainly affected by the difference of tectonic movements in both areas. In the frontal uplift, the traps were formed in the early stage and could capture the early formed oil and gas, and structural adjustment was slight in later stages, so the oil and gas could be effectively preserved. Multiperiodic oil and gas filling led to the complex distribution of natural gas. | CUI Jie ZHU Guangyou ZHANG Bin SU Jin LU Yuhong MA Chenglong | 2010 | Chinese Journal Of Geochemistry2010，29，3： | 5 |
| 7 | Total phenols, flavonoids, and procyanidins levels and total antioxidant activity of different Korean pine(Pinus koraiensis) varieties显示文摘Total phenols,flavonoids,procyanidins,and total antioxidant capacity,measured with ferric reducing antioxidant power,radical scavenging capacity,and oxygen radical absorption capacity assays were first evaluated in the extracts of the shells,skins and kernels of 10 varieties of Pinus koraiensis.Results indicate that these varieties had strong radical scavenging capacities,ferric reducing antioxidant power and oxygen radical absorption capacities.Phenolic,flavonoid and procyanidin values ranged from 138.6(#3 kernel)to 518.6(#10 shell)mg GAE/g,from 23.3(#2 kernel)to 70.8(#5 skin)mg RE/g,from 2.5(#2 kernel)to 142.1(#7 skin)mg CE/g,respectively.Radical scavenging capacity and ferric reducing antioxidant power values were positively correlated to the polyphenol contents which play a major role in antioxidant properties.The varieties may be divided into two groups by cluster analysis and the variables being measured.These results will be useful for breeding varieties and guiding their production. | Sitong Zhang Ligang Zhang Lu Wang Yuhong Zhao | 2019 | Journal of Forestry Research2019，30，5： | 5 |
| 8 | Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc显示文摘Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity,but the underlying molecular mechanisms remain incompletely understood.In this study,Sin1,a key component of mTOR complex 2(mTORC2),specifically regulates B cell growth and metabolism.Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism.Sin1 deficiency also severely impairs B-cell proliferation,antibody responses,and anti-viral immunity.At the molecular level,Sin1 controls the expression and stability of the c-Myc protein and maintains the activity of mTORC1 through the Akt-dependent inactivation of GSK3 and TSC1/2,respectively.Therefore,our study reveals a novel and specific role for Sin1 in coordinating the activation of mTORC2 and mTORC1 to control B cell growth and metabolism. | Man Li Adam S.Lazorchak Xinxing Ouyang Huihui Zhang Hongzhi Liu Omotooke A.Arojo Lichong Yan Jingsi Jin Yuheng Han Guojun Qu Yuhong Fu Xiaocao Xu Xiaobo Liu Wenqian Zhang Zhengfeng Yang Chuan Ruan Qijun Wang Dou Liu Chuanxin Huang Lu Lu Shibo Jiang Fubin Li Bing Su | 2019 | Cellular & Molecular Immunology2019，16，9： | 4 |
| 9 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 10 | Achievement of a near-perfect smooth silicon surface显示文摘During the ultra large scale integration(ULSI)process,the surface roughness of the polished silicon wafer plays an important role in the quality and rate of production of devices.In this work,the effects of oxidizer,surfactant,polyurethane pad and slurry additives on the surface roughness and topography of chemical-mechanical planarization(CMP)for silicon have been investigated.A standard atomic force microscopy(AFM)test method for the atomic scale smooth surface was proposed and used to measure the polished silicon surfaces.Finally,compared with the theoretical calculated Ra value of 0.0276 nm,a near-perfect silicon surface with the surface roughness at an atomic scale(0.5)was achieved based on an optimized CMP process. | LI Jing LIU YuHong DAI YuanJing YUE DaChuan LU XinChun LUO JianBin | 2013 | Science China(Technological Sciences)2013，56，11： | 3 |
