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| 1 | Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese显示文摘Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations. To investigate the contribution of the adiponectin genes and their receptors to T2DM, a case-control study was performed and 11 SNPs of ADIPOQ, ADIPOR1, and ADIPOR2 were genotyped in 985 T2DM and 1,050 control subjects. rs16861194 (-11426 A>G) in the putative promoter of ADIPOQ was associated with T2DM (P = 0.007; OR = 1.29, 95% CI 1.08-1.55). None of the other 10 SNPs were associated with T2DM in this study, although rs2241766 and rs1501299 were reported to be associated with T2DM in previous Chinese studies. There was also no significant difference found from the ADIPOQ haplotype analysis, which contains rs16861194. In addition, we also assessed potential gene-gene interactions in three genes and no interactions were found. In conclusion, our results supported the ADIPOQ gene as a possible risk factor for type 2 diabetes in Han Chinese population. | Yabing Wang Di Zhang Yun Liu Yifeng Yang Teng Zhao Jie Xu Sheng Li Zuofeng Zhang Guoyin Feng Lin He He Xu | 2009 | Journal of Genetics and Genomics2009，36，7： | 7 |
| 2 | Organic photovoltaic cell with 17% efficiency and superior processability显示文摘The development of organic photoactive materials,especially the newly emerging non-fullerene electron acceptors(NFAs),has enabled rapid progress in organic photovoltaic(OPV)cells in recent years.Although the power conversion efficiencies(PCEs)of the top-performance OPV cells have surpassed 16%,the devices are usually fabricated via a spin-coating method and are not suitable for large-area production.Here,we demonstrate that the fine-modification of the flexible side chains of NFAs can yield 17%PCE for OPV cells.More crucially,as the optimal NFA has a suitable solubility and thus a desirable morphology,the high efficiencies of spin-coated devices can be maintained when using scalable blade-coating processing technology.Our results suggest that optimization of the chemical structures of the OPV materials can improve device performance.This has great significance in larger-area production technologies that provide important scientific insights for the commercialization of OPV cells. | Yong Cui Huifeng Yao Ling Hong Tao Zhang Yabing Tang Baojun Lin Kaihu Xian Bowei Gao Cunbin An Pengqing Bi Wei Ma Jianhui Hou | 2020 | National Science Review2020，7，7： | 7 |
| 3 | miR-573 is a negative regulator in the pathogenesis of rheumatoid arthritis显示文摘风湿性关节炎(RA ) 是反常发炎, angiogenesis,和软骨破坏描绘的长期的自体免疫的疾病。我们的以前的学习在 RA 的 synovial 纸巾表明了包含 5 的 thioredoxin 领域(TXNDC5 ) 的增加的表情,并且它的 overexpression 在 RA 病理被含有。尽管 TXNDC5 变化被连接到基因危险性到 RA,它的反常表示的规定一直不是明确的。这里,我们证明 TXNDC5 被 microRNA (米尔) 直接指向接着, -573, 和 TXNDC5 调停 RA (RASF ) 的 synovial 成纤维细胞的侵略上的 miR-573 的镇压效果。miR-573 overexpression 压制了 interleukin 的表示 6 (IL-6 ) 并且 cyclooxygenase 2 在由响应 lipopolysaccharide (LPS ) 的激活的 THP-1 房间的肿瘤坏死 factor-alpha 和 interleukin-1 贝它的 RASF,以及生产刺激。而且,有有 miR-573 的 RASF transfected 的调节媒介的处理模仿禁止了人的脐的静脉 endothelial 房间(HUVEC ) 的 angiogenic 能力。笔记,表皮的生长因素受体和像使用费的受体, 2 作为 miR-573 的新直接目标被验证,并且调停象 HUVEC 的 angiogenesis 一样的 IL-6 生产上的 miR-573 的规定。另外,外长的 miR-573 表示压制了激活 mitogen 的蛋白质的激活 kinase (MAPK ) ,信号变换器和抄写 3 的使活跃之物,和在响应 LPS 的 RASF 的 phosphatidylinositol-3 kinase/activate 蛋白质 kinase B。确实, MAPK 发信号是必要的保证 miR-573 的功能。一起拿,我们的学习在 RA 的病理学的过程向 miR-573 的保护的角色指并且在 RA 的处理建议一个潜在的目标。 | Lin Wang Guanhua Song Yabing Zheng Dan Wang Hongyan Dong Jihong Pan Xiaotian Chang | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 4 | Registra- tion of images with affine geometric distortion based on maximally stable extremal regions and phase congruen- cy显示文摘 | ZHANG Qing WANG Yabing WANG Lin | 2015 | Image and Vision Computing2015，36，12： | 1 |
| 5 | A self-powered ultraviolet photodetector with van der Waals Schottky junction based on TiO_(2) nanorod arrays/Au-modulated V2CTx MXene显示文摘A self-powered ultraviolet photodetector(UV PD)with van der Waals(vdW)Schottky junction based on TiO_(2) nanorod arrays/Au-modulated V2 CTx MXene is reported.The Schottky junction enables the device to operate in self-powered mode.The dangling bond-free surface of V2 CTx MXene reduces the charge recombination at the junction interface.Meanwhile,V2 CTx MXene,with the work function(WF)increasing to 5.35 eV,forms a hole transport layer by contacting with Au electrode,which facilitates the carrier extraction.The electron lifetime in the device has prolonged to 8.95μs.As a result,the responsivity and detectivity of the PD have achieved 28 mA/W and 1.2×10^(11) cm Hz1/2/W(340 nm,65 mW/cm2,0 V),respectively.In addition,the presence of the Au electrode prevents the vanadium from coming into contact with oxygen and oxidizing,preserving the properties of the V2 CTx films.After 180 days of exposure to the atmosphere,the device performance remained at a particularly high level,indicating enhanced durability.This work points out an effective approach to modulate the properties of V2 CTx to obtain the high performance and stability of the UV PD. | Guangcan Luo Ziling Zhang Yabing Wang Qun Deng Shengtao Pan Tengfei Wang Qinghong Li Kaixiang Liu Pengfei Kong Jing Zhang Shengyun Luo Hong Lin | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
