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| 1 | Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction显示文摘Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction,but the mechanisms underlying this protection remain unclear.To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis,we induced a photochemical model of cerebral infarction in an inbred line of mice(BALB/c).Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment.Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction,mainly in neurons and vascular endothelial cells.Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31.Moreover,hypoxic preconditioning reduced the infarct volume and improved neurological function in mice.These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra,which promoted angiogenesis. | Sijie Li Yanbo Zhang Guo Shao Mingfeng Yang Jingzhong Niu Guowei Lv Xunming Ji | 2013 | Neural Regeneration Research2013，8，31： | 31 |
| 2 | Genome-wide identification, expression analysis of auxin-responsive GH_3 family genes in maize(Zea mays L.) under abiotic stresses显示文摘Auxin is involved in different aspects of plant growth and development by regulating the expression of auxinresponsive family genes. As one of the three major auxinresponsive families, GH3(Gretchen Hagen3) genes participate in auxin homeostasis by catalyzing auxin conjugation and bounding free indole-3-acetic acid(IAA) to amino acids.However, how GH3 genes function in responses to abiotic stresses and various hormones in maize is largely unknown.Here, the latest updated maize(Zea mays L.) reference genome sequence was used to characterize and analyze the Zm GH3 family genes from maize. The results showed that 13 Zm GH3 genes were mapped on fi ve maize chromosomes(total10 chromosomes). Highly diversi fi ed gene structures and tissue-speci fi c expression patterns suggested the possibility of function diversi fi cation for these genes in response to environmental stresses and hormone stimuli. The expression patterns of Zm GH3 genes are responsive to several abiotic stresses(salt, drought and cadmium) and major stress-relatedhormones(abscisic acid, salicylic acid and jasmonic acid)Various environmental factors suppress auxin free IAA contents in maize roots suggesting that these abiotic stresses and hormones might alter GH3-mediated auxin levels. The respon siveness of Zm GH3 genes to a wide range of abiotic stresses and stress-related hormones suggested that Zm GH3 s are involved in maize tolerance to environmental stresses. | Shangguo Feng Runqing Yue Sun Tao Yanjun Yang Lei Zhang Mingfeng Xu Huizhong Wang Chenjia Shen | 2015 | Journal of Integrative Plant Biology2015，57，9： | 17 |
| 3 | Gabapentin inhibits central sensitization during migraine显示文摘Peripheral and central sensitizations are phenomena that occur during migraine.The role of gabapentin,a migraine preventive drug,on central sensitization remains unclear.In this study,a rat model of migraine was established by electrical stimulation of the trigeminal ganglion,and the animals were given intragastric gabapentin.Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine.Electrophysiology,liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve,decreases excitatory amino acid content and inhibits the activation of protein kinase C.This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine.Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation. | Yanbo Zhang Guo Shao Wei Zhang Sijie Li Jingzhong Niu Dongmei Hu Mingfeng Yang Xunming Ji | 2013 | Neural Regeneration Research2013，8，32： | 12 |
| 4 | Daily variation characteristics of CO2 emission fluxes and contributions of environmental factors in semiarid grassland of Inner Mongolia, China显示文摘Fixed field experimental studies are carried out on daily variations of the undis- turbed community and soil respiration fluxes in different phenological phases of 2001―2002 in semiarid Aneurolepidium chinense steppe of Inner Mongolia, China using static black chamber method. Corresponding statistical analysis of the contributions of the water-heat factors (air temperature, ground temperature, surface soil water content) and ecological factors (above- ground biomass, underground biomass, litter biomass) to daily variation law of the undisturbed community and soil respiration fluxes as well as differences in daily respiration are also con- ducted. The results indicate that undisturbed community and soil respiration have apparent daily variation laws, daily variation patterns of respiration fluxes during different phenological phases are basically the same, and the variations of environmental factors only exert effect on CO2 emission intensities, while the effect on daily variation pattern of grassland CO2 emission fluxes is relatively small. The daily total respiration of the undisturbed community in different