| 11 | A universal pipeline for mobile mRNA detection and insights into heterografting advantages under chilling stress显示文摘Heterografting has long been used to enhance the chilling tolerance of temperature-sensitive crops,including watermelon,whose mechanism is known to involve bidirectional long-distance mRNA movements.Despite several studies reporting on mobile mRNA(mb-mRNA)profiles in plants,accurate identification of mb-mRNAs is challenging owing to an array of technical problems.Here,we developed a bioinformatical pipeline that took most of the known technical concerns into consideration and is considered to be a universal tool for mb-mRNA detection in heterografts.By applying this pipeline to a commercial watermelon–bottle gourd heterografting system,we detected 130 and 1144 mb-mRNAs upwardly and 167 and 1051 mb-mRNAs downwardly transmitted under normal and chilling-stress conditions,respectively.Quantitative real-time PCR indicated a high accuracy rate(88.2%)of mb-mRNA prediction with our pipeline.We further revealed that the mobility of mRNAs was not associated with their abundance.Functional annotation and classification implied that scions may convey the stress signal to the rootstock,subsequently triggering energy metabolism reprogramming and abscisic acid-mediated stress responses by upward movement of effective mRNAs,ultimately leading to enhanced chilling tolerance.This study provides a universal tool for mb-mRNA detection in plant heterografting systems and novel insights into heterografting advantages under chilling stress. | Ying Wang Lingping Wang Nailin Xing Xiaohua Wu Xinyi Wu Baogen Wang Zhongfu Lu Pei Xu Ye Tao Guojing Li Yuhong Wang | 2020 | Horticulture Research2020，7，1： | 3 |
| 12 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 13 | Shallow Convolutional Neural Networks for Acoustic Scene Classification显示文摘最近,深神经的网络,它包括 convolutional 神经网络(CNN ) ,广泛地被用于声学的景色分类(ASC ) 。由一些简化 CNN 在深 CNN 上看了改进的事实激发了,例如视觉几何学组网(VGG 网) ,我们弄明白怎么与改进性能简化 VGG 网风格体系结构到浅 CNN。分享的马克斯和正规化也是的批申请了更好的精确性。与声学的场面和事件(DCASE ) 的察觉和分类上的一系列控制测试, 2016 数据设定,我们的浅 CNN 完成 6.7% 改进,并且把时间复杂性归结为 5% ,与 VGG 网风格 CNN 相比。 | LU Lu YANG Yuhong JIANG Yuzhi AI Haojun TU Weiping | 2018 | Wuhan University Journal of Natural Sciences2018，23，2： | 3 |
| 14 | Tunable tribological properties in water-based lubrication of water-soluble fullerene derivatives via varying terminal groups显示文摘In this paper,three kinds of water-soluble fullerene derivatives were synthesized via electrophilic addition reaction and cycloaddition reaction,respectively.The chemical composition characterizations of these derivatives indicated the successful preparation of C60(OH)x,C60(C(COOH)2)x and C60(OH)x(NHCH2COOH)y fullerene derivatives.The aggregation and morphology characterizations showed that the three kinds of derivatives had an ideal spherical aggregating structures and excellent dispersibility in water,especially C60(OH)x and C60(C(COOH)2) x.The lubrication performance of the fullerene derivatives acted as lubricant additives were investigated at different concentrations in the range of 0-1 wt%.The results indicated that the addition of polyhydroxyl and carboxylic derivatives could improve the lubrication properties,which led to the reduction of wear to about 40% at most.It is attributed that the optimized substitutions of fullerene molecules may be of benefit to their distribution properties and lubricating behaviors in water based lubrication. | LIU YuHong LIU PengXiao CHE Lu SHU ChunYing LU XinChun | 2012 | Chinese Science Bulletin2012，57，35： | 3 |
| 15 | Performance Evaluation of a Single Carrier UWB System with MSE Channel Estimation显示文摘 | LI Yuhong GE Ning LU Jianhua | 2010 | Chinese Journal of Electronics2010，19，1： | 2 |
