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| 1 | Oncofetal antigen glypican-3 as a promising early diagnostic marker for hepatocellular carcinoma显示文摘BACKGROUND:Hepatocellular carcinoma (HCC) is characterized by a multi-cause,multi-stage and multi-focus process of tumor progression.Its prognosis is poor and early diagnosis is of utmost importance.This study was undertaken to investigate the dynamic expression of oncofetal antigen glypican-3 (GPC-3) and GPC-3 mRNA in hepatocarcinogenesis and to explore their early diagnostic value for HCC.METHODS:A hepatoma model was induced in male Sprague-Dawley rats with 0.05% 2-fluorenylacetamide and confirmed by hematoxylin and eosin staining and gamma-glutamyltransferase (GGT) expression.Total RNA was purified and transcribed into cDNA by reverse transcription.Fragments of the GPC-3 gene were amplified by nested RT-PCR,and confirmed by sequencing.GPC-3 was analyzed by immunohistochemistry,Western blotting or ELISA.RESULTS:Positive GPC-3 expression showed as brown granule-like staining localized in the cytoplasm.Histological examination of hepatocytes revealed three morphological stages of granule-like degeneration,atypical hyperplasia (precancerous),and cancer formation,with a progressive increase of liver total RNA and GGT expression.The incidence of liver GPC-3 mRNA and GPC-3,and serum GPC-3 was 100%,100% and 77.8% in the HCC group,100%,100%,and 66.7% in the precancerous group,83.3%,83.3%,and 38.9% in the degeneration group,and no expression in the liver or blood of the control group,respectively.There was a positive correlation between liver GPC-3 mRNA and total RNA level (r=0.475,P<0.05) or liver GPC-3 (r=1.0,P<0.001) or serum GPC-3 (r= 0.994,P<0.001).CONCLUSION:Abnormal oncofetal antigen GPC-3 and GPC-3 mRNA expression in hepatocarcinogenesis may be promising molecular markers for early diagnosis of HCC. | Research Center of Clinical Medicine,Affiliated Hospital of Nantong University,Nantong 226001,China (Yao M,Yao DF,Qiu LW,Wu W,Sai WL,Yang JL and Zhang HJ) Department of Oncology,Yancheng First People’s Hospital,Yancheng 224001,China (Bian YZ) Department of Oncology,Second Affiliated Hospital,Nanjing Medical University,Nanjing 210011,China (Zhang CG) | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 51 |
| 2 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 3 | A long-term Global LAnd Surface Satellite(GLASS)data-set for environmental studies显示文摘Recently,five Global LAnd Surface Satellite(GLASS)products have been released:leaf area index(LAI),shortwave broadband albedo,longwave broadband emissivity,incident short radiation,and photosynthetically active radiation(PAR).The first three products cover the years 19822012(LAI)and 19812010(albedo and emissivity)at 15 km and 8-day resolutions,and the last two radiation products span the period 20082010 at 5 km and 3-h resolutions.These products have been evaluated and validated,and the preliminary results indicate that they are of higher quality and accuracy than the existing products.In particular,the first three products have much longer time series,and are therefore highly suitable for various environmental studies.This paper outlines the algorithms,product characteristics,preliminary validation results,potential applications and some examples of initial analysis of these products. | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | International Journal of Digital Earth2013，6，S01： | 16 |
| 4 | MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1显示文摘MicroRNAs (miRNAs ) 是由指向多重 mRNAs 的定序明确地在基因表示的 post-transcriptional 规定有一个枢轴的角色的小 noncoding RNA。尽管 miR-33a 最近被报导在类脂化合物动态平衡,动脉粥样硬化,和肝的纤维变性起一个重要作用,在肿瘤前进和转移的 miR-33a 的功能大部分是未知的。这里,我们发现在乳癌纸巾的 downregulated miR-33a 与淋巴节点转移相关。MiR-33a 表示比 noncancerous 胸在高度变形的乳癌房间线是显著地更低的上皮的房间和非变形的乳癌房间。而且,在变形乳癌细胞的 miR-33a 的 overexpression 显著地减少在 vitro 并且显著地的细胞增长和侵略在 vivo 禁止肿瘤生长和肺转移,而它的在非变形的乳癌细胞击倒显著地在 vitro 提高细胞增长和侵略并且在 vivo 支持肿瘤生长和肺转移。联合生物信息学预言和生物化学的分析,我们证明 ADAM9 和 ROS1 是 miR-33a 的直接下游的目标。这些调查结果作为乳癌房间增长和转移的一个否定管理者识别了 miR-33a。 | Chuankai Zhang Yunda Zhang Weiji Ding Yancheng Lin Zhengjie Huang Qi Luo | 2015 | Protein & Cell2015，6，12： | 10 |