| 6 | Efficiency of community health centers in China during 2013-2015:A synchronic and diachronic study显示文摘Objective:We aimed to explore the efficiency of community health centers(CHCs)in China from 2013 to 2015,providing policy suggestions for optimizing the allocation of health resources.Methods:Data on the efficiency of CHCs in 30 provinces/autonomous regions/municipalities in China's Mainland(except Tibet)from 2013 to 2015 were collected from China’s Health and Family Planning Statistical Yearbook 2014,China’s Health and Family Planning Statistical Yearbook 2015,and China’s Health and Family Planning Statistical Yearbook 2016.Data envelopment analysis and Malmquist index analysis were performed to investigate the efficiency of sampled CHCs during this period at the national level and the regional level.The applied input indicators include the numbers of CHCs,community health workers,and beds,and the output indicators consist of the numbers of visits and inpatients,the occupancy rate of beds,and the average length of stay.Results:In 2015,the average annual overall technical efficiency,pure technical efficiency,and scale efficiency of CHCs in 30 regions at the national level were 0.715,0.705,and 0.972,respectively.Eight regions(Guangdong,Guizhou,Hainan,Ningxia,Qinghai,Shanghai,Zhejiang,and Chongqing,accounting for 26.7%of the total)had efficient CHCs with overall technical ef-ficiency of 1.000,and the other 22 regions had surpluses of 131 CHCs,5573 community health workers,and 2086 beds on average.In 2015,the average annual technical change index,pure technical efficiency change index,total factor productivity,technical efficiency change index,and scale efficiency change index of CHCs at the national level were 1.034,1.002,1.024,0.990,and 0.988,respectively.Compared with 2013,the former three increased by 3.4%,0.2%,and 2.4%,respectively,while the latter two decreased by 1.0%and 1.2%,respectively.Conclusion:On the whole,efficiency improvements of CHCs were achieved at the national level from 2013 to 2015,but with obvious interregional differences.In regions with inefficient CHCs identified by data envelopment analysis,there was a problem of coexistence of shortage and wastage of community health resources.In view of this,targeted measures should be taken to optimize the allocation of community health resources,and the management of CHCs should be strengthened to improve the efficiency of these institutions. | Lin Zhao Yao Zhang Yabing Hou Guiming Yan | 2018 | Family Medicine and Community Health2018，6，4： | 0 |
| 7 | Origin and geological control of desorbed gas in multi-thin coal seam in the Wujiu depression, Hailar Basin, China显示文摘To understand the natural gas characteristics of multi-thin coal seam,this study selected the desorbed gas of coal seams in different layers of Well A in the Wujiu depression,Hailar Basin in northeast Inner Mongolia.The results show that the heavy hydrocarbon content of desorbed gas increases significantly with the increasing depth.Methane carbon(δ13C_(1))and ethane carbon(δ13C_(2))isotope values are vertically become heavier downwards,while the δ13 values did not change significantly.The kerogen is close to the III–II mixed type with the source rocks mainly deposited in a shore/shallow lake or braided-river delta front,and the gas produced has certain characteristics of oil associated gas.However,the characteristics of oil associated gas produced by the organic formed in the shallow-water environment(braided-river delta plain)are not obvious.The sandstone pore and fracture systems interbedded with multi-thin coal seam are well developed.And it is conducive to the migration of methanogenic micro-organisms to coal seams via groundwater,making it easier to produce biogenic gas under this geological condition.During the burial evolution of coal-bearing strata in the study area,when the burial depth reaches the maximum,there are significant differences in the paleotemperature experienced by different vertical coal seams,caused by a high-paleogeothermal gradient,increasing the δ13C_(2) of desorbed gas with increasing depth.The above research indicates that there is less biogenic gas in the multi-thin coal seams with relatively developed mudstone,and the multi-thin coal seams with relatively developed sandstones have obvious biogenic gas characteristics.Therefore,for the exploration and development of biogenic gas in low-rank multi-thin coal seams,it is necessary to give priority to the layer with high sandstone content. | Geng LI Yong QIN Xuejuan SONG Boyang WANG Haipeng YAO Yabing LIN | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
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