| 16 | The System Performance for TD-LTE with Precoded MIMO显示文摘This paper introduces the rank adaptive precoded MIMO in TD-LTE downlink system. | Zhang Yong Jiang Dajie Shen Xiaodong Han Lu Liu Guangyi Cui Cunfeng Huang Yuhong | 2008 | China Communications2008，5，3： | 1 |
| 17 | 显示文摘 | Lu Yiqing Li Yongxiang Xiong Yuhong | 2004 | Microelectronics Journal2004，35，： | 1 |
| 18 | Disuccinimidyl suberate cross-linked hemoglobin as a novel red blood cell substitute显示文摘Disuccinimidyl suberate (DSS) intramolecularly cross-linked hemoglobin (Hb) was developed as a novel red blood cell substitute. A multi-angle laser light scattering detector coupled with size exclusion HPLC was applied to determine the molecular weight of the modified Hb. SDS-PAGE was also used as a complement. It was proved that 83.8% of the product was intramolecularly cross-linked Hb with weight-average molecular weights (Mw) of 67.5 kD, 12% was dimeric Hb with Mw of 146.6 kD, and 4.2% was trimeric Hb with Mw of 306.4 kD. The tetramer structure of the cross-linked Hb was stable as shown in size-exclusion chromatography using a mobile phase containing 1 mol/L MgCl2. Analysis by LC-MS demonstrated that the reaction of DSS with Hb mainly took place between the twoα subunits within a Hb molecule, resulting in stabilization of the tetramer structure. However, the cross-linking was not site-specific. The P50 of the cross-linked Hb decreased from 21.8 mmHg to 14.3 mmHg, and the Hill coefficient decreased from 2.22 to 1.41. Result of isoelectric focusing showed that the pI of DSS cross-linked Hb was in the range of 4.6-5.2, similar to that of serum albumin. The safety of DSS cross-linked Hb was favored by animal tests on rats and guinea pigs. Exchange transfusion experiment with DSS cross-linked Hb using rats as a model indicated no pressor effect or other significant side effects. The characteristics and properties of DSS cross-linked Hb were also compared with that of diaspirin cross-linked Hb reported in the literature. | LU Xiuling, ZHENG Chunyang, XU Yuhong & SU Zhiguo National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China School of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China | 2005 | Science China(Life Sciences)2005，48，1： | 1 |
| 19 | Region-based bas-relief generation from a single image显示文摘 | Qiong Zeng Ralph R. Martin Lu Wang Jonathan A. Quinn Yuhong Sun Changhe Tu | 2013 | Graphical Models2013，，： | 1 |
| 20 | Simulation experiments on secondary thermal stress of biodegraded bituminous sandstones显示文摘Secondary variation of reservoir is a hot problem in petroleum geochemistry field. Several kinds of secondary variations have taken place after the formation of bituminous sandstones in the Tarim Basin including biodegra-dation, washing, dissipation and secondary thermal stress. Biodegraded bituminous sandstones were used in the experiment. Pyrolysis experiment has been performed in a closed system, simulating secondary thermal stress with continual burial of Silurian bituminous sandstones which may cause the changes in molecular compositions, carbon isotope and physical properties of bituminous sandstones. The results are as follows: (i) Gases are mainly product during the experiment and carbon isotope of gas is lighter. (ii) Yield of C6+ hydrocarbon is relative smaller, and yielded oil is mainly light oil. (iii) Chromatogram character of biodegraded oil-sand is similar to that of saturated hydrocarbon in extracts from present-day bituminous sandstones, (iv) Porosity of bituminous sandstones gradually | GONG Se PENG Ping’an LU Yuhong XIAO Zhongyao JIA Wanglu WANG Zhenqi YU Chiling LIU Dehan LU Jialan LIU Jinzhong | 2004 | Chinese Science Bulletin2004，49，S1： | 1 |
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