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| 1 | Protein-Protein Interactions in the Regulation of WRKY Transcription Factors显示文摘自从一个 WRKY 抄写因素的第一份报告,现在是几乎 20 年, SPF1,从香甜的土豆。大进步从那以后在在植物生长,开发,和对关於生命、不能生活的应力的回答建立 WRKY 抄写因素的多样的生物角色被取得了。尽管有功能的差异,几乎所有分析 WRKY 蛋白质认出 TTGACC/T W 盒子序列并且,因此除核心 W 盒子倡导者元素的仅仅的识别以外的机制是必要的完成 WRKY 抄写因素的规章的特性。在过去的几年的研究表明了 WRKY 抄写因素身体上在发信号,抄写,并且染色质改变与角色与大量蛋白质交往。交往 WRKY 蛋白质的研究提供了重要卓见进抄写因素的重要家庭的成员的行动的规定和模式。稍微改变的 WRKY 领域和在每七个 WRKY 亚科以内保存的另外的蛋白质主题参予 proteinprotein 相互作用并且调停,这也出现了在 WRKY 蛋白质之间并且在在重要生物过程的调整的 WRKY 和另外的规章的蛋白质之间的复杂功能的相互作用。在这评论,我们为 WRKY 抄写因素总结 proteinprotein 相互作用的研究并且讨论交往的搭挡怎么作出贡献,到 WRKY 抄写因素的复杂规章、功能的网络的建立,在不同层次。 | Yingjun Chi Yan Yang Yuan Zhou Jie Zhou Baofang Fan Jing-Quan Yu Zhixiang Chen | 2013 | Molecular Plant2013，6，2： | 39 |
| 2 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 3 | Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression显示文摘Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose(150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain. | Jinhua Fu Yingjin Zhang Renrong Wu Yingjun Zheng Xianghui Zhang Mei Yang Jingping Zhao Yong Liu | 2014 | Neural Regeneration Research2014，9，5： | 10 |
| 4 | Preparation and evaluation of biomimetric nano-hydroxyapatite-based composite scaffolds for bone-tissue engineering显示文摘In the present study,novel biomimetic composite scaffolds with a composition similar to that of natural bone were prepared,using nano-hydroxyapatite,collagen,and phosphatidylserine.The scaffolds possess an interconnected porous structure with a porosity of 84%.The pore size ranges from several micrometers up to about 400 m.In-vitro studies in simulated body fluids showed that the morphologies of the products derived from mineralization can be regulated by the extracellular matrix components of the scaffolds;this in turn leads to creation of a large number of hydroxyapatite crystals on the scaffold surface.The regulatory properties of collagen and phosphatidylserine also influenced the cell response to the composite scaffolds.MC3T3-E1 cells attached and spread on the surfaces of the materials and interacted with the substrates;this may be the result of charged groups on the composite materials.Radiological analysis suggested that calluses and bone bridges formed in defects within 12 weeks.These composite scaffolds may therefore be a suitable replacement in bone-tissue engineering. | YANG ChunRong WANG YingJun CHEN XiaoFeng | 2012 | Chinese Science Bulletin2012，57，21： | 9 |
| 5 | Systematic characterization of transport and thermoelectric properties of a macroscopic graphene fiber显示文摘Graphene,有非凡的电、热、有弹性的性能的二维的材料,是未来技术的一个潜在的候选人。然而, graphene 的优异性质还没为 graphenederived 被认识到宏观的结构象 graphene 纤维那样。在这研究,我们系统地调查了温度(T) 依赖者运输和 graphene 纤维的热电的性质,包括热传导性() ,电的电导率() ,并且 Seebeck 系数(S) 。从 45.8 ~ 149.7 Wd | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Mincheng Yang Xing Zhang Chao Gao | 2016 | Nano Research2016，9，11： | 6 |
| 6 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 7 | Selection and experimental evaluation of shaking rods of canopy shaker to reduce tree damage for citrus mechanical harvesting显示文摘Canopy shaking system is one of the research hotspots for large-scale mechanized fruits harvesting.Shaking rods considered as one of the essential components of canopy shaker are responsible for transferring mechanical energy from shaking mechanism to different regions of tree canopy.This transfer depends on the characteristics of the shaking rods that directly strike the tree canopy.In order to evaluate the effects of the shaking rods on tree damage level and fruit removal percentage,three kinds of shaking rods with different materials or shapes were selected.Based on the results of bending deformation tests,it was proven that the rigid shaking rod(R_(1))with the material of Polyvinyl Chloride(PVC)did more resistance against producing bending deformation in comparison with the other two types of shaking rods with the material of Polyamide Nylon 12(PA).By contrast,the position close to the free end of the flexible shaking rod was easier to be deformed by less external force.In addition,dynamic analysis and vibration performance tests indicated that the rigid shaking rod could produce stronger vibration with higher shaking frequency of 4.8 Hz and maximum acceleration