phenological phases ranges from 1.34―10.13 g·m?2; soil daily total respiration ranges from 0.98―5.17 g·m?2; both daily variations of undisturbed community and soil respiration fluxes are significantly corre- lated (p < 0.05) or extremely significantly correlated (p < 0.01) with air temperatures and ground surface temperatures, but the correlativity with the soil temperature at 5 and 10 cm depths is relatively weak; multiple regression analysis indicates that about 80% of the difference in daily respiration of the undisturbed community among different phenological phases is induced by the variation of the aboveground biomass, while the variations of the remaining factors can jointly explain around 20% of the daily respiration variations of the whole grassland ecosystem; about 83% of the soil daily respiration variation of the different phenological phases is caused by 0―20 cm underground biomass. Besides, surface soil water content is also an important environmental factor affecting soil daily respiration variations of the Aneurolepidium chinense steppe, but its partial correlation coefficient with soil daily respiration amount does not reach the significance level of 0.05. | QI Yuchun DONG Yunshe LIU Jiyuan GENG Yuanbo LI Mingfeng YANG Xiaohong LIU Lixin | 2005 | Science China Earth Sciences2005，48，7： | 11 |
| 5 | Design of the Metal Precursors Molecular Structures in Impregnating Solutions for Preparation of Efficient Ni Mo/Al_2O_3 Hydrodesulfurization Catalysts显示文摘The molecular structures of metal precursors in the impregnating solution were designed so as to prepare efficient Ni Mo/Al_2O_3 hydrodesulfurization(HDS) catalysts. At first, five typical impregnating solutions were designed; the existing metal precursors, such as [Mo4(citrate)2O11]^(4-)-like, [P2Mo18O62]^(6-)-like and [P2Mo5O23]^(6-)-like species in the solutions were confirmed by laser Raman spectroscopy(LRS). The UV-Vis spectra results indicated that the solutions containing both phosphoric acid and citric acid could change the existing form of nickel species. Five corresponding Ni Mo/Al_2O_3 catalysts were prepared by the incipient wetness impregnation method. The LRS analysis results of dried catalysts showed that the above metal precursors could be partly retained on alumina support after impregnation and drying, although the interface reaction between different metal precursors and alumina support unavoidably took place. Then the catalysts were sulfided and characterized by N2 physisorption, TEM and XPS analyses. The results showed that different metal precursors in impregnating solution could mainly result in the difference in both the morphology of(Ni)Mo S2 slabs and the promoting effect of Ni species. The catalyst prepared mainly with [P2Mo5O23]^(6-)-like species used as precursors exhibited worse dispersion of(Ni)Mo S2 slabs and lower ratio of Ni–Mo–S active phases than the one with [Mo4(citrate)2O11]^(4-)-like species. Promisingly, the catalyst prepared with co-existing [Mo4(citrate)2O11]^(4-)-like, [P2Mo18O62]^(6-)-like and [P2Mo5O23]^(6-)-like species showed better hydrodesulfurization activity for 4,6-DMDBT thanks to its more well-dispersed Ni–Mo–S active phases. | Li Huifeng Li Mingfeng Chu Yang Liu Feng Nie Hong | 2015 | China Petroleum Processing & Petrochemical Technology2015，17，4： | 8 |
| 6 | Development of New Generation Catalysts for Selective Hydrodesulfurization of FCC Naphtha显示文摘The influence of active metal components of catalyst, additives and catalyst preparation method on the reactivity of catalyst for selective hydrodesulfurization (HDS) of FCC naphtha was investigated, and the RSDS-21 catalyst with high HDS performance and the RSDS-22 catalyst with high selectivity were developed by RIPP. The composite loading of a new series of catalysts for selective HDS of FCC gasoline has demonstrated excellent desulfurization activity and selectivity and can under conventional hydrotreating conditions manufacture clean gasoline product meeting the national IV emission standard and the Euro V emission standard with less loss in antiknock index. The finalized new series of FCC catalysts upon being adopted for selective HDS of FCC naphtha have good adaptability to different feedstocks along with good stability. | Chu Yang Li Mingfeng Li Huifeng Qu Jinhua Nie Hong Li Dadong (Research Institute of Petroleum Processing, SINOPEC Corp., Beijing 100083) | 2009 | China Petroleum Processing & Petrochemical Technology2009，11，1： | 5 |
