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| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 3 | A game theoretical model of DEA efficiency显示文摘 | G Hao QL Wei and H Yan | 2000 | Journal of the operational research society2000，51，11： | 1 |
| 4 | Development of a reverse transcription loop-mediated isothermal amplification assay for rapid detection of grass carp reovirus显示文摘 | Zhang QL Yan Y | 2013 | J Virol Methods2013，187，2： | 1 |
| 5 | Effect of adriamycin on BRCA1 and PARP-1 expression in MCF-7 breast cancer cells显示文摘 | Hui W Chang QL Yan T | 2014 | Int J Clin Exp Pathol2014，7，9： | 1 |
| 6 | A game theoretical model of DEA efficiency 显示文摘 | G Hao QL Wei H Yan | 2000 | Journal of the operational research society2000，51，11： | 1 |
| 7 | Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-delta显示文摘 | Yan ZC Liu DY Zhang LL Shen CY Ma QL Cao TB | | 0，，： | 1 |
| 8 | Primary cutaneous CD30-positive anaplastic large cell lymphoma analysis显示文摘 | Shi QL Zhou XJ Yan XW | 2002 | Chin Med J(Engl)2002，115，12： | 1 |
| 9 | Burial of canopy-stored seeds in the annual psammophyte Agriophyllum squarrosum (Chenopodiaceae) and its ecological significance显示文摘 | Liu ZM Yan QL Baskin CC | 2006 | Plant and Soil2006，288，： | 1 |
| 10 | The effect of crystal structure on the thermal reactivity of CL-20 and its C4 bonded ex- plosives (I): thermodynamic properties and decomposition kinetics显示文摘 | YAN QL ZEMAN S ELBEIH A | 2013 | J Therm Anal Calorim2013，112，2： | 1 |
| 11 | A Game Theoretical Model of DEA Efficiency显示文摘 | QL Wei and H Yan | 2000 | Journal of the Operational Research Society2000，51，11： | 1 |
| 12 | Coronary angiographicstudies of impaired glucose regulation and coronary arterydisease in Chinese nondiabetic subjects 显示文摘 | Yan QL Gu WQ Hong J | 2009 | Endocrine2009，36，3： | 1 |
| 13 | Roles of Ras and extracellular signal- regulated kinase- dependent IB degradation in oridonin- enhanced phagocytosis of apoptotic cells by human macrophage - like U937 ceils 显示文摘 | Yan QL Song Y Shinichi T | 2006 | Int J Immunopharmac2006，，6： | 1 |
| 14 | Survey of heavy metal pollution and assessment of agricultural soil in Yangzhong District, Jiangsu Province, China显示文摘 | Huang SS Liao QL Hua M Wu XM Bi KS Yan CY Chen B | 2007 | Chemosphere2007，67，11： | 1 |
| 15 | Effects of sodium fluoride treatment in vitro on cell proliferation, apoptosis and caspase-3 and caspase-9 mRNA expression by neonatal rat osteoblasts显示文摘 | Yan XY Feng CP Chen QL | 2009 | Arch Toxicol2009，83，5： | 1 |
| 16 | A game theoretical model of DEA efficiency 显示文摘 | G Hao QL Wei H Yan | 2000 | Journal of the operational research society2000，51，11： | 1 |
| 17 | Retraction显示文摘 | Witte ON Kabarowski JH Yan Xu Lu QL Zhu K | 2005 | Science2005，14，307： | 1 |
| 18 | Effects of Hyperbaric Oxygen on S-180 Sarcima in Mice显示文摘 | LIAN QL HANG RC YAN HF | 1995 | Undersea hyperbar Med(S1066-2936)1995，22，： | 1 |
| 19 | piRNA-823contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma显示文摘 | Yan H Wu QL Sun CY | 2015 | Leukemia2015，29，： | 1 |
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