| 5 | Metamorphic Petrology of Clinopyroxene Amphibolite from the Xigaze Ophiolite,Southern Tibet: P-T Constraints and Phase Equilibrium Modeling显示文摘The clinopyroxene amphibolite from the Bailang terrane is located in the central section of the Yarlung Zangbo suture zone(YZSZ),southern Tibet.The study of it is expected to provide important clues for the subduction of the Neo-Tethyan Ocean below the Asian Plate and thus for better understanding of the development of the India-Asia collision zone.Based on integrated textural,mineral compositional,metamorphic reaction history and geothermobarometric studies of the clinopyroxene amphibolite within a serpentinite mélange,four overprinted metamorphic stages are established.They are the first metamorphic record of M1 stage indicated by a relict assemblage of plagioclase+clinopyroxene+amphibole,an early M2 stage characterized by an assemblage of medium-grained clinopyroxene+amphibole+plagioclase+quartz as well as rutile inclusion in titanite,which is formed during burial process,an isobaric cooling M3 stage which is characterized by an assemblage of clinopyroxene+amphibole+plagioclase+titanite,and a decomposing retrograde stage M4,which is represented by the amphibolite+plagioclase symplectite+titanite+rutile+quartz.By applying the THERMOCALC(versions 6.2 and 6.3)technique in the NCFMASHTO system,the P-T conditions estimated from M1 to M4 stages are ca.8.6 kbar/880℃,10.8–13.4 kbar/800–840℃,12.7–13.2 kbar/650–660℃ and<11.2 kbar/640℃,respectively.The mineral assemblages and their P-T conditions define a counterclockwise P-T path for the clinopyroxene amphibolite of the Xigaze ophiolite,suggesting that the rocks underwent a cooling process during burial from magmatic protolith,and a decompressing stage after the pressure peak metamorphic conditions,which implies that the Bailang terrane of the Xigaze ophiolite may have experienced subduction/collision-related tectonic processes.The peak metamorphism reaches to the transitional P-T conditions among amphibolite facies,granulite facies and eclogite facies with a burial depth of 30–40 km.After exhumation of the ophiolitic unit to the shallow crustal levels,the clinopyroxene amphibolite exposes to a high fO2 condition on the basis of the stable epidotebearing assemblage in the T-MO2 diagrams.A late subgreenschist facies overprinting subsequently occurs,the relevant mineral assemblage is prehnite+albite+chlorite+epidote+quartz. | Yancheng Zhang Xu-Ping Li Guangming Sun Zeli Wang Wenyong Duan | 2019 | Journal of Earth Science2019，30，3： | 7 |
| 6 | Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells显示文摘 | Miguel Angel Esteban Tao Wang Baoming Qin Jiayin Yang Dajiang Qin Jinglei Cai Wen Li Zhihui Weng Jiekai Chen Su Ni Keshi Chen Yuan Li Xiaopeng Liu Jianyong Xu Shiqiang Zhang Feng Li Wenzhi He Krystyna Labuda Yancheng Song Anja Peterbauer Susanne Wolbank H | 2010 | Cell Stem Cell2010，，： | 3 |
| 7 | Light-weight refractory high-entropy alloys: A comprehensive review显示文摘In recent years,high-entropy alloys(HEAs)have become a research hotspot in materials community,and great progress has been made in exploring various high-performance HEAs.As a special class,the light-weight refractory high-entropy alloys(RHEAs)own both excellent high-temperature comprehensive properties and low density and have accordingly attracted more and more attention.In this paper,we presented a comprehensive review of the recent progress and status in light-weight RHEAs.Based on an exhausting search of the literature reports,one strategy in terms of phase numbers after preparation was first proposed to classify the light-weight RHEAs into three categories.Then,the status on the fundamental thermodynamic and thermophysical data/databases,computational approaches for alloy designing,and preparation/fabrication techniques of light-weight RHEAs was introduced one after another.After that,the progress on mechanical properties and oxidation/corrosion/wear behaviors of light-weight RHEAs at room and high temperatures was summarized.Finally,the conclusions of this review were drawn.By pointing out the shortcomings of the current research,the follow-up development directions in the field of light-weight RHEAs were also given. | Zechun Wang Shiyao Chen Shenglan Yang Qun Luo Yancheng Jin Wei Xie Lijun Zhang Qian Li | 2023 | Journal of Materials Science & Technology2023，，20： | 3 |
