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| 1 | A unified poroviscoelastic model with mesoscopic and microscopic heterogeneities显示文摘The wave-induced fluid flow(WIFF) is considered to be the main cause of dispersion and attenuation of seismic waves in fluid-saturated porous media. Among numerous theories, the mesoscopic and microscopic heterogeneities are considered to be the primary mechanisms causing the WIFF. Furthermore,in most rocks, the mesoscopic and microscopic heterogeneities exist simultaneously and can cause obvious transitions of the fast P-wave velocity, which means it is necessary to consider the influence of the two mechanisms on the dispersion and attenuation simultaneously. Numerous results have shown that the dispersions and attenuations caused by these two mechanisms can be approximated in terms of the Zener model. To combine the two mechanisms into a unified model, we introduce a new generalized Zener model into the Biot poroelasticity theory to obtain a new poroviscoelastic model. Comparisons between the numerical results and two groups of experimental data further confirm the validity of our new model. | Boya Zhang Dinghui Yang Yuanfeng Cheng Yunyin Zhang | 2019 | Science Bulletin2019，64，17： | 9 |
| 2 | Shake-table testing of a self-centering precast reinforced concrete frame with shear walls显示文摘The seismic performance of a self-centering precast reinforced concrete(RC)frame with shear walls was investigated in this paper.The lateral force resistance was provided by self-centering precast RC shear walls(SPCW),which utilize a combination of unbonded prestressed post-tensioned(PT)tendons and mild steel reinforcing bars for flexural resistance across base joints.The structures concentrated deformations at the bottom joints and the unbonded PT tendons provided the self-centering restoring force.A 1/3-scale model of a five-story self-centering RC frame with shear walls was designed and tested on a shake-table under a series of bi-directional earthquake excitations with increasing intensity.The acceleration response,roof displacement,inter-story drifts,residual drifts,shear force ratios,hysteresis curves,and local behaviour of the test specimen were analysed and evaluated.The results demonstrated that seismic performance of the test specimen was satisfactory in the plane of the shear wall;however,the structure sustained inter-story drift levels up to 2.45%.Negligible residual drifts were recorded after all applied earthquake excitations.Based on the shake-table test results,it is feasible to apply and popularize a self-centering precast RC frame with shear walls as a structural system in seismic regions. | Lu Xilin Yang Boya Zhao Bin | 2018 | Earthquake Engineering and Engineering Vibration2018，17，2： | 9 |
| 3 | Interfacial adsorption-insertion mechanism induced by phase boundary toward better aqueous Zn-ion battery显示文摘Biphasic and multiphasic compounds have been well clarified to achieve extraordinary electrochemical properties as advanced energy storage materials.Yet the role of phase boundaries in improving the performance is remained to be illustrated.Herein,we reported the biphasic vanadate,that is,Na_(1.2)V_(3)O_(8)/K_(2)V_(6)O_(16)·1.5H_(2)O(designated as Na0.5K0.5VO),and detected the novel interfacial adsorption-insertion mechanism induced by phase boundaries.Firstprinciples calculations indicated that large amount of Zn^(2+)and H^(+)ions would be absorbed by the phase boundaries and most of them would insert into the host structure,which not only promote the specific capacity,but also effectively reduce diffusion energy barrier toward faster reaction kinetics.Driven by this advanced interfacial adsorption-insertion mechanism,the aqueous Zn/Na_(0.5)K_(0.5)VO is able to perform excellent rate capability as well as long-term cycling performance.A stable capacity of 267 mA h g^(-1)after 800 cycles at 5 A g^(-1)can be achieved.The discovery of this mechanism is beneficial to understand the performance enhancement mechanism of biphasic and multiphasic compounds as well as pave pathway for the strategic design of highperformance energy storage materials. | Lutong Shan Yiren Wang Shuquan Liang Boya Tang Yongqiang Yang Ziqing Wang Bingan Lu Jiang Zhou | 2021 | InfoMat2021，3，9： | 8 |