of 31.4 m/s^(2).Finally,the results of field trials indicated that the flexible bow-shaped shaking rod(R_(3))has a better widespread performance to achieve comparative higher fruit removal percentage up to 82.6%while producing lower tree damage rate of 5.36%.This study demonstrates that the materials or shapes of the shaking rod could significantly influence the fruit detachment rate and tree damage level.This study would provide an essential reference for the application of shaking rods for canopy shaker. | Yingjun Pu Arash Toudeshki Reza Ehsani Fuzeng Yang Jaafar Abdulridha | 2018 | International Journal of Agricultural and Biological Engineering2018，11，2： | 4 |
| 8 | Design and evaluation of a two-section canopy shaker with variable frequency for mechanical harvesting of citrus显示文摘Canopy shaking is one of the most commonly used techniques for mechanical harvesting of citrus fruits in orange juice industry.However,tree damage and low harvesting efficiency are the top concerns of growers in adopting the existing harvesting equipment on a large scale.The purpose of this research was to develop a novel canopy shaking system to minimize tree damage and maximize fruit removal for mechanical citrus harvesting.In this study,a two-section canopy shaker composing of top and bottom shaking systems mounted on two rotating drums was proposed and developed.It was configured with two sets of flexible bow-shaped shaking rods in a staggered distribution,which can shake the top and bottom zones of the tree canopy independently.The shaking system was designed based on a linked crank-rocker mechanism.Kinematic simulation analysis was conducted to verify the quick return characteristics and differential properties of this mechanism.Vibration test showed that the frequency of the shaking rod could be adjusted within a range of 1.1-8.8 Hz related to hydraulic motor speeds.The field tests of the shaking system with an average frequency of 4.7 Hz achieved a fruit removal percentage of 82.6%and tree damage rate of 5.4%under a tractor speed of 3 km/h.By contrast,the combined shaking frequency of 4.7 Hz&4.1 Hz of the canopy shaker produced less tree damage with a percentage of 3.9%.This study indicated that the two-section canopy shaker with an optimized frequency combination could be adaptable to the different zones of the tree canopy,and obtain lower tree damage and higher fruit removal percentage. | Yingjun Pu Arash Toudeshki Reza Ehsani Fuzeng Yang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 4 |
| 9 | Progress of Geological Survey Using Airborne Hyperspectral Remote Sensing Data in the Gansu and Qinghai Regions显示文摘Hyperspectral remote sensing is now a frontier of the remote sensing technology.Airborne hyperspectral remote sensing data have hundreds of narrow bands to obtain complete and continuous ground-object spectra.Therefore,they can be effectively used to identify | ZHAO Yingjun QIN Kai SUN Yu LIU Dechang TIAN Feng PEI Chengkai YANG Yanjie YANG Guofang ZHOU Jiajing | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 10 | Transient response of carbon nanotube integrated circuits显示文摘所有的频率反应的速度出版了碳 nanotube (CNT ) 集成电路(IC ) 远离那被预言。CNT IC 的短暂反应通过联合系统地被探索试验性并且模拟方法。互补 field-effect-transistor (联邦货物税) 基于 inverters 在单个半导体的 CNT 上被制作,并且动态反应测量显示它能仅仅以出人意料地低的速度工作,即与 30 s 的大繁殖延期。由于 CNT 联邦货物税的更大的产量抵抗,寄生电容的存在应该导致大部分更大抵抗电容(RC ) 在 Si IC 比那推迟。通过联合模拟和试验性的大小的详细分析,在 CNT 联邦货物税 IC 的实际速度下面拖的几种寄生电容一个一个地被识别,并且他们中的每通过 RC 延期在不同层次限制速度。从测量系统的寄生电容是主导的,这被发现,并且大 RC 延期降低 CNT 联邦货物税逻辑电路的速度到仅仅类似于试验性的结果的几 kHz。各种各样的优化计划被建议并且示威了最小化寄生电容的效果,并且因此改进 CNT IC 的速度。 | Panpan Zhang Yingjun Yang Tian Pei Chenguang Qiu Li Ding Shibo Liang Zhiyong Zhang Lianmao Peng | 2015 | Nano Research2015，8，3： | 2 |