| 7 | Development and Application of Hydrocracking Catalysts RHC-1/RHC-5 for Maximizing High Quality Chemical Raw Materials Yield显示文摘To adapt to the change in the demand of the oil refining market,two hydrocracking catalysts,RHC-1 and RHC-5,were developed to improve the quality of tail oil.The catalysts were designed based on the theory of selective ring-opening.By selecting more acidic molecular sieves,the problem of poor selectivity of conventional materials can be solved to properly match up to the hydrogenation performance of catalysts.Compared with the performance of previous catalysts,the quality of the tail oil achieved by the said catalysts is better,and the BMCI is reduced by 1—2 units.In the long cycle operation of the petroleum industry,the good quality of the tail oil has been verified and the adaptability of the process conditions is good.When the RHC-1 catalyst is used to process heavy feed under medium pressure,a BMCI value of about12 can be obtained along with a nearly 60%yield of tail oil.The total yield of chemical raw material(steaming cracking feed+catalytic reforming feed)can exceed 80%,and the hydrogen consumption has dropped by nearly 50%as compared to the conventional hydrocracking conversion rate.When processing a mixed CGO and VGO feed with the full conversion mode under a hydrogen pressure of 13.0 MPa,the RHC-5 catalyst can yield about 68.4%of heavy naphtha with a potential aromatic content of up to 50.6,while the total yield of chemical raw materials can reach more than 98%.The results of industrial application of these catalysts show that more than 30%of high quality tail oil can be obtained via processing of inferior quality feed,and its BMCI value can reach 10.7.The total yield of chemical raw materials can reach more than65%.The industrial operation process has implemented two operating cycles totaling 8 years. | Mao Yichao Nie Hong Li Mingfeng Hu Zhihai Zhao Guangle Zhao Yang | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 5 |
| 8 | RNA Interference-based Suppression of Phosphoenolpyruvate Carboxylase Results in Susceptibility of Rapeseed to Osmotic Stress显示文摘The diverse functions of phosphoenolpyruvate carboxylase(PEPCase;EC 4.1.1.31) in C3 plants are not as well understood as in C4 plants.To investigate the functions of PEPCase in C3 plants,rapeseed(Brassica napus L.) PEPCase gene(referred to as BNPE15) was silenced by the RNA interference(RNAi) technique.Under normal growth conditions,no significant difference in lipid content and fatty acid composition were found between wild-type(WT) and transgenic rapeseed plants.However,when these plants were subjected to osmotic stress induced by osmoticum polyethylene glycol(PEG-6000),membrane permeability and membrane lipid peroxidization in roots and leaves of transgenic plants were higher than those of WT plants.It suggested that transgenic plants are more susceptible to osmotic stress than WT plants.Taken together,the results showed that the suppression of PEPCase by RNAi leads to susceptibility to osmotic stress in rapeseed,and PEPCase is involved in the response of C3 plants to environmental stress. | Mei Chen Yunlai Tang Jingmei Zhang Mingfeng Yang Yinong Xu | 2010 | Journal of Integrative Plant Biology2010，52，6： | 4 |
| 9 | Thioetherification of isoprene and butanethiol on transition metal phosphides显示文摘Thioetherification between mercaptan and diolefin is an efficient process to remove mercaptans in FCC gasoline at mild condition, during which the selective hydrogenation of diolefin to monoolefin is also expected. Here, Si O2 supported transition metal(Fe, Co, Ni, Mo and W) phosphides were tested for the thioetherification of isoprene and butanethiol on a fixed-bed reactor at 120 °C and 1.5 MPa H2, and their structure before and after reaction was characterized by means of XRD, HRTEM, N2 sorption, CO chemisorption, NH3-TPD, XPS and TG. It was found that, among different metal phosphides, Mo P/Si O2 showed the best performance, and the optimal nominal Mo P loading was 25%. Apart from the nature of metal, the density of metal and acid sites determined the catalyst performance. Metal site was mainly responsible for hydrogenation of isoprene, while acid site dominantly contributed to the thioetherification and the polymerization of olefins. Moreover, a balance between metallic and acidic functions is required to arrive at a desired performance. Excessive metal sites or acid sites led to the over-hydrogenation of isoprene or the severe polymerization of olefins, respectively. 25%Mo P/Si O2 was tested for 37 h time on stream, and butanethiol conversion maintained at 100%; although isoprene conversion remarkably decreased, the selectivity to isopentenes exceeded 80% after reaction for 11 h. We suggest that the deactivation of Mo P/Si O2 is mainly ascribed to the butanethiol poisoning and the carbonaceous deposit, especially the former. | Tianyu Ren Mingfeng Li Yang Chu Jixiang Chen | 2018 | Journal of Energy Chemistry2018，27，3： | 3 |
