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| 1 | Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy显示文摘C dots (CDs) have shown great potential in bioimaging and phototherapy.However, it is challenging to manipulate their fluorescent properties andtherapeutic efficacy to satisfy the requirements for clinic applications. In thisstudy, we prepared S, Se-codoped CDs via a hydrothermal method anddemonstrated that the doping resulted in excitation wavelength-independentnear-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm.Significantly, the CDs exhibited a photothermal conversion efficiency of -58.2%,which is the highest reported value for C nanostructures and is comparable tothat of Au nanostructures. Moreover, the CDs had a large two-photon absorptioncross section (-30,045 GM), which allowed NIR emissions and the photothermalconversion of the CDs through the two-photon excitation (TPE) mechanism. Invitro and in vivo tests suggested that CDs can function as new multi functionalphototheranostic agents for the TPE fluorescence imaging and photothermaltheraov of cancer cells. | Minhuan Lan Shaojing Zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang Zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang | 2017 | Nano Research2017，10，9： | 9 |
| 2 | Properties of Polysaccharides in Several Seaweeds from Atlantic Canada and Their Potential Anti-Influenza Viral Activities显示文摘To explore the polysaccharides from selected seaweeds of Atlantic Canada and to evaluate their potential anti-influenza virus activities, polysaccharides were isolated from several Atlantic Canadian seaweeds, including three red algae (Polysiphonia lanosa, Furcellaria lumbricalis, and Palmaria palmata), two brown algae (Ascophyllum nodosum and Fucus vesiculosus), and one green alga (Ulva lactuca) by sequential extraction with cold water, hot water, and alkali solutions. These polysaccharides were ana-lyzed for monosaccharide composition and other general chemical properties, and they were evaluated for anti-influenza virus activities. Total sugar contents in these polysaccharides ranged from 15.4% (in U. lactuca) to 91.4% (in F. lumbricalis); sulfation level was as high as 17.6% in a polysaccharide from U. lactuca, whereas it could not be detected in an alikali-extract from P. palmaria. For polysaccharides from red seaweeds, the main sugar units were sulfated galactans (agar or carrageenan) for P. lanosa, F. lumbricalis, and xylans for P. palmata. In brown seaweeds, the polysaccharides largely contained sulfated fucans, whereas the polysaccharides in green seaweed were mainly composed of heteroglycuronans. Screening for antiviral activity against influenza A/PR/8/34 (H1N1) virus revealed that brown algal polysaccharides were particularly effective. Seaweeds from Atlantic Canada are a good source of marine polysaccharides with potential antiviral properties. | JIAO Guangling YU Guangli WANG Wei ZHAO Xiaoliang ZHANG Junzeng Stephen H. Ewart | 2012 | Journal of Ocean University of China2012，11，2： | 6 |
| 3 | Structure and Anti-influenza A(H1N1) Virus Activity of Three Polysaccharides from Eucheuma denticulatum显示文摘Three polysaccharides(EW,EH and EA) were prepared from a red alga Eucheuma denticulatum by sequential extraction with cold water,hot water and sodium hydroxide water solution.Their monosaccharide compositions,relative molecular mass and structural characterization were determined by gas chromatography,high performance 1iquid chromatography,fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy methods.EW was hybrid ι/κ/ν-carrageenan(70 ι/17κ/13ν-carrabiose),EH was mainly ι-carrageenan,and EA was mainly α-1,4-Glucan(88%) but mixed with small amount of ι-carrageenan(12%).The relative molecular mass of EW,EH and EA was 480,580 and 510 kDa,respectively.The anti-influenza A(H1N1) virus activity of these three polysaccharides was evaluated using the Madin-Darby canine kidney cells model.EW showed good anti-H1N1 virus activity,its IC 50 was 276.5 μg mL-1,and the inhibition rate to H1N1 virus was 52% when its concentration was 250 μg mL-1.The IC 50 of ι-carrageenan EH was 366.4 μg mL-1,whereas EA showed lower anti-H1N1 virus activity(IC 50 >430 μg mL-1).Available data obtained give positive evidence that the hybrid carrageenan EW from Eucheuma denticulatum can be used as potential anti-H1N1 virus inhibitor in future. | YU Guangli LI Miaomiao WANG Wei] LIU Xin ZHAO Xiaoliang LV Youjing LI Guangsheng JIAO Guangling ZHAO Xia | 2012 | Journal of Ocean University of China2012，11，4： | 5 |
| 4 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 5 | Development and Application of Hydrocracking Catalysts RHC-1/RHC-5 for Maximizing High Quality Chemical Raw Materials Yield显示文摘To adapt to the change in the demand of the oil refining market,two hydrocracking catalysts,RHC-1 and RHC-5,were developed to improve the quality of tail oil.The catalysts were designed based on the theory of selective ring-opening.By selecting more acidic molecular sieves,the problem of poor selectivity of conventional materials can be solved to properly match up to the hydrogenation performance of catalysts.Compared with the performance of previous catalysts,the quality of the tail oil achieved by the said catalysts is better,and the BMCI is reduced by 1—2 units.In the long cycle operation of the petroleum industry,the good quality of the tail oil has been verified and the adaptability of the process conditions is good.When the RHC-1 catalyst is used to process heavy feed under