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| 1 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 2 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 3 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 4 | Distribution and their pollution assessment of heavy metals in the sediments of the Yalu River Estuary and its adjacent coastal waters显示文摘The present paper deals with the distribution patterns of heavy metals and the associated influencing factors in the Yalu River Estuary and its adjacent coastal waters.Based upon the analysis of the surficial and core sediments measurements,the pollution of heavy metal and potential ecological risk were evaluated.The burial flux and contents of heavy metals(except for copper) have been continuously increasing since the 1920s.Therefore,the gross potential ecological risk for the sedi-ments was high or very high,and the study area was endangered by heavy metals contamination.Heavy metals originated mainly from upstream pollutant input,correlation analysis showed that chromium,nickel,zinc,cadmium,lead,arsenic,and mercury in the sediments of the middle and west channels as well as the sea area of the western Yalu River Estuary concentrations were most probably derived from similar sources.In contrast,the metal of copper most probably originated from sources different from the other metals.Preliminary studies indicate that copper contamination was most likely the result of emission from mining activities situated at the upstream of the river.The contents of heavy metals in the sediments of estuarine turbidity maximum zone of Yalu River were larger than those of any other areas in the middle channel.With large portion of fine sediments,weaker hydrodynamics,and richer sources of heavy metals,the sediments of the west channel,were even more enriched with heavy metals than those of the middle channel. | GAO Jianhua LI Jun Wang Harry V WANG Yaping WANG Zhenyan BAI Fenglong GAO Shu CHENG Yan | 2009 | Acta Oceanologica Sinica2009，28，6： | 4 |
| 5 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 6 | Validation of Aura Microwave Limb Sounder water vapor and ozone profiles over the Tibetan Plateau and its adjacent region during boreal summer显示文摘We present validation studies of MLS V2.2 and V3.3 water vapor(WV) and ozone profiles over the Tibetan Plateau(Naqu and Lhasa) and its adjacent region(Tengchong) respectively by using the balloon-borne Cryogenic Frost point Hygrometer and Electrochemical Concentration Cell ozonesonde. Coincident in situ measurements were selected to compare the MLS V2.2 and V3.3 WV and ozone profiles for understanding the applicability of the two version MLS products over the region. MLS V2.2 and V3.3 WV profiles respectively show their differences within ?2.2±15.7%(n=74) and 0.3±14.9%(n=75) in the stratosphere at and above 82.5 h Pa. Accordingly, at 100 h Pa, the altitude approaching the tropopuase height, differences are within 9.8± 46.0%(n=18) and 23.0±45.8%(n=17), and they are within 21.5±90.6%(n=104) and 6.0±83.4%(n=99) in upper troposphere. The differences of MLS ozone are within ?11.7±16.3%(n=135, V2.2) and 15.6±24.2%(n=305, V3.3) at and above 82.5 h Pa. At 100 h Pa, they are within ?3.5±54.4%(n=27) and ?8.7±41.6%(n=38), and within 18.0±79.1%(n=47) and 34.2±76.6%(n=160) in the upper troposphere. The relative difference of MLS WV and ozone profile has significant oscillation and scatter at upper troposphere and lower stratosphere partly due to the stronger gradients of WV and ozone concentrations here as well the linear interpolation of sonde data for the intercomparison. At and below 70 h Pa, the relative differences of MLS ozone are significantly larger over Lhasa during the Tibetan Plateau 'ozone valley' season, which is also the Asian Summer Monsoon period. The MLS ozone differences over the three sites are similar in their vertical distributions during that period. A simple linear correlation analysis between MLS and sonde profiles indicates that the sensitivity of MLS profile products is related to concentrations at each pressure level. The MLS V3.3 product sensitivity is slightly improved for WV at and above 82.5 h Pa, whereas it is not obvious for ozone. The possible factors contributing to the differences of the MLS profile products of WV and ozone are discussed. | YAN XiaoLu ZHENG XiangDong ZHOU XiuJi Holger VMEL SONG JianYang LI Wei MA YongHong ZHANG Yong | 2015 | Science China Earth Sciences2015，58，4： | 4 |
