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| 1 | From MONEX to the Global Monsoon:A Review of Monsoon System Research显示文摘Substantial progress has been made over the past three decades since the Monsoon Experiments(MONEX) of 1978–79. Here, we review these achievements by highlighting four breakthroughs in monsoon research:(1) The identification of the coupled ocean–land–atmosphere nature of the monsoon in the process of the annual cycle of solar heating;(2) new understanding of the changes in the driving forces of monsoon systems, with anthropogenic factors(climate effects of increased greenhouse gas and aerosol emissions) playing an important role in the regulation of monsoons;(3) detection of the interdecadal- and centennial-scale variability of monsoon systems, and its attribution to the combined impact of global warming and natural(especially oceanic) effects; and(4) the emerging concept of the global monsoon and its long-term variation under the impact of global climate change. All the observational and model-derived evidence demonstrates that the monsoon system, as an important component of the global climate system, has already changed and will continue to change in the future. This picture of an evolving monsoon system poses great challenges for near-term prediction and long-term projection. | DING Yihui LIU Yanju SONG Yafang ZHANG Jin | 2015 | Advances in Atmospheric Sciences2015，32，1： | 14 |
| 2 | Environmental and Dynamic Conditions for the Occurrence ofPersistent Haze Events in North China显示文摘This paper presents a concise summary of recent studies on the long-term variations of haze in NorthChina and on the environmental and dynamic conditions for severe persistent haze events. Resultsindicate that haze days have an obviously rising trend over the past 50 years in North China. Theoccurrence frequency of persistent haze events has a similar rising trend due to the continuous riseof winter temperatures, decrease of surface wind speeds, and aggravation of atmospheric stability. InNorth China, when severe persistent haze events occur, anomalous southwesterly winds prevail in thelower troposphere, providing sufficient moisture for the formation of haze. Moreover, North China ismainly controlled by a deep downdraft in the mid-lower troposphere, which contributes to reducing thethickness of the planetary boundary layer, obviously reducing the atmospheric capacity for pollutants.This atmospheric circulation and sinking motion provide favorable conditions for the formation andmaintenance of haze in North China. | Yihui Ding Ping Wu Yanju Liu Yafang Song | 2017 | Engineering2017，3，2： | 13 |
| 3 | Inter-decadal variations,causes and future projection of the Asian summer monsoon显示文摘The present paper presents a concise summary of our recent studies on the Asian summer monsoon,with highting decadal and inter- decadal scales. The studies on the long- term variations of the Asian summer monsoon and its impacts on the change in the summer precipitation in China are reviewed. Moreover,recent changes in the Asian summer monsoon and summer precipitation in East Asia(including Meiyu precipitation)are discussed. Finally,the future changes of the Asian summer monsoon are also pointed out in this paper. | Ding Yihui Si Dong Sun Ying Liu Yanju Song Yafang | 2014 | Engineering Sciences2014，12，2： | 8 |
| 4 | Daytime HONO formation in the suburban area of the megacity Beijing, China显示文摘Nitrous acid(HONO),as a primary precursor of OH radicals,has been considered one of the most important nitrogencontaining species in the atmosphere.Up to 30%of primary OH radical production is attributed to the photolysis of HONO.However,the major HONO formation mechanisms are still under discussion.During the Campaigns of Air Quality Research in Beijing and Surrounding Region(CAREBeijing2006)campaign,comprehensive measurements were carried out in the megacity Beijing,where the chemical budget of HONO was fully constrained.The average diurnal HONO concentration varied from 0.33 to 1.2 ppbv.The net OH production rate from HONO,POH(HONO)net,was on average(from 05:00 to 19:00)7.1×106 molecule/(cm3 s),2.7 times higher than from O3 photolysis.This production rate demonstrates the important role of HONO in the atmospheric chemistry of megacity Beijing.An unknown