medium pressure,a BMCI value of about12 can be obtained along with a nearly 60%yield of tail oil.The total yield of chemical raw material(steaming cracking feed+catalytic reforming feed)can exceed 80%,and the hydrogen consumption has dropped by nearly 50%as compared to the conventional hydrocracking conversion rate.When processing a mixed CGO and VGO feed with the full conversion mode under a hydrogen pressure of 13.0 MPa,the RHC-5 catalyst can yield about 68.4%of heavy naphtha with a potential aromatic content of up to 50.6,while the total yield of chemical raw materials can reach more than 98%.The results of industrial application of these catalysts show that more than 30%of high quality tail oil can be obtained via processing of inferior quality feed,and its BMCI value can reach 10.7.The total yield of chemical raw materials can reach more than65%.The industrial operation process has implemented two operating cycles totaling 8 years. | Mao Yichao Nie Hong Li Mingfeng Hu Zhihai Zhao Guangle Zhao Yang | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，2： | 5 |
| 6 | Comparison of in vitro digestion methods for determining bioaccessibility of Hg in rice of China显示文摘Rice consumption can be a major pathway for mercury(Hg) exposure, which can cause health hazards to Chinese residents. To accurately assess the potential health risks, the bioaccessibility of Hg in rice samples collected at background and Hg-contamination sites was examined using four in vitro methods. The results showed that < 50% of the total mercury(THg) was bioaccessible in the studied rice samples. The THg bioaccessibility in the rice samples collected at the Hg-contaminated site was higher than that observed at the background area. The bioaccessibility of arsenic(As) and cadmium(Cd) was also evaluated for comparison of the four in vitro methods used in this study. The Physiologically Based Extraction Test was found to be the most accurate method based on the consistency of the results compared to those reported in previous studies. The estimated daily intakes of THg via rice consumption using the bioaccessibility data were found to meet the recommendation value set by the JECFA and the WHO in both sites. However, the potential health risk was not negligible at the Hg-contaminated sites, due to the high THg concentration and bioaccessibility in the rice samples. | Ze Wu Xinbin Feng Ping Li Che-Jen Lin Guangle Qiu Xun Wang Huifang Zhao Hui Dong | 2018 | Journal of Environmental Sciences2018，30，6： | 3 |
| 7 | Influence of the β-phase morphology on the corrosion of the Mg alloy AZ91显示文摘 | Ming-Chun Zhao Ming Liu Guangling Song Andrej Atrens | 2008 | Corrosion Science2008，，7： | 2 |
| 8 | The interaction of phenolic acids with Fe(III) in the presence of citrate as studied by isothermal titration calorimetry显示文摘 | Senpei Yang Guangling Bai Lingli Chen Qun Shen Xianmin Diao Guanghua Zhao | 2014 | Food Chemistry2014，，： | 1 |
| 9 | Influence of the β-phase morphology on the corrosion of the Mg alloy AZ91显示文摘 | Zhao Mingchun Liu Ming Song Guangling | 2006 | Corrosion Science2006，48，5： | 1 |
| 10 | Influence of microstructure on corrosion of as-cast ZE41显示文摘 | ZHAO Mingchun LIU Ming SONG Guangling | 2008 | Advanced Engineering Materials2008，10，112： | 1 |
| 11 | Environmental,social,and economic assessment of energy utilization of crop residue in China显示文摘This paper aims to discuss an environmental, social, and economic analysis of energy utilization of crop residues from life cycle perspectives in China. The methodologies employed to achieve this objective are environmental life cycle assessment (E-LCA), life cycle cost (LCC), and social life cycle assessment (S-LCA). Five scenarios are developed based on the conversion technologies and final bioenergy products. The system boundaries include crop residue collection, transportation, pre-treatment, and conversion process. The replaced amounts of energy are also taken into account in the E-LCA analysis. The functional unit is defined as 1 MJ of energy produced. Eight impact categories are considered besides climate change in E-LCA. The investment capital cost and salary cost are collected and compared in the life cycle of the scenarios. Three stakeholders and several subcategories are considered in the S-LCA analysis defined by UNEP/SETAS guidelines. The results show that the energy utilization of crop residue has carbon emission factors of 0.09–0.18 kg (CO2 eq per 1 MJ), and presents a net carbon emissions reduction of 0.03–0.15 kg (CO2 eq per 1 MJ) compared with the convectional electricity or petrol, but the other impacts should be paid attention to in the biomass energy scenarios. The energy utilization of crop residues can bring economic benefit to local communities and the society, but the working conditions of local workers need to be improved in future biomass energy development. | Yueling ZHANG Junjie LI Huan LIU Guangling ZHAO Yajun TIAN Kechang XIE | 2021 | Frontiers in Energy2021，15，2： | 1 |
| 12 | Influence of the β-phase morphology on the corrosion of the Mg alloy AZ91 显示文摘 | Zhao Ming-Chun Liu Ming Song Guangling | 2008 | Corrosion Science2008，50，7： | 1 |