| 8 | Pulse radiolysis study on gatifloxacin——A fluoroquinolone antibiotic显示文摘The reactions between gatifloxacin(GFX) and various one-electron oxidants,such as ˙OH,N3˙,Br2˙ˉ,and SO4˙ˉ,have been studied by pulse radiolysis techniques.The GFX radical anion formed in the reaction of GFX with eaqˉ could either be protonated or deprotonated,and the absorption of GFX radical anion was located at 390 nm.The transient species produced by the reaction of GFX with ˙OH radical shows a broad band in the 380?600 nm region with a shoulder,while the oxidation by N3˙,SO4˙ˉ,and Br2˙ˉ results in an absorption band with λmax = 370 nm.At neutral condition(pH 7),the rate constants of GFX reacting with ˙OH,N3˙,Br2˙ˉ,SO4˙ˉ and eaqˉ are estimated to be 1.0 × 1010,3.1 × 109,2.8 × 109,3.0 × 109,and 1.8 × 1010 dm3 mol?1 s?1,respectively.From the pH dependence on the formation of electron adducts and on the rate constant of GFX with eaqˉ,the pKa of GFX radical anion is estimated to be 5.5 and 9.3. | LI HaiXia LIU YanCheng TANG RuiZhi ZHANG Peng FU HaiYing YAO SiDe WANG WenFeng | 2012 | Science China Chemistry2012，55，7： | 3 |
| 9 | Use of NOMA for Maritime Communication Networks with P-DF Relaying Channel显示文摘In this paper,a partial decode-and-forward(P-DF)cooperative relaying network(CRN)with non-orthogonal multiple access(P-DF-CRN-NOMA)for maritime space communications is proposed.Without loss of generality,three kinds of relay forwarding protocols are studied to characterize the superiority of the proposed P-DF-CRN-NOMA scheme,where,after receptions from the coastal base station(BS),the island relay forwards the successful decoded symbols to the ship user to avoid the performance loss provided by the high decoding requirement in decode-and-forward(DF).To further improve the system performance,as well as for a fairness comparison,the maximum ratio combining(MRC)is utilized at the ship user.Specifically,to present the impact of the channel qualities,the scenarios of the weak and strong links that from the source to destination(S-D)are both considered.The closed-form expressions for the outage probability of the P-DF-CRN-NOMA are derived considering the three proposed forwarding cases.Qualitative numerical results corroborating our theoretical analysis,especially for the high signalto-noise ratio(SNR),show that the proposed P-DF-CRN-NOMA scheme significantly improves the outage probability performance in comparison to the conventional CRN-NOMA schemes.Furthermore,for an increased S-D link,the corresponding outage probability performance will be also better for all the cases. | Yancheng Ji Xiao Zhang Guoan Zhang Xiaojun Zhu Qiang Sun Wei Duan | 2020 | China Communications2020，17，7： | 2 |
| 10 | A Near Optimal Power Allocation Scheme for Cooperative Relay Networking with NOMA显示文摘In this paper, we propose cooperative relay networks with non-orthogonal multiple access in order to design a near-optimal power allocation strategy. Like other next generation wireless technologies, spatially multiplexed transmissions are achieved by relay nodes which enables decode-and-forward relaying of a new superposition code after reception from the source. It is worth noting that, since it is hard to exactly prove the proposed PA scheme, due the fact that it is one kind of the approximate conjectures. Therefore, mathematical and numerical methods have been used to clarify the feasibility of the proposal. Numerical results indicate that it is able to asymptotically achieve the optimal sum rate at the higher signal-to-noise ratio region with the proposed strategy applied instead of negligible performance loss. | Haiyang Yu Wei Duan Guoan Zhang Yancheng Ji Xiaojun Zhu Jaeho Choi | 2019 | China Communications2019，16，3： | 2 |