| 4 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids显示文摘The re-emergence of Zika virus(ZIKV)in the Western Hemisphere has resulted in global public health crisis since 2015.ZIKV preferentially infects and targets human neural progenitor cells(hNPCs)and causes fetal microcephaly upon maternal infection.hNPCs not only play critical roles during fetal brain development,but also persist in adult brain throughout life.Yet the mechanism of innate antiviral immunity in hNPCs remains largely unknown.Here,we show that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs,but not in the more differentiated progenies or somatic cells.Ablation of key RNAi machinery components significantly enhances ZIKV replication in hNPCs.Furthermore,enoxacin,a broad-spectrum antibiotic that is known as an RNAi enhancer,exerts potent anti-ZIKV activity in hNPCs and other RNAi-competent cells.Strikingly,enoxacin treatment completely prevents ZIKV infection and circumvents ZIKV-induced microcephalic phenotypes in brain organoid models that recapitulate human fetal brain development.Our findings highlight the physiological importance of RNAi-mediated antiviral immunity during the early stage of human brain development,uncovering a novel strategy to combat human congenital viral infections through enhancing RNAi. | Yan-Peng Xu Yang Qiu Boya Zhang Guilai Chen Qi Chen Miao Wang Fan Mo Jiuyue Xu Jin Wu Rong-Rong Zhang Meng-Li Cheng Na-Na Zhang Bao Lyu Wen-Liang Zhu Meng-Hua Wu Qing Ye Da Zhang Jiang-Hong Man Xiao-Feng Li Jie Cui Zhiheng Xu Baoyang Hu Xi Zhou Cheng-Feng Qin | 2019 | Cell Research2019，29，4： | 8 |
| 5 | SIRT5, functions in cellular metabolism with a multiple enzymatic activities显示文摘Mammalian Sirtuins are the homologs of yeast Saccharomyces cerevisiae Sir2(silen t information regulator 2),which functions in chromatin silencing to prevent genomic instability and aging by catalyzing the histone deacetylation[1].There are seven members in Sirtui n family(SIRT1-SIRT7).They all contain evolutionary conserved enzymatic domain which is nicotinamide adenine dinucleo- | YANG Xin LIU BoYa ZHU WeiGuo LUO JianYuan | 2015 | Science China(Life Sciences)2015，58，9： | 3 |
| 6 | Isolation and Characterization of a Cinnamoyl CoA Reductase Gene(CCR) in Pear(Pyrus pyrifolia)显示文摘Pear is a popular and commercially important fresh fruit, and its texture is related to the presence of sclereid formatted by parenchyma cell with lignification in vascular plants. Previous studies have demonstrated that content of lignin may be regulated by cinnamoyl CoA reductase(CCR) in various plants. However, the function of CCR in pears remains very limited. In the present study, we isolated a cDNA encoding CCR(PpCCR, GenBank accession No. KF999958) and its promoter(proPpCCR) from Whangkeumbae pear to investigate the function of CCR in lignin biosynthesis. PpCCR-GFP expressed in rice mesophyll protoplast demonstrated that PpCCR-GFP was localized in the cytoplasm, indicating that CCR may function in cytoplasm without localization signals. In transgenic plants carrying PpCCR, we observed higher lignin content compared with that in wild type plants, further suggesting that PpCCR can affect the lignin contents through regulating lignin biosynthesis in Arabidopsis thaliana. More studies in other plants are needed to confirm our conclusion. | Meng HU Boya TAN Tao WU Xianming LI Junfan TU Fuchen YANG Hongyan ZHU Zhongqi QIN | 2014 | Agricultural Science & Technology2014，15，6： | 2 |
| 7 | MOF-derived Co_(9)S_(8) nano-flower cluster array modified separator towards superior lithium sulfur battery显示文摘Lithium sulfur batteries with high energy density are thought to be the most potential energy storage technology that can be commercialized.However,the shuttle effect of polysulfides deteriorates its electrochemical performance.Herein,a novel Co_(9)S_(8)nanostructure derived from metal organic framework material(MOF)was explored by simple liquid phase reaction and heat vulcanization of2-methylimidazole and Co(NO_(3))_(2)·6 H_(2)O on the surface of the original PP separator.The Co_(9)S_(8)nano-flower cluster array wall was vertically and closely arranged with the thickness of 200 nm,and the polysulfide can be adsorbed by its physical and chemical action to slow down the'shuttle effect'.It is found that the cell with the modified separator can achieve an ideal discharge capacity of about 600 mAh/g at 1 C.The specific capacity is maintained at 500 mAh/g after 200 cycles,with only 0.11%of capacity decay per cycle.It provides a new way for the utilization of MOF material derivatives to modify the separator in order to improve the electrochemical performance of lithium-sulfur batteries. | Qi Wang Hanqing Zhao Boya Li Chenhui Yang Mingyang Li Yanan Li Peng Han Miaomiao Wu Tengyu Li Ruiping Liu | 2021 | Chinese Chemical Letters2021，32，3： | 2 |