HONO source(Punknown)with an average of 7.3×106molecule/(cm3 s)was derived from the budget analysis during daytime.Punknown provided four times more HONO than the reaction of NO with OH did.The diurnal variation of Punknown showed an apparent photo-enhanced feature with a maximum around 12:00,which was consistent with previous studies at forest and rural sites.Laboratory studies proposed new mechanisms to recruit NO2 and J(NO2)in order to explain a photo-enhancement of of Punknown.In this study,these mechanisms were validated against the observation-constraint Punknown.The reaction of exited NO2 accounted for only 6%of Punknown,and Punknown poorly correlated with[NO2](R=0.26)and J(NO2)[NO2](R=0.35).These results challenged the role of NO2 as a major precursor of the missing HONO source. | YANG Qiang SU Hang LI Xin CHENG YaFang LU KeDing CHENG Peng GU JianWei GUO Song HU Min ZENG LiMin ZHU Tong ZHANG YuanHang | 2014 | Science China Chemistry2014，57，7： | 8 |
| 5 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 6 | Effects of Y and Ce on Microstructures and Properties of Nb-Si System Composites显示文摘The effects of yttrium and cerium on microstructures and properties of Nb-Si system composites were investigated by scanning electron microscopy( SEM), energy dispersive spectrum(EDS), X-ray diffraction(XRD) and high temperature oxidation experiments.It is found that the coarse primary silicide phase became finer and more homogeneous with Y and Ce addition.The results of high temperature oxidation experiments show that the oxidation rates of NbSi system composites with an appropriate amount of Y and Ce decrease compared with those of alloys without Y or Ce addition, and oxidation products mainly distribute along the phase boundaries between the Nb solid solution and silicide. | Qu Shiyu Han Yafang Song Jinxia Xiao Chengbo Song Liguo | 2004 | Journal of Rare Earths2004，22，z1： | 4 |
| 7 | Electroacupuncture relieves irritable bowel syndrome by increasing expression of nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6 in water-avoidance stress mice显示文摘OBJECTIVE: To investigate the effect of electroacupuncture(EA) on irritable bowel syndrome(IBS) in mice through regulating nucleotide-binding oligomerization domain protein-like receptor family pyrin domain containing 6(NLRP6).METHODS: Water-avoidance stress(WAS) mice model was used to investigate the effects and the mechanism of EA. Abdominal withdrawal reflex test, open field test, and intestinal motility test were used to evaluate visceral sensitivity, anxiety,and intestinal motility in mice. The expressions of NLRP6, Mucin-2(MUC2) and E-cadherin were determined using immunofluorescence and Western blotting assays.RESULTS: EA significantly upregulated the expression of NLRP6 in the intestine of mice. Moreover, EA increased the expressions of MUC2 and E-cadherin in WAS mice.CONCLUSION: Our study found that the relief of IBS symptoms by EA may involve the increase in the expression of NLRP6 in WAS mice. | Song Yafang Geng Hao Chen Lu Wu Xiaoliang Yuan Mengqian Xu Wanli Guo Jing Sun Jianhua Pei Lixia | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 3 |
| 8 | Advances in Research of Green Tea Polyphenols in Drug Development显示文摘This paper elaborated the chemical components,biological metabolism,and progress in the field of drug development of green tea polyphenols,mainly in the prevention and treatment of cancer,neurodegenerative diseases,and diabetes.The potential anti-tumor activity of tea polyphenols can be achieved through intervening in various stages of tumor generation,development,and metastasis.However,the development of tea polyphenols as a therapeutic drug still faces many challenges,such as low bioavailability.Nanoparticle-based drug delivery systems have particular advantages over the simple tea polyphenols.Since there are emerging safety issues and potential local drug overdose effects,it is necessary to determine the actual dosage and pharmacological mechanism of the drug after encapsulating the nanoparticles. | Mu ZHANG Erqin DAI Yafang ZHANG Yajun YU Xinqiang SONG | 2020 | Medicinal Plant2020，11，4： | 3 |