| 7 | Ultra high magnification endoscopy: Is seeing really believing?显示文摘Endoscopy is an indispensible diagnostic and thera-peutic instrument for gastrointestinal diseases. Endo-cytoscopy and confocal endomicroscopy are two types of ultra high magnification endoscopy techniques.Standard endoscopy allows for 50 × magnification,whereas endocytoscopy can magnify up to 1400 × and confocal endomicroscopy can magnify up to 1000 ×.These methods open the realm of real time micros copicevaluation of the GI tract, including cellular and subcellular structures. Confocal endomicroscopy has the additional advantage of being able to visualize subsurface structures. The use of high magnification endoscopy inconjunction with standard endoscopy allows for a real-time microscopic assessment of areas with macroscopic abnormalities, providing 'virtual biopsies' with valuable information about cellular and subcellular changes. Thiscan minimize the number of biopsies taken at the time of endoscopy. The use of this technology may assistin detecting premalignant or malignant changes at anearlier state, allowing for earlier intervention and treatment. High magnification endoscopy has shown promising results in clinical trials for Barrett's esophagus,esophageal adenocarcinoma, esophageal squamous cell cancer, gastric cancer, celiac disease, colorectalcancer, and inflammatory bowel disease. As the use of high magnification endoscopy techniques increases,the clinical applications will increase as well. Of the two systems, only confocal endomicroscopy is currently commercially available. Like all new technologies there will be an initial learning curve before operators become proficient in obtaining high quality images and discerning abnormal from normal pathology. Validatedcriteria for the diagnosis of the various gastrointestinal diseases will need to be developed for each method. Inthis review, the basic principles of both modalities are discussed, along with their clinical applic ability and limitations. | Aman V Arya Brian M Yan | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，10： | 2 |
| 8 | Preparation and comparison of supported gold nanocatalysts on anatase, brookite, rutile, and P25 polymorphs of TiO2 for catalytic oxidation of CO 显示文摘 | Yan Wenfu Chen Bei Mahurin S M Schwartz V Mullins D R Lupini R Andrew Pennycook S J Dai Sheng Overbury S H | 2005 | Journal of Physical Chemistry B2005，109，10： | 1 |
| 9 | Beta-glucan,a specific biologic response modifier that uses antibodies to target tummors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18) 显示文摘 | Yan J VetvickA V Xia Y | 1999 | J Immunol1999，163，6： | 1 |
| 10 | Correlation between placental bacterial culture results and histological chorioamnionitis:a prospective study on 376 placentas 显示文摘 | Queiros da Mota V Prodhom G Yan P | 2013 | Clin Pathol2013，66，3： | 1 |
| 11 | Design,synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors显示文摘 | Yan A I Sergei V V Elena K B | 2015 | Bioorg Med Chem Lett2015，25，2： | 1 |
| 12 | EsxA might as a virulence factor induce antibodies in patients with Staphylococcus aureus infection 显示文摘 | Zhou HQ Du H Zhang HF Shen HY Yan RH He v Wang M Zhu X | 2013 | Braz J Microbiol2013，44，1： | 1 |
| 13 | The effect of out-of-plane motion on 2D and 3D digital image correlation measurements显示文摘 | Sutton M A Yan J H Tiwari V | 2009 | Optics and Lasers in Engineering2009，46，10： | 1 |
| 14 | Production of algae-based biodiesel using the continuous catalytic Mcgyan@ process显示文摘 | Krohn B J McNeffC V Yan B ctal | 2011 | Binresource Technology2011，102，1： | 1 |
| 15 | Differential ability to form the G Protein βγ complex among members of the β and γ subunit families显示文摘 | Yan K Kalyanaraman V Gautam N | 1996 | J Biol Chem1996，271，： | 1 |
| 16 | Simultaneous oxidation and reduction of arsenic by zero-valent iron nanoparticles: Understanding the significance of the core-shell structure显示文摘 | Ramos Mauricio A V Yan Weile Li Xiaoqin | 2009 | Journal of Physical Chemistry C2009，113，33： | 1 |
| 17 | The tribological performance and tribochemical analysis of novel borate esters as lubricant additives in rapeseedoil显示文摘 | YAN Jin-can ZENG Xiang-qiong HEIDE E V D REN Tian-hui | 2014 | Tribology International2014，71，： | 1 |
| 18 | The effect of out-of-plane motion on 2D and 3D digital image correlation measurement显示文摘 | SUTTON M A YAN J H TIWARI V | 2008 | Optics and Lasers in Engineering2008，46，10： | 1 |
| 19 | The electrochemical phenomena and kinetics of EDTA-copper wastewater reclamation by electrodeposition and uhrasound 显示文摘 | Chang J H Ellis A V Yan C T | 2009 | Separation and Purification Technology2009，68，2： | 1 |
| 20 | New Germanium Complexes Containing Ligands Based on 4,6-Di-tert- butyl-N-( 2, 6-diisopropylphenyl ) -o-iminobenzoquinone in Different Redox States 显示文摘 | Piskunov A V Aivaz' yan I A Poddel' sky A I | 2008 | Furopean Journal of Inorganic Chemistry2008，，： | 1 |
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