| 8 | Incidence and Clinical Risk Factors for Preeclampsia and Its Subtypes:A Population-Based Study in Beijing,China显示文摘Objective:This study aimed to evaluate the incidence and associated clinical risk factors for preeclampsia(PE)and its subtypes in a large multicentre retrospective study of Beijing,China.Methods:This study was conducted as a secondary analysis from the Gestational diabetes mellitus Prevalence Survey(GPS),a multicentre retrospective cohort study,which included 15 hospitals in Beijing,China.This analysis included 15,003 pregnant women who delivered in Beijing from June 20th to November 30th,2013.The incidence of PE was calculated.Risk factors for PE,including maternal age,pre-gestational body mass index(BMI),parity,chronic hypertension,pre-existing diabetes,and gestational diabetes mellitus,were assessed.PE was defined as early-or late-onset PE based on clinical manifestations during the week of delivery,and mild or severe PE based on the severity of the disease.Logistic regression analysis was used to quantify the association with the risk factors,and data were displayed as odds risks(OR)and 95%confidence interval(CI).Results:The overall incidence of PE was 2.65%(397/15,003).The prevalence of early-onset and late-onset PE was 0.36%(54/15,003)and 2.29%(343/15,003),respectively.The prevalence of mild and severe PE was 0.91%(137/15,003)and 1.73%(260/15,003),respectively.Risk factors including high BMI considered overweight(adjusted odds risk(aOR):1.48;95%CI:1.06-2.05;P=0.02)and obesity(aOR:2.15;95%CI:1.50-3.08;P<0.001),nulliparity(aOR:1.73;95%CI:1.32-2.25;P<0.001),multiple gestation(aOR:4.58;95%CI:2.86-7.32;P<0.001),and chronic hypertension(aOR:34.95;95%CI:26.60-45.93;P<0.001),were associated with increased risk for PE.Only chronic hypertension(aOR:13.75;95%CI:4.78-39.58;P<0.001)was a significant risk factors for early-onset PE,whereas high BMI considered both overweight(aOR:1.54;95%CI:1.09-2.18;P=0.01)and obesity(aOR:2.23;95%CI:1.53-3.27;P<0.001),nulliparity(aOR:2.00;95%CI:1.49-2.68;P<0.001),multiple gestation(aOR:4.11;95%CI:2.40-7.05;P<0.001),and chronic hypertension(aOR:35.57;95%CI:26.66-47.47;P<0.001)were more relevant risk factors for late-onset PE.Risk factors including obesity(aOR:2.20;95%CI:1.28-3.76;P<0.01 and aOR:1.80;95%CI:1.16-2.80;P=0.01),nulliparity(aOR:2.28;95%CI:1.44-3.60;P<0.001 and aOR:1.48;95%CI:1.09-2.02;P=0.01),multiple gestation(aOR:5.50;95%CI:2.87-10.67;P<0.001 and aOR:3.51;95%CI:1.93-6.41;P<0.001),and chronic hypertension(aOR:33.98;95%CI:22.20-52.01;P<0.001 and aOR:35.03;95%CI:25.40-48.31;P<0.001)were associated with mild and severe PE.Moreover,we found that women with an increasing number of these risk factors had a higher risk of developing PE than pregnant women without any identified risk factors.Conclusion:The incidence of PE in this study is consistent with previous reported studies.Our findings indicate chronic hypertension and multiple gestation are the most important risk factors for PE in Chinese pregnant women.The risk for developing PE is associated with both the type and abundance of risk factors.These factors are valuable when monitoring patients at risk for PE,as this can help ensure an earlier diagnosis and prediction in women who are more likely to develop PE. | Li Lin Jing Huai Rina Su Chen Wang Boya Li Huixia Yang | 2021 | Maternal-Fetal Medicine2021，3，2： | 1 |
| 9 | Energy consumption and CO 2 emission impacts of vehicle electrification in three developed regions of China显示文摘 | Ye Wu Zhengdong Yang Bohong Lin Huan Liu Renjie Wang Boya Zhou Jiming Hao | 2012 | Energy Policy2012，，： | 1 |