| 9 | Transcriptomic Response to Yersinia pestis:RIG-I Like Receptor Signaling Response Is Detrimental to the Host against Plague显示文摘Bacterial pathogens have evolved various mechanisms to modulate host immune responses for successful infection.In this study,RNAsequencing technology was used to analyze the responses of human monocytes THP1 to Yersinia pestis infection.Over 6000 genes were differentially expressed over the 12 h infection.Kinetic responses of pathogen recognition receptor signaling pathways,apoptosis,antigen processing,and presentation pathway and coagulation system were analyzed in detail.Among them,RIG-I-like receptor(RLR) signaling pathway,which was established for antiviral defense,was significantly affected.Mice lacking MAVS,the adaptor of the RLR signahng pathway,were less sensitive to infection and exhibited lower IFN-P production,higher Thl-type cytokines IFN-y and IL-12 production,and lower Th2-type cytokines EL-4 and IL-13 production in the serum compared with wild-type mice.Moreover,infection of pathogenic bacteria other than Y.pestis also altered the expression of the RLR pathway,suggesting that the response of RLR pathway to bacterial infection is a universal mechanism. | Zongmin Du Huiying Yang Yafang Tan Guang Tian Qingwen Zhang Yujun Cui Yanfeng Yan Xiaohong Wu Zuyun Chen Shiyang Cao Yujing Bi Yanping Han Xiaoyi Wang Yajun Song Ruifu Yan | 2014 | Journal of Genetics and Genomics2014，41，7： | 2 |
| 10 | Light-induced variation in environmentally persistent free radicals and the generation of reactive radical species in humic substances显示文摘Environmentally persistent free radicals(EPFRs)in humic substances play an essential role in soil geochemical processes.Light is known to induce EPFRs formation for dissolved organic matter in aquatic environments;however,the impacts of light irradiation on the variation of EPFRs in soil humic substances remain unclear.In this study,humic acid,fulvic acid,and humin were extracted from peat soil and then in situ irradiated using simulated sunlight.Electron paramagnetic resonance spectroscopy results showed that with the increasing irradiation time,the spin densities and g-factors of humic substances rapidly increased during the initial 20 min and then gradually reached a plateau.After irradiation for 2h,the maximum spin density levels were up to 1.63×10^17,2.06×10^17,and 1.77×10^×10^17 spins/g for the humic acid,fulvic acid,and humin,respectively.And the superoxide radicals increased to 1.05×10^l4-1.46×10^14spins/g while the alkyl radicals increased to 0.47×10^14-1.76×10^14 spins/g.The light-induced EPFRs were relatively unstable and readily returned back to their original state under dark and oxic conditions.Significant positive correlations were observed between the concentrations of EPFRs and reactive radical species(R2=0.65-0.98,/?<0.05),which suggested that the newly produced EPFRs contributed to the formation of reactive radical species.Our findings indicate that under the irradiation humic substances are likely to be more toxic and reactive in soil due to the formation of EPFRs. | Yafang Shi Yunchao Dai Ziwen Liu Xiaofeng Nie Song Zhao Chi Zhang Hanzhong Jia | 2020 | Frontiers of Environmental Science & Engineering2020，14，6： | 2 |
| 11 | Urea reactor integrity evaluation based on failure analysis显示文摘 | Song Mingda Wang Weiqiang Zhao Yafang | 2007 | Journal of Pressure Vessel Technology2007，129，4： | 1 |
| 12 | Electroacupuncture at Tianshu(ST25) and Zusanli(ST36) alleviates stress-induced irritable bowel syndrome in mice by modulating gut microbiota and corticotropin-releasing factor显示文摘OBJECTIVE: To investigate whether electroacupuncture(EA) at bilateral Tianshu(ST25) and Zusanli(ST36) acupoints could alleviate stress-induced irritable bowel syndrome(IBS) and evaluate its effect on gut microbiota and corticotropin-releasing factor(CRF). METHODS: Thirty C57BL/6 mice were randomly divided into the normal, water avoidance stress(WAS), and WAS+EA groups(10 mice per group). An experimental model of IBS was established by exposing the animals to WAS. The mice were treated with EA at the bilateral Tianshu(ST25) and Zusanli(ST36) acupoints. The abdominal withdrawal reflex test was conducted to evaluate visceral sensitivity in IBS. Gut microbiota was analyzed using 16S r RNA sequencing and analysis. The expression of CRF was determined using immuneofluorescence and quantitative real-time polymerase chain reaction. RESULTS: EA alleviated visceral hypersensitivity in a mouse model of WAS-induced IBS. It modulated the dysbiosis of gut microbiota induced by WAS. Moreover, it suppressed the WAS-induced overexpression of CRF in colon tissues. CONCLUSION: The findings of this study suggest that EA alleviated WAS-induced IBS via mechanisms possibly involving the modulation of the dysbiosis of gut microbiota and suppression of CRF expression. | SUN Mengzhu ZHANG Yujie SONG Yafang GUO Jing ZHAO Tingting WANG Yuhang PEI Lixia SUN Jianhua | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 1 |
