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| 1 | Molecular evolution of rice S_5~n and functional comparison among different sequences显示文摘The wide compatibility gene, S 5 n , can overcome embryo sac sterility between indica and japonica subspecies of rice. Therefore, it is very important to characterize the features of the S 5 n sequence to reveal the origin and evolution of S 5 n . In this paper, 26 cultivated rice haplotypes and 22 wild rice accessions harboring S 5 n were used to sequence S 5 n . The results showed that 15 genotypes among the 48 materials were fully consistent with control cultivar 02428 (CK). The other 33 accessions had different degrees of variation in the S 5 n sequence. Variations in the coding region mainly occurred in the second exon and eight materials showed a 10-bp deletion at 1710–1719 bp, including wild (O. nivara) and cultivated rice, such as IRW501 and Yuetai B. S 5 n sequences were not biased and evolved neutrally. The 48 materials could be divided into 4 categories using a phylogenetic tree of the amino acid sequences. Most of the wild rice clustered together, and the cultivated rice clustered into another group. Eight cultivated rice and O. nivara (wild rice) clustered in another group, which were found to lack 10 consecutive bases in exon 2. Eight rice varieties with high numbers of differences in their S 5 n coding regions were crossed with testers (typically indica and japonica) to produced test cross F 1 populations. The F 1 s were examined for their ability to overcome indica-japonica hybrid sterility. The result showed that the embryo sac fertility of S 5 n -containing hybrids increased significantly compared with control hybrids, but there were no differences among the materials with divergent sequences, indirectly proving that S 5 n is a non-functional gene. | TONG JingFei LI YanHong YANG YouXin SHAHID Muhammad Qasim CHEN ZhiXiong WANG Lan LI JinQuan LIU XiangDong LU YongGen | 2011 | Chinese Science Bulletin2011，56，19： | 2 |
| 2 | Enzyme-instructed and mitochondria-targeting peptide self-assembly to efficiently induce immunogenic cell death显示文摘Immunogenic cell death(ICD) plays a major role in cancer immunotherapy by stimulating specific T cell responses and restoring the antitumor immune system.However,effective type Ⅱ ICD inducers without biotoxicity are still very limited.Herein,a tentative drug-or photo sensitizer-free strategy was developed by employing enzymatic self-assembly of the peptide F-pY-T to induce mitochondrial oxidative stress in cancer cells.Upon dephosphorylation catalyzed by alkaline phosphatase overexpressed on cancer cells,the peptide F-pY-T self-assembled to form nanoparticles,which were subsequently internalized.These affected the morphology of mitochondria and induced serious reactive oxygen species production,causing the ICD characterized by the release of danger-associated molecular patterns(DAMPs).DAMPs enhanced specific immune responses by promoting the maturation of DCs and the intratumoral infiltration of tumor-specific T cells to eradicate tumor cells.The dramatic immunotherapeutic capacity could be enhanced further by combination therapy of F-pY-T and anti-PD-L1 agents without visible biotoxicity in the main organs.Thus,our results revealed an alternative strategy to induce efficient ICD by physically promoting mitochondrial oxidative stress. | Debin Zheng Jingfei Liu Limin Xie Yuhan Wang Yinghao Ding Rong Peng Min Cui Ling Wang Yongjie Zhang Chunqiu Zhang Zhimou Yang | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 1 |
| 3 | Atwo-dimensional numerical model for tidal motion in theTaiwan Strait显示文摘 | FANG GUOHONG YANG JINGFEI ZHAO XUCAI 1984 | 1984 | Marine Geophysical Research1984，7，： | 1 |
| 4 | Evolution and homologous recombination of the hemagglutinin–esterase gene sequences from porcine torovirus显示文摘 | Yingying Cong Dante S. Zarlenga Juergen A. Richt Xin Wang Yang Wang Siqingaowa Suo Jingfei Wang Yudong Ren Xiaofeng Ren | 2013 | Virus Genes2013，，1： | 1 |
| 5 | A twodimensional numerical model for tidal motion in the Taiwan Strait显示文摘 | FANG Guohong YANG Jingfei Thao Yucai | 1984 | Marine Geophysical Researches1984，7，12： | 1 |
| 6 | A two-dimensional numerical model for tidal motion in the Taiwan Strait显示文摘 | Fang Guohong Yang Jingfei Thao Yucai | 1984 | Marine Geophysical Research1984，7，1： | 1 |
| 7 | A two-dimensional nu- merical model of the tidal motions in the Bahai Sea显示文摘 | Fang Guohong Yang Jingfei | 1985 | Chinese Journal of Oceanology and liminology1985，3，2： | 1 |
