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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells显示文摘 | Obata T Brown GE Yaffe MB | 1994 | Science1994，265，5173： | 1 |
| 3 | MAP kinase pathways activated by stress: the p38 MAPK pathway显示文摘 | Obata T Brown G E Yaffe M B | 2000 | Crit Cace Med2000，28，4： | 1 |
| 4 | MAP kinase pathways activated by stress:the p38 MAPK pathway显示文摘 | Obata T Brown GE Yaffe MB | 2000 | Crit Care Med2000，28，4： | 1 |
| 5 | Rela- tionship between baseline glyeemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: The action to control cardiovascular risk in diabetes- memory in diabetes(ACCORD- MIND) trial显示文摘 | Cukierman - Yaffe T Gerstein HC Williamson JD | 2009 | Diabetes Care2009，32，2： | 1 |
| 6 | International di- versification and performance: A study of global law firms显示文摘 | Brock D M Yaffe T Dembovsky M | 2006 | Journal of International Management2006，12，4： | 1 |
| 7 | Depressive symptoms and cognitive decline in nondementia elderly women 显示文摘 | Yaffe K Blackwell T Gore R | 1999 | Arch Gen Psychiatry1999，56，5： | 1 |
| 8 | Glycosylated hemoglo- bin level and development of mild cognitive impairment or de- mentia in older women显示文摘 | Yaffe K Blackwell T Whitmer RA | 2006 | J Nutr Health Aging2006，10，4： | 1 |
| 9 | MAP kinase pathways activated by stress: The p38 MAPK pathway显示文摘 | Obata T Brown GE Yaffe MB | 2000 | Crit Care Med2000，28，4： | 1 |
| 10 | MAP kinase pathways acti- vated by stress: the p38 MAPK pathway显示文摘 | Obata T Brown G E Yaffe M B | 2000 | Crit Care Med2000，28，4： | 1 |
| 11 | The Metabolic syndrome and development of cognitive impairment among older women显示文摘 | Yaffe K Weston AL Blackwell T | 2009 | Arch Neurol2009，66，3： | 1 |
| 12 | Diabetes, impaired fasting glucose, and development of cognitive impairment in older women显示文摘 | K Yaffe T Blackwell A M. Kanaya N Davidowitz E Barrett-Connor K Krueger | 2004 | Neurology2004，，4： | 1 |
| 13 | Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women显示文摘 | Yaffe K Blackwell T Whitmer RA | 2006 | J Nutr Health Aging2006，10，4： | 1 |
| 14 | MAP kinase pathways activated by stress: the p38 MAPK pathway 显示文摘 | Obata T Brown G E Yaffe M B | 2000 | Crit Care Med2000，28，4： | 1 |
| 15 | Diabetes impaired fasting glucose,and development of cognitive impairment in older women显示文摘 | Yaffe K Blackwell T Kanaya A | 2004 | Neurology2004，63，： | 1 |
| 16 | Diabetes,impaired fasting glucose, and development of cognitive impairment in older women 显示文摘 | Yaffe K Blackwell T Kanaya AM | 2004 | Neurology2004，63，4： | 1 |
| 17 | MAP kinase pathways activated by stress: the p38 MAPK pathway 显示文摘 | Obata T Brown GE Yaffe MB | 2000 | Crit Care Med2000，28，4： | 1 |
| 18 | MAP kinase path- ways activated by stress: the p38 MAPK pathway显示文摘 | Obata T Brown G E Yaffe M B | 2000 | Crit Care Med2000，28，4： | 1 |
| 19 | Diabetes, impaired fasting glucose, and development of cognitive impairment in older women 显示文摘 | Yaffe K Blackwell T Kanaya AM | 2004 | Neurology2004，63，4： | 1 |
| 20 | Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women显示文摘 | Yaffe K Blackwell T Whitmer RA | 2006 | J Nutr Health Aging2006，10，4： | 1 |
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