| 13 | Effects of V and Al on Microstructure and Room Temperature Fracture Toughness of Nb-Si In-situ Composites显示文摘The effect of alloying elements V and Al on microstructure and room temperature fracture toughness of an experimental Nb-Si in-situ composite was investigated. The Nb-Si alloys with different amount of V and Al were prepared by non-consumable arc-melting furnace. The experimental results showed that with the addition of V and Al, the microstructure of the Nb-Si materials transformed from Nbss+Nb3Si to Nbss+Nb5Si3 and the lattice parameters of Nbss phase decreased, and the alloying element V promoted the formation of the finer Nbss structure. It was observed that the room temperature fracture toughness was improved by the addition of V and Al, and the optimum room-temperature fracture toughness of the material appeared in the alloy with 2.6at.%V and 3.6at.%Al. The improvement of room temperature fracture toughness may be mainly attributed to the increment of the volume fraction of Nbss phase and the decrement of the silicide phase size. | Kang Yongwang Qu Shiyu Song Jinxia Han Yafang | 2009 | 稀有金属材料与工程2009，38，A03： | 1 |
| 14 | Y ersinia protein kinase A phosphorylates vasodilator‐stimulated phosphoprotein to modify the host cytoskeleton显示文摘 | Yuehua Ke Yafang Tan Na Wei Fen Yang Huiying Yang Shiyang Cao Xiaohui Wang Jian Wang Yanping Han Yujing Bi Yujun Cui Yanfeng Yan Yajun Song Xiaoming Yang Zongmin Du Ruifu Yang | 2015 | Cell Microbiol2015，，： | 1 |
| 15 | Persistent free radicals in humin under redox conditions and their impact in transforming polycyclic aromatic hydrocarbons显示文摘The role of humic substance-associated persistent free radicals(PFRs)in the fate of organic contaminants under various redox conditions remains unknown.This study examined the characterization of original metal-free peat humin(HM),and HM treated with varying concentrations of H2O2 and L-ascorbic acid(VC)(assigned as H2O2-HM and VC-HM).The concentration of PFRs in HM increased with the addition of VC/H2O2 at concentrations less than 0.08 mol/L.The evolution of PFRs in HM under different environmental conditions(e.g.,oxic/anoxic and humidity)was investigated.Two types of PFRs were detected in HM:a relatively stable radical existed in the original sample,and the other type,which was generated by redox treatments,wa s relatively unstable.The spin densities of VC/H2O2-HM readily returned to the original value under relatively high humidity and oxic conditions.During this process,the HM-associated'unstable'free radicals released an electron to O2,inducing the formation of reactive oxygen species(ROS,i.e.,·OH and·O2-).Th e generated ROS promoted the degradation of polycyclic aromatic hydrocarbons based on the radical quenching measurements.The transformation rates followed the order naphthalene>phenanthrene>anthracene>benzo[a]pyrene.Our results provide valuable insight into the HM-induced transformation of organic contaminants under natural conditions. | Hanzhong Jia Yafang Shi Xiaofeng Nie Song Zhao Tiecheng Wang Virender K.Sharma | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 1 |
| 16 | COVID-19 in the immunocompromised population:data from renal allograft recipients throughout full cycle of the outbreak in Hubei province,China显示文摘Coronavirus disease 2019(COVID-19)is an infectious disease caused by a newly discovered coronavirus and has rapidly spread to most of the world and resulted in a global pandemic.However,there is a paucity of information available to characterize the immunodeficient population in the COVID-19 pandemic,especially information that focuses on patients after renal transplantation as the typical representative of this population. | Weijie Zhang Fei Han Xiongfei Wu Zhendi Wang Yanfeng Wang Xiaojun Guo Song Chen Tao Qiu Heng Li Yafang Tu Zibiao Zhong Jiannan He Bin Liu Hui Zhang Zhitao Cai Long Zhang Xia Lu Lan Zhu Dong Chen Jiangqiao Zhou Qiquan Sun Zhishui Chen | 2022 | Chinese Medical Journal2022，，2： | 1 |