| 8 | Radius of curvature measurement based on wavefront difference method by the point diffraction interferometer显示文摘 | Zhongming Yang Zhishan Gao Qun Yuan Jingfei Ye Minjue Li | 2014 | Optics and Lasers in Engineering2014，，： | 1 |
| 9 | Radius of curvature measurement based on wavefront difference method by the point diffraction interferometer显示文摘 | Zhongming Yang Zhishan Gao Qun Yuan Jingfei Ye Minjue Li | 2014 | Optics and Lasers in Engineering2014，，： | 1 |
| 10 | Research on the feasibility of storage and estimation model of storage capacity of CO_(2)in fissures of coal mine old goaf显示文摘The concept of the carbon cycle in the old goaf of a coal mine based on CO_(2)utilization and storage was put forward adhering to the principle of low-carbon development,utilization of space resources in old goafs,and associated gas resources development.Firstly,the evolution characteristics of overburden fissures in the goaf of the case was studied using a two-dimensional physical similarity simulation test,the sealing performance of the caprocks after stabilization was analyzed,and the fissures were counted and classi-fied.Then,the process of gaseous CO_(2)injection in the connected fissure was simulated by Ansys Fluent software,and the migration law and distribution characteristics of CO_(2)under the condition of gaseous CO_(2)injection were analyzed.Finally,the estimation models of free CO_(2)storage capacity in the old goaf were constructed considering the proportion of connected fissure and the effectiveness of CO_(2)injection.The CO_(2)storage capacity in the old goaf of the case coal mine was estimated.The results showed that a caprock group of“hard-thickness low-permeability hard-thickness”was formed after the caprock-fissures system in the goaf of the case tended to be stable vertically.The connected fissure,occlude cracks,and micro-fractures in the goaf accounted for 85.5%,8.5%,and 6%of the total fissures,respectively.Gaseous CO_(2)first migrated to the bottom of the connected fissure after CO_(2)was injected into the goaf,then spread horizontally along the bottom of the connected fissure after reaching the bottom,and finally spread longitudinally after filling the bottom of the entire connected fissure.The theoretical and effective storage capacities of free CO_(2)at normal temperature and pressure in the old goaf of the case were 9757 and 7477 t,respectively.The effective storage capacity of free CO_(2)at normal temperature and pressure in the old goaf after all minefield mined was 193404 t.The research can provide some reference for the coal mining industry to help the goal of“carbon peaking and carbon neutrality”. | Yang Ding Shugang Li Bing Zhu Haifei Lin Jingfei Zhang Junhong Tan Wenbin Chen | 2023 | International Journal of Mining Science and Technology2023，33，6： | 1 |
| 11 | Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand显示文摘 | Jingfei Hou Jiaxi Peng Yue Yu Yuchen Lin Changliang Liu Hongyang Duan Yanlian Yang Chen Wang | 2017 | Chinese Journal of Chemistry2017，35，8： | 1 |
| 12 | Homocysteine impedes neurite outgrowth recovery after intracerebral haemorrhage by downregulating pCAMK2A显示文摘Hyperhomocysteinemia(HHcy)is independently associated with poorer long-term prognosis in patients with intracerebral haemorrhage(ICH);however,the effect and mechanisms of HHcy on ICH are still unclear.Here,we evaluated neurite outgrowth and neurological functional recovery using simulated models of ICH with HHcy in vitro and in vivo.We found that the neurite outgrowth velocity and motor functional recovery in the ICH plus HHcy group were significantly slower than that in the control group,indicating that homocysteine(Hcy)significantly impedes the neurite outgrowth recovery after ICH.Furthermore,phosphoproteomic data and signalome analysis of perihematomal brain tissues suggested that calmodulin-dependent protein kinases 2(CAMK2A)kinase substrate pairs were significantly downregulated in ICH with HHcy compared with autologous blood injection only,both western blot and immunofluorescence staining confirmed this finding.Additionally,upregulation of pCAMK2A significantly increased neurite outgrowth recovery in ICH with HHcy.Collectively,we clarify the mechanism of HHcy-hindered neurite outgrowth recovery,and pCAMK2A may serve as a therapeutic strategy for promoting neurological recovery after ICH. | Guangyu Guo Jingfei Yang Wenliang Guo Hong Deng Haihan Yu Shuang Bai Gaigai Li Yingxin Tang Ping Zhang Yuming Xu Chao Pan Zhouping Tang | 2023 | Stroke & Vascular Neurology2023，8，4： | 0 |
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