| 13 | Preparation and Characteristic of Glass-Ceramics with Super Low Thermal Expansion Coefficient显示文摘The preparation technics of glass-ceramics with super low coefficient of thermal expansion containing β-quartz solid solution as a main crystal phase based on the glass in the system Li2O-Al2O3-SiO2 was introduced. The composition of base glass, technics of melting and heat treatment effecting on characteristic of glass-ceramics was described. Specimens were prepared by melting, anneal and controlled two steps heat treatment. Crystal phase, microstructure and elementary distributing were studied by using XRD, SEM and EDS respectively. Prepared specimens show excellent transparency and super low thermal expansion coefficient of 2×10-8 ·K-1, which reaches international advanced level. | Zhao Chunxia Fan Shigang Chen Guangle Jiang Hui Wang Shengjun Wang Kun | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 14 | Studies and Properties of Ceramics with High Thermal Conductivity显示文摘The sintering technology of the AlN ceramics power were discussed. It is discussed that the compound sintering aids is consistent with the enhancement of the the thermal conductivity of AlN ceramics, and sintering technics is helped to the improvement of density. It is analyzed how to sinter machinable AlN ceramics with high thermal conductivity. And the microstructure of compound ceramics based on AlN was studied. | Chen Guangle Fan Shigang Zhao Chunxia Wang Kun Xia Shuqin | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 15 | A self-assembling prodrug nanosystem to enhance metabolic stability and anticancer activity of gemcitabine显示文摘Self-assembly is a powerful approach in molecular engineering for biomedical applications,in particu-lar for creating self-assembling prodrugs.Here,we report a self-assembling prodrug of the anticancer drug gemcitabine(Gem)based on amphiphilic dendrimer approach.The prodrug reported in this study demonstrates high drug loading(40%)and robust ability to self-assemble into small nanomicelles,which increase the metabolic stability of Gem and enable entry into cells via endocytosis,hence bypassing transport-mediated uptake.In addition,this prodrug nanosystem exhibited an effective pH-and enzyme-responsive release of Gem,resulting in enhanced anticancer activity and reduced toxicity.Harboring ad-vantageous features of both prodrug-and nanotechnology-based drug delivery,this self-assembling Gem prodrug nanosystem constitutes a promising anticancer candidate.This study also offers new perspectives of the amphiphilic dendrimer nanoplatforms for the development of self-assembling prodrugs. | Mei Cong Guangling Xu Shaoyou Yang Jing Zhang Wenzheng Zhang Dinesh Dhumal Erik Laurini Kaiyue Zhang Yi Xia Sabrina Pricl Ling Peng Weidong Zhao | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 16 | A New Prediction System Based on Self-Growth Belief Rule Base with Interpretability Constraints显示文摘Prediction systems are an important aspect of intelligent decisions.In engineering practice,the complex system structure and the external environment cause many uncertain factors in the model,which influence the modeling accuracy of the model.The belief rule base(BRB)can implement nonlinear modeling and express a variety of uncertain information,including fuzziness,ignorance,randomness,etc.However,the BRB system also has two main problems:Firstly,modeling methods based on expert knowledge make it difficult to guarantee the model’s accuracy.Secondly,interpretability is not considered in the optimization process of current research,resulting in the destruction of the interpretability of BRB.To balance the accuracy and interpretability of the model,a self-growth belief rule basewith interpretability constraints(SBRB-I)is proposed.The reasoning process of the SBRB-I model is based on the evidence reasoning(ER)approach.Moreover,the self-growth learning strategy ensures effective cooperation between the datadriven model and the expert system.A case study showed that the accuracy and interpretability of the model could be guaranteed.The SBRB-I model has good application prospects in prediction systems. | Yingmei Li Peng Han Wei He Guangling Zhang Hongwei Wei Boying Zhao | 2023 | Computers, Materials & Continua2023，，5： | 0 |
| 17 | Removal of Stripes in Remote Sensing Images Based on Statistics Combined with Image Enhancement显示文摘A method to remove stripes from remote sensing images is proposed based on statistics and a new image enhancement method.The overall processing steps for improving the quality of remote sensing images are introduced to provide a general baseline.Due to the differences in satellite sensors when producing images,subtle but inherent stripes can appear at the stitching positions between the sensors.These stitchingstripes cannot be eliminated by conventional relative radiometric calibration.The inherent stitching stripes cause difficulties in downstream tasks such as the segmentation,classification and interpretation of remote sensing images.Therefore,a method to remove the stripes based on statistics and a new image enhancement approach are proposed in this paper.First,the inconsistency in grayscales around stripes is eliminated with the statistical method.Second,the pixels within stripes are weighted and averaged based on updated pixel values to enhance the uniformity of the overall image radiation quality.Finally,the details of the images are highlighted by a new image enhancement method,which makes the whole image clearer.Comprehensive experiments are performed,and the results indicate that the proposed method outperforms the baseline approach in terms of visual quality and radiation correction accuracy. | Xiaofei QU Weiwei ZHAO En LONG Meng SUN Guangling LAI | 2023 | Journal of Geodesy and Geoinformation Science2023，6，1： | 0 |
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