| 11 | Petrology,Metamorphic P-T Paths and Zircon U-Pb Ages for Paleoproterozoic Mafic Granulites from Xuanhua,North China Craton显示文摘The studied mafic granulites are located at Xiwangshan,Xuanhua region in the north of the Trans-North China Orogen(TNCO),occurring as lens within tonalite-trondhjemite-granodiorite(TTG)gneisses in the eastern part of the Xiwangshan area.The rocks contain the representative granulite-facies minerals such as garnet,clinopyroxene,orthopyroxene,plagioclase,amphibolite,rutile and quartz,and also well-developed melt pseudomorph and antiperthite.Although the prograde metamorphic stage(M1)cannot be retrieved due to rare preservation of pre-peak-stage mineral associations,three distinct mineral assemblages that formed in different metamorphic stages can be identified,based on petrography and mineralogy characteristics.The peak stage(M2)is characterized by Grt2+Cpx2+Amp2+Pl2+Rt+melt pseudomorphs,and a post-peak decompression stage(M3)contains a mineral assemblage of Grt3+Opx3+Cpx3+Amp3+Pl3,while a later-retrogression stage(M4)is featured by coronas of Amp4+Pl4 surrounding garnet.By calculating metamorphic P-T conditions using THERMOCALC,stage M2 was constrained to be 13.2–14.8 kbar and 1050–1080℃,and M3 recorded P-T conditions of 5.7–7.3 kbar and 825–875℃,while M4 yielded P of^5 kbar and T of^660℃,consistent with amphibolite facies metamorphism.Taking into account of all these petrological data,we propose that the mafic granulite experienced a high-pressure(HP)and ultra-high temperature(UHT)granulite-facies metamorphism during the peak metamorphism,which was accompanied with a clockwise P-T path.U-Pb dating of metamorphic zircons in the granulites yields two groups of ages at 1853±14 and 1744±44 Ma,respectively.We suggest that the older age corresponded to the HP-UHT metamorphism,while the younger age represented an retrograde metamorphic event during cooling. | Guidong Wei Fanmei Kong Hao Liu Xiaoman Wang Yancheng Zhang Xiaohan Liu | 2019 | Journal of Earth Science2019，30，6： | 2 |
| 12 | Photosensitive damage of lysozyme caused by pazufloxacin and the protective effect of ferulic acid显示文摘Laser flash photolysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE) experiments were carried out to study the photosensitive damage induced by pazufloxacin(PAX) and the protection of lysozyme(Lyso) by ferulic acid(FCA), an active antioxidant. Transient absorption spectra revealed electron transfer from Lyso and FCA to 3PAX*, with respective bimolecular reaction rate constants of 6.3×107 and 1.4×1010 dm3/(mol s). A pulse radiolysis study was also performed to investigate the formation of Lyso radical cations. Results showed that FCA effectively inhibited the cross-linking of protein induced by fluoroquinolones. Finally, a mechanism of the protective effect of FCA on Lyso was proposed. | Yulie Xu Yancheng Liu Haixia Li Peng Zhang Jianfeng Zhao Wenfeng Wang | 2015 | Science China Chemistry2015，58，3： | 2 |
| 13 | Physiological and anatomical changes in two rapeseed (Brassica napus L.) genotypes under drought stress conditions显示文摘Understanding the mechanisms of drought resistance in crop species is crucial for the selection and breeding of tolerant rapeseed(Brassica napus L.)varieties.The present study aimed to assess the physiological and anatomical responses of two rapeseed genotypes,P287(drought-tolerant)and T88(drought-sensitive)under three intensities of drought stress.All physiological and anatomical parameters related to drought acclimation were significantly altered in both genotypes under stress conditions.At the fourth-leaf stage,the relative water content,chlorophyll content,protein content,malondialdehyde content,and the activities of peroxidase and catalase in P287 were significantly higher than those in T88,particularly under severe drought conditions.After rehydration,all physiological indexes recovered rapidly,especially in P287.In addition,under drought stress,compared with T88,P287 had thicker palisade tissue,thinner spongy tissue,higher ratio of chloroplast length to chloroplast width,higher stomatal density and stomatal closure rate.Overall,the interaction between physiological and anatomical features improved the drought tolerance of P287 under drought stress conditions. | Jiacheng Zhu Dongfang Cai Jianping Wang Jinhua Cao Yancheng Wen Junping He Lei Zhao Dongguo Wang Shufen Zhang | 2021 | Oil Crop Science2021，6，2： | 2 |
