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| 1 | Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression. | Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 2 | Electro-mechanical response of functionally graded beams with imperfectly integrated surface piezoelectric layers显示文摘The time-dependent behavior of a simply-supported functionally graded beam bonded with piezoelectric sensors and actuators is studied using the state-space method. The creep behavior of bonding adhesives between piezoelectric layers and beam is characterized by a Kelvin-Voigt viscoelastic model, which is practical in a high temperature circumstance. Both the host elastic functionally graded beam and the piezoelectric layers are orthotropic and in a state of plane stress, with the former being inhomogeneous along the thickness direction. A laminate model is employed to approximate the host beam. Moreover, the coupling effect between the elastic deformation and electric field in piezoelectric layers is considered. Results indicate that the viscoelastic property of interfacial adhesives has a significant effect on the function of bonded actuators and sensors with time elapsing. | YAN Wei1 & CHEN Weiqiu1,2 1. Department of Civil Engineering, Zhejiang University, Hangzhou 310027, China 2. State Key Lab of CAD & CG, Zhejiang University, Hangzhou 310027, China | 2006 | Science China(Physics,Mechanics & Astronomy)2006，49，5： | 4 |
| 3 | Cloning of environmental genomic fragments as physical markers for monitoring microbial populations in coking wastewater treatment system显示文摘 | Yan X Xu ZM Feng XX Liu YD Liu BB Zhang X J Zhu CG Zhao LP | 2007 | 中国生物学文摘2007，21，8： | 4 |
| 4 | Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor κB activation in mouse colonocytes显示文摘 | Kaiser CG Yan F Polk B | | 0，，： | 1 |
| 5 | DPARSF: A MATLAB Toolbox for 'Pipeline' Data Analysis of Resting-State fMRI 显示文摘 | YAN CG ZANG YF | 2010 | Front Syst Neurosci2010，4，： | 1 |
| 6 | Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein显示文摘 | Rogers CG Yan G Zha S | 2004 | J Urol2004，172，41： | 1 |
| 7 | Granger causality analysis implementation on MATLAB: a graphic user interface toolkit for fMRI data processing显示文摘 | Zang ZX Yan CG Dong ZY | 2012 | J Neurosci Methods2012，203，： | 1 |
| 8 | Addressing head motion dependencies for small-world topologies in functional connectomics显示文摘 | Yan CG Craddock RC He Y | 2013 | Front Hum Neurosci2013，7，： | 1 |
| 9 | Identification of synthetic peptides that inhibitlipopolysaccharide (LPS) binding to myeloid differentiationProtein-2 (MD-2)显示文摘 | Yan H Gu CG Xu FL Wu XH Yin HH Hu CX ZhuXD Liu F Ge HJ Chen LY Zhang XY Wang ZG XingZ Li L | 2013 | J Immunotherapy2013，36，3： | 1 |
| 10 | A comprehensive assessmett of regiottal variation i the impact of head micromovements on functional conneetomies显示文摘 | Yan CG Cheung B Kelly C | 2013 | Neuroimage2013，76，： | 1 |
| 11 | Granger causality analysis implementation on MATLAB:a graphic user interface toolkit for fMRI data processing显示文摘 | Zang ZX Yan CG Dong ZY | | 0，，： | 1 |
| 12 | Status of trace element emission in a coal combustion process:a review显示文摘 | Xu MH Yan R gheng CG | 2004 | Fuel Processing Technology2004，85，23： | 1 |
| 13 | DPARSF:A MATLAB Toolbox for 'Pipeline' Data Analysis of Resting-state fMRI 显示文摘 | Yan CG Zang YF | 2010 | Front Syst Neurosci2010，4，： | 1 |
| 14 | The autism brain imaging data exchange:Towards large-scaleevaluation of the intrinsic brain architecture in autism 显示文摘 | Di Martino A Yan CG Li Q | 2014 | Mol Psychiatry2014，19，6： | 1 |
| 15 | Physical structure and combustion properties of super fine pulverized coal particle显示文摘 | Jiang XM Zheng CG Yan C Liu DC Qiu JR Li JB | 2002 | Fuel2002，81，6： | 1 |
| 16 | A comprehensive assessment of regional variation in the impact of head micromovements on function- al connectomics显示文摘 | Yan CG Cheung B Kelly C | 2013 | Neuroimage2013，76，： | 1 |
| 17 | Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein显示文摘 | Rogers CG Yan G Zha S | 2004 | J Urol2004，172，4： | 1 |
| 18 | Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein显示文摘 | Rogers CG Yan G Zha S | 2004 | J Urol2004，172，4： | 1 |
| 19 | Standardizing the intrinsic brain: towards robust measurement of inter-individual variation in 1000 functional connectomes显示文摘 | Yan CG Craddock RC Zuo XN | 2013 | Neuroimage2013，80，： | 1 |
| 20 | The significance of platelet activation inrheumatoid arthritis 显示文摘 | WangF Wang NS Yan CG | 2007 | Clin Rheu- matol2007，26，5： | 1 |
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