| 10 | Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice显示文摘Nanoplastics-induced developmental and reproductive toxicity,neurotoxicity and immunotoxicity are a focus of widespread attention.However,the effects of nanoplastics(NPs)on glycolipid metabolism and the precise underlying mechanisms are unclear at present.Here,we showed that oral administration of polystyrene nanoparticles(PS-NPs)disrupts glycolipid metabolism,with reactive oxygen species(ROS)identified as a potential key signaling molecule.After PS-NPs treatment,excessive production of ROS induced the infammatory response and activated the antioxidant pathway through nuclear factor-erythroid factor 2-related factor 2.The activation of nuclear factor-κB(NFκB)signaling pathway induced the phosphorylation of the mitogen-activated protein kinases(MAPK)signaling pathway,which induced the activation of extracellular regulated kinases(ERK)and p38.Constitutive activation of the MAPK signaling proteins induced high continued phosphorylation of insulin receptor substrate-1,in turn,leading to decreased protein kinase B(Akt)activity,which weakened the sensitivity of liver cells to insulin signals and induced insulin resistance.In parallel,phosphorylation of Akt led to loss of control of Fo XO1,a key gene of gluconeogenesis,activating transcription of glucose-6-phosphatase(G6PC)and phosphoenolpyruvate carboxykinase(PEPCK)in a manner dependent on PGC1α.Moreover,the activated ERK promoted lipid accumulation through ERK-PPARγcascades.Therefore,sterol regulatory element-binding protein-1 and levels of its downstream lipogenic enzymes,ACC-1,were up-regulated.Upon treatment with the antioxidant resveratrol,PS-NPs-induced glucose and lipid metabolic disorders were improved by inhibiting ROS-induced activation of NFκB and MAPK signaling pathway in mice.Based on above,PS-NPs exposure disrupts glycolipid metabolism in mice,with ROS identified as a potential key signaling molecule. | Xingpei Fan Xiaoyan Li Jiaxin Li Yuxia Zhang Xiangjuan Wei Hailong Hu Boya Zhang Haining Du Meimei Zhao Ruijiao Zhu Daqian Yang Yuri Oh Ning Gu | 2024 | Journal of Environmental Sciences2024，，3： | 0 |
| 11 | Reaction mechanism of dicofol removal by cellulase显示文摘It remains unclear whether dicofol should be defined as a persistent organic pollutant. Its environmental persistence has gained attention. This study focused on its degradation by cellulase. Cellulase was separated using a gel chromatogram, and its degradation activity towards dicofol involved its endoglucanase activity. By analyzing the kinetic parameters of cellulase reacting with mixed substrates, it was shown that cellulase reacted on dicofol and carboxyl methyl cellulose through two different active centers. Thus, the degradation of dicofol was shown to be an oxidative process by cellulase. Next, by comparing the impacts of tert-butyl alcohol(a typical OH free-radical inhibitor) on the removal efficiencies of dicofol under both cellulase and Fenton reagent systems, it was shown that the removal of dicofol was initiated by OH free radicals produced by cellulase. Finally, 4,4′-dichlorodibenzophenone and chloride were detected using gas chromatography mass spectrometry and ion chromatography analysis, which supported our hypothesis. The reaction mechanism was analyzed and involved an attack by OH free radicals at the orthocarbon of dicofol, resulting in the degradation product 4,4′-dichloro-dibenzophenone. | Ziyuan Wang Ting Yang Zihan Zhai Boya Zhang Jianbo Zhang | 2015 | Journal of Environmental Sciences2015，27，10： | 0 |
| 12 | Night warming increases wheat yield by improving pre-anthesis plant growth and post-anthesis grain starch biosynthesis显示文摘Global climate change is characterized by asymmetric warming,i.e.,greater temperature increases in winter,spring,and nighttime than in summer,autumn,and daytime.Field experiments were conducted using four wheat cultivars,namely‘Yangmai 18’(YM18),‘Sumai 188’(SM188),‘Yannong 19’(YN19),and‘Annong 0711’(AN0711),in the two growing seasons of 2019-2020 and 2020-2021,with passive night warming during different periods in the early growth stage.The treatments were night warming during the tillering-jointing(NW_(T-J)),jointing-booting(NWJ-B),and booting-anthesis(NWB-A)stages,with ambient temperature(NN)as the control.The effects of