| 14 | Pulse radiolysis and laser flash photolysis study of balofloxacin显示文摘 | XU Yulie LIU Yancheng LI Haixia ZHANG Peng TANG Ruizhi CAO Xiyan WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 15 | FE-model for titanium alloy(Ti-6Al-4V) cutting based on the identification of limiting shear stress at tool-chip interface显示文摘 | ZHANG Yancheng MABROUKI T NELIAS D | 2011 | International journal of material forming2011，4，1： | 1 |
| 16 | Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells显示文摘 | Miguel Angel Esteban Tao Wang Baoming Qin Jiayin Yang Dajiang Qin Jinglei Cai Wen Li Zhihui Weng Jiekai Chen Su Ni Keshi Chen Yuan Li Xiaopeng Liu Jianyong Xu Shiqiang Zhang Feng Li Wenzhi He Krystyna Labuda Yancheng Song Anja Peterbauer Susanne Wolbank H | 2010 | Cell Stem Cell2010，，1： | 1 |
| 17 | Highly efficient lithium composite anode with hydrophobie molten salt in seawater 显示文摘 | Yancheng Zhang Mima Urquidi-Macdonald | 2004 | Journal of Power Sources2004，129，： | 1 |
| 18 | Detection and Analysis of Pesticide Residues in Chinese Chives and Risk Assessment of Dietary Intake显示文摘[Objectives]This study was conducted to understand the status of pesticide residues and dietary intake risk of Chinese chives in Tangshan area. [Methods] Sixty eight kinds of pesticide residues in 415 Chinese chive samples collected from Tangshan area were qualitatively and quantitatively determined by high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) and gas chromatography(GC) in 2020. [Results] The results showed that 41 kinds of pesticide residues were detected in the 415 Chinese chive samples, and the detection rate was 69.4%(288/415), and there was a combination of pesticides in many samples. According to the National Food Safety Standard―Maximum Residue Limits of Pesticides in Food(GB 2763-2019), the residues of 12 pesticides exceeded the maximum residue limits(MRLs), and the unqualified rate was 38.07%(158/415). The highest detection rate of clothianidin was 41.20%(171/415), but there was no MRL in GB 2763-2019. The next was procymidone, the detection rate of which was 35.42%(147/415), and the over-standard rate was 30.12%(125/415). Forbidden and restricted pesticides were detected in some samples. According to the dietary exposure risk assessment, the NEDI/ADI values were all less than 1 and the intake risk was within acceptable range. In Tangshan area, the types of pesticides used in Chinese chive production are complex, and there are risks of multi-residue pollution and use of banned and restricted pesticides and unregistered pesticides. It is suggested that routine monitoring of pesticide residues and management of pesticide use should be strengthened to ensure the quality and safety of agricultural products. [Conclusions] This study provides a theoretical basis for the safe production of Chinese chive and the standardized and rational use of pesticides. | Lei WANG Huihui LIU Shuo YANG Ying WANG Shuai WANG Haitao ZHAO Huifang YAO Yajing WANG Liang ZHANG Yancheng ZHOU Sining TANG Yanhua YAN | 2023 | Agricultural Biotechnology2023，12，1： | 1 |
| 19 | Cycling degradation of an automotive LiFePO4 lithium-ion battery 显示文摘 | Zhang Yancheng Wang Chaoyang Tang Xidong | 2011 | Journal of Power Sources2011，196，3： | 1 |
| 20 | FE-model for titanium alloy (Ti-6A1-4V) cutting based on the identification of limiting shear stress at tool-chip in- terface显示文摘 | ZHANG Yancheng TAREK Mabrouki DANIEL Nelias | 2011 | Int J Mater Form2011，，4： | 1 |
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