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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes显示文摘 | Wu CS Yu CL Wu CS | 2004 | Exp Dermatol2004，13，12： | 1 |
| 3 | The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats 显示文摘 | Keoqh CL Yu SP Wei L | 2007 | J Pharmacol Exp Ther2007，322，： | 1 |
| 4 | Osteoporosis and fractures after solid organ transplantation: a nationwide population-based cohort study 显示文摘 | Yu TM Lin CL Chang SN | 2014 | Mayo Clin Proc2014，89，7： | 1 |
| 5 | Protection of chickens against highly lethal H5N1 and H7N1 avian influenza viruses with a recombinant fowlpox virus co-expressing H5 hemagglutinin and NI neuraminidase genes 显示文摘 | Qiao CL Yu KZ Jiang YP | 2003 | Avian Pathol2003，32，1： | 1 |
| 6 | Embryonic apoptosis-inducing proteins exhibited anticancer activity in vitro and in vivo显示文摘 | Yu CL Tsai MH | 2001 | Anticancer Research2001，21，3： | 1 |
| 7 | Regulation of muscle fiber type and running endurance by PPARdelta显示文摘 | Wang YX Zhang CL Yu RT | 2005 | PLoS Biol2005，3，1： | 1 |
| 8 | Narrow-band ultraviolet-B stimu-lates proliferation and migration of cultured melanocytes显示文摘 | WU CS YU CL WU CS | 2004 | ExpDermatol2004，13，12： | 1 |
| 9 | Measuring quality of life of Chinese cancer patients, a validation of the Chinese ver- sion of the functional assessment of cancer therapy-general (FACT-G)scale显示文摘 | YU CL FIELDING R CHAN CL | 2000 | Cancer2000，88，7： | 1 |
| 10 | Targeting Src homology 2 do-main-containing tyrosine phosphatic (SHP-1) into lipid rafts inhibits CD3-induced T cell activation显示文摘 | Su MW Yu CL Burakoff SJ | 2001 | J Immunol2001，166，6： | 1 |
| 11 | 查看详情显示文摘 | Chen X B Liao H B Zhang C L Yu CL Pan W Hu L L Wu Z L | | 0，，： | 1 |
| 12 | TALEN mediated Nanog disruption r esults in less invasiveness, more chemosensitivity and reversal of EMT in Hela cells显示文摘 | Ding Y Yu AQ Li CL | 2014 | Oncotarget2014，5，18： | 1 |
| 13 | Acute graft versus host disease in non- myeloablative allogeneic stem cell transplantation 显示文摘 | Qiao JH Wang DH Yu CL | 2008 | Zhongguo Shi Yah Xue Ye Za Zhi2008，16，1： | 1 |
| 14 | Association of inflammation and oxidative stress with obstructive sleep apnea in ischemic stroke patients显示文摘 | Chen CY Chen CL Yu CC | 2015 | Sleep Med2015，16，1： | 1 |
| 15 | IL-18 gene promoter -137C/G and -607C/A polymorphisms in Chinese Han ehildren with type 1 diabetes mellitus显示文摘 | Dong GP Yu ZS Liang L Zou CC Fu JF Wang CL | 2007 | Int J Immu nogenet2007，34，2： | 1 |
| 16 | Measuring quality of life of Chinese cancer patients: A validation of the Chinese version of the Functional Assessment of Cancer Therapy-General ( FACT- G) scale 显示文摘 | Yu CL Fielding R Chan CL | 2000 | Cancer2000，88，7： | 1 |
| 17 | Regulation of Nrf2 signaling for cancer ehemoprevention : antioxidant coupled with anti-inflammatory显示文摘 | Hu R Saw CL Yu R | 2010 | Antioxid RedoxSignal2010，13，11： | 1 |
| 18 | Pre-B-eell colony-enhmlcing factor gene polymorphisms and risk of acute respiratory distress syndrome显示文摘 | Bajwa EK Yu CL Gong MN | 2007 | Crit Care Med2007，35，5： | 1 |
| 19 | Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes 显示文摘 | Wu CS Yu CL Wu CS | 2004 | Exp Dermatol2004，13，12： | 1 |
| 20 | Low-energy helium-neon laser irradiation stimulates interleukin-1 alpha and interleukin-8 release from cultured human keratinocytes显示文摘 | Yu HS Chang KL Yu CL | 1996 | J Invest Dermatol1996，107，4： | 1 |
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