|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | H pylori eradication:A randomized prospective study of triple therapy with or without ecabet sodium显示文摘AIM: To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate. METHODS: Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative 13C-urea breath test 6-8 wk after completion of treatment. RESULTS: After completion of therapy, 194/257 patients showed negative 13C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups. CONCLUSION: Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori. | Hyung Wook Kim Gwang Ha Kim Jong Yun Cheong Ung Suk Yang Seung Keun Park Chul Soo Song Dae Hwan Kang Geun Am Song | 2008 | World Journal of Gastroenterology2008，14，6： | 9 |
| 2 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 3 | Further evidence for the involve- ment of inhibition of eeU proliferation arid development in thymic and splenic atrophy induced by the peroxisome proliferator perfluorooctanoic acid in mice显示文摘 | Yang Q Xie Y Eriksson AM | 2001 | Biochem Pharmacol2001，62，8： | 1 |
| 4 | The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells显示文摘 | Leng AM Liu T Yang J | 2012 | Cell Biol Int2012，36，10： | 1 |
| 5 | Regulating the p53 system through ubiquitination显示文摘 | Yang Y Li CC Weissrnan AM | 2004 | Oncogene2004，23，11： | 1 |
| 6 | Prevention of apoptosis by Bcl-2:release of cytochrome c from mitochondria blocked显示文摘 | Yang J Liu X Bhalla K Kim CN Ibrado AM Cai J | 1997 | Science1997，275，5303： | 1 |
| 7 | In vivo activa-tion of human pregnane X receptor tightens theblood-brain barrier to methadone through P-glyco-protein up-regulation显示文摘 | Bauer B Yang X Hartz AM | 2006 | Mol Pharmacol2006，70，4： | 1 |
| 8 | The role of cell adhesion molecules in the development of IDDM显示文摘 | Yang XD Sara AM Reina EM | 2003 | Diabetes2003，45，6： | 1 |
| 9 | The protective role of tea polyphenols against methyhnercury-induced neurotoxie effects in rat cerebral cortex via inhibition of oxidative stress 显示文摘 | Liu W Xn Z Yang T et am | 2014 | Free Radie Res2014，48，： | 1 |
| 10 | The application of target informationand preclinical pharmacokinetic/pharmacodynamic modeling in predic-ting clinical doses of a Dickkopf-1 antibody for osteoporosis显示文摘 | Betts AM Clark TH Yang J | 2010 | JPharmacol Exp Ther2010，333，1： | 1 |
| 11 | PI3K blockade by Ad-PTEN inhibits invasion and induces apoptosis in radial growth phase and metastatic melanoma cells显示文摘 | Stewart AL Mhashilkar AM Yang XH | 2002 | Molecular Medicine2002，8，： | 1 |
| 12 | Abnormal regulation of DNA methyltranderase expression during colorectal carcinogenesis 显示文摘 | De Marzo AM Marchi VL Yang ES | 1999 | Cancer Res1999，59，16： | 1 |
| 13 | Changes in spine loading patterns throughout the workday as a unction of experience,lift frequency,and personality 显示文摘 | Chany AM Parakkat J Yang G | 2006 | Spine J2006，6，3： | 1 |
| 14 | Alanine-glutamine dipeptide(AGD) inhibits expression of inflammation-related genes in hemorrhagic shock显示文摘 | Yang R Tan X Thomas AM | 2007 | Jpen2007，31，1： | 1 |
| 15 | Pegfilgrastim, a sus- tained-duration form of filgrastim, significantly improves neu- trophil recovery after autologous marrow transplantation in rhesus macaques 显示文摘 | Farese AM Yang BB Roskos L | 2003 | Bone Marrow Transplant2003，32，4： | 1 |
| 16 | PI3Kinase blockade by ad-PTEN inhibits invision and induces apoptosis in RGP and metastasis melanoma cells 显示文摘 | Stewart AL Mhashilkar AM Yang XH | 2002 | Mol Med2002，8，8： | 1 |
| 17 | Human endothelial cell life extension by telomerase expression显示文摘 | Yang JE Chang AM Cherry CD | 1999 | J Biol Chem1999，274，26： | 1 |
| 18 | Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model显示文摘 | Reich SJ Fosnot J Kuroki A Tang W Yang X Magutre AM | 2003 | Mol Vis2003，9，： | 1 |
| 19 | Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes显示文摘 | Yang X Xu AM Hui XY | | 0，，： | 1 |
| 20 | The protein product of the tumor suppressor gene, melanoma differentiation-associated gene 7, exhibits immunostimulatory activity and is designated IL-24 显示文摘 | Cauden EG Mumm JB Poindexter N Ekmekcioglu S Mhashilkar AM Yang XH | 2002 | J Immunol2002，168，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员