night warming during different stages on wheat yield formation were investigated by determining the characteristics of dry matter accumulation and translocation,as well as sucrose and starch accumulation in wheat grains.The wheat yields of all four cultivars were significantly higher in NW_(T-J)than in NN in the 2-year experiment.The yield increases of semi-winter cultivars YN19 and AN0711 were greater than those of spring cultivars YM18 and SM188.Treatment NW_(T-J)increased wheat yield mainly by increasing the 1,000-grain weight and the number of fertile spikelets,and it increased dry matter accumulation in various organs of wheat at the anthesis and maturity stages by increasing the growth rate at the vegetative growth stage.The flag leaf and spike showed the largest increases in dry matter accumulation.NW_(T-J)also increased the grain sucrose and starch contents in the early and middle grain-filling stages,promoting yield formation.Overall,night warming between the tillering and jointing stages increased the pre-anthesis growth rate,and thus,wheat dry matter production,which contributed to an increase in wheat yield. | Yonghui Fan Boya Qin Jinhao Yang Liangliang Ma Guoji Cui Wei He Yu Tang Wenjing Zhang Shangyu Ma Chuanxi Ma Zhenglai Huang | 2024 | Journal of Integrative Agriculture2024，23，2： | 0 |
| 13 | Effects of metal ions on the catalytic degradation of dicofol by cellulase显示文摘A new technique whereby cellulase immobilized on aminated silica was applied to catalyze the degradation of dicofol, an organochlorine pesticide. In order to evaluate the performance of free and immobilized cellulase, experiments were carried out to measure the degradation efficiency. The Michaelis constant, Km, of the reaction catalyzed by immobilized cellulase was9.16 mg /L, and the maximum reaction rate, Vmax, was 0.40 mg /L /min, while that of free cellulase was Km= 8.18 mg /L, and Vmax= 0.79 mg /L /min, respectively. The kinetic constants of catalytic degradation were calculated to estimate substrate affinity. Considering that metal ions may affect enzyme activity, the effects of different metal ions on the catalytic degradation efficiency were explored. The results showed that the substrate affinity decreased after immobilization. Monovalent metal ions had no effect on the reaction, while divalent metal ions had either positive or inhibitory effects, including activation by Mn2+, reversible competition with Cd2+, and irreversible inhibition by Pb2+. Ca2+promoted the catalytic degradation of dicofol at low concentrations, but inhibited it at high concentrations. Compared with free cellulase, immobilized cellulase was affected less by metal ions. This work provided a basis for further studies on the co-occurrence of endocrine-disrupting chemicals and heavy metal ions in the environment. | Zihan Zhai Ting Yang Boya Zhang Jianbo Zhang | 2015 | Journal of Environmental Sciences2015，27，7： | 0 |
| 14 | The dichotomous role of immunoproteasome in cancer:Friend or foe?显示文摘Immunoproteasome is a variant of proteasome with structural differences in 20S subunits optimizing them for the production of antigenic peptides with higher binding affinity to major histocompatibility complex(MHC)-I molecules.Apart from this primary function in antigen presentation,immunoproteasome is also responsible for the degradation of proteins,both unfolded proteins for the maintenance of protein homeostasis and tumor suppressor proteins contributing to tumor progression.The altered expression of immunoproteasome is frequently observed in cancers;however,its expression levels and effects vary among different cancer types exhibiting antagonistic roles in tumor development.This review focuses on the dichotomous role of immunoproteasome in different cancer types,as well as summarizes the current progression in immunoproteasome activators and inhibitors.Specifically targeting immunoproteasome may be a beneficial therapeutic intervention in cancer treatment and understanding the role of immunoproteasome in cancers will provide a significant therapeutic insight for the prevention and treatment of cancers. | Boya Chen Haiying Zhu Bo Yang Ji Cao | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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