| 11 | Whole-exome sequencing reveals twovariants in thegene in two Chinese patients with left ventricular non-compaction cardiomyopathy显示文摘Importance:Pathogenic variants in theRBM20 gene are associated with aggressive dilated cardiomyopathy(DCM).Recently,RBM20 was found to be associated with left ventricular non-compaction cardiomyopathy(LVNC).Thus far,only five families with LVNC have been reported to carry variants inRBM20.It remains unknown whether the variants inRBM20 associated with DCM can also cause LVNC.Objective:To elucidate the causativeRBM20 variant in two unrelated patients with both LVNC and DCM,and to identify the clinical characteristics associated with variants inRBM20.Methods:Trio whole-exome sequencing(WES)was performed.Variants were filtered and classified in accordance with the guidelines of the American College of Medical Genetics and Genomics(ACMG).Results:We identified two distinctde novo variants inRBM20(one per patient)in these two patients with LVNC.Both variants have been reported in patients with DCM,without the LVNC phenotype.Patient 1 was an 11-year-old girl who had DCM,LVNC,and heart failure;the ratio of noncompacted-to-compacted myocardium was 2.7:1.Ade novo heterozygous variant c.1907G>A(p.Arg636His)in exon 9 was identified in this patient.Patient 2 was a 13-year-old boy who had clinical phenotypes identical to those of Patient 1;the ratio of noncompacted-to-compacted myocardium was 3.2:1 in this patient.WES revealed ade novo heterozygous variant c.1909A>G(p.Ser637Gly)in exon 9.Both variants were previously characterized as pathogenic,and our study classified them as pathogenic variants based on the ACMG guidelines.Interpretation:We found that two patients with LVNC had variants inRBM20.Our results extended the clinical spectrum of the twoRBM20 variants and illustrated that the same variant inRBM20 can cause DCM,with or without the LVNC phenotype. | Qiqing Sun Jun Guo Chanjuan Hao Ruolan Guo Xuyun Hu Yuanying Chen Weili Yang Wei Li Yingjun Feng | 2020 | Pediatric Investigation2020，4，1： | 2 |
| 12 | Two new steroidal tetraglycosides from the rhizomes of Smilacina atropurpurea显示文摘Smilacina atropurpurea(family Convallariaceae)is a perennial herb used medicinally for the trea tment of lung ailments,rheumatism,menstrual disorders,and cuts and bruises,by the local people of its growing areas in southwest China.The tender aerial part has also been used as a wild vegetable by Lisu,Naxi and Tibetan people.Chemical analysis of the rhizomes of this plant has allowed us to isolate two new minor steroidal tetraglycosides,specifically atropurosides H(1) and I(2),by repeated column chromatography over silica gel and reversed phase silica.The structures were determined to be(25R,S)-12β-hydroxy-spirost-5-ene-3β-yl-O-β-D-glucopyranosy1-(1→2)-[β-D-xylopyranosyl-(1→3)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside(1)and(25S)-5α-spirost-17α-hydroxy-3β-yl-O-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopy-ranosyl-(1→4)-β-D-galacto pyranoside(2),respectively,on the basis of detailed spectroscopic analysis including ID and 2D NM R techniques. | Ying Zhang Haizhou Li Chongren Yang Yingjun Zhang | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 2 |
| 13 | 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration显示文摘Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone regeneration.However,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,making the structure design of scaffolds for bone repair challenging.To address this issue,we have carefully assessed diverse cell behaviors of bone mesenchymal stem cells(BMSCs)on theβ-tricalcium phosphate(β-TCP)scaffolds with three representative pore morphologies(i.e.,cross column,diamond,and gyroid pore unit,respectively).Among the scaffolds,BMSCs on theβ-TCP scaffold with diamond pore unit(designated as D-scaffold)demonstrated enhanced cytoskeletal forces,elongated nucleus,faster cell mobility,and better osteogenic differentiation potential(for example,the alkaline phosphatase expression level in D-scaffold were 1.5-2 times higher than other groups).RNA-sequencing analysis and signaling pathway intervention revealed that Ras homolog gene family A(RhoA)/Rho-associated kinase-2(ROCK2)has in-depth participated in the pore morphology-mediated BMSCs behaviors,indicating an important role of mechanical signaling transduction in scaffold-cell interactions.Finally,femoral condyle defect repair results showed that D-scaffold could effectively promote endogenous bone regeneration,of which the osteogenesis rate was 1.2-1.8 times higher than the other groups.Overall,this work provides insights into pore morphology-mediated bone regeneration mechanisms for developing novel bioadaptive scaffold designs. | Qiji Lu Jingjing Diao Yingqu Wang Jianlang Feng Fansen Zeng Yan Yang Yudi Kuang Naru Zhao Yingjun Wang | 2023 | Bioactive Materials2023，，8： | 2 |
