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| 1 | Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component显示文摘AIM: To predict the rate of lymph node(LN) metastasis in diffuse- and mixed-type early gastric cancers(EGC) for guidelines of the treatment.METHODS: We reviewed 550 cases of EGC withdiffuse- and mixed-type histology. We investigated the clinicopathological factors and histopathological components that influence the probability of LN metastasis, including sex, age, site, gross type, presence of ulceration, tumour size, depth of invasion, perineural invasion, lymphovascular invasion, and LN metastasis status. We reviewed all slides and estimated the proportions of each tumour component; pure diffuse type, mixed-predominantly diffuse type(diffuse > intestinal type), mixed-predominantly intestinal type(intestinal > diffuse type), and mixed diffuse = intestinal type. We calculated the extents of the respective components.RESULTS: LN metastasis was observed in 12.9%(71/550) of early gastric cancers cases [15/288 mucosal EGCs(5.2%) and 56/262 submucosal EGCs(21.4%)]. Of 550 cases, 302 were diffuse-type and 248 were mixed-type EGCs. Of 248 mixed-type EGCs, 163 were mixed-predominantly diffuse type, 82 were mixed-predominantly intestinal type, and 3 were mixed diffuse = intestinal type. Mixed-type cases with predominantly diffuse type histology showed a higher frequency of LN metastasis(20.2%) than cases of pure diffuse type(9.3%) and predominantly intestinal type(12.2%) histology. We measured the dimensions of each component(intestinal and diffuse type) to determine the association of the extent of each component with LN metastasis in mixed-type gastric carcinoma. The total tumour size and the extent of poorly differentiated components was associated with LN metastasis, while that of signet ring cell components was not.CONCLUSION: We recommend careful identification and quantitative evaluation of mixed-type early gastric cancer components after endoscopic resection to determine the intensity of the treatment. | Chung-Su Hwang Sangjeong Ahn Bong-Eun Lee So-Jeong Lee Ahrong Kim Chang In Choi Dae Hwan Kim Tae-Yong Jeon Gwang Ha Kim Geum Am Song Do Youn Park | 2016 | World Journal of Gastroenterology2016，22，15： | 8 |
| 2 | Significant risk and associated factors of active tuberculosis infection in Korean patients with inflammatory bowel disease using anti-TNF agents显示文摘AIM:To evaluate the incidence and risk factors of Korean tuberculosis(TB) infection in patients with inflammatory bowel disease(IBD) undergoing anti-TNF treatment.METHODS:The data of IBD patients treated with anti-TNFs in 13 tertiary referral hospitals located in the southeastern region of Korea were collected retrospectively.They failed to show response or were intolerant to conventional treatments,including steroids or immunomodulators.Screening measures for latent TB infection(LTBI)and the incidence and risk factors ofactive TB infection after treatment with anti-TNFs were identified.RESULTS:Overall,376 IBD patients treated with antiTNF agents were recruited(male 255,mean age of anti-TNF therapy 32.5±13.0 years);277 had Crohn’s disease,99 had ulcerative colitis,294 used infliximab,and 82 used adalimumab.Before anti-TNF treatment,screening tests for LTBI including an interferon gamma release assay or a tuberculin skin test were performed in 82.2%of patients.Thirty patients(8%)had LTBI.Sixteen cases of active TB infection including one TB-related mortality occurred during 801 personyears(PY)follow-up(1997.4 cases per 100000 PY)after anti-TNF treatment.LTBI(OR=5.76,95%CI:1.57-21.20,P=0.008)and WBC count<5000 mm3(OR=4.5,95%CI:1.51-13.44,P=0.007)during follow-up were identified as independently associated risk factors.CONCLUSION:Anti-TNFs significantly increase the risk of TB infection in Korean patients with IBD.The considerable burden of TB and marked immunosuppression might be attributed to this risk. | Eun Soo Kim Geun Am Song Kwang Bum Cho Kyung Sik Park Kyeong Ok Kim Byung Ik Jang Eun Young Kim Seong Woo Jeon Hyun Seok Lee Chang Heon Yang Yong Kook Lee Dong Wook Lee Sung Kook Kim Tae Oh Kim Jonghun Lee Hyung Wook Kim Sam Ryong Jee Seun Ja Park Hyun Jin Kim | 2015 | World Journal of Gastroenterology2015，21，11： | 5 |