| 10 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 11 | Deoxygenation of methyl laurate to hydrocarbons on silica-supported Ni-Mo phosphides: Effect of calcination temperatures of precursor显示文摘SiO2-supported Ni-Mo bimetallic phosphides were prepared by temperature-programmed reduction(TPR) method from the phosphate precursors calcined at different temperatures. Their properties were characterized by means of ultraviolet-visible diffuse reflectance spectroscopy(UV-Vis DRS), H2temperature-programmed reduction(H2-TPR), X-ray diffraction(XRD), transmission electron microscopy(TEM), CO chemisorption, H2 and NH3temperature-programmed desorptions(H2-TPD and NH3-TPD). Their catalytic performances for the deoxygenation of methyl laurate were tested in a fixed-bed reactor. When the precursors were calcined at 400 and 500?C, respectively, Ni Mo P2 phase could be formed apart from Ni2 P and Mo P phases in the prepared C400 and C500 catalysts. However, when the precursors were calcined at600, 700 and 800°C, respectively, only Ni2 P and Mo P phases could be detected in the prepared C600, C700 and C800 catalysts. Also, in C400, C500 and C600 catalysts, Mo atoms were found to be entered in the lattice of Ni2 P phase, but the entering extent became less with the increase of calcination temperature. As the calcination temperature of the precursor increased, the interaction between Ni and Mo in the prepared catalysts decreased, and the phosphide crystallite size tended to increase, subsequently leading to the decrease in the surface metal site density and the acid amount. C600 catalyst showed the highest activity among the tested ones for the deoxygenation of methyl laurate. As the calcination temperature of the precursor increased, the selectivity to C12 hydrocarbons decreased while the selectivity to C11 hydrocarbons tended to increase. This can be mainly attributed to the decreased Ni-Mo interaction and the increased phosphide particle size. In sum, the structure and performance of Ni-Mo bimetallic phosphide catalyst can be tuned by the calcination temperature of precursor. | Zhengyi Pan Rijie Wang Mingfeng Li Yang Chu Jixiang Chen | 2015 | Journal of Energy Chemistry2015，24，1： | 2 |
| 12 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 13 | Essential role of citric acid in preparation of efficient NiW / AI, 03 HDS catalysts显示文摘 | LI Huifeng LI Mingfeng CHU Yang | 2011 | Applied Catalysis A: General2011，403，： | 1 |
| 14 | Blocking TRAIL-DR5 signaling with soluble DR5 reduces delayed neuronal damage after transient global cerebral ischemia显示文摘 | Min Cui Limei Wang Xiaohong Liang Xuelian Ma Yugang Liu Mingfeng Yang Kejing Liu Xinbing Wei Zhiqiang Zhou Youhai H. Chen Wensheng Sun | 2010 | Neurobiology of Disease2010，，2： | 1 |
| 15 | A New Method to Detect Useless Service Failure Model in SPN 显示文摘 | Zhao Mingfeng Zhou Yajian Yang Yixian | 2010 | Journal of Convergence Information Technology2010，5，3： | 1 |
| 16 | Study on the Weld-Bonding Process Optimization and Mechanical Performance of Aluminum Alloy Joints显示文摘The 5754 aluminum alloy has been widely used in the automotive industry to reduce the weight of vehicles.The weld-bonding(WB)process comprising resistance spot welding and adhesive bonding processes effectively improves the mechanical properties of joints.However,it is still a great challenge in the WB process to obtain high-quality and defect-free nuggets of aluminum alloys.In this study,the parameters of the WB process are optimized and the mechanism of generation of defects during WB is analyzed.The results show that the welding parameters have a significant effect on the nugget sizes,among which the welding current plays the most important role.The residual adhesive can easily cause defects during welding,e.g.,expulsion and porosity in the nugget.This can be effectively avoided by optimizing the welding parameters.In addition,the gas in the joints is effectively reduced by adding an appropriate preheating pulse prior to welding,thus lowering the damage degree of the adhesive layer.As a result,welded joints with better weld nugget quality and more stable mechanical properties are obtained. | Mingfeng Li Yanjun Wang Zhen Niu Shanglu Yang | 2020 | Automotive Innovation2020，3，3： | 1 |
| 17 | Essential Role of Citric Acid in Preparation of Efficient NiW/A1203 HDS Cata- lysts显示文摘 | Li Huifeng Li Mingfeng Chu Yang | 2011 | Appl Catal A2011，403，1： | 1 |
| 18 | Study on preperation of LixCoO2 and its rechargeability as cathode in secondary battery显示文摘 | Guo Mingfeng Yang Ruimin Feng Xikang | 1993 | Chinese J Power Sources1993，17，2： | 1 |
| 19 | Applying the linear particle swarm optimization to a serial multi-echelon inventory model显示文摘 | Yang Mingfeng Lin Yi | 2010 | Expert Systems with Applications2010，37，3： | 1 |
| 20 | Essential role of citric acid in preparation of efficient NiW/Al2O3 HDS cata lysts显示文摘 | Li Huifeng Li Mingfeng Chu Yang | 2011 | Applied Catalysis A: General2011，403，1： | 1 |
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