| 14 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 15 | Kinematic-parameter identification for serial-robot calibration based on POE formula显示文摘 | HE Ruibo ZHAO Yingjun YANG Shunian | 2010 | IEEE Transactions on Robotics2010，26，3： | 1 |
| 16 | Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds显示文摘Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies.In the present study,novel biomimetic composite scaffolds,with similar properties to natural bone,were prepared,blended and cross-linked with bioactive glass,type I collagen and phosphatidylserine.When exposed to cell culture solution in the absence of a cellular source,the composite scaffolds form crystals with octahedral structure.These crystals are similar to the products derived from MC3T3-E1 cell mineralization within the composite scaffolds,with respect to both composition and morphology.Furthermore,crystals with octahedral structure were observed to develop into plate-like hydroxyapatite.The bio-mineralization behavior of the composite scaffolds is likely influenced by inorganic components.Finally,a rabbit tibia defect model shows that the highly bioactive properties of the investigated composites result in excellent bone repair. | YANG ChunRong WANG YingJun CHEN XiaoFeng | 2012 | Science China(Life Sciences)2012，55，3： | 1 |
| 17 | Development and characterization of novel biomimetic composite scaffolds based on bioglass-collagen-hyaluronicacid-phosphatidylsefine for tissue engineering applications显示文摘 | Wang Yingjun Yang Chunrong Chen Xiaofeng | 2006 | Macromol Mater Eng2006，291，： | 1 |
| 18 | Phenolic antioxidants from Chinese toon (fresh young leaves and shoots of Toona sinensis) 显示文摘 | Wang Kaijin Yang Chongren Zhang Yingjun | 2007 | Food Chemistry2007，，101： | 1 |
| 19 | Investigation on Inlet Recirculation Characteristics of Double Suction Centrifugal Compressor with Unsymmetrical Inlet显示文摘The inlet recirculation characteristics of double suction centrifugal compressor with unsymmetrical inlet structures were studied in numerical method,mainly focused on three issues including the amounts and differences of the inlet recirculation in different working conditions,the circumferential non-uniform distributions of the inlet recirculation,the recirculation velocity distributions of the upstream slot of the rear impeller.The results show that there are some differences between the recirculation of the front impeller and that of the rear impeller in whole working conditions..In design speed,the recirculation flow rate of the rear impeller is larger than that of the front impeller in the large flow range,but in the small flow range,the recirculation flow rate of the rear impeller is smaller than that of the front impeller.In different working conditions,the recirculation velocity distributions of the front and rear impeller are non-uniform along the circumferential direction and their non-uniform extents are quite different.The circumferential non-uniform extent of the recirculation velocity varies with the working conditions change.The circumferential non-uniform extent of the recirculation velocity of front impeller and its distribution are determined by the static pressure distribution of the front impeller,but that of the rear impeller is decided by the coupling effects of the inlet flow distortion of the rear impeller,the circumferential unsymmetrical distribution of the upstream slot and the asymmetric structure of the volute.In the design flow and small flow conditions,the recirculation velocities at different circumferential positions of the mean line of the upstream slot cross-section of the rear impeller are quite different,and the recirculation velocities distribution forms at both sides of the mean line are different.The recirculation velocity distributions in the cross-section of the upstream slot depend on the static pressure distributions in the intake duct. | YANG Ce WANG Yingjun LAO Dazhong TONG Ding WEI Longyu LIU Yixiong | 2016 | Journal of Thermal Science2016，25，4： | 1 |
| 20 | Performance of a two-stage multi-effect desalination system based on humidification-dehumidification process 显示文摘 | Kang Huifang Yang Yingjun Chang Zehui | 2014 | Desalination2014，344，1： | 1 |
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