| 3 | EMR for early gastric cancer in Korea: a multicenter retrospective study显示文摘 | Jae J. Kim Jun Haeng Lee Hwoon-Yong Jung Gin Hyug Lee Joo Yong Cho Chang Beom Ryu Hoon Jai Chun Jong Jae Park Wan Sik Lee Hyun Soo Kim Moon Gi Chung Jeong Seop Moon Seok Reyol Choi Geun Am Song Hyun Yong Jeong Sam Ryong Jee Sang Yong Seol Yong Bum Yoon | 2007 | Gastrointestinal Endoscopy2007，，4： | 2 |
| 4 | A controlled trial of psycho -educational interventions in preparing Chinese women for elective hysterectomy显示文摘 | Cheung LH Callaghan P Chang AM | 2003 | International Journal of Nursing Studies2003，40，2： | 1 |
| 5 | Milrionone,nystemic and pulmonary hemodynamic effects in neonates and infants after cardiac surgery显示文摘 | Chang AC Atz AM Wernovsky G | 1995 | Cnt Care Med1995，23，： | 1 |
| 6 | Lack of association between left bundle-branch block and acute myocardial infarction in symptomatic ED patients显示文摘 | Chang AM Shofer FS TabasJ A | 2009 | AmJ Emerg Med2009，27，8： | 1 |
| 7 | Mechanism of the therapeutic effect of anisodamine in disseminated intravascular coagulation:study of platelet adhesion and aggregation,malondialdehyde,thromboxane B2,6-keto-prostaglandin F1 alpha,and microcirculation显示文摘 | Zhang S Chang AM Li CF | 1987 | Exp Hematol1987，15，1： | 1 |
| 8 | Neuropathic pain memory is maintained by Racl-regulated dendritic spine remodeling after spinal cord injury显示文摘 | Tan AM Starnboulian S Chang YW | 2008 | J Neurosci2008，28，13： | 1 |
| 9 | Acute treatment of migraine headache显示文摘 | CHANG M RAPOPORT AM | 2009 | Tech Reg Anesth Pain Manag2009，13，1： | 1 |
| 10 | Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department显示文摘 | Perman SM Chang AM Hollander JE | 2011 | Acad Emerg Med2011，18，2： | 1 |
| 11 | Mutagenesis and map ping of a mouse gene,Clock,essential for circadian behavior显示文摘 | Vitaterna MH King DP Chang AM | 1994 | Sci ence1994，264，5159： | 1 |
| 12 | State self-esteem following stroke显示文摘 | Chang AM Mackenzie AE | 1998 | Stroke1998，29，11： | 1 |
| 13 | Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal micro RNA mi R-124 and reduced AMPA receptors显示文摘 | Dutta R Chomyk AM Chang A | 2013 | Ann Neurol2013，73，： | 1 |
| 14 | The effect of progressive muscle relaxation training on anxiety and quality of life after stoma surgery in colorectal cancer patients 显示文摘 | Cheung YL Molassiotis A Chang AM | 2003 | Psychooncology2003，12，3： | 1 |
| 15 | Neuropathic pain memory is maintained by Racl-regulated dendritic spine remodeling after spinal cord injury显示文摘 | Tan AM Stamboulian S Chang YW | 2008 | J Neurosci2008，28，49： | 1 |
| 16 | Anastomotic leak after double-stapled low colorectal resection 显示文摘 | Averbach AM Chang D Koslowe P Sugarbaker PH | 1996 | Dis Colon Rectum1996，39，7： | 1 |
| 17 | A pilot project to evaluate implementation of clinical guidelines显示文摘 | Lee FK Chang AM Mackenzie AE | 2002 | J Nuts Care Qual2002，16，2： | 1 |
| 18 | Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department显示文摘 | Perman SM Chang AM Hollander JE | 2011 | Acad Emerg Med2011，18，2： | 1 |
| 19 | Mutangenesis and mapping of a mouse gene Clock essential for circadian behavior 显示文摘 | Vitatema MH King DP Chang AM | 1994 | Science1994，264，： | 1 |
| 20 | Repetitive febrile seizures in rat pups cause long-lasting deficits in Synaptic plasticity and NR2A tyrosine phosphorylation显示文摘 | Chang YC Kuo YM Huang AM | 2005 | Neurobiol Dis2005，18，3： | 1 |
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