| 17 | Microstructure and properties of refractory niobium-silicide-based composites显示文摘 | Qu Shiyu Han Yafang Song Liguo | 2005 | Materials Science Forum Vols2005，，： | 1 |
| 18 | Effect of Salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells显示文摘 | Zhigang Lv Yafang Song Dongying Xue Wenwei Zhang Yang Cheng Lieming Xu | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 19 | The Tianlai Cylinder Pathfinder array: System functions and basic performance analysis显示文摘The Tianlai Cylinder Pathfinder is a radio interferometer array designed to test techniques for 21 cm intensity mapping in the post-reionization Universe,with the ultimate aim of mapping the large scale structure and measuring cosmological parameters such as the dark energy equation of state.Each of its three parallel cylinder reflectors is oriented in the north-south direction,and the array has a large field of view.As the Earth rotates,the northern sky is observed by drift scanning.The array is located in Hongliuxia,a radio-quiet site in Xinjiang,and saw its first light in September 2016.In this first data analysis paper for the Tianlai cylinder array,we discuss the sub-system qualification tests,and present basic system performance obtained from preliminary analysis of the commissioning observations during 2016-2018.We show typical interferometric visibility data,from which we derive the actual beam profile in the east-west direction and the frequency band-pass response.We describe also the calibration process to determine the complex gains for the array elements,either using bright astronomical point sources,or an artificial on site calibrator source,and discuss the instrument response stability,crucial for transit interferometry.Based on this analysis,we find a system temperature of about 90 K,and we also estimate the sensitivity of the array. | JiXia Li ShiFan Zuo FengQuan Wu YouGang Wang JuYong Zhang ShiJie Sun YiDong Xu ZiJie Yu Reza Ansari YiChao Li Albert Stebbins Peter Timbie YanPing Cong JingChao Geng Jie Hao QiZhi Huang JianBin Li Rui Li DongHao Liu YingFeng Liu Tao Liu John PMarriner ChenHui Niu Ue-Li Pen Jeffery BPeterson HuLi Shi Lin Shu YaFang Song HaiJun Tian GuiSong Wang QunXiong Wang RongLi Wang WeiXia Wang Xin Wang KaiFeng Yu Jiao Zhang BoQin Zhu JiaLu Zhu XueLei Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，12： | 0 |
| 20 | Electroacupuncture alleviates water avoidance stress-induced irritable bowel syndrome in mice by improving intestinal barrier functions and suppressing the expression of inflammatory cytokines显示文摘OBJECTIVE:To evaluate the effects and related mechanisms of electroacupuncture(EA)on irritable bowel syndrome(IBS).METHODS:Male C57BL/6 mice were randomly allocated into normal,model,and EA groups.Experimental IBS mice models were established by exposure to water avoidance stress(WAS).Mice in the EA group were treated with EA at bilateral Tianshu(ST 25)and Zusanli(ST 36)for 7 consecutive days,15 min each day.Abdominal withdrawal reflex(AWR)tests and intestinal motility tests were performed to evaluate visceral sensitivity and intestinal motility of mice.Expression levels of tight junction proteins(TJPs)and inflammatory cytokines in colon tissues were determined through immunofluorescence,real-time polymerase chain reactions(PCR)and Western blot assays.RESULTS:EA alleviated visceral hypersensitivity and intestinal hypermotility in WAS-induced IBS mice.Moreover,EA promoted the expression of zonula occludens(ZO)-1,claudin-1,and occludin while suppressing the expression of interleukin(IL)-8,interferon(IFN)-γ,and tumor necrosis factor(TNF)-αin water avoidance stress(WAS)-induced irritable bowel syndrome(IBS)mice.CONCLUSION:EA alleviated WAS-induced IBS in mice by promoting intestinal barrier functions and suppressing the expression of inflammatory cytokines. | SUN Mengzhu ZHANG Yujie SONG Yafang GUO Jing WANG Yuhang XIN Chen GU Dongmei SUN Jianhua PEI Lixia | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 0 |
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